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| | NIH Guide: DEVELOPMENTAL PROCESSES IN DIFFERENTIAL EXPRESSION OF GLOBIN GENES |
 | | In addition to its fundamental importance, studies in this area are anticipated to contribute to design of approaches to expand the erythroid compartment in bone marrow or to expand erythroid precursors in vitro and to promote their appropriate differentiation. | | | Some therapeutic approaches currently being studied are based on the fact that a number of naturally occurring mutations, such as HPFH and delta beta-thalassemia, are associated with significantly elevated levels of fetal hemoglobin (Hb F) in adult RBC. | | | The elucidation of precise molecular mechanisms responsible for increased Hb F production in these disorders could lead to the development of novel future therapeutic approaches to treat hemoglobinopathies. |
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http://grants.nih.gov/grants/guide/pa-files/PAS-98-060.html
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| | The α globin gene cluster |
| | But efforts to evaluate gene therapy in mice for this disease have been disappointing, possibly because some regulators of globin gene expression have been missing from the constructs used. | | | The current study did not yield new regulators for the human gene cluster. | | | globin gene expression, and they determined that a comparative method they used may facilitate future cross-species gene comparisons. |
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http://www.genomenewsnetwork.org/articles/03_01/Globin_gene_cluster.shtml
(401 words)
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| | Hemoglobin Synthesis |
| | The mechanism by which DNA elements so distant from the genes control their expression is the source of intense investigation. | | | The mechanism of this balanced expression is unknown. | | | A number of variables influence the nature of the non-alpha chain in the hemoglobin molecule. |
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http://sickle.bwh.harvard.edu/hbsynthesis.html
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| | Globin Evolution |
| | Globin gene clusters have evolved by a process of duplication and divergence. | | | Globin genes in humans are found at two locations, each on a different chromosome (16 and 11). | | | The phylogenetic distribution of globin genes is consistent with their degrees of divergence. |
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http://opbs.okstate.edu/~melcher/PE/PE41.html
(280 words)
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| | Beta Globin: Genetic Music |
| | The common function of the globins is to bind oxygen. | | | The use of both speaking and singing human voices to represent parts of both the human and whale sequences underscores the similarities in their respective blood proteins. | | | The folded protein encloses the iron-containing heme group to which the oxygen is bound. |
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http://whozoo.org/mac/Music/bglobin.htm
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| | Chick Globin |
| | This result suggests that normally the two globin gene promoters "compete" for the same enhancer and that their ability to retain the enhancer depends upon the transcription factors present in the nucleus. | | | As erythroid development continues, new trans factors are synthesized that bind to the promoter and enhancer and that lead to protein-protein interactions between the enhancer and promoter regions. | | | Some of these sites are bound by trans-regulatory factors while others are not. |
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http://zygote.swarthmore.edu/chrom2.html
(657 words)
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| | Developmental regulation of human gamma and beta globin genes |
| | This will provide novel approaches to the treatment of hemoglobinopathies by the augmentation of transcription of the fetal gene. | | | The ultimate goal of this research is to understand the molecular mechanisms for the switch from human fetal (gamma) to adult (beta) beta-like globin gene expression. | | | The linked cosmids will be used to generate transgenic mice. |
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http://www.gen.vcu.edu/grant/HL60080.shtml
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| | Globin Gene Server home page |
| | It includes information about naturally-occurring human hemoglobin mutations and their effects, experimental data related to the regulation of the beta-like globin gene cluster, and software tools for comparing sequences with one another to discover regions that are likely to play significant roles. | | | DNA sequences from the beta-like globin gene clusters of several mammals | | | A relational database of Hb variants and thalassemias, initially derived |
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http://globin.cse.psu.edu
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| | MedlinePlus Medical Encyclopedia: Bilirubin |
| | Bilirubin metabolism begins with the breakdown of red blood cells. | | | Heme is converted to bilirubin, which is then carried by albumin in the blood to the liver. | | | Red blood cells contain hemoglobin, which is broken down to heme and globin. |
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http://www.nlm.nih.gov/medlineplus/ency/article/003479.htm
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| | Human Globin Genes II |
| | Human Globin Genes II Human Globin Genes: Gene Cluster Maps | | | This document maintained by Robert J. Huskey Last updated on December 22, 2000. |
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http://www.people.virginia.edu/~rjh9u/hgenemap.html
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| | Current Research Focusing on Euchromatin Within the Cell Nucleus. |
| | Kapranov P, Drenkow J, Cheng J, Long J, Helt G, Dike S, and Gingeras TR, "Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays". | | | -globin Locus Control Region Initiates Synthesis of Non-coding, Polyadenylated RNAs Independent of a cis-linked Globin Promoter". |
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http://www.euchromatin.net/current1.html
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