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| | New Page 0 |
 | | In addition, the results of the study may result in a lowering of target cholesterol levels or the elimination of the concept of an LDL level at which to initiate therapy with statins. | | | Patients in the study were kept informed as to the latest clinical data involving statin therapy and could chose to be administered a statin, other than simvastatin, if so desired. | | | The results of the Heart Protection Study (HPS) were presented at the American Heart Association Scientific Sessions 2001 meeting in Anaheim, California. |
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http://www.uic.edu/pharmacy/services/di/hps.htm
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| | NHF Research in Coronary Heart Disease |
| | This study is definitive for cholesterol lowering therapy in these groups. | | | In this study (of 18 practices in the Midlands) only 21% of the patients had HDL (high density lipoprotein) cholesterol levels documented in their medical records. | | | Seventeen hospitals in England took part in this study which looked at interventions to help patients who were admitted post-myocardial infarction or for coronary heart bypass surgery, to give up smoking. |
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http://www.heartforum.org.uk/research.html
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| | The International Network of Cholesterol Skeptics |
| | Sir-The authors of the Heart Protection Study state that its size provides "considerable reassurance" that long term simvastatin therapy to lower cholesterol is unlikely to induce cancer.1 However, we believe that an important aspect of this potentially serious problem has been overlooked. | | | If statin therapy and or low cholesterol are associated with an increased incidence of malignancy, both of which have been reported, the first clinical evidence is likely to be from superficial skin lesions that are more readily detected than internal cancers. | | | Evidence from HPS that cancer may be a long-term consequence of statin therapy |
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http://www.thincs.org/unpublic.LancetHPS.htm
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| | Zocor (Simvastatin) Saves Lives In High-Risk Patients, Regardless Of Cholesterol Level, Study In Lancet Shows - ... |
| | During the study, all treatment groups received standard community-based medical care, which may have included cardiovascular medications such as aspirin, anticoagulants, nitrates, beta-blockers, calcium antagonists, and ACE inhibitors. | | | The results from the Heart Protection Study offered additional, conclusive evidence of the excellent tolerability profile of simvastatin which has been demonstrated in more than 15 years of clinical experience. | | | MONTREAL, QC -- July 5, 2002 -- In the largest clinical study ever conducted with a cholesterol-modifying medication, Zocor® (simvastatin) saved lives and significantly reduced the risk of heart attack and stroke in a broad range of patients at high-risk of coronary heart disease (CHD). |
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http://www.docguide.com/dg.nsf/PrintPrint/6F1EE839E9D4F81C85256BED00520D3D
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| | MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised ... |
| | Epidemiologic studies of antioxidants and cancer in humans. | | | The mean duration of follow-up was 5 years for all randomised patients: 5·3 years for those who survived to the scheduled end of study treatment and about half that for those who did not (yielding 50 837 person-years among all those allocated the study vitamins and 50 948 among all those allocated matching placebo). | | | These differences were not significant, and nor were there significant differences between the treatment groups in the incidence of cancers in any particular body system (figure 9), or in non-melanoma skin cancer (only one of which was fatal). |
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http://www.vaccinationnews.com/DailyNews/2003/June/25/MRC-BHFHeartProtection25.htm
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| | CNN.com - This week in the medical journals - May 12, 2005 |
| | Heart rate is controlled by the autonomic nervous system -- the body's "unconscious" wiring that controls all organ functions -- and the researchers suggested that an exercise-training program might re-wire the system to reduce the sudden death risk. | | | A study by researchers at the Minneapolis Heart Institute Foundation, published in Circulation, a journal of the American Heart Association, found aneurysms in more than 30 percent of cocaine abusers while in nonusers the aneurysm rate was less than eight percent. | | | Researchers from the California Pediatric HIV study group reported that babies started on the HIV cocktail therapy called highly active multidrug antiretroviral therapy, or HAART, are less likely to progress to AIDS by their 3rd birthdays. |
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http://www.cnn.com/2005/HEALTH/05/12/journal.roundup/index.html
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| | Globeinvestor.com: Newly Published Results of Landmark Heart Protection Study with ZOCOR 40 mg Show Benefits for People ... |
| | Over the course of the study, treatment with ZOCOR led to mean reductions in total-C, LDL-C and TG of 25%, 35%, and 10%, respectively, and a mean increase in HDL-C of 8%. | | | In 4S (see CLINICAL PHARMACOLOGY, Clinical Studies) involving 4,444 patients treated with 20-40 mg/day of ZOCOR (n=2,221) or placebo (n=2,223), the safety and tolerability profiles were comparable between groups over the median 5.4 years of the study. | | | Elevated transaminases resulted in the discontinuation of 8 patients from therapy in the simvastatin group (n=2,221) and 5 in the placebo group (n=2,223). |
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http://www.globeinvestor.com/servlet/WireFeedRedirect?cf=GlobeInvestor/config&vg=BigAdVariableGenerator&date=20030612&archive=bwire&slug=231635619
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| | Heart Protection |
| | One of the most encouraging aspects of the study was that the majority of people now shown to benefit from statins would already be known to their doctors because of their past medical history. | | | The study overturns conventional wisdom in a number of other areas. | | | This could have a significant impact in reducing the high rates of heart attacks and strokes in the UK and other developed countries. |
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http://www.mrc.ac.uk/prn/index/public-interest/public-news/public-heart_protection.htm
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| | Vitamin C protection against heart disease doubted |
| | They conducted the current study to examine the relationship among serum vitamin C, life course socioeconomic position and coronary heart disease risk. | | | The researchers analyzed data from the British Women's Heart and Health Study. | | | During follow-up, which lasted an average of 4 years, 158 of the women developed coronary heart disease. |
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http://www.dental.am/heart-disease/18212_0_22_0_C
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| | Heart Protection Study |
| | Such a study will provide important additional information about the combined effects of this cholesterol-lowering therapy and of antioxidant supplementation (which, it has been suggested, could well be additive or even synergistic | | | Long-term experience with reductase inhibitors is more limited, so future mortality studies must assess not only the efficacy but also any major long-term side-effects. | | | High-risk patients were randomly allocated to receive 40 mg simvastatin daily, 20 mg simvastatin daily or matching placebo, and then carefully assessed for efficacy and side-effects at 2-6 monthly intervals in special nurse-run clinics (like those in the present study). |
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http://www.heartprotection.nl/pages/option10/section1.html
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| | AltMedConsult: Alternative Medicine Consulting Services |
| | In a study of 321 people with low back pain, chiropractic manipulation was quite helpful, but no more helpful than giving patients an educational booklet on low back pain. | | | The problem with such single-blind studies, though, is that the practitioners may convey enthusiasm when they are providing a real treatment and lack of enthusiasm when they apply a fake one. | | | In such cases, most researchers settle for a "single-blind" design, in which the study participants (and the people who evaluate the participants to see if they've responded to therapy), but not the practitioners of the therapy. |
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http://www.altmedconsult.com
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| | lipidhealth :: LipidManagement Newsletter |
| | Risk of heart attack and stroke was reduced by at least one-third in both high-risk and lower-risk individuals taking an HMG-CoA reductase inhibitor (statin) in the largest cholesterol-lowering study ever conducted. | | | Antonio Gotto, Jr, MD, DPhil, chairman of the National Lipid Education Council, concurred, "The Heart Protection Study has important implications for the optimal management of patients with a broad range of high-risk profiles. | | | Heart Protection Study Reveals Promising Results of Statin Therapy |
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http://www.lipidhealth.org/content/newsletter/vol6no4/pg5.asp
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| | The Heart Protection Study and Other Developments in Atherosclerosis |
| | Although prior studies have suggested -- based on post-hoc analysis, meta-analysis, and even in some cases as a predefined prospective end point -- that statins decreased stroke event rates, the epidemiologic database prior to HPS had not suggested that total cholesterol levels were a strong predictor of stroke risk. | | | This somber mood was offset by some of the clinically exciting data presented during the scientific sessions -- information that will have a far-reaching influence on current thinking and practice as well as on future research regarding preventive cardiology and mechanisms of atherosclerosis. | | | The Heart Protection Study and Other Developments in Atherosclerosis |
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http://www.thaiheart.org/aha2001/heart_protection_study_and_other.htm
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| | Heart Protection Study |
| | The study found a large reduction in the incidence of cardiac deaths in all participants, a significant reduction in peripheral vascular events (including stroke) and no change in the number of cardiac deaths. | | | The incidence of muscle aching was the same in the treated as well as control groups. | | | You are strongly encouraged to see the physician of your choice to receive such advice as well as to discuss the information available at this site as it may apply to your particular condition. |
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http://www.tickerfixers.com/Papers/heart_protection_study_statins.htm
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| | Heart protection study zocor |
| | lipitor vs zocor (zocor) zocor online, information on zocor, zocor study is the same as danger of zocordrug zocor, problem with zocor - effects of zocor or zocor lawsuit, also known as zocor muscle pain of zocor cholesterol medication of zocor grapefruit etc. | | | compare lipitor zocor is the same as prescription drug zocormuscle zocor into zocor statin and attack heart zocor. | | | Purchase joint pain zocor, prescription drug zocor resources. |
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http://www.zocor.buycheapfreeonline.com/heart-protection-study-zocor.htm
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| | News - Heart Protection Study Supports Use of Statins In Elderly, Women, and Those With Low LDL |
| | The HPS study, reported in 1999, "took a novel approach to patient randomisation involving decision-making by both the physician and the patient," Dr. Farmer and Dr. Gotto, Jr., note. | | | Women Receive Less Aggressive Treatment for Chest Pain and Heart Attacks than Men, Study Finds | | | "If the physician thought a participant's lipid profile offered compelling evidence either for or against statin therapy, the patient was excluded from the study." |
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http://www.docguide.com/news/content.nsf/news/8525697700573E1885256D68002C6EB6
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| | ABC News: Statins Do More Than Lower Cholesterol |
| | SATURDAY, April 2 (HealthDay News) — There's more evidence statin drugs, which include popular medications like Lipitor, Pravachol and Zocor, prevent heart attack and stroke by means other than lowering blood cholesterol. | | | Even as laboratory work goes on, "clinical use is beginning," he added. | | | In contrast, rats that did not receive Zocor displayed higher levels of these dangerous, reactive molecules and greater arterial rigidity. |
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http://abcnews.go.com/Health/Healthology/story?id=636307
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| | Lipids Online Slides: heart protection study, simvastatin, HPS, diabetes |
| | Lipid interventions should be equally effective in CHD equivalents as in CHD patients. | | | ATP III: New Approaches in Identifying and Treating High-Risk Patients (Steven Haffner, MD) | | | Combination Lipid-altering Drug Therapy with Statins: An Update (Harold Bays, MD, FACP) |
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http://lipidsonline.org/slides/slide01.cfm?q=heart+protection+study&dpg=42
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| | PJ Online News: Call for change to guidelines following publication of Heart Protection Study |
| | The researchers comment that most patients who would benefit from statins would already be known to their doctors because of their past medical history. | | | However, they did not produce any significant reductions in the five-year risk of heart attacks, strokes, cancers or other major outcomes (ibid p23). | | | Guidelines on the management of coronary heart disease should be changed so that a statin is considered for anybody at increased risk of heart attack or stroke regardless of their blood cholesterol level. |
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http://www.pharmj.com/Editorial/20020706/news/callforchange.html
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| | Statin simvastatin linked to protection against endothelial dysfunction in diabetic rats |
| | Unlike the untreated rats, treated rats had no elevation of nitrotyrosine in the retina or lipid peroxidation in the heart and retina. | | | The rats that received 5 mg of simvastatin daily showed no or little such damage. | | | Ma concludes, "The data indicate that simvastatin protects against diabetes induced dysfunction," and Dr. Caldwell says, "The usefulness of statins in the treatment of diabetic patients is being realized." |
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http://www.medicalnewstoday.com/medicalnews.php?newsid=22176&nfid=mnf
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| | HPS Summary |
| | • Cholesterol-lowering with statin treatment reduced the risk of heart attacks and strokes by at least one third, as well as reducing the need for arterial surgery, angioplasty and amputations. | | | • The benefits of statins were additional to those of other treatments used to prevent heart attacks or strokes, such as aspirin and blood pressure-lowering drugs | | | Based on WHO estimates of the numbers of people with coronary heart disease, stroke and diabetes, it can be estimated that the results are relevant to the treatment of some hundreds of millions of people worldwide (see table). |
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http://rum.ctsu.ox.ac.uk/~hps/summary.shtml
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| | News - Heart Protection Study Implications for Lipid Management Guidelines and Practices |
| | A DGReview of :"Current and future aims of lipid-lowering therapy: changing paradigms and lessons from the heart protection study on standards of efficacy and safety" | | | "Current and future aims of lipid-lowering therapy: changing paradigms and lessons from the heart protection study on standards of efficacy and safety" | | | Research indicates that rosuvastatin is more effective than other statins in reducing LDL cholesterol, enabling more patients to achieve LDL cholesterol goals. |
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http://www.docguide.com/news/content.nsf/news/8525697700573E1885256D96002C0D87
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| | HPS Information |
| | Substantial uncertainty had existed about the long-term benefits of cholesterol-lowering drug therapy for particular types of patient, and the extent of its use is limited. | | | The MRC/BHF Heart Protection Study is much the largest trial in the world of cholesterol-lowering therapy and of antioxidant vitamin supplementation in people at increased risk of heart disease. | | | To help resolve these uncertainties, the MRC/BHF Heart Protection Study was designed to be really large, to involve a substantial reduction in blood LDL cholesterol levels and a substantial increase in antioxidant vitamin levels, and to include a wide range of patients at substantial risk of death from heart disease and other causes. |
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http://rum.ctsu.ox.ac.uk/~hps
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| | Conclusions from the heart protection study were premature |
| | For example, it was claimed that the study | | | National Institute for Clinical Excellence should assess statins | | | Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian simvastatin survival study (4S). |
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http://www.chelationtherapyonline.com/technical/p34.htm
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| | Lancet study finds no health benefit from antioxidants supplements in high-risk individuals |
| | Researchers found no significant differences between the two groups in mortality (deaths) -- or in incidence of any kind of vascular disease (heart attacks or strokes), cancer, or other major outcomes. | | | Although 41% of the study population had treated hypertension, only 1% were included in the study on the basis of this finding alone. | | | This randomized, double-blind study followed 20,536 patients over a 5-year period. |
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http://www.supplementquality.com/efficacy/Lancet_antiox_null.html
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| | Diabetes Monitor - the heart protection study |
| | Experts say the findings, published in The Lancet, demand a change in current recommendations, which do not advise statin therapy unless cholesterol levels are elevated. | | | The present study provides direct evidence that cholesterol-lowering therapy is beneficial for people with diabetes even if they do not already have manifest coronary disease or high cholesterol concentrations. | | | The study found that statin drugs cut the risk of heart attacks, strokes and the need for angioplasty or bypass surgery in people with diabetes by one-third. |
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http://diabetesmonitor.com/statins.htm
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| | BBC NEWS UK Scotland Heart disease a 'huge challenge' |
| | Monday's report said wider prescribing of statins could prevent 30,000 heart attacks and 20,000 strokes in the UK over the next five years and save 14,000 lives from CHD. | | | And, with effective diagnosis and treatment of diabetes and CHD, doctors would also be able to treat more than 100,000 extra patients per year in 20 years' time. | | | The UK rate of doses of the drug, which has already saved some 6,000 lives, was 24 per 1,000 patients in the five years to 2002, compared to 52 in Norway. |
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http://news.bbc.co.uk/2/hi/uk_news/scotland/3719507.stm
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| | Heart Protection Study |
| | So say Dr. Patricia Gum and colleagues at the Cleveland Clinic. | | | That’s the outcome of a 160 patient study at the University of Washington in Seattle. | | | Those who benefited the most: older patients with heart disease or who couldn’t exercise much.. |
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http://www.drgrimshaw.com/newsletters/NewNews102/NewNews102.html
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| | Zocor Side Effects, Interactions and Information - Zocor on ThePills.info |
| | Only your doctor can weigh the risks versus the benefits of any prescription drug. | | | In clinical studies with ZOCOR, less than 1.5% of patients dropped out of the studies because of side effects. | | | Only 8 patients on ZOCOR and 5 on placebo discontinued therapy due to elevated liver enzyme levels. |
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http://zocor.thepills.info
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| | adderall - The Complete picture of ritalin sr Directory of Sites With information on methadone Content |
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http://stevecraddock.com/nitroglycerin/heart
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| | Find out about the Heart Protection Study at heartprotectionstudy.com |
| | The Study was the largest of its kind, researching groups who had not previously been extensively studied. | | | It was the largest clinical trial of its kind, conducted over 5 years with more than 20,000 patients with heart disease, diabetes, and noncoronary vascular disease. | | | The purpose of the Heart Protection Study was to explore whether lowering cholesterol provides benefits to a wide range of people at high risk for coronary events. |
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http://www.zocor.com/simvastatin/zocor/consumer/heartprotectionstudy/index.jsp
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| | PCEL - Alphabetical list of sites - M |
| | Moving to paperlessness: a case study from a large general practice. |
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http://nelhpc.sghms.ac.uk/index.cfm?fuseaction=home.alphabet&letters=m
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| | Heart Protection Study |
| | HPS - a mixed primary/secondary prevention study aimed at “real world” patients - showed that taking 40mg of simvastatin daily over five years, compared to placebo, reduced myocardial infarctions and strokes by about a third among patients aged 40 or over who were deemed to be at “high risk”. | | | Publication of the landmark Heart Protection Study (HPS), the world largest statin study is fuelling calls for the guidelines on cholesterol lowering to be emphasize a strategy of treating high risk, not high cholesterol. | | | Dr Salim Yusuf (McMaster University, Ontario, Canada) says the past 25 years have seen the establishment of aspirin, beta blockers, ACE-inhibitors, and lipid-lowering therapies to prevent the risk of future vascular events by about a quarter each, in high-risk patients. |
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http://www.heartscan.com.my/new_page_1.htm
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| | Need for large scale randomised evidence about lowering LDL cholesterol in people with diabetes mellitus: MRC/BHF heart ... |
| | Treating dyslipidaemia in the patient with type 2 diabetes | | | Need for large scale randomised evidence about lowering LDL cholesterol in people with diabetes mellitus: MRC/BHF heart protection study and other major trials | | | Need for large scale randomised evidence about lowering LDL cholesterol in people with diabetes mellitus: MRC/BHF heart protection study and other major trials -- ARMITAGE and COLLINS 84 (4): 357 -- Heart |
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http://heart.bmjjournals.com/cgi/content/extract/84/4/357
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| | - Google Scholar |
| | Found no articles citing Brown: Implications of the Heart Protection Study for Reducing Coronary Events in High-risk Patients. |
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http://www.biomedcentral.com/pubmed/gs/12911845
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| | Cholesterol Screening |
| | Moderator: John Sheffield, M.D. Heart Protection Study Collaborative Group "MRC/BHF Heart Protection Study of Cholesterol Lowering with Simvastatin in 20 536 high-risk individuals: a Randomised Placebo-Controlled Trial" LANCET 2002,360:7-22 | | | Copies of this article have been placed in the AMC Provider Room and in 10EH15. |
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http://depts.washington.edu/gim/calendar/hmcjc_abstracts/jcfeb_03.htm
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| | [No title] |
| | Find heart protection study zocor and more at Lycos Search. | | | Turn your $2,000 into $3,000+ monthly earnings - our Team Leaders do it all for you! | | | If you're new, the Lobby is a great place to get started. |
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http://zocor.msk.ru/heart+protection+study+zocor
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| | Cardio Renew |
| | The time we have knowing we have heart disease. | | | Saturday: 9 am - 6 pm ~ Central Standard Time |
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http://www.CardioRenew.com
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| | Log In Problems |
| | You can read more about our use of cookies in our privacy policy. | | | All material on this website is protected by copyright, Copyright © 1994-2005 by Medscape. |
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http://www.medscape.com/viewarticle/437563?src=search
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