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| | Human Biology: Maternal Cigarette Smoking, Metabolic Enzyme Polymorphism, and Developmental Events in the Early Stages ... |
 | | The relationship between haptoglobin development in the neonatal period, ACP1 genotype, and smoking is not significantly influenced by the haptoglobin phenotype of the newborn (data not shown). | | | Haptoglobin behaves as an aspecific bacteriostat (Lewis and Dyer 199; Otto et al. | | | We found that an interaction between ACP1 genotype and smoking has an effect on haptoglobin development: A significant delay of haptoglobin development in infants born to smoking mothers is observed only in infants with the ACP1*B/*B genotype, which shows the highest concentration of the ACP1 F isoform. |
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http://www.findarticles.com/p/articles/mi_qa3659/is_200404/ai_n9363132
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| | Type of Blood Protein May Predict Diabetes Severity |
| | Paul Jellinger, MD, president of the American Association of Clinical Endocrinologists, calls the studies "fascinating," but he cautions that no one should take the studies to mean that patients with the superior form of haptoglobin don't have to be treated intensely. | | | In addition to knowing which patients are more likely to develop complications, the haptoglobin research could prove useful for another reason, according to Levy. | | | In three separate studies, Andrew Levy, MD, PhD, senior lecturer at the Technion-Israel Institute of Technology at Rambam Medical Center, in Haifa, Israel, and colleagues studied whether the type of haptoglobin a diabetes patient had could predict whether he or she would develop certain complications. |
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http://www.webmd.com/content/article/28/1728_61983.htm
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| | ARUP: Haptoglobin by PCR |
| | For additional interpretive data see Haptoglobin by PCR in "ARUP's Guide to Clinical Laboratory Testing" |
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http://www.aruplab.com/guides/ug/tests/0040116.jsp
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| | Method of determining a risk of hyperglycemic patients of developing a cardiovascular disease (US6613519) |
| | Langlois et al "Biological and clinical significance of haptoglobin polymorphism in humans" Clinical Chemistry, vol. | | | Prabha et al "Haptoglobin patterns in essential hypertension and associated conditions--increase risk for Hp (2-2)" Hum. | | | The method comprises determining a haptoglobin phenotype of the diabetic patient and thereby evaluating the risk of the diabetic patient to develop the cardiovascular disease (CVD), wherein the risk is decreased in diabetic patients with haptoglobin 1-1 phenotype as compared to patients with haptoglobin 1-2 or haptoglobin 2-2 phenotypes. |
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http://www.delphion.com/details?pn=US06613519__
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| | Haptoglobin test |
| | Haptoglobin levels can be used to monitor the course of these conditions. | | | Haptoglobin increases as a reaction to illness, trauma, or rheumatoid disease. | | | Haptoglobin is known as an acute phase reactant. |
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http://www.lifesteps.com/gm/Atoz/ency/haptoglobin_test.jsp
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| | Vitamins and Mineral Supplements and Herbal Supplements for your Health |
| | The change in minimum luminal diameter from baseline to the concluding angiogram was assessed. | | | The authors have a theory as to why vitamin therapy may be harmful in patients with haptoglobin type 2-2. | | | Haptoglobin typing may become a useful tool to identify individuals who will benefit from antioxidant therapy. |
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http://www.herbalgram.org/naturemade/herbclip/review.asp?i=44013
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| | Vitamin E may help some diabetics |
| | However, Dr. Levy notes, the study did not segregate patients according to their haptoglobin type, analyzing instead the benefits of vitamin E in all patients. | | | The results of that study showed no benefit from vitamin E therapy on cardiovascular risk. | | | The new study shows that when these at-risk patients, who have the 2-2 form of haptoglobin, took 400 international units of vitamin E daily, they reduced their risk of heart attack by 43 percent, and their risk of dying of heart disease by 55 percent. |
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http://www.medicalnewstoday.com/medicalnews.php?newsid=16603
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| | New Test Predicts Complications in Diabetes |
| | In about 20 percent of individuals, this hemoglobin clean-up is more effective than in others, because these individuals produce a form of haptoglobin that is relatively small and can seek out the hemoglobin in the nooks and crannies of the circulatory system. | | | Of those patients who had the more effective type of haptoglobin, none suffered from nephropathy or restenosis and only one of 12 had retinopathy. | | | Since haptoglobin type is determined genetically and does not change during life, physicians can use a haptoglobin test to see who is at high risk for complications and who is not. |
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http://www.ats.org/news.php?id=16
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| | Medical Encyclopedia: Haptoglobin (Print Version) |
| | When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. | | | Haptoglobin levels may be affected by the presence of liver disease or kidney disease, extensive blood loss, and a variety of conditions that affect liver and kidney function. | | | Veins and arteries vary in size from one patient to another and from one side of the body to the other. |
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http://www.nlm.nih.gov/medlineplus/print/ency/article/003634.htm
(677 words)
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| | Vitamins Can Be Friend or Foe for Older Women with Diabetes |
| | Animal studies offer some tantalizing clues, Levy says. | | | The effects of the vitamin therapy differed depending on the women’s haptoglobin type. | | | The new research may help clear up some of the controversy surrounding the use of antioxidant vitamins in patients with heart disease. |
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http://www.ats.org/news.php?id=84
(674 words)
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| | Proteomic-based identification of haptoglobin-1 precursor as a novel circulating biomarker of ovarian cancer |
| | Keywords: proteomics; biomarkers; ovarian cancer; haptoglobin; haptoglobin-1 precursor (HAP1) | | | These data highlight the need to assess circulating concentration of HAP1 in the serum of ovarian cancer patients and evaluate its potential as a biomarker in the early diagnosis of ovarian cancer. | | | Six of the protein spots that were significantly upregulated in all groups of ovarian cancer patients were identified by nano-electrospray quadrupole quadrupole time-of-flight mass spectrometry (n-ESIQ(q)TOFMS) and matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOFMS) as isoforms of haptoglobin-1 precursor (HAP1), a liver glycoprotein present in human serum. |
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http://www.nature.com/doifinder/10.1038/sj.bjc.6601882
(413 words)
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| | Journal SLEEP |
| | Haptoglobin Phenotype, Sleep-Disordered Breathing, and the Prevalence of Cardiovascular Disease: the Sleep Heart Health Study | | | Sleep-disordered breathing did not appear to interact with haptoglobin phenotype in modifying the association with prevalent cardiovascular disease in the Sleep Heart Health Study. | | | Possible modification by haptoglobin phenotype of the association of sleep-disordered breathing with cardiovascular disease prevalence was explored by examining interaction terms. |
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http://www.journalsleep.org/citation/sleepdata.asp?citationid=2504
(422 words)
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| | FBR Resource Guide: Haptoglobin (HPT) |
| | Increased levels are seen in chronic and acute inflammatory conditions. | | | Decreased haptoglobin levels are associated with hemolysis from all causes. | | | Haptoglobin levels are best interpreted in combination with other acute phase proteins, in particular alpha-1-acid glycoprotein, and to a lesser extent, C-reactive protein and alpha-1-antitrypsin. |
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http://www.fbr.org/publications/resguide/rg-t_hpt.html
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| | The Application of Immunoblotting to the Phenotyping of Haptoglobin |
| | An immunoblotting method for phenotyping haptoglobin in serum and bloodstains has been developed. | | | The Application of Immunoblotting to the Phenotyping of Haptoglobin | | | This detection limit is approximately 8 times lower than that of group specific-component analysis by immunoblotting. |
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http://www.astm.org/JOURNALS/FORENSIC/PAGES/1872.htm
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| | HAPTOGLOBIN |
| | Normal values for haptoglobin are 27 to 139 mg/dl. | | | Greater than normal values can indicate: acute rheumatic disease, ulcerative colitis, peptic ulcer disease, or biliary obstruction. | | | In conditions of hemolysis the haptoglobin concentration decreases (due to increased recycling in the liver). |
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http://www.medhelp.org/glossary/new/GLS_2119.HTM
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| | Haptoglobin: A major susceptibility gene for diabetic vascular complications |
| | These studies point towards haptoglobin phenotype as a new risk factor for vascular disease in diabetes. | | | The authors recently published evidence that haptoglobin phenotype may serve as a predictor of the relative risk of diabetes-related vascular disorders. | | | Several mechanisms whereby haptoglobin phenotype may determine diabetic vascular complications are presented. |
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http://www.pulsus.com/ecc/07_02/szaf_ed.htm
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| | Effect of stress transport on serum haptoglobin in pigs |
| | Conclusion:Further studies with more individuals are needed to assess the utility of haptoglobin as a general stress indicator. | | | Finally, haptoglobin levels do not present significant circadian oscillations, avoiding the problems in other parameters (i.e. | | | Aim:Haptoglobin is an acute phase protein that has been proposed as a possible indicator of stress in pigs. |
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http://www.gla.ac.uk/faculties/vet/research/protein/03_doorn_2002/abstracts/Saco1.html
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| | Bovine haptoglobin in blood and milk after intramammary application of LPS |
| | Furthermore we aimed to characterise haptoglobin response in blood and milk after LPS inoculation. | | | Results: Haptoglobin blood concentration was 30 ± 50 µg/ml (mean ± SD) before treatment and started to increase after 9 h. | | | Besides current methods for the determination of haptoglobin (haemoglobin-binding method) can not be performed in milk samples. |
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http://www.gla.ac.uk/faculties/vet/research/protein/03_doorn_2002/abstracts/Hiss.html
(304 words)
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| | 1to1vitamins.com: Advanced Vitamins and Supplements from Dr. Cinque |
| | Diabetics with a particular form of a blood protein called haptoglobin who took vitamin E cut their risk of dying from cardiovascular disease by 55 percent and decreased their risk of nonfatal heart attack by 43 percent, say Levy and colleagues. | | | People with diabetes who have haptoglobin's 2-2 form of the protein have a higher risk of cardiovascular "events," such as heart attacks, write the researchers. | | | Haptoglobin comes in three forms: "2-2," "1-1," and "2-1." Haptoglobin's 2-2 form is the worst of the three at fighting disease-causing free radicals. |
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http://www.1to1vitamins.com/news/2004/artl5758.html
(325 words)
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| | haptoglobin - General Practice Notebook |
| | Haptoglobin is an acute phase protein, rising in concentration during acute inflammation. | | | The haptoglobin-haemoglobin complexes are removed by the reticuloendothelial system, resulting in a reduction in the concentration of haptoglobin. | | | The function of haptoglobin is to bind free haemoglobin in the blood, with a capacity of up to 1.4 grams per litre. |
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http://www.gpnotebook.co.uk/medwebpage.cfm?ID=-187695061
(209 words)
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| | ARUP: Haptoglobin |
| | Haptoglobin is an acute phase protein used in the detection of in vivo hemolysis. | | | The primary function of haptoglobin is the irreversible binding of free oxyhemoglobin in plasma. | | | Note: Test numbers link to the corresponding test in the User's Guide |
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http://www.aruplab.com/guides/clt/tests/clt_291a.jsp
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| | Test may help diabetic women choose vitamins - Diabetes - MSNBC.com |
| | Levy believes haptoglobin affects oxidative stress, or damage to cells in everyday life or from exposure to chemicals or radiation. | | | They said a simple blood test, to detect genetic variations in a blood protein called haptoglobin, may predict which patients would benefit from supplements and who should avoid them. | | | Diabetes greatly increases the risk of heart disease, so the test may offer useful alternatives to the millions of patients worldwide with type-2 diabetes, the team from the Technion-Israel Institute of Technology in Haifa, George Washington University in Washington and elsewhere said. |
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http://msnbc.msn.com/id/4609487
(560 words)
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| | H6395 Monoclonal Anti Haptoglobin antibody produced in mouse |
| | The antibody recognizes human haptoglobin as purified antigen, in human serum, or when complexed with human hemoglobin in a native or denatured, but non | | | The antibody is specific for the 3 major haplotypes of human haptoglobin (Types 1 | | | Sigma-Aldrich brand products are sold exclusively through Sigma-Aldrich, Inc. Best viewed in IE6 or higher |
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http://www.sigmaaldrich.com/catalog/search/ProductDetail?ProdNo=H6395&Brand=SIGMA
(131 words)
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| | Haptoglobin-{alpha} Subunit As Potential Serum Biomarker in Ovarian Cancer: Identification and Characterization Using ... |
| | Langlois M. R., Delanghe J. Biological and clinical significance of haptoglobin polymorphism in humans. | | | Thompson S., Dargan E., Turner G. Increased fucosylation and other carbohydrate changes in haptoglobin in ovarian cancer. | | | Fish R. G., Gill T. S., Adams M., Kerby I. Serum haptoglobin and alpha 1-acid glycoprotein as indicators of the effectiveness of cis-diamminedichloroplatinum (CDDP) in ovarian cancer patients—a preliminary report. |
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http://clincancerres.aacrjournals.org/cgi/content/full/9/8/2904
(4153 words)
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| | haptoglobin |
| | The first non-species specific, colorimetric, rapid Haptoglobin assay, for the measurement of the Acute Phase Protein, Haptoglobin as a marker of: | | | This new biochemical assay can be used to quantify Haptoglobin levels in any species, including: | | | The assay is available in both manual and autoassay formats, to view further information, data sheet and methods, please select from menu at top of page. |
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http://www.trideltaltd.com/hp1.html
(82 words)
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| | THE MERCK MANUAL, Sec. 11, Ch. 127, Anemias |
| | Hb is reabsorbed into renal tubular cells where Fe is converted to hemosiderin, part of which is assimilated for reutilization and part of which reaches the urine when the tubular cells slough. | | | Intravascular hemolysis is uncommon; it results in hemoglobinuria when the Hb released into plasma exceeds the Hb-binding capacity of plasma-binding proteins (eg, haptoglobin). | | | Severely abnormal RBCs or those coated with cold antibodies or complement (C3) are destroyed within the circulation or in the liver, which (because of its large blood flow) can remove damaged cells efficiently. |
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http://www.merck.com/mrkshared/mmanual/section11/chapter127/127d.jsp
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| | Anti-Haptoglobin, Haptoglobin, Haptoglobin antibody |
| | Koda, Y.; Watanabe, Y.; Soejima, M.; et al : Simple PCR detection of haptoglobin gene deletion in anhaptoglobinemic patients with anti-haptoglobin antibody that causes anaphylactic transfusion reactions. | | | Haptoglobin combines with free plasma hemoglobin, prevent loss of iron through the kidneys and protect the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. | | | Direct ELISA: Plasma Haptoglobin protein as test antigen. |
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http://www.prosci-inc.com/Antibody-XW-TDS/XW-7243.html
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| | ICL Lab - antibodies epitope tag dog rat mouse crp anti flag ha myc 6xhis V5 IgE IgM IgG VSV HSVT7 |
| | ICL's Mouse haptoglobin ELISA kit is for Research and Manufacturing Only; Not for Use in Diagnostic Applications | | | ICL Lab - antibodies epitope tag dog rat mouse crp anti flag ha myc 6xhis V5 IgE IgM IgG VSV HSVT7 | | | Each kit contains: sensitized 96-strip micro-well plate (Rabbit anti-Mouse Haptoglobin), 50ml (5X) diluent, 50 ml(10X) wash solution, enzyme-antibody conjugate (HRP anti-mouse haptoglobin), 12mL TMB substrate, 12mL stop solution and pre-diluted mouse haptoglobin reference standards. |
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http://www.icllab.com/commerce/catalog/product.jsp?product_id=1893
(80 words)
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