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| | Hairy Cell Leukemia |
 | | In 35 of 78 evaluable patients DCF was the first-line therapy; the remaining 43 patients had received other therapies. | | | Immunophenotypic analysis of peripheral blood by flow cytometry is not widely recognized as a method for diagnosing HCL, perhaps due to the expectation of low yield of neoplastic cells in patients who are characteristically leukopenic. | | | We studied 86 specimens from 24 patients with hairy cell leukemia (HCL) to determine the sensitivity of routine flow cytometry (FC) and consensus primer PCR (cpPCR) in this disease. |
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http://www.thedoctorsdoctor.com/diseases/leukemia_hairycell.htm
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| | Leukemia Hairy Cell |
| | Three kinds of treatment are used: - surgery - chemotherapy (using drugs to kill cancer cells) - biological therapy (using the body's immune system to fight cancer) Bone marrow transplants are being tested in clinical trials. | | | Chemotherapy may be taken by pill, or it may be put into the body by a needle in the vein, muscle, or under the skin. | | | The bone marrow is the spongy tissue inside the large bones in the body. |
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http://www.medhelp.org/lib/cancernet/201651.htm
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| | Hairy Cell Leukemia |
| | Biologic therapy is a cancer treatment that uses the patient’s immune system to fight cancer. | | | When chemotherapy is placed directly into the spinal column, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy). | | | Bone marrow biopsy: The removal of a small piece of bone and bone marrow by inserting a needle into the hipbone or breastbone. |
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http://www.meb.uni-bonn.de/cancer.gov/CDR0000258013.html
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| | eMedicine - Hairy Cell Leukemia : Article by Emmanuel C Besa, MD |
| | The first-line therapy for HCL is 2-chlorodeoxyadenosine (2-CdA) 0.1 mg/kg/d by continuous intravenous infusion for 7 days—which can be performed on an outpatient basis with a pump—using a midline percutaneous intravenous central catheter (PICC). | | | Infiltration of the bone marrow by HCL makes aspirating cells through a needle difficult. | | | Medicine is a constantly changing science and not all therapies are clearly established. |
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http://www.emedicine.com/med/topic937.htm
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| | Hairy cell leukemia |
| | Your doctor will want to rule out other diseases that are similar to hairy cell leukemia. | | | Splenic rupture is a life-threatening condition that requires emergency surgery to remove your spleen. | | | Even if you achieve remission with your treatment, you'll likely require follow-up visits with your doctor to monitor your cancer and your blood counts. |
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http://www.cnn.com/HEALTH/library/DS/00673.html
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| | Gale Encyclopedia of Medicine: Hairy cell leukemia |
| | During this procedure, a needle is inserted into the bone and a small amount of marrow is withdrawn for microscopic examination. | | | Modern therapy relies heavily on the use of 2CDA (cladribine, pentastatin, fludarabine, interferon). | | | Biological therapy or immunotherapy, where the body's own immune cells are used to fight cancer is also being investigated in clinical trials for hairy cell leukemia. |
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http://www.findarticles.com/p/articles/mi_g2601/is_0006/ai_2601000615
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| | Hairy Cell Leukemia |
| | Certain patients may be treated with Bone Marrow Transplantation. | | | A bone marrow test will make this determination. | | | Other drugs that may be used in treatment of HCL are: Chlorambucil, Vincristine, Prednisone, Cytoxan and Fludarabine. |
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http://www.tirgan.com/hairylk.htm
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| | Hairy Cell Leukemia |
| | The initial therapies of choice are either cladribine (2-chlorodeoxyadenosine, 2-CdA) or pentostatin. | | | It should not be considered unless other, more frequently effective therapies have been exhausted. | | | Progressive hairy cell leukemia, postsplenectomy (or following any systemic therapy) is characterized by progressive bone marrow replacement by hairy cells with pancytopenia refractory to treatment. |
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http://www.meb.uni-bonn.de/cancer.gov/CDR0000062926.html
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| | Hairy Cell Leukemia |
| | Researchers said "this drug -- and similar ones under study -- may eventually prove useful for some other types of cancer, too." " People thought this kind of thing was going to happen 25 years ago, and it just didn't happen," said immunologist Dr. Terry Strom of Beth Israel Deaconess Hospital in Boston. | | | The early experiment was designed largely to find out if the drug can be taken safely. | | | The researchers at the National Cancer Institute in Bethesda, MD, developed and tested the drug, a so-called immunotoxin known as BL22, on 16 patients with Hairy-Cell Leukemia untreatable by the usual chemotherapy. |
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http://www.grg.org/HairyCell.htm
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| | MedlinePlus: Leukemia, Adult Chronic |
| | The primary NIH organization for research on Leukemia, Adult Chronic is the National Cancer Institute | | | Treatment of Chronic Lymphocytic Leukemia by Risk Group (American Cancer Society) | | | Complementary & Alternative Therapies for Leukemia, Lymphoma, Hodgkin's Disease, & Myeloma (Leukemia and Lymphoma Society) |
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http://www.nlm.nih.gov/medlineplus/leukemiaadultchronic.html
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| | What Is HCL? |
| | HCL develops in the bone marrow as does the blood. | | | Finally, unexplained weight loss and a loss of a sense of well-being may bring patients to their physician. | | | It does not develop into acute (rapid progressing) leukemia. |
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http://www.hairycellleukemia.org/hcl.htm
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| | ACOR Leukemia Links: Resources for HCL |
| | Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia by Kreitman RJ,et al., New England Journal of Medicine, Vol. | | | Hairy Cell Leukemia by Emmanuel C Besa, MD and Ulrich Woermann, MD, from the eMedicine World Medicine Library. | | | The NCI PDQ patient statement on Hairy Cell leukemia. |
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http://www.acor.org/leukemia/hcl.html
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| | Hairy Cell Leukemia |
| | Students wishing to view jpgs of the text slide's from Dr. Krause's lecture on HCL may view them HERE. | | | Recently there has been great success in treating hairy cell leukemia. | | | Back to Leukemias ; Hematopathology ; Department of Pathology ; or Tulane University Medical Center. |
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http://www.mcl.tulane.edu/classware/pathology/Krause/Leukemias/HCL.html
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| | Hairy cell leukemia definition - Medical Dictionary definitions of popular medical terms |
| | Splenectomy (surgical removal of the spleen) provides palliation (some help but not a cure). | | | Leukemia - Learn about Leukemia including possible causes, the types of leukemia, symptoms, how it is diagnosed, and treatment | | | Hairy cell leukemia: A form of chronic leukemia in which malignant B-lymphocytes (a type of white blood cell) are seen in the bone marrow, spleen, and peripheral blood and when viewed under the microscope, these cells appear to be covered with tiny hair-like projections. |
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http://www.medterms.com/script/main/art.asp?articlekey=33213
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| | The Leukemia & Lymphoma Society : Disease Information - Hairy Cell Leukemia |
| | Hairy cell leukemia may be difficult to diagnose early because its symptoms are vague and resemble those of other illnesses. | | | Promising New Therapies: Leukemia, Lymphoma, Myeloma - A Closer Look at Clinical Trials | | | Unexplained weight loss and loss of a sense of well-being may bring patients to their physician. |
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http://www.leukemia-lymphoma.org/all_page?item_id=8507
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| | Hairy Cell Leukemia |
| | At CTCA we treat hairy cell leukemia with a powerful combination of conventional and alternative therapies. | | | This is a natural substance produced by your body in response to infection and disease. | | | Our Leukemia Cancer Center is your source for hairy cell leukemia treatment information. |
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http://www.cancercenter.com/hairy-cell-leukemia.htm
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| | hairy cell leukemia |
| | neoplastic disease of the lymphoreticular cells which is considered to be a rare type of chronic leukemia; it is characterized by an insidious onset, splenomegaly, anemia, granulocytopenia, thrombocytopenia, little or no lymphadenopathy, and the presence of hairy or flagellated cells in the blood and bone marrow. |
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http://crisp.cit.nih.gov/Thesaurus/00003505.htm
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| | ACS :: Treatment of Hairy Cell Leukemia (HCL) |
| | If a patient does have a relapse, a second course of treatment is usually effective. | | | Some patients with hairy cell leukemia (HCL) live for many years without having any symptoms or receiving any treatment. | | | Patients without symptoms are not given any treatment but do have careful follow-up exams. |
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http://www.cancer.org/docroot/CRI/content/CRI_2_4_4X_Treatment_of_Hairy_Cell_Leukemia_HCL_62.asp?sitearea=
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| | Hairy Cell Leukaemia - Genetics |
| | Trisomy 12 in chronic lymphocytic leukemia and hairy cell leukemia: a cytogenetic and interphase cytogenetic study. | | | Hairy Cell Leukaemia : Clinical and Epidemiological Information | | | Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment. |
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http://www.cancerindex.org/geneweb/X1209.htm
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| | Hairy cell leukemia |
| | This slide illustrates the peripheral blood from a patient with leukemia reticuloendotheliosis (hairy cell leukemia). | | | The most distinguishing characteristic of the "hairy cell" is the hair-like cytoplasmic projections: The nuclear chromatin pattern may be confused with that either of a monocyte or a lymphocyte. | | | At times these cells may be confused with those seen in some cases of CLL. |
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http://www.academic.marist.edu/~jzmz/topics/lymphocytic_leukemia/lympholeukemia27.html
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| | Hairy Cell Leukemia Research Foundation |
| | The Hairy Cell Leukemia Research Foundation is a non-profit, all volunteer, patient run organization whose primary goal is to provide support, information. | | | We also support research with funds received from patients, their families and their friends. |
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http://www.hairycellleukemia.org
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| | Welcome to Introna.com |
| | INTRON A therapy has been approved for use in the treatment of malignant melanoma, hairy cell leukemia, chronic hepatitis B, chronic hepatitis C, condylomata acuminata, follicular (non-Hodgkin's) lymphoma, and AIDS-related Kaposi's sarcoma. | | | A (Interferon alfa-2b, recombinant) for Injection is an interferon used as a frontline treatment for a number of indications. | | | For more on indications, dosages, and other prescription information, click on INTRON A Prescribing Information. |
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http://www.introna.com
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| | Hematology Hairy cell leukemia |
| | Hairy cell leukemia, or leukemic reticuloendotheliosis, is a rare malignant disorder. | | | Bone marrow aspiration is often unsuccessful because of complete infiltration by hairy cells, resulting in a dispersed spongy web of cells in an increased meshwork of reticulin fiber. | | | Hairy cells are characterized by their fine, irregular pseudopods and immature nuclear features. |
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http://www.wadsworth.org/chemheme/heme/microscope/hairycellleukemia.htm
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| | hairy cell leukemia |
| | a form of cancer in which abnormal cells with many hairlike cytoplasmic projections appear in the bone marrow, liver, spleen, and blood. |
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http://www.infoplease.com/dictionary/hairy+cell+leukemia
(39 words)
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| | Hairy Cell Leukemia - CancerIndex |
| | Patient's information for Hairy Cell Leukaemia (CancerNet) Information about the disease, staging, and treatment overviews. | | | Physician's PDQ statement for Hairy Cell Leukaemia (CancerNet) A referenced overview of the disease, cellular classification, staging, and current treatment overviews. | | | It is reviewed each month by a panel of medical experts. |
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http://www.cancerindex.org/clinks4q.htm
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| | Leukemia, hairy cell |
| | A neoplastic disease of the lymphoreticular cells which is considered to be a rare type of chronic leukemia. | | | It is characterized by an insidious onset, splenomegaly, anemia, granulocytopenia, thrombocytopenia, little or no lymphadenopathy, and the presence of "hairy" or "flagellated" cells in the blood and bone marrow. | | | 202.40 leukemic reticuloendotheliosis (hairy-cell leukemia), unspecified site, extranodal and solid organ sites |
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http://www.5mcc.com/Assets/SUMMARY/TP0536.html
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| | DBA.44(Hairy Cell Leukemia) |
| | The antibody is NOT specific for HCL since it is positve also in some marginal cell lymphomas(MZL) and large cell lymphomas. | | | DBA.44, a B subset antibody, also CD72, reacts with very few normal cells...however, 50-97%(depending who you read) of hairy cell leukemias(HCL) cases are positive; about 35% of low grade B-cell lymphomas are positive; and about 30-80%(depending on who you read) of splenic lymphomas are positive. | | | It's important to have a "known positive" case to use as a control. |
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http://www.histosearch.com/histonet/Dec02A/DBA.44HairyCellLeukemia.html
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