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Topic: Hepatic steatosis



  
 New CDC HIV Prevention Funding Emphasizes Effectiveness, Focuses on Those Already Infected
To test the association of steatosis with parameters related to activity and stage of CHC, univariate analysis was used to assess 12 clinical and biochemical parameters.
Interestingly, we also found that BMI ≥25 kg/m2 was associated with any grade of steatosis, indicating that being overweight/obese may not affect grade of steatosis in these patients.
To further examine the pathogenic role of steatosis on CHC progression, the same univariate analysis was also performed to compare patients lacking steatosis to those with grade II/III steatosis.
http://www.natap.org/2003/dec/122903_9.htm

  
 Prevalence of hepatic steatosis (fatty liver) in an urban population in the United States: Impact of ethnicity
This is the largest study to date to use 1H-MRS, a highly sensitive and quantitative technique, to determine the prevalence of hepatic steatosis in a population-based sample.
Previous studies of NAFLD in the general population have relied on qualitative or semiquantitative techniques to assess hepatic fat content.
Why only a subset of at-risk individuals develop steatosis and a smaller fraction ultimately develop steatohepatitis remains unclear.
http://www.natap.org/2004/HCV/121304_03.htm

  
 The Turkish Journal of Gastroenterology
Forty six of the patients complained of a blunt pain in the right upper quadrant of the abdomen and were referred to Department of Gastroenterology, Çukurova university with suspected cholelithiasis.
The new sonographic grading system was found to be valuable, but it needs to be further investigated in large patient populations.
Following ultrasonographic evaluation, a complete physical examination, past medical history and informed consent was taken from the patients in this study.
http://www.turkgastro.org/text.php?id=202

  
 Alcohol Research Center - Steatosis (fatty liver disease) - Louisiana State University Health Sciences Center New ...
One potential explanation for this lack of association may be the exclusion of...
Mechanisms of liver steatosis in rats with systemic carnitine
and Alcoholic and Non Alcoholic Steatosis - 5/11/05 Association...
http://alcoholresearch.lsuhsc.edu/effects/steatosis.asp

  
 Hepatitis Central, Hepatic Steatosis: Innocent Bystander or Guilty
This information provides a basis for evaluating the prognosis of patients with steatosis and a rationale for their management.
Experimental studies in both human beings and animal models have at last begun to unravel the pathogenic mechanisms responsible for disease progression.
Information at this website is for educational purposes only; statements about products and health conditions have not been evaluated by the U.S. Food and Drug Administration.
http://hepatitis-central.com/hcv/liver/hepatic/steatosis.html

  
 MVI Newsflash: Hepatic Cholestasis In Patients Receiving Chronic PN
Since the number of septic episodes is associated with hepatic complications of PN, adherence to a rigid protocol of catheter care would be beneficial.
Patients on long-term PN with severe malabsorption should be considered for intravenous choline supplementation; however, this product is not commercially available yet so patients would have to be enrolled in a clinical trial where they could receive a sterile product.
In the last decade, there has been a major emphasis on feeding fewer calories to patients receiving PN.
http://www.imakenews.com/mvius/e_article000183277.cfm

  
 Evaluation of abnormal liver function tests -- Limdi and Hyde 79 (932): 307 -- Postgraduate Medical Journal
Hepatic ALP is present on the canalicular and luminal domain
Hepatic infiltration such as metastatic or even primary hepatocellular
A reliable history is helpful; in reality this can be difficult.
http://pmj.bmjjournals.com/cgi/content/full/79/932/307

  
 Concurrent exercise prevents high-fat-diet-induced macrovesicular hepatic steatosis -- Gauthier et al. 94 (6): 2127 -- ...
hepatic steatosis in rats and the extent to which exercise training
steatosis by exercise training occurs mainly by preventing the
The major finding of the present study is that, when an exercise training program is pursued at the same time as the HF diet,
http://jap.physiology.org/cgi/content/full/94/6/2127

  
 Hepatitis Neighborhood : Green Tea Ingredient Might Block Fatty Liver: Study
"Liver steatosis is now a primary factor in determining the usability of potential organs," wrote lead study author Kenneth Chavin, MD, PhD, in the division of Transplant Surgery and department of Microbiology and Immunology at the Medical University of South Carolina.
In this study, doctors only looked at hepatic steatosis, the more benign condition.
Hepatic steatosis is a condition in which fat accumulates in the cells that make up the
http://www.hepatitisneighborhood.com/content/in_the_news/archive_2263.aspx

  
 Weighty issues in hepatitis C -- Heathcote 51 (1): 7 -- Gut
the degree of steatosis and fibrosis correlates well with body
There is another study from Japan which also combined
In this current study, even those individuals with genotype
http://gut.bmjjournals.com/cgi/content/full/51/1/7

  
 Liver Issues (Steatosis) - HCV News Articles
Effect of Significant Histologic Steatosis or Steatohepatitis on Response to Antiviral Therapy in Patients with Chronic Hepatitis C
Steatosis and Fibrosis in Patients with Chronic Hepatitis C
Steatosis Does Not Affect the Result of Antiviral Treatment in HCV Patients with Genotype 3
http://www.hivandhepatitis.com/hep_c/hepc_news_liver_steatosis.html

  
 Cirrhosis
"Hepatic Steatosis in Patients Undergoing Bariatric Surgery and Its Relationship to Body Mass Index and Co-Morbidities." Obesity Surgery 13 (August 2003): 622-624.
taking precautions (practicing safe sex, avoiding dirty needles) to prevent hepatitis
Interferon medicines may be used by patients with chronic hepatitis B and hepatitis C to prevent post-hepatic cirrhosis.
http://www.healthatoz.com/healthatoz/Atoz/ency/cirrhosis.jsp

  
 Prevalence of Hepatic Steatosis After Islet Transplantation and Its Relation to Graft Function -- Bhargava et al. 53 ...
Steatosis was observed on MRI in six (20%) subjects.
steatosis may be associated with insulin resistance or graft
subjects with steatosis (0.98 ± 0.12 vs. 0.70 ±
http://diabetes.diabetesjournals.org/cgi/content/abstract/53/5/1311

  
 JPMA :::
However, imaging techniques cannot distinguish between benign steatosis and steatohepatitis.
Hepatic steatosis is increasingly being recognized as a condition that may progress to end-stage liver disease.
Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection.
http://jpma.org.pk/JPMA/3Mar04/fulltext1.htm

  
 Ruth Lilly Medical Library
However, there existed no relationship between hepatic TG content and the steatosis grade as assessed by any of the pathologists (see figure below).
of Medicine; IN Background: Excessive accumulation of triglyceride (TG) in the hepatocytes leads to macrovesicular steatosis and in some patients it is associated with steatohepatitis and cirrhosis.
Aim: To examine if the degree of hepatic steatosis as graded by pathologists correlates with the hepatic TG content in human liver tissue.
http://www.medlib.iupui.edu/faculty/scs2004/P1152004.html

  
 Prevalence of nonalcoholic fatty liver disease varies by ethnicity
They also found further evidence that a normal serum ALT level offers little diagnostic or prognostic value when assessing patients for NAFLD.
In conclusion, the authors report, "Understanding the mechanisms responsible for the ethnic differences in the prevalence of hepatic steatosis and steatosis-related liver injury may provide clues to the development of new therapeutic approaches for the prevention and treatment of this disorder."
Limitations of this study include possible underestimation of alcohol intake, since this was self-reported by the patients in the study.
http://www.medicalnewstoday.com/medicalnews.php?newsid=17458

  
 Simple FactSheet: Lactic Acidosis and Hepatic Steatosis
More research is needed to confirm these findings and work out how best to treat the problem.
There is no proven treatment for lactic acidosis other than stopping the NRTI drugs as quickly as possible.
The liver can also become enlarged, a condition which doctors call hepatomegaly.
http://www.atdn.org/simple/lactic.html

  
 Liver Peroxisome Proliferator-activated Receptor {gamma} Contributes to Hepatic Steatosis, Triglyceride Clearance, and ...
a role for SREBP-1 in development of the steatosis (53, 54).
Improvement in hepatic steatosis has also been achieved in the
The aim of this study is to understand the role of liver PPAR
http://www.jbc.org/cgi/content/full/278/36/34268

  
 Reversal of Nonalcoholic Hepatic Steatosis, Hepatic Insulin Resistance, and Hyperglycemia by Moderate Weight Reduction ...
The meal was consumed over 15 min, and the patients then
These changes in hepatic sensitivity were associated with an
steatosis, were reversed by treating the rats with a low dose
http://diabetes.diabetesjournals.org/cgi/content/full/54/3/603

  
 Liver Volume and Visceral Obesity in Women with Hepatic Steatosis Undergoing Gastric Banding -- Busetto et al. 10 (5): ...
Both this leptin-induced reduction and the direct surgical
hepatic steatosis with high sensitivity and specificity (5).
In this study, the diagnosis of hepatic steatosis was simply
http://www.obesityresearch.org/cgi/content/full/10/5/408

  
 Hepatic Hyperplasia in Noncirrhotic Fatty Livers: Is Obesity-related Hepatic Steatosis a Premalignant Condition? -- ...
Articles by Yang, S. Articles by Diehl, A. Cancer Research
Hepatic Hyperplasia in Noncirrhotic Fatty Livers: Is Obesity-related Hepatic Steatosis a Premalignant Condition?
present in most NAFLD patients with hepatic steatosis (64),
http://cancerres.aacrjournals.org/cgi/content/full/61/13/5016

  
 Hepatitis C Outreach Project
The implications of this study are that liver biopsy may be avoided in subjects with a normal BMI and absence of other comorbid conditions.
In all patients with steatosis on imaging studies, steatosis was confirmed by liver biopsy.
No patient with a BMI less than 25 had hepatic steatosis.
http://www.hcop.org/hcvinfo/articles/index.cfm?articleid=198

  
 Molecular mediators of hepatic steatosis and liver injury -- Browning and Horton 114 (2): 147 -- Journal of Clinical ...
Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis.
Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes.
Molecular mediators of hepatic steatosis and liver injury
http://www.jci.org/cgi/content/full/114/2/147

  
 Clinical Care Options for Hepatitis - Hepatic Steatosis Associated With More Advanced Fibrosis in HCV/HIV-coinfected ...
Hepatic Steatosis Associated With More Advanced Fibrosis in HCV/HIV-coinfected Patients
Histologic findings and clinical characteristics associated with steatosis in HIV/HCV co-infected patients.
Use of antiretroviral therapies (duration or type) not associated with steatosis grade
http://clinicalcareoptions.com/hep/conf/aasld2004/cs/675.asp

  
 Non-alcoholic steatohepatitis and hepatic steatosis in patients with adult onset growth hormone deficiency -- Ichikawa ...
None of the patients was positive for hepatitis
relationship of GH deficiency to hepatic steatosis and NASH
showed hepatic steatosis (53.8%) while in five patients without
http://gut.bmjjournals.com/cgi/content/full/52/6/914

  
 The Healing Power of Herbs
The therapeutic effect of silymarin in these disorders is described below, along with a discussion on a new form of silymarin (phosphatidylcholine-bound silymarin) and its clinical effects.
It is effective in both acute and chronic viral hepatitis.
In one of the first extensive double-blind clinical trials investigating silymarin's therapeutic effect in liver disorders, silymarin demonstrated impressive results in 129 patients with toxic metabolic liver damage, fatty degeneration of the liver of various origins, or chronic hepatitis, as compared with a control group composed of fifty-six patients.
http://www.liversupport.com/info3.htm

  
 Does High Body Mass Index Affect Hepatic Fibrosis, Steatosis and Inflammation in Patients with Chronic Hepatitis C? -- ...
The aim of this study is to assess the potential association between body mass index and stage of hepatic fibrosis in HCV patients.
In summary, higher BMI values were associated with more severe hepatic fibrosis in patients with chronic HCV infection.
> >The aim of this study is to assess the potential >association between body mass index and stage of >hepatic fibrosis in HCV patients.
http://www.voy.com/17059/345.html

  
 Altered expression of fatty acid-metabolizing enzymes in aromatase-deficient mice -- Nemoto et al. 105 (12): 1819 -- ...
Hepatic steatosis is a frequent complication in nonobese patients
Effects of Tamoxifen on Hepatic Fat Content and the Development of Hepatic Steatosis in Patients with Breast Cancer: High Frequency of Involvement and Rapid Reversal After Completion of Tamoxifen Therapy
receptor-signaling pathways in the control of constitutive hepatic
http://www.jci.org/cgi/content/full/105/12/1819

  
 Diabetes Care: Hypoadiponectinemia is closely associated with nonalcoholic hepatic steatosis in obese subjects
Hypoadiponectinemia is closely associated with nonalcoholic hepatic steatosis in obese subjects
Diabetes Care: Hypoadiponectinemia is closely associated with nonalcoholic hepatic steatosis in obese subjects
Thus, these results show that hypoadiponectinemia is closely associated with nonalcoholic hepatic steatosis in obese healthy individuals, thus suggesting that hypoadiponectinemia might be, at least partly, responsible for hepatic steatosis and liver test abnormalities found in these subjects.
http://www.findarticles.com/p/articles/mi_m0CUH/is_8_27/ai_n6151741

  
 Lactic acidosis and hepatic steatosis associated with use of stavudine: report of four cases.
CONCLUSION: Because hepatic steatosis may be life-threatening, physicians should consider it as a possible cause of elevated hepatic aminotransferase levels among patients taking stavudine.
MEASUREMENTS: Levels of lactic acid, alanine aminotransferase, aspartate aminotransferase, amylase, and lipase; computed tomography of the abdomen; liver biopsy (two patients); and muscle biopsy (two patients).
OBJECTIVE: To describe the syndrome of hepatic steatosis, lactic acidosis, and myopathy in four patients taking stavudine.
http://www.aegis.com/aidsline/2000/oct/A00A0852.html

  
 Lecithin increases plasma free choline and decreases hepatic steatosis in long-
It was concluded that hepatic steatosis in many patients receiving long term TPN is caused by plasma-free choline deficiency and may be reversed with lecithin supplementation.
Nonsignificant changes were seen in the placebo group.
In a group of 15 patients receiving home TPN who had low plasma free choline levels (6.3 +/- 0.8 mmol/L), we found 50% had hepatic steatosis.
http://www.hankintatukku.com/medlineLecithin-1.html

  
 Nutrition Research Newsletter: Liver volume visceral obesity in women with hepatic steatosis undergoing gastric banding ...
The patients were evaluated with a total-body multislices MRI scan immediately before and 8 and 24 weeks after surgery.
In the present study, the relationship between visceral obesity and hepatic steatosis was investigated in a small group of morbidly obese women treated by means of adjustable silicone gastric banding with the LAP-BAND.
All patients had an ultrasonographic diagnosis of mild liver steatosis according to standardized criteria.
http://www.findarticles.com/p/articles/mi_m0887/is_6_21/ai_87852144

  
 FindArticles search for "Liver diseases / Causes of"
Nonalcoholic fatty liver is defined as hepatic steatosis in the absence of alcohol use or another chronic liver disease.
Hepatitis C virus (HCV) infection frequently causes chronic hepatitis, which is linked to the development of liver cirrhosis and hepatocellular carcinoma.
These include side effects of drugs and medical herbs, autoimmune hepatitis, hemochomatos
http://www.findarticles.com/p/search?tb=art&qt=Liver+diseases+/+Causes+of

  
 Fatty liver
Also called steatosis, fatty liver can be a temporary or long-term condition, which is not harmful itself, but may indicate some other type of problem.
Left untreated, it can contribute to other illnesses.
"Hepatic Steatosis (Fatty Liver) and Steatohepatitis." Harrison's Principles of Internal Medicine 14th Edition, Volume 2, New York, NY: McGraw-Hill, 1998.
http://www.chclibrary.org/micromed/00048080.html

  
 Dietary Oligofructose Lessens Hepatic Steatosis, but Does Not Prevent Hypertriglyceridemia in Obese Zucker Rats -- ...
Dietary Oligofructose Lessens Hepatic Steatosis, but Does Not Prevent Hypertriglyceridemia in Obese Zucker Rats
in the development of liver disorders (steatosis and steatohepatitis)
Dietary Oligofructose Lessens Hepatic Steatosis, but Does Not Prevent Hypertriglyceridemia in Obese Zucker Rats -- Daubioul et al.
http://www.nutrition.org/cgi/content/full/130/5/1314

  
 Mice Lacking Phosphatidylinositol Transfer Protein-{alpha} Exhibit Spinocerebellar Degeneration, Intestinal and Hepatic ...
Exhibit Spinocerebellar Degeneration, Intestinal and Hepatic Steatosis, and Hypoglycemia
The intestinal and hepatic steatosis results from the intracellular
Mice Lacking Phosphatidylinositol Transfer Protein-{alpha} Exhibit Spinocerebellar Degeneration, Intestinal and Hepatic Steatosis, and Hypoglycemia -- Alb et al.
http://www.jbc.org/cgi/content/full/278/35/33501

  
 Neonatal hepatic steatosis by disruption of the adenosine kinase gene.
Neonatal hepatic steatosis (OMIM 228100) is a fatal condition of unknown etiology characterized by a pale and yellow liver and early postnatal mortality.
Adenine nucleotides were decreased and S-adenosylhomocysteine, a potent inhibitor of transmethylation reactions, was increased in the mutant liver.
Thus, a deficiency in adenosine metabolism is identified as a powerful contributor to the development of neonatal hepatic steatosis, providing a model for the rapid development of postnatally lethal fatty liver.
http://www.arclab.org/medlineupdates/abstract_11997462.html

  
 Concentration of Free Amino Acids in Blood Plasma of Dairy Cows with developing Hepatic Steatosis
The aim of this experiment was to study the changes in free amino acid (AA) concentration in blood plasma of dairy cows developing hepatic steatosis after parturition and to establish the diagnosis by means of Fischer´s index.
The concentration of free amino acids in blood is not a sensitive indicator of liver function impairment, therefore cannot be used in the diagnosis of liver steatosis.
Liver impairment made itself felt in high variability of measured values in both groups.
http://www.vfu.cz/acta-vet/vol69/093-00.htm

  
 Photooxidation of Parenteral Multivitamins Induces Hepatic Steatosis in a Neonatal Guinea Pig Model of Intravenous ...
induction of steatosis observed with infusion of photo-exposed
lipids, and light exposure in the ethiology of hepatic complications
steatosis and fibrosis as well as cholestasis, we questioned
http://www.pedresearch.org/cgi/content/abstract/52/6/958

  
 Component Of Green Tea Protects Injured Livers In Mice
Pretreatment Increases Liver Transplant Survival In Rats (July 7, 2003) -- Pretreating transplanted livers with the immune molecule interleukin-6 (IL-6) dramatically increased survival of rats receiving organs with fatty degeneration -- a common condition in humans that...
Further tests revealed an increase in hepatic energy stores (one of the liver's functions is to store energy in the form of glycogen) in EGCG mice and showed that EGCG was acting as an antioxidant, thereby protecting fatty livers from I/R injury.
Approximately one-fifth of the U.S. population is afflicted with hepatic steatosis due to a rising incidence of obesity.
http://www.sciencedaily.com/releases/2005/02/050223151300.htm

  
 Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic ...
approach to treatment/prevention of hepatic steatosis and several
AS1 + 3 indicates the combination therapy of AS1 and AS3, and control (Cont) includes C1, C3, and PBS groups.
Inhibition of the expression of SOCS-1 or -3 in liver improves hepatic steatosis in db/db mice.
http://www.pnas.org/cgi/content/full/101/28/10422

  
 Genesis Health System - Alternative Medicine General Info - Lecithin
Buchman AL, Moukarzel A, Dubin M et al: Lecithin supplementation causes a decrease in hepatic steatosis in choline-deficient long-term TPN patients.
Buchman AL, Dubin M, Jenden D et al: Lecithin increases plasma free choline and decreases hepatic steatosis in long-term total parenteral nutrition patients.
http://www.genesishealth.com/micromedex/altmedgen/ame0308.aspx

  
 Hepatic Subcapsular Steatosis in Response to Intraperitoneal Insulin Delivery: CT Findings and Prevalence -- Khalili et ...
—Photomicrograph of histopathologic specimen of percutaneous core needle biopsy of subcapsular lesion in 41-year-old woman shows hepatic fatty deposition within vacuolar spaces (white arrows).
Peritoneal dialysis and therefore intraperitoneal insulin were stopped immediately after scan because of peritonitis.
Hepatic Subcapsular Steatosis in Response to Intraperitoneal Insulin Delivery: CT Findings and Prevalence -- Khalili et al.
http://www.ajronline.org/cgi/content/figsonly/180/6/1601

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