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| | Dorlands Medical Dictionary |
 | | the most commonly expressed antigen of platelets; patients not expressing this isoantigen are at risk for transfusion-induced hematologic disorders of platelets, such as thrombocytopenic purpura. | | | The primary use of CEA is in monitoring response to treatment of colorectal cancer. | | | a K antigen of Salmonella typhi originally thought to be responsible for virulence. |
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http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_a_47zPzhtm
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| | Patent 6,602,510 |
| | This CTL response was similar to that observed with a lipopeptide of known immunogenicity in humans, and significantly greater than immunization using peptides in oil-based adjuvants. | | | Junctional epitopes are generally to be avoided because the recipient may generate an immune response to that non-native epitope. | | | Immunization of HLA transgenic mice with this plasmid construct resulted in strong CTL induction responses against the nine CTL epitopes tested. |
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http://pharmcast.com/Patents/Yr2003/August2003/080503/6602510_Tumor080503.htm
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| | PCBE: Monitoring Stem Cell Research: Appendix L: Stem Cells and Tissue Regeneration: Lessons From Recipients of Solid ... |
| | Extending the approaches discussed above using donor-derived blood transfusions to induce a tolerogenic state to the subsequent organ, the most promising clinical strategy for tolerance induction at present is the use of donor-derived hematopoietic stem cells in conjunction with reduced myeloablative conditioning. | | | In currently used immunosuppressive protocols, azathioprine is used as part of a triple therapy regimen along with CyA or tacrolimus and prednisone. | | | Two distinct pathways of allorecognition have been described, direct and indirect. |
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http://www.bioethics.gov/reports/stemcell/appendix_l.html
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| | Association of Tapasin and HLA Class I Antigen Down-Regulation in Primary Maxillary Sinus Squamous Cell Carcinoma ... |
| | with changes in their HLA antigenic profile (1). | | | In contrast, HLA class I antigen expression was correlated significantly | | | Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical College, Asahikawa, Hokkaido 078-8510 Japan [T. H.]; Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263 [T. F.]; and Surgical Pathology Section, Asahikawa Medical College Hospital, Asahikawa 078-8510, Japan [N. Purpose: The purpose of this research was to assess the frequency |
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http://clincancerres.aacrjournals.org/cgi/content/full/9/11/4043
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| | [No title] |
| | correlating each antigen preparation with the positive or negative reactivity with the biological sample ; and determining a correlation indicator between the presence of that data pair and a positive reactivity with the biological sample. | | | The method of claim 1, further comprising determining a set of antigens containing at least one identified reactive epitope. | | | The system of claim 13, wherein the test system is an ELISA system. |
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http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=00/13028.000309&ELEMENT_SET=DECL
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| | IBMT: FAQ - HLA Typing |
| | If a patient cannot find a fully matched related or unrelated donor, it may be necessary to look at other options, such as using a patient's own bone marrow, a partially matched family donor or umbilical cord blood. | | | The most likely place to find a bone marrow match is within the patient's own family. | | | In some instances, the HLA type of the patient may be so unique that finding a matched unrelated donor is impossible. |
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http://www.ibmtindy.com/faq/hla-typing.htm
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| | Genetic Link and Immunology of AS to HLA-B27 |
| | The pain index mentioned in Calin's article suggests that the closer two people are genetically linked (siblings for example), the closer the pain indexes were for the individuals. | | | However, healthy individuals also test positive for the HLA-B27 antigen. | | | The age of the patient will usually determine the susceptibility to AS, but genetic factors, such as the presence of the HLA-B27 antigen, influence the course of the disease. |
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http://www.chem.fsu.edu/editors/learn/genetic.htm
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| | eMedicine - HLA-B27 Syndromes : Article by A Luisa Di Lorenzo, MBBCh |
| | The third theory suggests that the T-cell antigen is the true susceptibility factor, and a fourth theory implicates an innate etiology unrelated to HLA. | | | Synonyms and related keywords: acute unilateral alternating nongranulomatous iridocyclitis, seronegative spondyloarthropathies, acute anterior uveitis, AAU, human leukocyte antigen | | | The first human leukocyte antigen (HLA) haplotype association with inflammatory disease was discovered in 1972 correlating HLA-B27 with ankylosing spondylitis. |
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http://www.emedicine.com/OPH/topic721.htm
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| | [No title] |
| | - relative risk quantifies the chance of an individual with the specific HLA antigen to acquire a specific disease compared with an individual who does not have that HLA antigen. | | | D. HLA antigens and disease association - certain diseases have a propensity for persons with a particular HLA antigen. | | | - are associated with the presentation of antigen on APCs. |
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http://www.d.umn.edu/medweb/micro/outlines/IX_HistoAnt.txt
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| | University of Michigan - MLabs |
| | Qualitative analysis of antibody specificity is performed by analysis of a reactivity pattern. | | | Class I antigens are detected by molecular analysis of patient DNA. | | | HLA-A, B, and C antigens are expressed on nearly all human cells. |
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http://www.pathology.med.umich.edu/MLabs/SpecializedSvcs/MLTissueTyp/MLTissueTypTests.html
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| | Tissue Type Test |
| | If you have bleeding or clotting problems, or if you take blood-thinning medication, tell your health professional before your blood is drawn. | | | Having an antigen pattern only associated with a certain disease does not mean that the disease is present or will definitely develop. | | | Antigens on the surface of body cells and tissues can tell the difference between normal body tissue or foreign tissue (for example, tissue from another person's body). |
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http://www.webmd.com/hw/health_guide_atoz/hw40261.asp
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| | British Journal of Biomedical Science: HLA-B27 allele diversity in Indians: impact of ethnic origin and the caste system |
| | The present study aims to identify the HLA-B27 antigen frequencies among different Indian caste/tribal population groups reported in the literature, and to identify the subtypes among 58 B27-positive individuals belonging to different caste and tribal groups from western India. | | | HLA class I profile in Asian Indian patients with pulmonary tuberculosis. | | | HLA B*2704 and B*2705 subtypes were found in most of the caste and tribal groups, while B*2708, B*2707 and B*2714 showed a restricted distribution among the selected caste or tribal groups studied. |
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http://www.findarticles.com/p/articles/mi_qa3874/is_200301/ai_n9320945
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| | Major histocompatibility complex - definition of Major histocompatibility complex in Encyclopedia |
| | Indeed, much theory has been devoted to explaining why this particular region of the genome harbors so much diversity, especially in light of its immunological importance. | | | Foreign peptides that provoke an immune response are termed antigens. | | | The classical Mhc molecules (also referred to as HLA molecules in humans) have a vital role in the complex immunological dialog that must occur between T cells and other cells of the body. |
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http://encyclopedia.laborlawtalk.com/Major_histocompatibility_complex
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| | AllRefer Health - HLA-B27 Antigen (Human Leukocyte Antigen B27) - Test/Medical Exams/Tests |
| | AllRefer Health - HLA-B27 Antigen (Human Leukocyte Antigen B27) - Test/Medical Exams/Tests | | | For example, HLA-B27 is found in 80-90% of people with ankylosing spondylitis and Reiter's syndrome. | | | Many HLA antigens exist, but some are of special interest since they are more common in certain autoimmune diseases. |
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http://health.allrefer.com/health/hla-b27-antigen-info.html
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| | HLA-DQ molecules |
| | The last change was made in the beginning of 1997. | | | HLA molecules with bound peptides are recognized by T-lymphocytes and immune reactions against intruders are generated. | | | This requires a system which can distinguish between self and non-self, and some of the proteins in the HLA system is a part of this system. |
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http://depts.washington.edu/rhwlab/dq/intro.html
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| | HLA-DR antigen in neuroendothelium is detected during SIVSM encephalitis. |
| | Low passage NEC cultured from uninfected animals expressed HLA-DR antigens upon stimulation with interferon gamma. | | | Although latent infection of NEC with SIV cannot be excluded by in situ hybridization, our data suggest that induction of HLA-DR may be mediated by factors released in response to SIV infection as opposed to direct infection. | | | The state of the art may have changed since the publication date. |
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http://www.aegis.com/aidsline/1991/jul/M9170931.html
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| | HLA-B27: The Test |
| | If one of your family members has a HLA-B27 related spondyloarthropathy (AS or other related condition), and you have the HLA-B27 antigen, then you have a higher risk of developing a spondyloarthropathy. | | | If a patient has HLA-B27 and has symptoms such as: chronic pain, inflammation, and/ or degenerative changes to his bones (as seen on X-ray), then it supports a diagnosis of AS, Reiter’s syndrome, or another autoimmune disorder that is associated with the presence of HLA-B27. | | | Under these circumstances HLA-B27 is not diagnostic but adds additional information, increasing or decreasing the likelihood that the patient has ankylosing spondylitis. |
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http://www.labtestsonline.org/understanding/analytes/hla_b27/test.html
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| | Human Histocompatibility Leukocyte Antigen (HLA)-G Molecules Inhibit NKAT3 Expressing Natural Killer Cells -- Münz ... |
| | A class I antigen, HLA-G, expressed in human trophoblasts. | | | Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility complex molecules. | | | The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immnoglobulinlike domains and is expressed as a 140-kD disulphide-linked dimer. |
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http://www.jem.org/cgi/content/full/185/3/385
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| | HLA-B27: Test Sample |
| | (This is important when someone needs a bone marrow or organ transplant, as the donor’s HLA antigens must be matched up with the recipient’s.) | | | While HLA-B27 has not been established as a cause of these conditions, there is a higher prevalence of this antigen in those affected. | | | A blood sample is obtained by inserting a needle into a vein in the arm. |
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http://www.labtestsonline.org/understanding/analytes/hla_b27/sample.html
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| | HLA antigen frequencies in HIV-1 seropositive disease-free individuals and patients with AIDS. |
| | Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/*IMMUNOLOGY Human HIV Seropositivity/*IMMUNOLOGY *HIV-1 HLA Antigens/*ANALYSIS HLA-A Antigens/ANALYSIS HLA-B Antigens/ANALYSIS HLA-C Antigens/ANALYSIS HLA-DQ Antigens/ANALYSIS HLA-DR Antigens/ANALYSIS Male Opportunistic Infections/COMPLICATIONS/IMMUNOLOGY Sarcoma, Kaposi's/ETIOLOGY/IMMUNOLOGY JOURNAL ARTICLE | | | HLA antigen frequencies in HIV-1 seropositive disease-free individuals and patients with AIDS. | | | The state of the art may have changed since the publication date. |
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http://www.aegis.com/aidsline/1989/may/M8950608.html
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| | CBER - 510(k) number: BK980015, FlowPRA, One Lambda, Inc. |
| | This test utilizes a flow cytometer for data analysis. | | | The technology of FlowPRA utilizes flow cytometry based technique for HLA antibodies detection and obtains statistically similar results as the predicted device LCT. | | | The HLA antibody will attach to the complementary antigen of a HLA specificity. |
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http://www.fda.gov/CBER/510ksumm/K980015S.htm
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| | Human leukocyte antigen -- Facts, Info, and Encyclopedia article |
| | HLA types are inherited, and some of them are connected with (Any of a large group of diseases characterized by abnormal functioning of the immune system that causes your immune system to produce antibodies against your own tissues) autoimmune disorders and other diseases. | | | Scientists think that people with certain types of HLA antigens are more likely to develop certain autoimmune diseases, such as SLE (Lupus), Myasthenia Gravis, and Sjogren's Syndrome. | | | The (A system (including the thymus and bone marrow and lymphoid tissues) that protects the body from foreign substances and pathogenic organisms by producing the immune response) immune system uses the HLAs to differentiate self cells and non-self cells. |
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http://www.absoluteastronomy.com/encyclopedia/h/hu/human_leukocyte_antigen.htm
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| | Acute Anterior Uveitis |
| | This may suggest that the HLA-DR8 antigen is a factor in developing AAU in AS patients who are Japanese, but not in patients without | | | In a study of 42 Japanese patients with AAU, an association to the HLA-DR8 antigen was found. | | | AS did not have a significant increase in the HLA-DR8 antigen as did the patients with |
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http://www.chem.fsu.edu/editors/learn/aau.htm
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| | Introduction - Continuing Medical Education: Spondyloarthropathies. |
| | The spondyloarthropathies are a heterogeneous set of disorders characterized by axial skeletal involvement and an association with the HLA B27 antigen. | | | Below is the relative percentages of HLA B27 in patients with these diseases. | | | At least one family study suggests that up to 25% of HLA B27 positive relatives of patients with ankylosing spondylitis may have signs and symptoms of inflammatory back pain but do not meet full criteria for ankylosing spondylitis. |
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http://www.orthop.washington.edu/uw/tabID__3376/ItemID__130/mid__10313/Articles/Default.aspx
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| | Cancer Immunity 2:14 (2002) |
| | Telomerase as a universal tumor-associated antigen for cancer immunotherapy. | | | Another approach is to transfect the restricting HLA molecule in cells endogenously expressing the antigen and to determine whether this results in susceptibility to lysis. | | | The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes. |
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http://www.cancerimmunity.org/v2p14/021014.htm
(2062 words)
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| | HLA-DR antigen-negative acute myeloid leukemia |
| | HLA-DR antigens were not detected on AML cells from 43 patients, including 20 with acute promyelocytic leukemia (APL), and 23 with other subtypes of AML. | | | Human leukocyte antigen (HLA) Class II antigens are variably expressed on acute myeloid leukemia (AML) blasts. | | | The biological and clinical significance of HLA Class II antigen expression by AML cells is not known. |
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http://www.nature.com/cgi-taf/DynaPage.taf?file=/leu/journal/v17/n4/abs/2402865a.html
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| | GenomicsHuGENetReviewsHLA-DPB1 and Chronic Beryllium Disease |
| | Continued research in the beryllium-exposed population will be important for improving personal risk assessment and identifying high-risk genes associated with disease progression. | | | The human leukocyte antigen (HLA) complex is a series of genes located on chromosome 6 that are important in normal immune function. | | | Susceptibility to chronic beryllium disease, a granulomatous lung disease that appears in workers exposed to beryllium, is modified by genetic variants of the HLA-DP subregion. |
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http://www.cdc.gov/genomics/hugenet/reviews/beryllium.htm
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| | HLA Type Cord Blood Unit Search - National Cord Blood Program |
| | To do a public search, all you need to have is the patient's HLA type. | | | The purpose of this feature is to provide a preliminary view of a patient's likelihood of finding a suitable match from the NYBC's National Cord Blood Program inventory of publicly banked cord blood units. | | | Enter patient's HLA types using the drop down menus below. |
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http://www.nationalcordbloodprogram.org/public_hla_search.html
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| | A Feasibility Study of Human Leukocyte Antigen (HLA) Typing for Dried Bloodstains |
| | A Feasibility Study of Human Leukocyte Antigen (HLA) Typing for Dried Bloodstains | | | antigen systems, forensic science, genetic typing, human leukocyte antigen | | | This paper constitutes a feasibility report on the use of the human leukocyte antigen (HLA) system for the typing of dried bloodstains. |
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http://www.astm.org/JOURNALS/FORENSIC/PAGES/276.htm
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| | Epstein−Barr virus-specific cytotoxic T-cell clones restricted through a single HLA antigen |
| | Clonal expansion of individual cells from such preparations in medium containing T-cell growth factor (TCGF-medium) not only offers a means of testing this hypothesis but should also provide monospecific populations ideal for the analysis of human cytotoxic T-cell function. | | | If individual effector cells of this kind recognize viral antigen in association with one particular HLA determinant, then it follows that cytotoxic T-cell preparations from HLA-hetero-zygous donors must be polyclonal with discrete component populations each functionally linked to one of the relevant HLA-A or -B antigens. | | | We describe here the establishment in vitro of EB virus-specific human cytotoxic T-cell clones each recognizing the virus-induced lymphocyte-detected membrane antigen (LYDMA) in association with one particular HLA-A or -B determinant. |
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http://www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/v297/n5865/abs/297413a0.html
(317 words)
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| | HLA-B27 - Wikipedia, the free encyclopedia |
| | It presents microbial antigens to T-cells and is strongly associated with certain immunity diseases (SpA spondyloarthropathies). | | | In the general population, about 8% Caucasian, 4% African, 2-9% Chinese, and 0.1-0.5% Japanese have the HLA-B27 antigen. | | | Human Leukocyte Antigen B*27 (subtypes B*2701-2724) is a class I surface antigen encoded by the B locus in the MHC on chromosome 6. |
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http://en.wikipedia.org/wiki/HLA-B27
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| | Howstuffworks "How Your Immune System Works" |
| | Why doesn't a white blood cell attack every cell in the body?" There is a system built into all of the cells in your body called the Major Histocompatibility Complex (MHC) (also known as the Human Leukocyte Antigen (HLA)) that marks the cells in your body as "you". | | | Anything that the immune system finds that does not have these markings (or that has the wrong markings) is definitely "not you" and is therefore fair game. | | | There are millions of different antibodies in your blood stream, each sensitive to a specific antigen. |
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http://health.howstuffworks.com/immune-system.htm/printable
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| | HLA antigen |
| | an antigen of the HLA group, designated by a letter (HLA-A, HLA-B, etc.) according to the chromosome locus on which the controlling HLA gene appears and additionally by a number (HLA-A1, HLA-A2, etc.) according to the order of discovery and identification. |
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http://www.infoplease.com/ipd/A0477120.html
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| | Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations |
| | Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link. | | | Comparison of Class II HLA antigen expression in normal and carcinomatous human breast cells | | | For a journal article, please see the Resource Relation field. |
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http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=5681527
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| | (WO 00/13028) METHOD FOR IDENTIFYING SHARED ANTIGENIC EPITOPES |
| | (57) The invention provides a method, and a system implementing the method, for determining a set of antigenic epitopes against which a biological sample is reactive. | | | (WO 00/13028) METHOD FOR IDENTIFYING SHARED ANTIGENIC EPITOPES |
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http://wipo.int/cgi-pct/guest/getbykey5?KEY=00/13028.000309&ELEMENT_SET=DECL
(101 words)
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