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| | Hemoglobinopathies |
 | | Hemoglobinopathy resource centers are available for parent counseling and continual observation of the child’s health. | | | Parents of these infants are referred to Hemoglobinopathy Resource Centers contracted by the Missouri Department of Health for treatment and follow-up care. | | | Recommend whole blood samples collected from parents to ascertain risk for having a future child with a hemoglobinopathy condition. |
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http://www.health.state.mo.us/Lab/Newborn/Hemoglobinopathies.html
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| | Clinical Discussions, vol 2 no 9 |
| | One of the areas of greatest controversy regarding the management of maternal hemoglobinopathy is the treatment of vaso-occlusive pain crisis. | | | Patients with hemoglobin SS disease represent the classic example of vaso-occlusive pain "crisis" found among hemoglobinopathies. | | | Some clinicians have questioned whether patients with these hemoglobinopathies should be counseled against attempting pregnancy. |
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http://www.atlanta-mfm.com/clindisc/vol2no9.html
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| | RFA-HG-05-002: Training in Genomics and Hemoglobinopathies |
| | The purpose of this RFA is to train the next generation of researchers who will utilize genomic and proteomic technologies to facilitate the understanding of the biology of hemoglobinopathies in order to prevent the disease and/or to develop effective therapeutic interventions. | | | Trainee interactions — must be of sufficient quantity and quality to ensure that the trainees and associated faculty develop an internal sense of the identity of their interdisciplinary field and its rewards and challenges. | | | Postdoctoral fellows appointed to the training program must have the opportunity to obtain the necessary didactic training and develop the appropriate genomics/proteomics research skills with the primary objective of developing or extending their research skills and knowledge in preparation for an independent research career in hemoglobinopathy research. |
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http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-05-002.html
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| | [Clinical Preventive Services] Screening for Hemoglobinopathies |
| | Prenatal diagnosis of sickle cell disease and other hemoglobinopathies in the fetus has been aided by advances in techniques of obtaining and analyzing specimens. | | | Their families should receive genetic counseling regarding testing of family members and risks to future offspring, information about the disease, education about early warning signs of serious complications, and referrals for peer support groups and sources of medical and mental health services. | | | There is no direct evidence, however, that individual genetic counseling by itself significantly alters reproductive behavior or the incidence of births of infants with hemoglobin disorders.9,41 |
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http://cpmcnet.cpmc.columbia.edu/texts/gcps/gcps0053.html
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| | Hemoglobinopathies |
| | Another promising development for the treatment of hemoglobinopathies is gene therapy, which has interested researchers since the early 1990s. | | | "Pregnancy Complicated by Disease: Hemoglobinopathies." Section 18, Chapter 251 in The Merck Manual of Diagnosis and Therapy, edited by Mark H. Beers, MD, and Robert Berkow, MD. Whitehouse Station, NJ: Merck Research Laboratories, 2002. | | | The effects of long-term hydroxyurea treatment are unknown; however, a nine-year follow-up study of 299 adults with frequent painful crises reported in 2003 that taking hydroxyurea was associated with a 40% reduction in mortality. |
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http://www.healthatoz.com/healthatoz/Atoz/ency/hemoglobinopathies.jsp
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| | Clinical Evaluation of Hemoglobinopathies: Part II Structural Changes |
| | Fishleder and Hoffman pointed out that the clinical severity of homozygous and doubly heterozygous hemoglobinopathies varies considerably. | | | A practical approach to the detection of hemoglobinopathies: Part III. | | | This together with the environmental factors such as iron deficiency, vitamin B12 and folate deficiency and other clinical conditions that alter the CBC can make interpretation of these variants and their clinical consequences extremely difficult. |
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http://www.wardelab.com/arc_14-3.html
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| | CTF Structured Abstract: Hemoglobinopathies |
| | Good evidence to support the recommendation that the condition be specifically considered in a PHE. | | | One large study in Colorado that screened more than 525 000 infants with dried blood samples had only 4 false negative and 32 false positive results. | | | The National Institutes of Health Consensus Development Conference on Newborn Screening for Sickle Cell Disease and other hemoglobinopathies recommends universal screening for sickle cell disease as does the Agency for Health Care Policy and Research. |
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http://www.ctfphc.org/Abstracts/Ch20abs.htm
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| | eMedicine - Hematologic Disease and Pregnancy : Article by Sarah Hougen Poggi, MD |
| | Despite the improvement in survival of both mother and fetus, remember that patients with the sickle hemoglobinopathies remain at risk for renal insufficiency, cerebrovascular accident, cardiac dysfunction, leg ulcers, and sepsis, particularly from encapsulated organisms. | | | In many hemoglobinopathies, including sickle cell disease and most beta-thalassemias, point mutations exist for which specifically designed oligonucleotide probes can be used, especially in combination with knowledge of the patient's ethnicity. | | | This technique can only work in hemoglobinopathies in which the mutation has been identified because only a small amount of fetal cells can be purified. |
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http://www.emedicine.com/med/topic3254.htm
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| | eMedicine - Retinopathy, Hemoglobinopathies : Article by Brian A Phillpotts, MD |
| | Medical Care: This condition usually is treated by or with an internist/hematologist. | | | Angioid streaks are not specific to hemoglobinopathies but are seen in patients with other hemolytic anemia, Paget disease, Ehlers-Danlos syndrome, and pseudoxanthoma elasticum. | | | Although treatments are not indicated or required for stages I and II, most advocate the treatment of sickle retinopathy for stage III. |
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http://www.emedicine.com/oph/topic416.htm
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| | [No title] |
| | I have been given the opportunity to ask questions concerning this testing and these conditions, and all of my questions have been fully answered to my satisfaction. | | | EFFECT ON ENVIRONMENT AND PUBLIC HEALTH: There will be no effect on the environment. | | | DETRIMENTAL EFFECT ON THE ENVIRONMENT AND PUBLIC HEALTH IF THE REGULATION IS NOT IMPLEMENTED: There will be no detrimental effect on the environment. |
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http://www.scstatehouse.net/regs/2803.doc
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| | Info |
| | The clinical picture of hemoglobinopathies ranges from mild, asymptomatic anemia to severe anemia that requires lifelong transfusion therapy. | | | Hemoglobinopathies occur often in combination in a patient due to the overlap of endemic areas. | | | Hemoglobinopathies are conditions in which the hemoglobin synthesis is abnormal. |
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http://www.aum.iawf.unibe.ch/HemoSurf/Demo_E/Info/HbP.htm
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| | Hemic and Lymphatic Diseases |
| | Screening for Hemoglobinopathies - Clinical Preventive Services Guide, via CMPCNet (US) | | | About Hemoglobinopathies (hemoglobin Disorders) - Info C. for Sickel Cell and Thalassemic Disorders, Harvard (US) | | | Polycythemia Vera [slide collection; McLay and Krause] - Tulane Univ. Medical C. Polycythemia Vera information from Virtual Hosp., Iowa (US) |
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http://www.mic.ki.se/Diseases/c15.html
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| | Hemoglobinopathy - Wikipedia, the free encyclopedia |
| | Anemia - Hemochromatosis - Sickle-cell disease - Thalassemia - Hemolysis - G6PD - Hereditary spherocytosis - other hemoglobinopathies | | | Some hemoglobinopathies (and also related diseases like glucose-6-phosphate dehydrogenase deficiency) seem to have given an evolutionary benefit, especially to heterozygotes, in areas where malaria is endemic. | | | Symptoms vary for the different diseases: in sickle cell disease the red blood cells tend to assume a different shape under anerobic conditions, leading to organ damage and circulatory problems, while in thalassemia there is ineffective production of red blood cells (ineffective erythropoiesis). |
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http://en.wikipedia.org/wiki/Hemoglobinopathy
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| | Newborn Screening Program - Sickle Cell Disease and Other Hemoglobinopathies |
| | These individuals may have questions about the disorders that are best answered by hematology specialists and genetic counselors. | | | Many different forms of hemoglobinopathies exist, with great variation in the effects of these disorders on individuals. | | | As an autosomal recessive disorder, the parents of a child with one of these conditions are unaffected, healthy carriers of the condition and have one normal gene and one abnormal gene. |
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http://www.idph.state.il.us/HealthWellness/fs/sickle.htm
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| | TBDHU - Hemoglobinopathies Factsheet |
| | Hemoglobinopathies are a group of disorders that cause changes in the type or amount of the hemoglobin that is produced. | | | Both parents must be carriers of the gene that causes a particular hemoglobinopathy for there to be a chance of having a child affected with the disease. | | | A carrier is a person who has one working copy of the gene and one gene that does not work normally. |
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http://www.tbdhu.com/factsheets/Hemoglobinopathies.htm
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| | Hemoglobinopathies and Thalassemias |
| | Although the suffix "-pathy" would conjure an image of "disease," most of the hemoglobinopathies are not clinically apparent. | | | Note that these two definitions are not mutually exclusive -- some hemoglobinopathies may also be thalassemias, in that a structurally abnormal hemoglobin (hemoglobinopathy) may also be underproduced (thalassemia). | | | thalassemias include the most common of all hemoglobinopathies and thalassemias. |
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http://web2.airmail.net/uthman/hemoglobinopathy/hemoglobinopathy.html
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| | Clinical Evaluation of Hemoglobinopathies: Part 1 Thalassemia |
| | Knowing the country where the patient or the patient's ancestors originated may be helpful in the differential diagnosis of unusual hemoglobinopathies or some of the forms of thalassemia. | | | For instance, the hemoglobin electrophoresis (or HPLC) on blood from a transfused patient with homozygous sickle cell disease may resemble sickle cell trait. | | | When a patient is evaluated for the presence of a hemoglobinopathy, the laboratory needs to know several pieces of clinical information to optimize the interpretation (Table 2). |
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http://www.wardelab.com/arc_14-2.html
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| | Hemoglobinopathies -- Atweh et al. 2003 (1): 14 -- Hematology |
| | HbF production for the treatment of patients with hemoglobinopathies. | | | models, auger well for the future of gene therapy in hemoglobinopathies, | | | Decitabine is clearly a very effective agent for stimulating |
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http://www.asheducationbook.org/cgi/content/full/2003/1/14
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| | Amazon.ca: Books: The Hemoglobinopathies |
| | Look for books like The Hemoglobinopathies by subject: | | | If you would like to purchase this title, we recommend that you occasionally check this page to see if it has become available. |
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http://www.amazon.ca/exec/obidos/ASIN/082476529X
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| | Hemoglobinopathies Clinical Resources |
| | For additional Hemoglobinopathies Sub-Topics, go to General Hematology Clinical Resources | | | Service provided by the Clinical Digital Libraries Project of the UA and UNT Schools of Library and Information Studies |
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http://cchs-dl.slis.ua.edu/clinical/hematology/hemoglobinopathies
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| | Health Professionals Guide to Newborn Screening: Hemoglobinopathies |
| | Affected individuals with sickle cell disease may have early overwhelming sepsis and require prompt evaluation at a comprehensive care facility. | | | Those hemoglobinopathies characterized by synthesis of an abnormal molecule are detectable at birth. | | | S, E, C) or decreased synthesis of a beta globin chain. |
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http://www.slh.wisc.edu/newborn/guide/hemoglobinopathies.php
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| | Hemoglobinopathies |
| | Reynolds J: Radiologic manifestations of sickle cell hemoglobinopathy. |
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http://www.gentili.net/list4.asp?ID=427
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