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| | Hospital Practice: Drug-Induced Thrombocytopenia |
 | | For example, in a patient whose thrombocytopenia developed in response to a sulfonamide, therapy might be switched to a cephalosporin, depending on the sensitivity of the infecting organism. | | | I believe that it is worthwhile to expand on some of the points Kelton makes in his overview of drug-induced thrombocytopenia--namely, the indications for treatment of thrombocytopenia, the medicolegal challenges of heparin therapy in a litigious era, and the role of low-molecular-weight heparin in current therapy. | | | Thrombocytopenia usually begins within days or weeks after drug therapy is started. |
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http://www.hosppract.com/issues/1998/05/dmmkelt.htm
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| | Perfusion Line - Review Online |
| | Cardiac surgery in patients with heparin-induced thrombocytopenia using | | | II, heparin therapy was immediately halted and an alternative treatment of | | | criteria for acute thrombolysis, in 4 patients a HIT was preoperatively assured. |
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http://perfline.com/main/journal.cgi?folder=revonline&next=21
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| | Heparin-induced thrombocytopenia - FAQs |
| | Heparin-induced thrombocytopenia is a serious side effect of a drug that is widely used in clinical practice. | | | Furthermore, confirming laboratory tests still have limitations, including a high incidence of false-positive and false-negative results, and some are not available for use in the clinical setting. | | | What is the clinical importance of Heparin-Induced Thrombocytopenia? |
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http://www.argatroban.com/hit_02.htm
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| | Heparin Induced Thrombocytopenia |
| | One fraction, the high-affinity heparin, is responsible for nearly all of the anticoagulant activity. | | | With increasing use, laboratories are increasingly called upon to develop rapid and effective monitoring strategies. | | | Patients with this disorder are receiving heparin therapy and develop antibodies to antigens on platelets. |
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http://www.thedoctorsdoctor.com/diseases/heparin_induced_thrombocytopenia.htm
(1713 words)
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| | Clinician Reviews: Heparin-Induced Thrombocytopenia |
| | HIT type II, by contrast, is an immune-mediated process that may result in life- or limb-threatening thrombosis. | | | However, HIT should be strongly suspected in any patient who develops thrombocytopenia and unexpected thrombotic complications while undergoing heparin therapy. | | | Several laboratory tests (functional assays or antigen assays) may be used to investigate whether heparin therapy is causing immune-mediated thrombocytopenia. |
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http://www.findarticles.com/p/articles/mi_m0BUY/is_2_11/ai_71710879
(1299 words)
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| | NGC - NGC Summary |
| | Patient groups most likely to benefit from platelet count monitoring are those at the highest risk of HIT (1 to 5%) and include postoperative orthopedic, cardiac, and vascular surgery patients who are receiving unfractionated heparin for 1 to 2 weeks. | | | The participants—in the view of lack of sufficient evidence for all patient groups—disagreed about making this recommendation. | | | The American College of Chest Physicians (ACCP) conference members examined the question of whether they should make a general recommendation favoring LMWH over UFH for the prevention of HIT. |
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http://www.guideline.gov/summary/summary.aspx?ss=15&doc_id=5891&nbr=3877
(4526 words)
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| | International Symposium on Heparin-Induced Thrombocytopenia |
| | These findings are in contrast with the standard clinical approach to HIT, simple discontinuation of heparin therapy, which Warkentin and Kelton's research suggests may not be adequate. | | | In our experience at Loyola, argatroban is the only available drug useful as a substitute for heparin," stated Jawed Fareed, Ph.D., Professor of Pathology and Pharmacology, Loyola University Medical Center, and Director of Hemostasis and Thrombosis Research Laboratory. | | | for the treatment and prevention of thrombosis in HIT patients. |
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http://www.docguide.com/dg.nsf/PrintPrint/CEF39A37196A2FD8852563FB00669BF7
(656 words)
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| | Heparin-induced thrombocytopenia - Wikipedia, the free encyclopedia |
| | Heparin (UFH) is used in cardiovascular surgery, as prevention or treatment for deep-vein thrombosis and pulmonary embolism and in various other clinical scenarios. | | | Type II HIT develops in about 3% of all patients on UFH and in 0.1% of patients on LMWH, and causes thrombosis in 30-40% of these patients. | | | It occurs in 10-20% of all patients on heparin. |
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http://en.wikipedia.org/wiki/Heparin-induced_thrombocytopenia
(509 words)
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| | [No title] |
| | The study was designed to reflect conventional clinical practice, whereby treatment of patients with HIT was initiated upon clinical suspicion. | | | The clinical efficacy and safety of lepirudin have been the subject of three clinical trials and one large drug monitoring program. | | | however, no differences were observed in HIT patients with acute thrombosis. |
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http://www.chez.com/orthopedix/text/hit_thromboses.html
(322 words)
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| | FRAGMIN - About Blood Clots |
| | Spinal or epidural hematomas can occur with the associated use of low—molecular-weight heparins or heparinoids and neuraxial (spinal/epidural) anesthesia or spinal puncture, which can result in long-term or permanent paralysis. | | | FRAGMIN, like other anticoagulants, should be used with extreme caution in patients who have an increased risk of hemorrhage; bleeding can occur at any site during therapy. | | | FRAGMIN is also indicated for the prophylaxis of DVT, which may lead to PE in patients undergoing hip replacement surgery, in patients undergoing abdominal surgery who are at risk for thromboembolic complications, and in medical patients who are at risk for thromboembolic complications due to severely restricted mobility during acute illness. |
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http://www.fragmin.com/patient/about_blood_clots.asp
(520 words)
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| | Critical Care Full text Heparin-induced thrombocytopenia |
| | Onset is usually about a week after the start of heparin therapy (typical-onset HIT), but it can occur more rapidly if the patient has previously been treated with heparin (rapid-onset HIT). | | | Heparin-induced thrombocytopenia (HIT) is a relatively common antibody-mediated drug reaction in the ICU and paradoxically is associated with thrombosis. | | | This study identifies the timing of onset of HIT in relation to present and previous heparin treatment. |
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http://ccforum.com/paperreport/ccf-2001-73302
(305 words)
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| | Heparin-Induced Thrombocytopenia (HIT) |
| | In practice, patients on haemodialysis present the biggest diagnostic problems. | | | Danaparoid (Heparinoid), for thromboembolic disease requiring parenteral anticoagulation in patients with (or with history of) HIT. | | | It should also be considered if the patient develops ‘resistance’ to normal doses of heparin (in terms of clotting times) or if new thromboses develop while on treatment. |
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http://www.clinicalschool.swan.ac.uk/wics/itugl/hit.htm
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| | HIT: Heparin-induced Thrombocytopenia |
| | Vascular endothelial injury may contribute to the pathogenesis of thrombosis | | | Resolution of sx after heparin therapy is discontinued. | | | Intravenous gamma globulin and ASA attenuate the thrombocytopenic response to heparin. |
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http://www.unc.edu/~rvp/RP_Anesthesia/Basics/HIT.html
(677 words)
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| | Refludan Approved For Heparin-Induced Thrombocytopenia |
| | The drug is the first product available in the United States to treat the condition. | | | However, these patients are still at high risk to suffer severe thromboembolic complications and have an immediate need for ongoing anticoagulation therapy. | | | HIT type II is a rare, allergy-like adverse reaction to heparin, a standard anticoagulant therapy. |
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http://www.pslgroup.com/dg/608c2.htm
(311 words)
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| | Heparin-Induced Thrombocytopenia |
| | Nand S, Wong W, Yuen B, et al, "Heparin-Induced Thrombocytopenia With Thrombosis: Incidence, Analysis of Risk Factors, and Clinical Outcomes in 108 Consecutive Patients Treated at a Single Institution,"Am J Hematol, 1997, 56(1):12-6. | | | Patients with HIT are often treated with danaparoid, hirudin, or argatroban. | | | Heparin should be permanently discontinued in HIT patients (special arrangements are made for patients who require bypass surgery). |
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http://www.mgh.harvard.edu/labmed/lab/coag/handbook/CO006400.htm
(1271 words)
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| | Perfusion Line: Heparin_Induced_Thrombocytopenia |
| | Understanding Heparin Induced Thrombocytopenia: Historical and Clinical - Diane Wallis, MD, Theodore Warkentin, MD | | | Heparin-Induced Thrombocytopenia- In pediatric Intensive Care Patients - Markus Schumugge | | | HIT - Practical Treatment Guidelines - The Thrombosis Interest Group of Canada. |
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http://www.perfline.com/links/Heparin_Induced_Thrombocytopenia
(212 words)
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| | January 1997 - Heparin-Induced Thrombocytopenia |
| | Copies of the Transfusion Medicine Update can be obtained by contacting | | | Some patients (with white clot syndrome) may require thrombolytic therapy or surgical embolectomy. | | | HIT is not dose dependent and can occur with minute doses of heparin, including heparin flushes and in patients with indwelling heparin-coated catheters. |
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http://www.itxm.org/TMU1997/tmu1-97.htm
(630 words)
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| | Search Tuna Report for Deep Vein Thrombosis |
| | In patients with a history of heparin-induced thrombocytopenia, LOVENOX should be used with extreme caution.... | | | Unless otherwise indicated, agents that may affect hemostasis should be discontinued prior to LOVENOX therapy.... | | | What has been found to be just as effective as treatment with IV heparin is low molecular weight heparin.... |
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http://www.searchtuna.com/ftlive2/591.html
(2876 words)
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| | Heparin Induced Thrombocytopenia - "HIT" |
| | This happens in only 2% of patients, why should we worry? | | | HIT is a clotting, not bleeding, disorder and platelets may worsen. | | | Won't solve the problem and can cause warfarin necrosis. |
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http://aacn.org/chapters/hgcc.nsf/(articles)/6CE6760502484D0F88256CDE0078402F
(187 words)
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| | thrombocytopenia (heparin-induced) - General Practice Notebook |
| | Heparin-induced thrombocytopenia in patients treated with low-molecular weight or unfractionated heparin. | | | Heparin-induced thrombocytopenia: a prospective study of 142 patients. | | | Heparin-induced thrombocytopaenia (HIT) and associated thrombotic events are relatively common side effects of heparin therapy. |
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http://www.gpnotebook.co.uk/medwebpage.cfm?ID=1456472128
(1137 words)
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| | Compare Prices on Heparin-Induced Thrombocytopenia at Smarter |
| | Low-Molecular-Weight Heparins in Prophylaxis and Therapy of Thromboembolic Diseases | | | Home > Books > Medical > Hematology > Heparin > Heparin-Induced Thrombocytopenia | | | Your use of this Web site constitutes acceptance of the Smarter.com Privacy Policy and Terms & Conditions |
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http://smarter.com/books-1/product/heparin-induced_thrombocytopenia-764295
(176 words)
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| | Thrombocytopenia |
| | However, accurately determining the medical reason for this conditions is complex. | | | Thrombocytopenia can result in fatal bleeding, but it also can indicate various other, more serious, cancers and disorders that affect the blood cells. | | | Thrombocytopenia is a blood disease characterized by an abnormally low number of platelets in the bloodstream. |
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http://www.healthatoz.com/healthatoz/Atoz/ency/thrombocytopenia.jsp
(886 words)
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| | Medical Books - Compare Shop Books |
| | Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn |
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http://www.compareshopbooks.com/books_list.htm
(4457 words)
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| | [No title] |
| | 1997;17:325-341 Danaparoid (Orgaran) for the treatment of heparin-induced thrombocytopenia (HIT) and thrombosis Warkentin TE. | | | £ 9 / ó ! ¨ Risks for HIT ¨“ Type I intravenous high-dose heparin Type II varies with dose of heparin unfractionated heparin > LMWH bovine > porcine surgical > medical patients ¡f g g ª I | | | 50%) count in the 50,000 - 80,000 /mm range typical onset of 4-14 days occurs with any dose by any route induced by immunologic mechanisms rarely causes bleeding (think of alternative Dx) potential for development of life-threatening thromboembolic complications ¡ |
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http://www.kfshrc.edu.sa/perfusion/education/HIT.ppt
(442 words)
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| | Biotechnology Stocks -- Biotech100 Index |
| | Argatroban (FDA approved) was developed to treat heparin-induced thrombocytopenia (HIT), a serious immune reaction to heparin that causes abnormal clotting and often leads to limb amputation and even death. | | | Encysive has one of the broadest product pipelines in the sector. |
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http://www.pipelinedrugs.com/encysive.htm
(142 words)
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