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| | Hepatotoxicity is a Common Complication of HIV Antiretroviral Therapy |
 | | Hepatotoxicity is a Common Complication of HIV Antiretroviral Therapy | | | The results of this analysis were presented at Digestive Disease Week and indicate that hepatotoxicity is a common complication of HIV antiretroviral therapy. | | | To better define the incidence of antiretroviral-related hepatotoxicity, investigators performed a retrospective review of 21 adult AIDS clinical Trials Group (ACTG) studies, with a total patient enrollment of 9,003 patients. |
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http://www.hivandhepatitis.com/recent/lipo/052501.html
(393 words)
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| | Hepatotoxicity associated with protease inhibitor-based antiretroviral regimens with or without concurrent ritonavir |
| | The objective of this study was to determine the incidence of severe hepatotoxicity following the initiation of PI-based antiretroviral therapy with or without co-administration of RTV in an urban HIV clinic, and to define the role of chronic viral hepatitis in its development. | | | For example, we observed hepatotoxicity among approximately 16 and 13% of HCV-infected patients and 6.5 and 6% of HCV-uninfected patients to prescribed nelfinavir and lopinavir/RTV-based ART, respectively. | | | The outcome of PI-based HAART was analyzed in a heterogeneous cohort of patients receiving medical care from January 1996 to March 2003 in the Johns Hopkins Hospital HIV Clinic. |
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http://www.natap.org/2004/HIV/120804_03.htm
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| | Acetaminophen Hepatotoxicity -- Neurotransmitter.net |
| | Finally, our current understanding of the pathophysiology of experimental drug hepatotoxicity is examined, focusing on acetaminophen, particularly with respect to the role of the innate immune system and control of cell-death pathways, which might provide targets for exploration and identification of risk factors and mechanisms in humans. | | | Differential induction of heme oxygenase-1 in macrophages and hepatocytes during acetaminophen-induced hepatotoxicity in the rat: effects of hemin and biliverdin. | | | The primary outcome measure was development of hepatotoxicity, defined as a serum AST or alanine aminotransferase concentration >1000 IU/L. RESULTS: Twenty-seven patients were included in the study, 17 in the short-course group, 4 in the intermediate-course group, and 6 in the long-course group. |
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http://www.neurotransmitter.net/acetaminophen.html
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| | RFA-DK-02-033: HEPATOTOXICITY CLINICAL RESEARCH NETWORK |
| | Among the disciplines and expertise that may be appropriate for this program are gastroenterology, hepatology, internal medicine, pediatrics, epidemiology, toxicology, clinical pharmacology, public health and clinical database management. | | | This is a one-time solicitation to support a feasibility phase of a Hepatotoxicity Clinical Research Network for 3 years. | | | In the first year, DCC applicants should include all costs associated with the organization of all administrative aspects of the Hepatotoxicity Clinical Research Network to be developed. |
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http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-02-033.html
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| | USCAP 2003 Annual Meeting |
| | The purpose of this brief review is to focus on a mechanistic and practical approach to the problem of drug hepatotoxicity, in the context of clinical liver disease. | | | Recent research has focused on the role of the immune system in drug hepatotoxicity. | | | In practice, most instances of hepatotoxicity, mainly those associated with medications, are unpredictable, infrequent, and thus apparently sporadic. |
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http://www.uscap.org/site~/92nd/companion08h3.htm
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| | HIV and AIDS - Hepatotoxicity (Liver Disease) |
| | Therefore, it is not necessary to withhold NNRTI therapy from patients with chronic viral hepatitis. | | | Risk of Severe Hepatotoxicity Is Associated with Anti-HIV Therapy in the HIV-NAT Cohort, Thailand | | | Risk of Severe Hepatotoxicity Associated with Antiretroviral Therapy |
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http://hivandhepatitis.com/hiv_and_aids/hepatotoxicity/hepatotoxicity.html
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| | iHerb: HerbalGram The Journal of the American Botanical Council |
| | The purpose of the workshop was to review and discuss methods of assessing the hepatotoxicity of botanical dietary supplements with an emphasis on in vitro laboratory techniques that might be applied in screening for assessment and eventually, prediction of hepatotoxic potential. | | | The most problematic incidences of botanical-induced hepatotoxicity are those that represent “unpredictable” or idiosyncratic reactions. | | | However, one might envision development of a battery of tests based on the thorough characterization of known hepatotoxic botanicals and correlation to in vivo liver injury. |
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http://www.herbalgram.org/iherb/herbalgram/articleview.asp?a=2783&p=Y
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| | 724-T. Hepatotoxicity among a Cohort of Thai HIV-Infected Patients Enrolled in HIV-NAT Antiretroviral Therapy Trials |
| | Methods: Hepatotoxicity was examined within a cohort of Thai HIV-infected patients enrolled in 8 HIV-NAT randomized controlled trials. | | | Conclusions: Incidence of severe hepatotoxicity among Thai HIV-infected patients receiving antiretroviral therapy appears similar to other settings. | | | 724-T. Hepatotoxicity among a Cohort of Thai HIV-Infected Patients Enrolled in HIV-NAT Antiretroviral Therapy Trials |
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http://www.retroconference.org/2002/Abstract/12944.htm
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| | Severe hepatotoxicity uncommon with combination antiretroviral treatment |
| | The incidence of severe hepatotoxicity did not differ by treatment regimen or specific prescribed drug, the report indicates. | | | Massimo Puoti from Universita degli Studi in Brescia, Italy, and colleagues followed 755 HIV-positive patients who initiated ART during an 18-month period in an effort to define prospectively the incidence and factors associated with the occurrence of severe hepatotoxicity. | | | All but 1 of 26 patients with severe hepatotoxicity were reactive for anti-HCV and HCV RNA, the researchers note, and 5 patients also had HBsAg or anti-HDV IgM. |
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http://www.aidsmeds.com/news/20030404clin004.html
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| | A Review of Two Studies on Hepatotoxicity and HIV Antiretroviral Drugs |
| | Severe hepatotoxicity, defined as a grade 3 or 4 change in levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), evaluated before and during therapy. | | | There have been a number of reports about the first study authored by Mark Sulkowski, MD, from Johns Hopkins. | | | Although hepatotoxicity may be more common in persons with chronic viral hepatitis, these data do not support withholding protease inhibitor therapy from persons coinfected with hepatitis B or C virus. |
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http://www.natap.org/2000/june/a_review_of_two060500.htm
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| | AASLD: Severe Hepatotoxicity Rare in Patients With Elevated Liver Enzymes on Statin Therapy |
| | "The chance of severe hepatotoxicity is so rare I don't think it should prevent doctors from prescribing statin drugs to patients who are at risk of heart disease," said Dr. Naga Chalasani, associate professor of medicine at the Indiana University School of Medicine, Indianapolis, United States. | | | That difference achieves a non-significant p value of 0.2, Dr. Chalasani said. | | | But, according to new research, the risk of developing severe hepatotoxicity is the same for people with elevated liver enzymes at the start of therapy as it is for those who begin statin therapy with normal liver function tests. |
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http://www.pslgroup.com/dg/23d6d6.htm
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| | eMedicine - Halothane Hepatotoxicity : Article by Karl A Poterack, MD |
| | Type I hepatotoxicity is benign, self-limiting, and relatively common (up to 25-30% incidence). | | | Type I probably results from reductive (anaerobic) biotransformation of halothane rather than the normal oxidative pathway. | | | Type 1 hepatotoxicity is not characterized by jaundice or clinically evident hepatocellular disease. |
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http://www.emedicine.com/med/topic942.htm
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| | Progress in Transplantation: Hepatotoxicity of herbal remedies: an emerging dilemma |
| | The use of herbal remedies has gained widespread popularity in Western countries because of the public's perception that herbs are harmless because they come from natural sources and are effective in treating and preventing a variety of illnesses. | | | Isoniazid, an important drug in the fight against tuberculosis, offers a contrasting example of how a drug can be used safely despite its well-known hepatotoxicity. | | | Herbal remedies have been used for centuries for the treatment of various ailments such as anxiety, depression, and arthritis. |
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http://www.findarticles.com/p/articles/mi_qa4117/is_200406/ai_n9423693
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| | EFFECTS OF GLYCYRRHIZA DERIVATIVES AGAINST ACETAMINOPHEN-INDUCED HEPATOTOXICITY |
| | DGL and GAMHPH are observed to be more effective than HGL in protecting against acetaminophen-induced hepatotoxicity in rats. | | | Our results show that glycyrrhizin and its analogs are effective in decreasing acetaminophen-induced hepatotoxicity and probably act according to the above mentioned mechanism(s). | | | Therefore, we selected these derivatives to study their protective effects on an experimental model of acetaminophen-induced hepatotoxicity in rats. |
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http://www.sums.ac.ir/~ijms/9912/dehpour9912.html
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| | Alternative Medicine Review: Hepatotoxicity in acute iron poisoning - Abstract |
| | An understanding of the pathogenesis of the hepatotoxicity of acute iron poisoning is central to the identification of rational and effective interventions. | | | Alternative Medicine Review: Hepatotoxicity in acute iron poisoning - Abstract | | | Review of this literature and of experimental animal studies demonstrates that it occurs early in the clinical course and has a relatively high mortality. |
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http://www.findarticles.com/p/articles/mi_m0FDN/is_2_7/ai_85523011
(242 words)
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| | Hepatotoxicity - Wikipedia, the free encyclopedia |
| | This, together with its role as first filter of blood loaded with substances absorbed from the gut, makes hepatotoxicity one of the main concerns of pharmaceutical companies in their research for new drugs. | | | Idiosyncratic hepatotoxicity has led to the withdrawal of several drugs from market even after rigorous clinical testing as part of the FDA approval process (troglitazone, Rezulin®). | | | One of the main causes of drug-induced hepatotoxicity in western countries is acetaminophen (paracetamol) poisoning, which is a symptomatic hepatotoxin. |
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http://en.wikipedia.org/wiki/Hepatotoxicity
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| | Letter to State Boards of Pharmacy: Acetaminophen Hepatotoxicity and Nonsteroidal Anti-Inflammatory Drug ... |
| | This letter is intended to raise the awareness of pharmacists about the important educational role that they can play in preventing acetaminophen induced hepatotoxicity and NSAID-related gastrointestinal bleeding and renal toxicity in consumers using these medicines. | | | Should you have any questions regarding this communication, please contact Dr. Charles Ganley, Director, Division of Over-the Counter Drug Products, 301-827-2222. | | | The danger of hepatotoxicity in association with acetaminophen use has been well recognized. |
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http://www.fda.gov/cder/drug/analgesics/letter.htm
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| | Risks To Your Liver (hepatotoxicity) |
| | There have been a number of studies looking at the percentage of patients who develop hepatotoxicity, according to the different anti-HIV medications they are taking. | | | What's more, most clinical trials enroll patients who don't have other conditions that can further increase the risk of hepatotoxicity. | | | Overall, 6.2% of the clinical trial participants experienced severe hepatotoxicity. |
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http://www.aidsmeds.com/lessons/Hepatotoxicity4.htm
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| | Hotline - Reports of Leflunomide Hepatotoxicity in Patients with Rheumatoid Arthritis |
| | If leflunomide is discontinued for reasons of hepatotoxicity and a change to another hepatotoxic DMARD is contemplated, washout and monitoring procedures should be adhered to. | | | Both patients with cirrhosis had concomitant and/or previous methotrexate use, and one of them had pre-existing evidence of hepatitis and cirrhosis on methotrexate therapy. | | | Reports of Leflunomide Hepatotoxicity in Patients with Rheumatoid Arthritis |
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http://www.rheumatology.org/publications/hotline/0801leflunomide.asp
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| | News - Less Hepatotoxicity With Isoniazid Versus Pyrazinamide/Rifampin For Latent Tuberculosis |
| | Once the monitoring program was in place, there were no more instances of severe hepatotoxicity. | | | Thirteen percent of the pyrazinamide plus rifampin patients exhibited hepatotoxicity compared with 4% of the isoniazid patients. | | | Isoniazid therapy results in lower rates of hepatotoxicity compared with pyrazinamide plus rifampin for the treatment of latent tuberculosis. |
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http://docguide.com/news/content.nsf/news/8525697700573E1885256CB1000BD411
(416 words)
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| | eMedicine - Isoniazid Hepatotoxicity : Article by Richard A Weisiger, MD |
| | Lack of effective alternative drugs often requires that isoniazid be continued despite low-grade hepatotoxicity. | | | Patients who are affected often are taking other potentially hepatotoxic drugs, such as pyrazinamide or protease inhibitors, making it difficult to determine which drug is causing the liver damage. | | | While the most common presentation of isoniazid hepatotoxicity is hepatocellular damage, patients occasionally may present with true drug hypersensitivity characterized by skin rash, fever, and eosinophilia. |
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http://www.emedicine.com/med/topic1193.htm
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| | Signs and symptoms of hepatotoxicity - a drug user's primer - DrugIntel |
| | Charles M. Nolan, MD; Stefan V. Goldberg, MD; Susan E. Buskin, PhD; Hepatotoxicity Associated With Isoniazid Preventive Therapy - | | | Signs and symptoms of hepatotoxicity - a drug user's primer - DrugIntel | | | Initially hepatotoxicity may be marked by acute gastrointestinal symptoms, including severe diarrhea. |
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http://www.drugintel.com/drugs/ti/liver/liver_damage.htm
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| | Accutane News - Liver Damage - Hepatotoxicity - Hepatitis |
| | Before you decide, ask us to send you free written information about our qualifications and experience. | | | Have you or a member of your family developed a serious medical condition such as: | | | One could only imagine about how many serious Adverse Side Effects there are from taking Accutane, that have never been reported to anyone! |
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http://www.accutanenews.com/liver_damage.html
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| | Letters: Skin Cap Hepatotoxicity |
| | Against the background of pre-existing alcohol intake in this patient, it is possible that the additional alcohol content of Skin Cap may have directly precipated pustular psoriasis and hepatotoxicity in this patient. | | | This case report describes a patient in whom the use of Skin Cap spray for treatment of stable plaque-type psoriasis vulgaris was associated with pustular psoriasis and hepatotoxicity. | | | The temporal association of Skin Cap use and development of pustular psoriasis along with symptoms and laboratory evidence of hepatotoxicity suggest a probable linkage in these events. |
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http://dermatology.cdlib.org/DOJvol3num2/editorials/hepatotoxicity.html
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| | Infliximab (Remicade) associated with hepatotoxicity |
| | These cases occurred as soon as 2 weeks following infliximab administration and also in patients receiving therapy for over one year. | | | Infliximab (Remicade) has been associated with hepatotoxicity including cholestasis, hepatitis, jaundice, and liver failure. |
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http://uuhsc.utah.edu/pharmacy/alerts/1.html
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| | Hepatotoxicity |
| | This test aids in the differential diagnosis of hepatotoxicity and is specifically indicated to rule out autoimmune liver conditions, unknown origin/non-specific autoimmune or autoimmune caused by Hepatitis C. Conditions Assessed | | | If antibodies to Cytochrome P-450 and/or Hepatitis C are present it may be indicative of an auto-immune process occurring. | | | Conditions that may be assessed include liver toxicity, autoimmune liver disease, and Hepatitis C. Logical Sequence of Testing |
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http://www.biodia.com/test375.html
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| | Click here now! bodybuilding supplements. |
| | to claim how irresponsible the industry is in offering compounds this potent, with potential for hepatotoxicity, and which are so easy to obtain and |
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http://www.weight-gain.org/anabolicsteroids/72_bodybuilding_supplements.html
(445 words)
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