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| | HIV vaccine - Wikipedia, the free encyclopedia |
 | | The second problem with HIV is its attack on the immune system itself which means that, to date, no effective cell-mediated immune response has been determined. | | | Finally, individuals who become infected with HIV do not succumb to the disease for years even in the absence of anti-retroviral therapy, suggesting that the human immune system is capable of controlling HIV infection partially or temporarily. | | | Only a vaccine will be able to halt the pandemic. |
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http://en.wikipedia.org/wiki/HIV_vaccine
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| | HIV Vaccine Glossary |
| | The precise correlates of immunity in HIV transmission are unknown. | | | A means of protecting a drug or vaccine antigen from rapid breakdown. | | | Challenge experiments are never done in human HIV vaccine research. |
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http://www.webmd.com/content/article/5/1680_50211.htm
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| | HIV vaccine and risk behavior model |
| | Vaccine effectiveness is calculated by looking at a fraction of the cumulative incidence for a vaccinated group over the cumulative incidence for an unvaccinated group. | | | Forecasting the future of HIV epidemics: the impact of antiretroviral therapies and imperfect vaccines. | | | Prophylactic vaccines, risk behavior change and the probability of eradicating HIV in San Francisco. |
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http://www.biomath.medsch.ucla.edu/faculty/sblower/applets/HIVVAC/hivvac.html
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| | The Science of HIV Vaccine Development |
| | Factors other than vaccine efficacy, however, may affect the impact of a vaccine to reduce HIV transmission, including the duration of immunity and potential adverse effects of vaccination on risk behavior.(8,9) For instance, a partly effective HIV-1 vaccine that increased risk-taking behavior might paradoxically increase HIV transmission. | | | For vaccine studies, the implication is that the choice of a particular species and vaccine strain has a significant effect on the results of the study. | | | Although HIV transmission is in theory largely preventable, in practice, without the development of an effective vaccine, HIV will continue to infect millions throughout the world. |
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http://hivinsite.ucsf.edu/InSite?page=kb-02-01-06
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| | Bio160- HIV Vaccine Strategies |
| | For HIV in particular, further research is needed to understand what level of attenuation is needed so that AIDS or other disease is avoided while still eliciting a protective immune response. | | | They are mostly being developed as single-approach vaccines, but it may ultimately be determined that the most effective immunization strategy will be to combine approaches. | | | One disadvantage of subunit vaccines, like whole-killed pathogen, is that the primary response is antibody mediated with very little induction of cell-mediated activity. |
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http://www.brown.edu/Courses/Bio_160/Projects1999/hiv/vacstrat.html
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| | HIV VACCINE ETHICS COMMITTEE REPORT |
| | The vaccine to be studied is based on this HIV subtype so that countries in the Caribbean and Brazil are particularly appropriate for studies with this vaccine. | | | The Committee was divided as to the responsibility of researchers, in the event that volunteers contracted HIV as a result of their risk behaviour. | | | Through the Honourable Minister of Health the Committee received an application for the conduct of an HIV Vaccine trial in Trinidad and Tobago, from the Medical Research Foundation of Trinidad and Tobago (MRFTT). |
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http://www.healthsectorreform.gov.tt/whitepapers/hivethics.htm
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| | NIH Guide: HIV VACCINE RESEARCH AND DESIGN |
| | This PA, “HIV VACCINE RESEARCH AND DESIGN,” is related to the focus areas of immunization and infectious diseases; HIV infection; and sexually transmitted diseases. | | | Clinical studies involving humans would not be considered appropriate for this PA. In addition, vaccine research focused solely on therapeutic application is not responsive to this announcement. | | | NIAID supports the progressive stages of AIDS vaccine research and development including basic research, iterative product development, and clinical trials. |
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http://grants.nih.gov/grants/guide/pa-files/PAR-00-093.html
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| | The AIDS Vaccine Fiasco |
| | Mathieson pointed out, "It has already been proven that Gp-120 stimulates some immune response against HIV whether or not the specific trials are successful, there is a very good chance a successful approach will be found." The NIH clings to that hope despite the criticism. | | | All the individuals in the program tested negative for HIV prior to being vaccinated, and 25 of them had been immunized three or more times. | | | Mathieson says recent combination therapies have made outstanding progress toward viral reduction, buying more time for vaccine research to be conducted. |
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http://www.chronicillnet.org/online/Fiasco.html
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| | HIV symptoms, HIV prevention, HIV vaccine, HIV AIDS, HIV treatment, HIV infection, AIDS symptoms, AIDS virus |
| | Pregnancy, Birth and HIV - HIV infection is increasing most rapidly in women and it could be passed from the mother to the baby. | | | At the moment though, in spite of much research, there is no cure for HIV or for AIDS and so, sadly, it is almost certain that people diagnosed with AIDS will die. | | | They may not know they now have the virus, but could pass it on to someone else through having sex, or by sharing needles or syringes. |
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http://www.health.indiamart.com/hiv-aids
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| | ScienceDaily: NIAID Launches First Phase II Trial Of A 'Global' HIV/AIDS Vaccine |
| | AIDS Vaccine Developed At Emory And The NIH Moves To Clinical Trials (January 24, 2003) -- A vaccine aimed against AIDS, developed at the Yerkes National Primate Research Center of Emory University, the Emory Vaccine Center, and the Laboratory of Viral Diseases at the National Institute of... | | | First AIDS Vaccine Made At NIAID's Vaccine Research Center Enters Clinical Trial (October 10, 2001) -- National Institute of Allergy and Infectious Diseases (NIAID) researchers at the Dale and Betty Bumpers Vaccine Research Center (VRC) today announced the start of a clinical trial testing the first... | | | The study will determine the vaccine's ability to prevent genital... |
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http://www.sciencedaily.com/releases/2005/10/051018070342.htm
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| | New Scientist Breaking News - Edible HIV vaccine breakthrough |
| | The HIV form of gp120 would not be used alone as a vaccine, Schlesinger points out. | | | This development brings an edible, more effective, HIV vaccine for people a step closer, says the US National Institutes of Health. | | | "First, the HIV virus usually gets into the body through the mucosa, when it is transmitted either sexually or homosexually - so to have a good mucosal immune response is really important," he says. |
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http://www.newscientist.com/article.ns?id=dn2161
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| | The Seattle Times: Local News: HIV vaccine results are promising |
| | But the three-gene vaccine has increased the T-cell response in those people considerably. | | | "It looks like we have a good killer-cell vaccine, so now we need to find out if this approach works" to protect against actual HIV infection, says Dr. Julie McElrath, program director for the HIV Vaccine Trials Network and a veteran HIV researcher. | | | "That makes it more likely to work in most people," said McElrath, a veteran HIV researcher. |
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http://seattletimes.nwsource.com/html/localnews/2002576494_hivvaccine22m.html
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| | The Science of HIV Vaccine Development: Related Resources |
| | Assessing the Attitudes, Knowledge, and Awareness of HIV Vaccine Research Among Adults in the United States | | | Works to expand access to existing vaccines in the developing world and accelerate research on needed vaccines, including HIV vaccines. | | | Part of the NIH's National Institute of Allergy and Infectious Diseases (NIAID), the Dale and Betty Bumpers Vaccine Research Center (VRC) was established to facilitate research in vaccine development. |
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http://hivinsite.ucsf.edu/InSite?page=kbr-02-01-06
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| | [No title] |
| | Report on Drug Development from the HIV Immune-based Therapies Workshop | | | Status of AIDS Vaccine Research at the National Institutes of Health (NIH) | | | Proposed human safety trial of a live-attenuated HIV vaccine raises ethical questions |
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http://www.aids.org/LinkLibrary/vaccine.htm
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| | International AIDS Vaccine Initiative IAVI - International AIDS Vaccine Initiative |
| | The piece addresses the weaknesses in our current health system’s approach to vaccine development for infectious diseases, and suggests lessons learned from a decade of AIDS vaccine research can help public health leaders develop a vaccine against a potential pandemic flu outbreak. | | | The Indian Council of Medical Research (ICMR), the National AIDS Control Organization (NACO) and the International AIDS Vaccine Initiative (IAVI) announced India’s second Phase I AIDS vaccine trial to be conducted at the Tuberculosis Research Centre (TRC) in Chennai. | | | The Kenya Medical Research Institute (KEMRI) and the International AIDS Vaccine Initiative (IAVI) opened two new buildings today to serve the Kilifi Community and prepare for future preventive HIV/AIDS vaccine trials. |
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http://www.iavi.org
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| | BBC NEWS Health Live HIV vaccine 'is possible' |
| | A spokesman for the HIV charity The Terrence Higgins Trust said: "Vaccine research is a vital part of the fight against the worldwide spread of HIV, and any developments in this field are welcome. | | | They plan to test their theory in experiments on animals. | | | Ruth Ruprecht of Harvard Medical School: "It looks like an interesting approach and has potential." |
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http://news.bbc.co.uk/hi/english/health/newsid_790000/790559.stm
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| | Human Test: Novel Vaccine Stops HIV |
| | "The results suggest that [these] vaccines could be a promising strategy for treating people with chronic HIV infection," Andrieu and colleagues write. | | | And now in humans, a therapeutic vaccine has stopped HIV in its tracks. | | | The vaccine is made from a patient's own dendritic cells and HIV isolated from the patient's own blood. |
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http://www.webmd.com/content/Article/97/104268.htm
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| | HIV/AIDS Prevention CDC HIV/AIDS |
| | Since HIV infection is spread primarily through sexual practices or by sharing needles, prevention messages and programs may address these topics. | | | MMWR: Methamphetamine Use and HIV Risk Behaviors Among Heterosexual Men --- Preliminary Results from Five Northern California Counties, December 2001--November 2003 | | | Rapid HIV tests can play an important role in HIV prevention activities by substantially increasing the number of persons... |
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http://www.cdc.gov/hiv/dhap.htm
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| | HealthScout-Consumer Health News, Information and Resources Updated Daily-Kid-Interferon-Linked Protein Key to HIV ... |
| | By identifying the active component of HIV-1 that stimulates pDC function, the researchers believe they have pinpointed an important pathway that may prove a useful target in the development of HIV vaccines or immunotherapies. | | | The new study, published in the Oct. 13 online issue of the Journal of Clinical Investigation, outlines the mechanisms by which HIV-1 activates human pDCs. | | | To find more information on specific conditions, please visit our partner sites: |
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http://www.healthscout.com/news/1/528478/main.html
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| | Global HIV Vaccine Enterprise |
| | Three phases of clinical trials in humans are required to fully test a vaccine candidate. | | | The laboratory assays that researchers use to assess immune response may not be comparable, severely hampering decisions about which candidates to pursue for further testing. | | | National regulatory oversight of clinical trials is the cornerstone of safe and scientifically valid medical research. |
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http://www.hivvaccineenterprise.com
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| | WHO WHO-UNAIDS HIV Vaccine Initiative |
| | The mission of the WHO-UNAIDS HIV Vaccine Initiative (HVI) is to promote the development, facilitate evaluation, and address future availability of preventive HIV vaccines, with a focus on the need of developing countries. | | | within the unique social, cultural and political environment of HIV vaccine research, UNAIDS contributes with its expertise in social and behavioural research, ethical issues, political mobilization and its strong link with community; | | | As it is the case with other infectious diseases, a safe, effective and available vaccine is ultimately required to complement and enhance the effectiveness of existing prevention strategies to control the HIV/AIDS pandemic, especially in developing countries. |
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http://www.who.int/vaccine_research/diseases/hiv/en
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| | AVAC - Vaccine Primer |
| | Why an infected person would advocate for a preventive vaccine | | | The AIDSVAX envelope vaccine story; first phase 3 trial | | | Seventy-one HIV Vaccine Trial Sites in the U.S |
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http://www.avac.org/primer.htm
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| | Vanderbilt HIV Vaccine Program |
| | Below are some links to websites that provide additional links and basic information on HIV and AIDS. | | | Adenovirus and modified vaccinia Ankara (MVA) are examples of live vector-based vaccines undergoing evaluation as HIV vaccines in humans. | | | A vaccine is a preparation or compound that is designed to create an immune response that will protect people from diseases. |
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http://www.hivvaccineresearch.com/science.html
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| | CNN.com - Experts: AIDS vaccine years away - Nov 25, 2004 |
| | Most of the protesters were Thais who called for greater availability of generic drugs as well as the expansion of prevention programs that include condom distribution and access to needles for IV drug users. | | | Despite this only 440,000 of AIDS sufferers there now receive such drugs, the WHO said. | | | Researchers even said they could be forced to go back to the drawing board if the current batch of drugs, all focused on one approach, fails. |
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http://www.cnn.com/2004/HEALTH/07/12/aids.conference
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| | CNN.com - Human HIV vaccine trial begins - Nov. 3, 2003 |
| | AIDS is notoriously successful at beating the body's immune system and so far has resisted every vaccine tried. | | | The treatment, which is also being tested in the United States, is one of about two dozen potential vaccines being tested by some 12,000 human volunteers in experiments around the world. | | | The first human trials are aimed at establishing the safety of the drug and are expected to last two years. |
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http://www.cnn.com/2003/HEALTH/11/03/safrica.aids.vaccine.ap
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| | NIAID teams with Wyeth on HIV/AIDS vaccine |
| | “In this way, we encourage continual movement towards a clinically viable vaccine and also reward companies for their accomplishments along the way,” she adds. | | | The vaccine itself did not cause any illness, and it could be administered nasally, a potentially important advantage for any vaccine destined for widespread use. | | | Researchers hope the vaccine will stimulate both parts of the immune system: antibodies to neutralize any free-floating HIV and specialized immune cells to kill any cells that HIV does manage to infect. |
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http://www.eurekalert.org/pub_releases/2002-05/nioa-ntw051702.php
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| | Capital Area Vaccine Effort |
| | News Search Results for "hiv vaccine" or "aids Vaccine" | | | CAVE's AIDS Vaccine Worskshop is the best way to learn about the state of vaccines, HIV and what CAVE is doing end the AIDS pandemic. | | | Will Sexual Risk Behaviour Increase After Being Vaccinated for AIDS? |
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http://www.aidsvaccine.org
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| | HIV Vaccine Trials Unit |
| | The Seattle HIV Vaccine Trials Unit (HVTU) is currently conducting research studies to try to find a vaccne that would prevent HIV infections. | | | There’s no doubt that the world desperately needs an HIV vaccine. | | | With facts like these, a vaccine can’t come soon enough. |
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http://www.seattlevaccines.org
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| | Global HIV Vaccine Enterprise |
| | The President also announced plans to establish a second HIV Vaccine Research and Development Center in the U.S., and urged his G-8 counterparts to increase their commitment to vaccine development. | | | But, the human and economic toll of the HIV pandemic demands that these activities be complemented by accelerated efforts to develop an HIV vaccine. | | | New U.S. Vaccine RandD Center: President Bush announced today plans to establish a second HIV Vaccine Research and Development Center, in addition to the one at the U.S. National Institutes of Health. |
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http://www.state.gov/e/eb/rls/fs/33569.htm
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| | Global HIV Vaccine Scientific Update |
| | Phase I studies of the two vaccines indicate that they are well-tolerated and elicit cellular and humoral immune responses. | | | They encode for selected protein sequences from HIV clades A, B, and C. These HIV clades cause about 85 percent of all HIV infections around the world. | | | Vaccine Research Center / 40 Convent Drive / Bethesda, Maryland 20892 |
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http://www.vrc.nih.gov/VRC/scientificupdates_hiv.htm
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