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| Â | The implications of Steele's soma-to-germline feedback for human gene therapy. |
 | | The implications of Steele's soma-to-germline feedback for human gene therapy. | | | "The crucial difference between somatic and germline gene therapy is that in the first, any genetic changes are restricted to the lifetime of the person treated, while in germline therapy any change is passed on to subsequent generations. | | | Somatic gene therapy poses few ethical problems, but germline gene therapy represents a fundamentally new type of human activity whose consequences need to be thought through carefully before any experiments are attempted." |
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http://home.wxs.nl/~gkorthof/kortho39a.htm
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| Â | Interactive Fly, Drosophila |
| | From a phylogenetic perspective, the simplest solution for germline sex determination is that germ cells strictly follow the same sexual fate as that of the soma in securing the development of a fully functional organism. | | | Of course, if the default pathway within the germline is male, then this pathway will be followed 'autonomously' in the absence of a feminizing signal from the soma (Waterbury, 2000). | | | This model was tested by introducing transgenes that ectopically express the female forms of tra and dsx into XY animals and by assaying their effects on germline sexual identity. |
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http://bioinformatics.weizmann.ac.il/pub/databases/flybase/allied-data/interactive-fly/dbzhnsky/transf27.htm
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| Â | Lamarck's Signature. (Ted Steele) |
| | However Steele interprets them as the final step of his soma-to-germline feedback mechanism. | | | And this seems a unique and perfect opportunity to detect soma-to-germline feedback, because somatic configurations simply should not be present in the germline. | | | Orthodox neo-Darwinism can't explain expression of tissue-specific genes in germline cells, because they are not supposed to be expressed at all in germline cells. |
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http://home.wxs.nl/~gkorthof/kortho39.htm
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| Â | soma from World Wide Web Find |
| | See live article Soma -to-germline feedback The soma -to-germline feedback is the movement of hereditary information from body cells into germ cells. | | | External links Edward J. Steele - Research site The implications of Steele's soma -to-germline feedback for the safety of somatic gene therapy in humans. | | | Edward J. Steele in his book "Lamarck's Signature", points out many observations that were made over the years that confirm the existence of this feedback. |
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http://www.worldwidewebfind.com/soma.html
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| Â | Cell biology, molecular embryology, Lamarckian and Darwinian selection as evolvability |
| | The outline shows the end result of the Neo-Lamarckian soma-to-germline feedback to which we adhere and which should be understood to represent an extreme form of synergism between the gene level of selection and the individual level, where the latter proclaims its final triumph in the vertebrate immune system (Blanden and Steele, 1998). | | | Such organisms developed a germline after the primordia of major organ systems of the adult had become established (e.g., annelids). | | | In fact, the conflict between the two selection processes permitted a Lamarckian soma-to-germline feedback loop. |
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http://www.funpecrp.com.br/gmr/year2003/vol1-2/gmr0041_full_text.htm
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| Â | Allen and Unwin - Extracts - Non-Fiction |
| | It is against this brief historical backdrop that we will outline here our reasons for thinking that both Lamarckian concepts of environmentally triggered rapid genetic change, and soma-to-germline feedback, are necessary to rationalise the new molecular genetics as embodied in the vertebrate immune system. | | | In this chapter we also review evidence pro and con the possibility that a soma-to-germline feedback loop exists for other organs and tissues in the body. | | | As we will reveal in the following chapters, Darwin was prescient not only with respect to natural selection of random variants but also with his idea of the role of somatically emitted gemmules registering an inherited effect on what we would now call the `germline DNA'. |
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http://www.allenandunwin.com/Extracts/silamarck.asp
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| Â | The future of selection: individuality, the twin legacies of Lamarck & Darwin |
| | The hypothesis that the germline and the self-policing system evolved a progressive adaptation of reducing and controlling withinorganism change, because this orthoselective mechanism presumably served to facilitate the transition between cells and multicellularity, should be seriously considered. | | | Early germline sequestration would reduce the opportunity for conflicting genomes and at the same time would get out of selection’s reach because cells would tend to be homogeneously cooperative and cell duplication would be limited or would produce similar cells. | | | The appearance in the germline of a gene structure (a specific gene sequence) thought to be present only in the soma cannot be ignored. |
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http://www.funpecrp.com.br/gmr/year2002/vol1-1/gmr0009_full_text.htm
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| Â | Weismann barrier |
| | \n* Edward J. Steele - Research site \n* The implications of Steele's soma-to-germline feedback for the safety of somatic gene therapy in humans. | | | In more precise terminology hereditary information moves only from germline cells to somatic cells (or soma to germline feedback is impossible).\nThis is often confused with the central dogma of molecular biology which in its modern form states that information travels from DNA | | | If the cell they infect is a germline cell then that integrated DNA can become part of the gene pool of that species. |
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http://encyclopedia.codeboy.net/wikipedia/w/we/weismann_barrier.html
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| Â | Soma definition of Soma. What is Soma? Meaning of Soma. What does Soma mean? Soma synonyms, Soma antonyms by Free Online Dictionary, Thesaurus and Encyclopedia. |
| | soma - alternative names for the body of a human being; "Leonardo studied the human body"; "he has a strong physique"; "the spirit is willing but the flesh is weak" | | | This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. | | | U.S. licensed pharmacy, FDA approved drugs, we cannot ship to FL and NV. |
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http://dict.thefreelibrary.com/Soma
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| Â | Lamarck's Signature : How Retrogenes Are Changing Darwin's Natural Selection Paradigm by Edward J. Steele, Robyn A. Lindley, Robert V. Blanden |
| | The strong approach to show that soma-to-germline transmission occurs in addition to conventional germline mutation/selection is by experiment. | | | They could still be correct that there is some soma-to-germline transmission in vertebrate immune systems, but I think it needs to be shown through direct genetic experiments and not by merely hunting high and low for more observations that are consistent with a neo-Lamarckian mechanism. | | | Indeed, if it were shown that acquired tolerence could be "retro-coded" into the germline, they would have to invent an entirely new mechanism involving the deletion of specific germline V genes. |
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http://www.2think.org/lamarck.shtml
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| Â | soma - OneLook Dictionary Search |
| | Phrases that include soma : soma cube, soma net, aura soma, aurasomatherapy aura soma therapy, soma to germline feedback, more... | | | Words similar to soma : anatomy, bod, build, chassis, figure, flesh, form, frame, haoma, physique, shape, somata, human body, material body, physical body, sarcostemma acidum, more... | | | Soma : Street Terms: Drugs and the Drug Trade [ home, info ] |
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http://www.onelook.com/?w=soma
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| Â | Interactive Fly, Drosophila |
| | The results demonstrate that capu and otu, which are both required in the germline, interact genetically with cut and may facilitate cut -mediated events originating in the soma. | | | This soma-to-germline interaction then influences cAMP-dependent function in the germline cells. | | | Since it is not yet known if agn is required in the germline cells or follicle cells, the possibility that cut influences agn levels directly by regulating agn transcription in the follicle cells cannot be ruled out. |
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http://www.infobiogen.fr/db/flybase/FLYBASE/allied-data/interactive-fly/gene/cut4.htm
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| Â | TalkOrigins Archive - Feedback for February 1999 |
| | Second, none of this is in opposition to neo-Darwinism as such, for although it denies the germline sequestration theory, it does not affect questions of selection, drift, or adaptation. | | | We review all our recent evidence and analysis of our data and others on how the "somatic hypermutation" pattern of antibody genes is written into the germline DNA ie. | | | (After all, I thought that's what this feedback was for!) Although the reader's criticism is welcomed, it would help us more if the reader provided specific detail to a FAQ author or to the archive about how a particular article might be improved. |
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http://www.talkorigins.org/origins/feedback/feb99.html
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| Â | Re: AiG and the immune system |
| | I think the soma-to germline hypothesis > is effectively dead, unless something totally unexpected happens. | | | I didn't trust the soma-to-germline arguments, but really was convinced of the hypothesis that hypermutation involved reverse transcription. | | | saying that the sequence of germline > antibody genes seems to bear the signs of the somatic processes that > occur during immune responses (this argument also quite weak, IMO). |
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http://www.usenet.com/newsgroups/talk.origins/msg07062.html
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| Â | virus: virus: Fwd: What Is Lamarck's Signature? |
| | Antibody genes, however, may contain evidence for a Lamarckian-type transfer of genetic information from the soma to the germline. | | | Antibody genes have a unique property: their DNA sequence rearranges from the original "germline configuration" to a "somatic configuration." This rearrangement occurs only in lymphocytes (a type of white blood cell) and is essential for the production of antibodies by a subset of these cells, termed B cells. | | | All the molecular mechanisms needed for such feedback are completely documented in the scientific literature. |
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http://www.lucifer.com/virus/virus.2Q99/2150.html
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