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Topic: Hereditary spastic paraplegia


  
 eMedicine - Hereditary Spastic Paraplegia : Article by Nam-Jong Paik, MD, PhD
Spasticity is an increase in muscle tone with resulting stiffness.
Causes: Familial spastic paraplegia is a hereditary condition.
Because familial spastic paraplegia is a hereditary condition, no deterrence or prevention measures exist.
http://www.emedicine.com/pmr/topic45.htm

  
 UMHS News Release
For example, in autosomal dominant HSP families, there is a 50 percent risk that each child will develop this condition.
Fink and his colleagues also see the new gene as a key to understanding why people with HSP, spinal cord injuries, primary lateral sclerosis and amyotrophic lateral sclerosis (Lou Gehrig's disease) all experience a progressive degeneration of certain nerve fibers in their spinal cords.
Though an application of that knowledge toward treatment could be years away, it is this goal that drives the research, says Fink, an associate professor in the Department of Neurology of the U-M Medical School and a member of the Geriatrics Research, Education and Clinical Center at the Ann Arbor Veterans Affairs Medical Center.
http://www.med.umich.edu/opm/newspage/2001/hspgene.htm

  
 Hereditary spastic paraparesis: a review of new developments -- McDermott et al. 69 (2): 150 -- Journal of Neurology, ...
spinocerebellar pathways are preferentially affected in HSP, it
There are families with HSP who do seem to have involvement of the peripheral nerves.
in association with HSP, with chronic painless cutaneous ulcers
http://www.jnnp.com/cgi/content/full/69/2/150

  
 Geometry.Net - Health_Conditions: Familial Spastic Paralysis
Hereditary Spastic Paraplegia (HSP) refers to a group of degenerative spinal cord
Information about the spinal cord disorder known as Familial Spastic Paraparesis (FSP), also known as Hereditary Spastic Paraplegia (HSP) or StrumpellLorrain.
spastic congenital paraplegia, spastic spinal familial paralysis, hereditary spastic paraparesis, and familial spastic
http://www.988.com/health_conditions/familial_spastic_paralysis.php

  
 Paraplegia, Hereditary Spastic - Trustworthy, Physician-Reviewed Information from WebMD
Hereditary spastic paraplegia (HSP) is a group of inherited neurological disorders characterized by progressive weakness (paraplegia) and increased muscle tone and stiffness (spasticity) of leg muscles.
NORD recommends that affected individuals seek the advice or counsel of his or her own personal physician(s).
HSP is also sometimes referred to as familial spastic paraplegia (FSP) or Strumpell-Lorraine syndrome.
http://content.health.msn.com/hw/health_guide_atoz/nord398.asp

  
 Mutation analysis of the spastin gene (SPG4) in patients with hereditary spastic paraparesis -- Lindsey et al. 37 (10): ...
This patient has no affected relatives with HSP.
of lower limb spastic paraparesis were found in all affected subjects.
who was presumed from history to be affected with HSP, had a late
http://www.jmedgenet.com/cgi/content/full/37/10/759

  
 WE MOVE - Hereditary Spastic Paraplegia
WE MOVE makes every effort to present medical information that is up-to-date and accurate.
Editorial Review: Judith Blazer, MS Medical Review: Alberto Esquenazi, MD Our Mission
» Hereditary Spastic Paraplegia Information for Medical Professionals at MDVU
http://www.wemove.org/hsp

  
 Genetic Model For Devastating Form Of Paraplegia Suggests New Treatments
This result suggests that drugs that stabilize microtubule activity might provide a new approach for treating HSP.
This suggests that treatment of this common defect may be effective for many, perhaps most, HSP patients."
The organism that the researchers used in the study is the fruit fly, Drosophila melanogaster, the "lab rat" of genetics research.
http://www.sciencedaily.com/releases/2004/07/040719091207.htm

  
 Hereditary Spastic Paraplegia
(Strumpell-Lorrain Familial Spasmodic Paraplegia, Strumpell's Familial Paraplegia, Spasmodic Infantile Paraplegia, Spastic Congenital Paraplegia, Spastic Spinal Familial Paralysis)
Hereditary Spastic Paraplegia / Familial Spastic Paraparesis - web page: http://www.geocities.com/HotSprings/Spa/2847/
http://www.kumc.edu/gec/support/hsp.html

  
 Cellular Localization, Oligomerization, and Membrane Association of the Hereditary Spastic Paraplegia 3A (SPG3A) ...
Hereditary spastic paraplegias comprise a group of clinically
The abbreviations used are: HSPs, hereditary spastic paraplegias;
cord, and their dysfunction results in a spastic paraparesis,
http://www.jbc.org/cgi/content/full/278/49/49063

  
 Hereditary Spastic Paraplegia Home Page
This information is provided for individuals with HSP, their family members, health care providers, and other investigators.
My laboratory is committed to finding the causes and developing treatments for hereditary spastic paraplegia.
Working together, we can discover treatments to prevent, reverse, and retard the progression of this condition.
http://www.med.umich.edu/hsp

  
 HEALTHMEDNET ILLNESS AND DISEASE URL DIRECTORY
Hereditary Cancer Institute - Cancer Helpline [shc]            
Hereditary peroneal nerve dysfunction see Charcot-Marie-Tooth disease (hereditary)           
Hereditary Spastic Paraplegia (92 sites / 100 books)        
http://www.healthmednet.com/HERE-HIS.htm

  
 Arch Neurol -- Abstract: Subtle Cognitive Impairment but No Dementia in Patients With Spastin Mutations, August 2003, ...
hereditary spastic paraparesis is associated with the SPG4 locus,
Objective  To investigate cognitive function in 10 families
Background  The most frequent form of autosomal dominant
http://archneur.ama-assn.org/cgi/content/abstract/60/8/1113

  
 Further evidence of dementia in SPG4-linked autosomal dominant hereditary spastic paraplegia -- McMonagle et al. 62 ...
HSP patients and 1/11 controls ( p = 0.001).
lower for the 10 HSP patients (73.5/107) than for 10 control
Conclusion: This study indicates an active progression of cognitive
http://www.neurology.org/cgi/content/abstract/62/3/407

  
 MedlinePlus: Paralysis
Hereditary Spastic Paraplegia (National Institute of Neurological Disorders and Stroke) - Short Summary
http://www.nlm.nih.gov/medlineplus/paralysis.html

  
 SPF - Spastic Paraplegia Foundation Home Page
In very rare conditions, they can also cause mental retardation, dementia, epilepsy or other neurological problems.
The Spastic Paraplegia Foundation is a 100% volunteer-managed and operated organization devoted to finding the causes and cures for these devastating diseases and to providing critical information and support programs to people affected by them.
Please contact us to help support our vision of the day when all individuals with HSP or PLS are diagnosed, treated and cured.
http://www.sp-foundation.org/

  
 Open Directory - Health: Conditions and Diseases: Genetic Disorders: Hereditary Spastic Paraplegia
Open Directory - Health: Conditions and Diseases: Genetic Disorders: Hereditary Spastic Paraplegia
Top : Health : Conditions and Diseases : Genetic Disorders : Hereditary Spastic Paraplegia
Hereditary Spastic Paraplegia - In depth look at this disease by John K. Fink, M.D., including genetic analysis, clinical features and FAQs.
http://dmoz.org/Health/Conditions_and_Diseases/Genetic_Disorders/Hereditary_Spastic_Paraplegia

  
 GeneReviews: Hereditary Spastic Paraplegia Overview
Your browser does not support HTML frames so you must view Hereditary Spastic Paraplegia Overview in a slightly less readable form.
http://www.geneclinics.org/profiles/hsp

  
 [No title]
Abnormality of the urea cycle - hereditary; Urea cycle - hereditary abnormality Definition Return to top.
http://www.diseasedirectory.net/Genetic_Disorders/Urea_Cycle/default.aspx

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