|
| |
| | Publications - Granulocyte Transfusions |
 | | The conclusion was that in the proper clinical circumstances granulocyte transfusion therapy is beneficial. | | | The role of traditional granulocyte therapy in fungal infection is not clear. | | | Granulocyte transfusion therapy and amphotericin B: adverse reactions? |
|
http://www.scbcinfo.org/publications/bulletin_v2_n4.htm
(1550 words)
|
|
| |
| | Granulocyte transfusions for neonates with confirmed or suspected sepsis and neutropaenia |
| | Immunologic follow-up of infants treated with granulocyte transfusion for neonatal sepsis. | | | Randomized trial of granulocyte transfusions versus intravenous immune globulin therapy for neonatal neutropenia and sepsis. | | | This is an appropriate time to review the role of granulocyte transfusions as an adjunct to antibiotics in the treatment of neutropaenic septic newborns, and to clarify their effects in specific situations. |
|
http://www.nichd.nih.gov/cochraneneonatal/Mohan3/mohan.HTM
(6827 words)
|
|
| |
| | Cancer Control Journal:Infections in Oncology |
| | Filtration leukapheresis for granulocyte transfusion therapy: clinical and laboratory studies. | | | G-CSF–stimulated granulocyte transfusion therapy is still investigational; hence, the specific indication for granulocyte transfusion should be determined on the basis of previous experience treating patients with comparable infections in the same institution. | | | In this regard, granulocyte transfusion therapy is indicated when outcome is uncertain and when the risks are outweighed by the benefits. |
|
http://www.moffitt.usf.edu/pubs/ccj/v4n1/department5.html
(5384 words)
|
|
| |
| | Granulocyte Transfusion in the G-CSF Era: Thomas H. Price, MD; Medical Director, Puget Sound Blood Center; Professor of ... |
| | Numerous studies have suggested that the success of granulocyte transfusion therapy is likely to be dependent on the dose of granulocytes provided. | | | However, in spite of the fact that some degree of clinical utility was subsequently demonstrated in controlled trials, granulocyte transfusion therapy fell into disuse in the 1980s and 1990s, largely because the results were not impressive to clinicians. | | | Promising results from early uncontrolled trials led to great enthusiasm for this therapy. |
|
http://www.bbanys.org/0803.htm
(1142 words)
|
|
| |
| | February 1997 - Granulocyte Transfusion |
| | Continuation of treatment is based upon clinical judgment and the response of the patient. | | | Neutropenic Patients: Severely neutropenic patients (ANC <500/uL) with sepsis unresponsive to at least 48 hours of appropriate antimicrobial therapy and expected bone marrow recovery are candidates for GTx. | | | Widespread use of both of these techniques awaits further study and FDA approval. |
|
http://www.itxm.org/TMU1997/tmu2-97.htm
(847 words)
|
|
| |
| | G-CSF for Granulocyte Donation |
| | A clinical trial or clinical study is a research project with human volunteer subjects. | | | Participants will answer questions about how they feel before the drugs are given and at the various intervals after taking the drugs. | | | Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. |
|
http://www.clinicaltrialssearch.org/gcsf_for_granulocyte_donation.html
(893 words)
|
|
| |
| | Granulocyte transfusion as a treatment for enterococcal meningoencephalitis after allogeneic bone marrow ... |
| | In the present study, although the patient received granulocytes from an HLA-mismatched sibling and engraftment was not achieved, it is difficult to attribute the engraftment failure to leukocyte incompatibility alone. | | | Further, we were able to clinically confirm the migratory activity of transfused granulocytes into the CSF. | | | No serious adverse events, apart from bone pain, insomnia, and flushing, were observed in the donor. |
|
http://www.nature.com/cgi-taf/DynaPage.taf?file=/bmt/journal/v31/n1/full/1703780a.html
(2290 words)
|
|
| |
| | Granulocyte transfusions: an overlooked therapeutic modality |
| | One potential problem that could be encountered is adverse reaction between amphotericin B therapy and granulocyte transfusion. | | | Since antibacterial and antifungal prophylaxis has not proved beneficial in combating this problem, the author suggests a role for granulocyte transfusion therapy as an ancillary modality. | | | Infection, particularly fungal infections with candida and aspergillus organisms, remains the major obstacle to safe administration of potentially curative intensive postremission therapy in leukemia patients (pts) experiencing prolonged therapy-induced granulocytopenia. |
|
http://www.meb.uni-bonn.de/cgi-bin/mycite?ExtRef=ICDB/92686455
(242 words)
|
|
| |
| | Specialty Laboratories ::: we help doctors help patients |
| | Currently, the method of choice for detection and quantitation of granulocytes autoantibodies of any isotype is by FC. | | | The frequency of granulocyte autoantibodies in SLE is reportedly about 50%. | | | Serum granulocyte colony-stimulating factor levels are not increased in patients with autoimmune neutropenia of infancy. |
|
http://www.specialtylabs.com/books/display.asp?id=679
(528 words)
|
|
| |
| | Granulocyte-associated immunoglobulins in asymptomatic HIV-infected subjects. |
| | The purpose of this study was to determine the prevalence of granulocyte-associated immunoglobulins (GA-IgG) during the follow-up of asymptomatic human immunodeficiency virus (HIV)-infected subjects. | | | An increase in GA-IgG was detected in 32 asymptomatic HIV seropositive subjects by a granulocyte immunofluorescence test (GIFT). |
|
http://www.aegis.com/aidsline/1990/may/M9050723.html
(339 words)
|
|
| |
| | Granulocyte - Wikipedia, the free encyclopedia |
| | This condition reduces the body's resistance to many infections. | | | Their names are derived from their staining characteristics; for example, the most abundant granulocyte is the neutrophil granulocyte, which has neutrally-staining cytoplasmic granules. | | | Granulocytes are a category of white blood cells, characterised by the fact that all types have differently staining granules in their cytoplasm on light microscopy. |
|
http://en.wikipedia.org/wiki/Granulocyte
(201 words)
|
|
| |
| | Prophylactic Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor Decrease ... |
| | Heath JA, Steinherz PG, Altman A, et al: Human granulocyte colony-stimulating factor in children with high-risk acute lymphoblastic leukemia: A Children's Cancer Group Study. | | | Michon JM, Hartmann O, Bouffet E, et al: An open-label, multicentre, randomised phase 2 study of recombinant human granulocyte colony-stimulating factor (filgrastim) as an adjunct to combination chemotherapy in paediatric patients with metastatic neuroblastoma. | | | Lyman GH, Kuderer NM, Djulbegovic B: Prophylactic granulocyte colony-stimulating factor in patients receiving dose-intensive cancer chemotherapy: A meta-analysis. |
|
http://www.jco.org/cgi/content/full/22/16/3350
(3728 words)
|
|
| |
| | Clinical Trial: Prevalence and Risk of Cataracts in Granulocyte Donors |
| | Though the relationship or corticosteroid administration to the development of PSCs is well established, not all steroid recipients develop such lesions. | | | The donors were unaware that they had the cataracts, which were small and did not affect their vision. | | | This study will investigate whether people who donate granulocytes (a type of white blood cell) by leukapheresis are at increased risk of developing cataracts (changes in the lens of the eye that can impair vision). |
|
http://clinicaltrials.gov/ct/gui/show/nct00042627
(818 words)
|
|
| |
| | Florida College of Integrative Medicine |
| | The information in this article comes under the major subject areas of Biotechnology, Complementary & Alternative Medicine, Herbal, Immunology, Pharmaceutical & Drug Development and Rheumatology. | | | Sekiya and coauthors published their study in Phytotherapy Research (Suppressive effects of Stephania tetrandra on the neutrophil function in patients with rheumatoid arthritis. | | | In their study, "[a]fter the administration of ST for 12 weeks, the proportion of granulocytes and the granulocyte count in peripheral blood decreased significantly." "The lipid peroxide and human granulocyte elastase levels of stored plasma declined significantly" as well, according to the report. |
|
http://fcim.edu/story.cfm?loc=69
(242 words)
|
|
| |
| | Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor |
| | We have determined the crystal structure of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) at 2.8 Å resolution using multiple isomorphous replacement techniques. | | | Colony stimulating factors are glycoproteins that are required for the survival, proliferation, and differentiation of hematopoietic progenitor cells of myeloid and erythroid linkage. | | | Granulocyte-macrophage colony stimulating factor (GM-CSF) stimulates the growth and differentiation of hematopoietic precursor cells from various linearges, including granulocytes, macrophages, erythrocytes, and eosinophils. |
|
http://arginine.chem.cornell.edu/Structures/GMCSF.html
(189 words)
|
|
| |
| | Amazon.ca: Books: Granulocyte Responses to Cytokines |
| | Look for books like Granulocyte Responses to Cytokines by subject: | | | Use Your Account to view or change your orders | | | Top of Page : Granulocyte Responses to Cytokines |
|
http://www.amazon.ca/exec/obidos/ASIN/0824786556
(99 words)
|
|
| |
| | Recombinant Human Granulocyte-Colony Stimulating Factor - CYT- 220 |
| | Granulocyte colony-stimulating factor (G-CSF) could enhance Fcgamma receptor expression in neutrophils of patients with B-cell lymphoma treated with rituximab. | | | Subcutaneous administration of granulocyte colony stimulating factor and stem cell factor ameliorates the outcome of acute myocardial infarction. | | | [Cyclic neutropenia with anti-NA2 antibodies and treatment with recombinant granulocyte colony-stimulating factor] |
|
http://www.prospec.co.il/~prospec/cart/catalog/rHuGCSF.html
(485 words)
|
|
| |
| | Granulocyte Colony-Stimulating Factor Serum and Urine Concentrations in Neutropenic Neonates Before and After ... |
| | Bonilla M, Gillio A, Ruggeiro M, Effects of recombinant human granulocyte colony-stimulating factor on neutropenia in patients with congenital agranulocytosis. | | | Recombinant granulocyte colony-stimulating factor (rG-CSF) has been advocated as a treatment for neonates with certain forms | | | Dale D A randomized controlled phase III trial of recombinant human granulocyte colony stimulating factor (filgrastim) for treatment of severe chronic neutropenia. |
|
http://pediatrics.aappublications.org/cgi/content/full/105/2/392
(3591 words)
|
|
| |
| | Granulocyte definition - Medical Dictionary definitions of popular medical terms |
| | Granulocytes are part of the innate immune system and have somewhat nonspecific, broad-based activity. | | | Granulocyte definition - Medical Dictionary definitions of popular medical terms | | | This classification dates back to a time when certain structures could be identified in cells by histochemistry, but the functions of these intracellular structures were still not yet fathomed. |
|
http://www.medterms.com/script/main/art.asp?articlekey=8780
(281 words)
|
|
| |
| | Granulocyte-colony stimulating factor - Wikipedia, the free encyclopedia |
| | Mouse granulocyte colony stimulating factor (G-CSF) was first recognised and purified in Australia in 1983, and the human form was cloned by groups from Japan and the U.S.A. in 1986. | | | Granulocyte-Colony Stimulating Factor (G-CSF) is a glycoprotein, growth factor or cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes. | | | The receptor, G-CSF-receptor, is present on precursor cells in the bone marrow that, in response to stimulation by G-CSF, proliferate and differentiate into mature granulocytes. |
|
http://www.netipedia.com/index.php/G-CSF
(419 words)
|
|
| |
| | Granulocyte Colony-Stimulating Factor or Neutrophil-Induced Pulmonary Toxicity: Myth or Reality? : Systematic Review of ... |
| | Key Words: antitumoral chemotherapy • ARDS • cancer patients • granulocyte colony-stimulating factor • neutropenia • neutropenia recovery • neutrophils &; pneumonia | | | Heyll, A, Aul, C, Gogolin, F, et al (1991) Granulocyte colony-stimulating factor (G-CSF) treatment in a neutropenic leukemia patient with diffuse interstitial pulmonary infiltrates. | | | Stoltz, DA, Bagby, GJ, Nelson, S (1997) Use of granulocyte colony-stimulating factor in the treatment of acute infectious diseases. |
|
http://www.chestjournal.org/cgi/content/full/120/5/1695
(3768 words)
|
|
| |
| | Granulocyte Transfusions for Severe Infections after HSCT |
| | Phase I/II studies of granulocyte transfusions for patients with severe infections during the neutropenic period after HSCT are ongoing, and will soon be superceded by a multicenter Phase III randomized controlled trial that will seek to prove that they are effective for this indication. | | | The possibility of enhancing host defenses via the infusion of neutrophils (often referred to as granulocyte transfusion therapy) from blood donors has been investigated for over 60 years, but has historically been limited by the low number of granulocytes that could be collected. | | | With the administration of granulocyte colony stimulating factor (G-CSF) to blood donors, however, the number of active granulocytes that can be collected has been significantly increased, rekindling interest in this approach. |
|
http://www.fhcrc.org/clinical/id/research/gran_transfusions_hsct.htm
(225 words)
|
|
| |
| | Follicle.com - Zinc salts effects on granulocyte zinc concentration and chemotaxis in acne patients |
| | To explore the mechanism by which zinc acts on cutaneous inflammatory lesions, we studied granulocyte zinc levels and in vitro polymorphonuclear leukocyte chemotaxis in 20 acne patients before and after 2 months of zinc therapy (200 mg/day zinc gluconate). | | | After 2 months of treatment, a significant decrease in granulocyte zinc level associated with inhibition of chemotaxis (r = 0.69) was observed in 16 patients. | | | Zinc salts effects on granulocyte zinc concentration and chemotaxis in acne patients. |
|
http://www.follicle.com/section3/4_5_1.html
(327 words)
|
|
| |
| | Neupogen, Filgrastim, G-CSF, Granulocyte - Colony Stimulating Factor - Chemotherapy Drugs |
| | Filgrastim is used to stimulate the production of granulocytes (a type of white blood cell) in patients undergoing therapy that will cause low white blood cell counts. | | | Neupogen, Filgrastim, G-CSF, Granulocyte - Colony Stimulating Factor - Chemotherapy Drugs | | | In some cases, health care professionals may use the trade name Neupogen or other names G-CSF and Granulocyte - Colony Stimulating Factor when referring to the generic drug name Filgrastim. |
|
http://www.chemocare.com/bio/bio.sps?iBiographyID=9246
(1230 words)
|
|
| |
| | Revisión de Temas |
| | Granulocyte- and granulocyte-macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate. | | | Kubota N, Orita T, Hattori K. Structural characterization of natural and recombinant human granulocyte colony-stimulating factor. | | | Chegini N, Tang XM, Dou Q. The expression, activity and regulation of granulocyte macrophage-colony stimulating factor in human endometrial epithelial and stromal cells. |
|
http://www.encolombia.com/medicina/alergia/alergiavol10-001rev-factor5.htm
(976 words)
|
|
| |
| | Neutrophil granulocyte -- Facts, Info, and Encyclopedia article |
| | PMNs in turn account for 70% of all leukocytes in humans. | | | This can be (Click link for more info and facts about congenital) congenital ((A disease or disorder that is inherited genetically) genetic disorder) or due to acquired factors. | | | They are the most common PMNs (polymorphonuclear cells, see (A leukocyte that has granules in its cytoplasm) granulocytes), constituting about 99% of circulating PMNs. |
|
http://www.absoluteastronomy.com/encyclopedia/n/ne/neutrophil_granulocyte.htm
(472 words)
|
|
| |
| | Diabetes: Treatment with granulocyte colony--stimulating ... @ HighBeam Research |
| | Accumulating evidence that granulocyte colony--stimulating factor (G-CSF), the key hematopoietic growth factor of the myeloid lineage, not only represents a major component of the endogenous response to infections, but also affects adaptive immune responses, prompted us to investigate the therapeutic potential of G-CSF in autoimmune type 1 diabetes. | | | There is compelling evidence that granulocyte colony--stimulating factor (G-CSF), well known as the hematopoietic growth factor of the myeloid lineage (1) and a major response factor to infections (2), also exerts profound immunoregulatory influence in adaptive immunity. | | | All inquiries regarding rights should be directed to the Gale Group. |
|
http://www.highbeam.com/library/doc0.asp?DOCID=1G1:128712506&refid=holomed_1
(5097 words)
|
|
| |
| | Granulocyte-colony stimulating factor and erythropoietin therapy in children with human immunodeficiency virus ... |
| | Keywords: Antiviral Agents/ADMINISTRATION and DOSAGE Child Child, Preschool Drug Therapy, Combination Drug Tolerance Erythropoietin/*ADMINISTRATION and DOSAGE/ADVERSE EFFECTS Female Granulocyte Colony-Stimulating Factor/*ADMINISTRATION and DOSAGE/ ADVERSE EFFECTS Human HIV Infections/BLOOD/*DRUG THERAPY Infant Leukocyte Count Male Neutrophils Zidovudine/ADMINISTRATION and DOSAGE JOURNAL ARTICLE | | | Granulocyte-colony stimulating factor and erythropoietin appear to be safe and useful agents in the management of HIV-infected children. |
|
http://www.aegis.com/aidsline/1996/oct/M96A0859.html
(428 words)
|
|
| |
| | Fas Ligand, Bcl-2, Granulocyte Colony-Stimulating Factor, and p38 Mitogen-activated Protein Kinase: Regulators of ... |
| | Fas Ligand, Bcl-2, Granulocyte Colony-Stimulating Factor, and p38 Mitogen-activated Protein Kinase: Regulators of Distinct Cell Death and Survival Pathways in Granulocytes | | | Fas Ligand, Bcl-2, Granulocyte Colony-Stimulating Factor, and p38 Mitogen-activated Protein Kinase: Regulators of Distinct Cell Death and Survival Pathways in Granulocytes -- Villunger et al. | | | The Journal of Experimental Medicine, Volume 192, Number 5, September 5, 2000 647-658 |
|
http://www.jem.org/cgi/content/abstract/192/5/647
(949 words)
|
|
| |
| | Comparative Effects of Three Cytokine Regimens After High-Dose Cyclophosphamide: Granulocyte Colony-Stimulating Factor, ... |
| | Bretti S, Gilleece MH, Kamthan A, et al: An open phase I study to assess the biological effects of a continuous intravenous infusion of interleukin-3 followed by granulocyte macrophage-colony stimulating factor. | | | Bregni M, Siena S, Di Nicola M, et al: Comparative effects of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor after high-dose cyclophosphamide cancer therapy. | | | Comparative Effects of Three Cytokine Regimens After High-Dose Cyclophosphamide: Granulocyte Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), and Sequential Interleukin-3 and GM-CSF -- Ballestrero et al. |
|
http://www.jco.org/cgi/content/full/17/4/1296
(3677 words)
|
|
| |
| | G0407 Granulocyte Colony Stimulating Factor |
| | CSF, bone marrow cells of neutrophilic granulocyte lineage, and on placental trophoblasts, plus a soluble form may be expressed. | | | colony stimulating factor is a proliferation, differentiation, survival, and activation factor for hematopoietic cells of the restricted neutrophilic granulocyte lineage. | | | The biological activity is measured in a cell proliferation assay using a murine myeloblastic cell line, NFS |
|
http://www.sigmaaldrich.com/catalog/search/ProductDetail?ProdNo=G0407&Brand=SIGMA
(412 words)
|
|
| |
| | Tyrosine 763 of the murine granulocyte colony-stimulating factor receptor mediates Ras-dependent activation of the ... |
| | Nosaka, Y., Arai, A., Miyasaka, N., Miura, O. CrkL Mediates Ras-dependent Activation of the Raf/ERK Pathway through the Guanine Nucleotide Exchange Factor C3G in Hematopoietic Cells Stimulated with Erythropoietin or Interleukin-3. | | | Dong, F., Larner, A. Activation of Akt kinase by granulocyte colony-stimulating factor (G-CSF): evidence for the role of a tyrosine kinase activity distinct from the janus kinases. | | | Tyrosine 763 of the murine granulocyte colony-stimulating factor receptor mediates Ras-dependent activation of the JNK/SAPK mitogen- activated protein kinase pathway -- Rausch and Marshall 17 (3): 1170 -- Molecular and Cellular Biology |
|
http://mcb.asm.org/cgi/content/full/17/3/1170
(1028 words)
|
|
| |
| | Untitled Document |
| | The effect of these agents on donor granulocyte counts is well known, but effects on other blood elements are not well described. | | | On day 2, granulocyte concentrates were collected by processing 7 liters on a CS3000 blood cell separator. | | | Summary of Work: Granulocyte colony-stimulating factor (G-CSF), alone or in combination with dexamethasone, is becoming a standard mobilizing regimen for granulocyte donors. |
|
http://www.cc.nih.gov/about/ar_archives/ar99/Z01CL-02093-03.htm
(334 words)
|
|
| |
| | Untitled Document |
| | Because granulocyte-colony-stimulating factor (G-CSF) inhibits granulocyte apoptosis, it may be possible to store G-CSF-mobilized granulocytes for longer periods while maintaining cell viability and function. | | | Since acidic conditions are detrimental to cell survival, 13 granulocyte concentrates (six dexamethasone, two G-CSF, and five G-CSF plus dexamethasone) underwent serial twofold dilution in autologous plasma prior to storage. | | | However, G-CSF mobilization increases the yield of granulocytes several-fold and the resulting higher cell concentrations may diminish viability during storage and significant levels of pyrogenic cytokines maybe produced. |
|
http://www.cc.nih.gov/ccc/annual_report/rpt992/Z01CL-02098-01.htm
(345 words)
|
|
|
