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| | Prevalence of HLA-B27.. |
 | | The ankylosing spondilitis and the non granulomatosus alternate bilateral acute anterior uveitis associated to HLA | | | Proceedings: The acute anterior uveitis associated to HLA | | | Fisher accurate test did not showed any significant difference between the negative and positive B27 groups. |
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http://www.imbiomed.com.mx/HG/Hgv61n2/english/Zhg82-01.html
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| | Kimball Genetics - HLA-B27 DNA TEST |
| | This group of disorders is associated with human leukocyte antigen (HLA) B27 suggesting a possible autoimmune etiology. |
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http://www.kimballgenetics.com/tests-hlab27.html
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| | HLA B27 |
| | The research of my group is focused on the role of HLA B27 in these disorders. | | | HLA B27, a class I product of the human major histocompatibility complex, is strongly associated with ankylosing spondylitis (AS) and reactive arthritis (ReA): 70% of patients with ReA and 90% with AS posses the B27 gene compared with 7% of the general population. | | | Most of the Hom-CTL identified in B27-positive patients are restricted by B27. |
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http://homepages.which.net/~ks.burrell/nassdb/hlab27.htm
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| | HLA-B27 associated uveitis |
| | The HLA-B27 patients were also more likely than the idiopathic patients to require systemic therapy for the ocular condition, and this was even more so in patients with systemic disease associated with the B27 positive uveitis. | | | Classically, B27 associated uveitis presents with sudden onset acute anterior uveitis in a young patient. | | | Unlike the classic uveitis associated with the B27 gene, uveitis in IBD may occur in both eyes simultaneously and is subacute or chronic in up to 50% of cases of Crohn’s associated uveitis. |
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http://www.uveitis.org/WebEyeMD_htmbank/md_hlab27.htm
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| | Animal Models - HLA-B27 Transgenic Rats |
| | Features: The HLA-B27 transgenic rat, expressing HLA-B27 and human ß2m, exhibits a phenotype similar to humans suffering B27 related rheumatic disorders such as reactive arthritis, ankylosing spondylitis, psoriasis and inflammatory bowel disease. | | | This rat model is useful for research and pharmacological studies of spontaneous systemic inflammation, arthritis, inflammatory bowel disease and skin diseases including psoriasis and alopecia. |
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http://www.taconic.com/anmodels/HLAB27.htm
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| | iritis.com: HLA B27 |
| | HLA's are what the body's immune system uses to keep track of "self" and "non-self". | | | Your doctor may diagnose you as having B27 associated iritis by your symptoms and course. | | | If you have B27 it means you have a statistically higher chance of developing the symptoms of other B27-associated diseases. |
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http://www.iritis.co.uk/b27.htm
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| | The Pathogenetic Role of HLA-B27 |
| | HLA-B27 derived peptides may themselves elicit an immune response if there is loss of immune tolerance. | | | B*2706 is a common subtype among B27 positive individuals in Southeast Asia, while B*2709 is primarily observed in the Italian island of Sardinia. | | | Such cells were not present in B27 positive healthy individuals. |
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http://www.rheuma21st.com/archives/report_050225_hlab27.html
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| | eMedicine - HLA-B27 Syndromes : Article by A Luisa Di Lorenzo, MBBCh |
| | The third theory suggests that the T-cell antigen is the true susceptibility factor, and a fourth theory implicates an innate etiology unrelated to HLA. | | | In ophthalmology, HLA associations are strongest in diseases of the uvea. | | | An HLA disease association is defined as a statistically increased frequency of the HLA haplotype in individuals with the disease compared to the frequency in individuals without the disease. |
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http://www.emedicine.com/OPH/topic721.htm
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| | Reactive arthritis and HLA-B27 - mechanisms - antigen processing - Chlamydia |
| | Popov et al., 2002 explored this question using HLA-B27 transgenic rats expressing human B27 antigen. | | | Unlike their normal (wild type) counterparts, HLA-B27-transgenic rats are tolerant of B27 immunization using either B27(+) splenocytes [as source of T and B lymphocytes] or B27-expressing plasmid DNA. | | | Nor was it observed if rats were immunised with non-transgenic spleen cells or with a DNA construct expressing a different antigen, HLA-A2. |
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http://chlamydiae.com/restricted/docs/infections/arthritis_pathogenesis.asp
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| | HLA-B27: Test Sample |
| | Human leukocyte antigen B27 (HLA-B27) is found in about 5-10% of the U.S. population. | | | (This is important when someone needs a bone marrow or organ transplant, as the donors HLA antigens must be matched up with the recipients.) | | | While not as unique as a fingerprint, the presence or absence of each antigen creates a distinctive HLA combination for each person. |
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http://www.labtestsonline.org/understanding/analytes/hla_b27/sample.html
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| | HLA-B27 |
| | Approximately 85% of patients with ankylosing spondylitis and Reiter's syndrome will have the HLA-B27 antigen present on the leukocytes. | | | Some HLA antigens have been identified to be correlated with the presence of certain autoimmune diseases. | | | Human leukocyte antigens, or HLA antigens, are present on the surface of all nucleated cells. |
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http://www.medhelp.org/glossary/new/gls_2284.htm
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| | MedlinePlus Medical Encyclopedia: HLA-B27 antigen |
| | For example, HLA-B27 is found in 80 - 90% of people with ankylosing spondylitis and Reiter's syndrome. | | | Many HLA antigens exist, but some are of special interest since they are more common in certain autoimmune diseases. | | | The human leukocyte antigens (HLAs) are proteins present on the surface of all body cells that contain a nucleus, and are in especially high concentrations in white blood cells (leukocytes). |
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http://www.nlm.nih.gov/medlineplus/ency/article/003551.htm
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| | Medcyclopaedia - Hla-b27 antigen |
| | Among the conditions in which HLA-B27 antigen may play a causative role are ankylosing spondylitis, psoriatic arthritis, Reiters syndrome, Crohns disease and ulcerative colitis. | | | a histocompatibility antigen of the HLA group that is found in many diseases with musculoskeletal manifestations. |
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http://medcyclopaedia.com/library/topics/volume_iii_1/h/HLA_B27_ANTIGEN.aspx
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| | HLA-B27 - Wikipedia, the free encyclopedia |
| | HLA B27 in health and disease: a double-edged sword? | | | It presents microbial antigens to T-cells and is strongly associated with certain immunity diseases (SpA spondyloarthropathies). | | | Human Leukocyte Antigen B*27 (subtypes B*2701-2724) is a class I surface antigen encoded by the B locus in the MHC on chromosome 6. |
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http://en.wikipedia.org/wiki/HLA-B27
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| | HLA-B27 - Information and Side Effects |
| | This test is sometimes ordered to help assess the likelihood that you have an autoimmune disorder that is associated with the presence of HLA-B27. | | | To determine whether you have human leukocyte antigen B27 (HLA-B27) on the surface of your cells. | | | Consult a physician regarding the applicability of any information found on GoldBamboo.com to your symptoms or medical condition. |
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http://goldbamboo.com/topic-t4276.html
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| | AFCG Clinical Standards: HLA-B27 |
| | For HLA B27 typing, a putative positive result requires confirmation if the primary antibody is known to cross-react with other antigens. | | | Problems may arise, however, when antibody cross-reactivity occurs between different HLA antigens. | | | The development of monoclonal antibodies to HLA antigens has rendered flow cytometry a proficient alternative procedure. |
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http://jcsmr.anu.edu.au/facslab/AFCG/Standards/hla-b27.html
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| | health.iafrica.com doc online ask the doctor musculoskeletal Hla b27 |
| | The HLA B27 antigen is closely associated with the inflammatory disorder, ankylosing spondylitis. | | | My son has recently been found to have the HLA B27 antigen. | | | Since your son has the peripheral joint involvement which is one of the characteristics of this disease, he probably has early signs of the illness. |
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http://health.iafrica.com/doconline/qa/musculoskeletal/hlab27.htm
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| | Ankylosing spondylitis - Genetics Home Reference |
| | HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. | | | The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders (such as viruses and bacteria). | | | The HLA-B gene has many different normal variations, allowing each person's immune system to react to a wide range of foreign invaders. |
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http://0-ghr.nlm.nih.gov.portia.nesl.edu/condition=ankylosingspondylitis/sho...
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| | Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations |
| | Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series | | | Energy Citations Database (ECD) Document #5563011 - Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series | | | Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link. |
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http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=5563011
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| | HLA-B27: The Test |
| | If one of your family members has a HLA-B27 related spondyloarthropathy (AS or other related condition), and you have the HLA-B27 antigen, then you have a higher risk of developing a spondyloarthropathy. | | | If a patient has HLA-B27 and has symptoms such as: chronic pain, inflammation, and/ or degenerative changes to his bones (as seen on X-ray), then it supports a diagnosis of AS, Reiters syndrome, or another autoimmune disorder that is associated with the presence of HLA-B27. | | | Under these circumstances HLA-B27 is not diagnostic but adds additional information, increasing or decreasing the likelihood that the patient has ankylosing spondylitis. |
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http://www.labtestsonline.org/understanding/analytes/hla_b27/test.html
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| | Genetic Link and Immunology of AS to HLA-B27 |
| | However, healthy individuals also test positive for the HLA-B27 antigen. | | | The age of the patient will usually determine the susceptibility to AS, but genetic factors, such as the presence of the HLA-B27 antigen, influence the course of the disease. | | | The prevalence of the HLA-B27 antigen occurs in the following percentages: 5 to 10 percent in white populations, less than 1 percent in Asian and black African populations, 3 to 4 percent in North American blacks, 4 percent in Mexican populations, and as high as 50 percent in Native American populations. |
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http://www.chem.fsu.edu/editors/learn/genetic.htm
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