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| | Texas Medicaid Vendor Drug Program, HMG-CoA Reductase Inhibitors |
 | | Patients requiring concurrent therapy with certain HMG CoA reductase inhibitors and some macrolide antibiotics should be monitored regularly for muscular symptoms such as pain, tenderness, or weakness. | | | Patients requiring concurrent therapy with atorvastatin, cerivastatin, lovastatin,pravastatin, or simvastatin and niacin should be regularly monitored for muscular symptoms such as pain, tenderness, or weakness. | | | Fluvastatin and pravastatin appear to be less likely to interact with nefazodone and may be reasonable alternatives in patients requiring both nefazodone and HMG-CoA reductase inhibitor therapy. |
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http://www.hhsc.state.tx.us/HCF/vdp/Criteria/hmg-coa.html
(2201 words)
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| | [No title] |
| | In times of demand the mouse is able to utilise the hydroxymethyl-glutaryl-CoA (HMG CoA) reductase/synthase pathway of endogenous cholesterol synthesis while upregulation of this pathway has been demonstrated to be poor in the rat. | | | In studies comparing the responses of rat, hamster and rabbit adrenocortical cells to ACTH stimulation Spady and Dietschy (16) found that rat steroidogenic cells preferentially used HDL cholesterol from the culture medium while the ability to utilise the HMG CoA reductase pathway was extremely limited. | | | Although the dog produces appreciable levels of molinate sulphoxide, its lack of dependence upon HDL cholesterol for steroidogenesis means that toxicity to steroidogenic organs is not observed. |
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http://ecb.jrc.it/classlab/5399a48_IND_molinate.doc
(3562 words)
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| | Terpenoid |
| | DMAPP is a common metabolite in both pathways and and exchange of | | | independent pathway is located in the plastids of plants. | | | Many organisms manifacture terpenoids/isoprenoids through the HMG-CoA reductase pathway, |
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http://www.infothis.com/find/Terpenoid
(218 words)
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| | Dyslipidemia: HMG-CoA Reductase |
| | • The statins are metabolized by the CYP3A4 pathway. | | | Since protease inhibitors inhibit this pathway, the resulting increased levels of statins may place patients at a greater risk for skeletal muscle toxicity. |
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http://www.hivandhepatitis.com/recent/metabolic/dyslipidemias/1h.html
(218 words)
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| | Dolichol |
| | It is a product of the HMG-CoA reductase pathway. |
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http://www.worldhistory.com/wiki/D/Dolichol.htm
(113 words)
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| | British Journal of Pharmacology - HMG-CoA reductase inhibitors and P-glycoprotein modulation |
| | It is of interest to note that the cytochrome P450 system, especially the isoform P450 3A, has an overlapping substrate specificity to that of P-gp (Kim et al., 1999; Wacher et al., 1995). | | | HUNTER, J. and, HIRST, B.H. (1997) Intestinal secretion of drugs: The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption.. | | | YAMAZAKI, M.,, AKIYAMA, S.,, NI'INUMA, K.,, NISHIGAKI, R. and, SUGIYAMA, Y. (1997) Biliary excretion of pravastatin in rats: contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter.. |
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http://www.nature.com/bjp/journal/v132/n6/full/0703920a.html
(5832 words)
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| | HMG-CoA_reductase_pathway |
| | Plants have two pathways to create Isoprenoids: this one and the methylerythritol phosphate (MEP) pathway (also called MVA independent pathway) in plastids. | | | A number of drugs targets the HMG-CoA reductase pathway: | | | The HMG-CoA reductase pathway, also known as MVA pathway or mevalonate-dependent (MAD) route, is an important cellular metabolic pathway present in virtually all organisms. |
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http://www.freecaviar.com/search.php?title=HMG-CoA_reductase_pathway
(355 words)
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| | British Journal of Pharmacology - A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on ... |
| | Therefore, rosuvastatin is a new HMG-CoA reductase inhibitor able to exert potent anti-inflammatory effects in normocholesterolemic rats. | | | In the current study, we investigated the effect of a new HMG-CoA reductase inhibitor, rosuvastatin, on thrombin-stimulated leukocyte-endothelium interactions in vivo in normocholesterolaemic rats. | | | We used intravital microscopy of the rat mesenteric microvasculature to examine the effects of rosuvastatin, a new HMG-CoA reductase inhibitor, on leukocyte-endothelium interactions induced by thrombin. |
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http://www.nature.com/bjp/journal/v133/n3/full/0704070a.html
(4334 words)
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| | The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by ... |
| | pathway mediates CAM-DR and that targeting this pathway may | | | The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion–mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase | | | The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase -- Schmidmaier et al. |
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http://www.bloodjournal.org/cgi/content/abstract/104/6/1825
(327 words)
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| | Articles - Statin |
| | Fermentation-derived statins appear more effective in reducing LDL, but no clear explanation has accounted for this phenomenon. | | | Statins act by competitively inhibiting HMG-CoA reductase, an enzyme of the HMG-CoA reductase pathway, the body's metabolic pathway for the synthesis of cholesterol. | | | This team reasoned that certain micro-organisms may produce inhibitors of the enzyme to defend themselves against other organisms, as mevalonate is a precursor of many substances required by organisms for the maintenance of their cell wall (ergosterol) or cytoskeleton (isoprenoids). |
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http://www.gaple.com/articles/Statin
(826 words)
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| | Cholesterol - Wikipedia, the free encyclopedia |
| | Cholesterol is primarily synthesized from acetyl CoA through the HMG-CoA reductase pathway in many cells/tissues. | | | The cleaved SREBP then migrates to the nucleus and acts as a transcription factor to bind to the "Sterol Regulatory Element" of a number of genes to stimulate their transcription. | | | A large part of this mechanism was clarified by Dr Michael S. Brown and Dr Joseph L. Goldstein in the 1970s. |
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http://en.wikipedia.org/wiki/Cholesterol
(1712 words)
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| | Hyperimmunoglobinemia D with recurrent fever: Information From Answers.com |
| | Virtually all patients with the syndrome have mutations in the gene for mevalonate kinase, which is part of the HMG-CoA reductase pathway, an important cellular metabolic pathway. | | | Statin drugs might decrease the level of mevalonate and are presently being investigated. | | | Indeed, similar fever attacks (but normal IgD) have been described in patients with mevalonic aciduria - an inborn error of metabolism now seen as a severe form of HIDS. |
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http://www.answers.com/topic/hyperimmunoglobinemia-d-with-recurrent-fever
(301 words)
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| | Coenzyme A |
| | Furthermore, it contributes the acetyl group to acetylcholine; the addition of the acetyl group to choline a reaction that is catalysed by choline acetyltransferase. | | | It is the precursor to HMG CoA, which is a vital component in cholesterol and ketone synthesis. | | | Its main function is to carry acyl groups such as acetyl as thioesters. |
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http://coenzyme-a.ask.dyndns.dk
(218 words)
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| | REGULATION OF TOMATO FRUIT DEVELOPMENT AND DIFFERENTIATION BY HMG COA REDUCTASE |
| | The differential expression is correlated with the accumulation of different end-products, synthesized via the isoprenoid pathway, that are specifically needed during different stages of development. | | | This record is from the Current Research Information System (CRIS) database. | | | To address this question transgenic plants have been constructed that express modified HMG1 and HMG2 genes under the control of their own promoters to produce proteins which are tagged with an amino acid sequence recognized by a monoclonal antibody. |
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http://www.nal.usda.gov/pgdic/pggrantinfo/1992/9157089.html
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