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| | Resistance to Therapy: p53 and Chemosensitivity in Gastric Cancer by James M Ford, MD |
 | | Resistance to Therapy: p53 and Chemosensitivity in Gastric Cancer | | | This is a larger schema of the regulation of P53 both upstream and downstream, and I think it is one of the major points I want to make today, which is that simply looking at P53 status in isolation is not surprisingly confusing in terms of trying to make predictions, given this very complicated regulation. | | | And these are genes that appear to be involved in this mitotic spindle check point regulated by P53 and these are starting to be identified, and they include the MAD genes and the BUB genes, which are homologous of yeast genes involved in that process. |
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http://www.webtie.org/sots/Meetings/Gastrointestinal/March62001/lectures/FORD/transcripts/transcripts.htm
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| | Recent Publications |
| | Dent, A.L, Vasanwala, F.H., and Toney, L.M. Regulation of Gene Expression by the proto- oncogene BCL-6. | | | Regulation of the c-jun gene in p210 bcr-abl transformed cells corresponds with activity of JNK, the c-jun N-terminal kinase. | | | Regulation of myelopoiesis as assessed by gene deletion and gene transduction. |
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http://www.iupui.edu/~woc/Recent_Publications/recent_publications.html
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| | Gene Therapy for Human Patients |
| | Since the 1970s, general interest in human gene therapy has increased both here and abroad, along with awareness of the need for oversight and regulation. | | | This kind of complete success is unlikely in the beginning stages of human gene therapy but will remain the long-term goal of research scientists working in this field. | | | First, hospitals and universities involved in experiments with human subjects are required to have Institutional Review Boards (IRB) to ensure that the research complies with Department of Health and Human Services (DHHS) regulations for protection of human subjects. |
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http://www4.od.nih.gov/oba/rac/cover.htm
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| | Kassel University Genetics Dept. Projects Mechanisms of antisense mediated gene silencing |
| | The aim of our investigations is to dissect the molecular machinery which mediates gene silencing by antisense RNA and RNAi and to see how this is related to the regulation by endogenous antisense RNA. | | | Gene constructs expressing dsRNA can mediate RNAi in Dictyostelium, i.e. | | | With the information available on antisense and RNAi mechanisms in Dictyostelium we will now be able to investigate if there are really two mechanistically distinct pathways for RNA mediated gene silencing. |
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http://www.uni-kassel.de/fb19/genetics/projects/prj_as.html
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| | The Battle of Darkness and Light |
| | Serotonin's molecular messaging role is so vast and important in the body, it is sometimes referred to as the "serotonin system." It is a key player in the regulation of mood and behavior. | | | Because of its role in the regulation of apoptosis, when the melatonin is able to send and receive its messages properly, its messages tell cancer cells to self-destruct, while keeping other cells on task. | | | It is also an extremely important regulator of apoptosis and it also plays a role in the regulation of insulin. |
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http://www.rense.com/general45/bll.htm
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| | texte |
| | This element could be used as a paradigm for such kind of large scale, multi-gene regulation, a concept which may become important in the future. | | | This work has reinforced our views that such genes are likely linked to the evolution of the actual tetrapod limb. | | | Subsequently, however, some gene-specific traits are observed which do not correspond to the pattern expected for the new position. |
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http://www.unige.ch/sciences/biologie/biani/duboule/texte.htm
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| | Drosophila gene families: Proneural and neurogenic genes |
| | Other functions are also served by these genes: regulation of sex determination (scute); participation in specification of muscle progenitors (lethal of scute), and regulation of sequential fates in Malpighian tubule development (achaete). | | | Gene regulation in two dimensions: the proneural achaete and scute genes are controlled by combinations of axis-patterning genes through a common intergenic control region. | | | These genes are termed proneural, since they promote neuroblast differentiation and are thus essential for the differentiation of the central and peripheral nervous system and the brain. |
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http://www.flybase.net/allied-data/lk/interactive-fly/aignfam/neuropro.htm
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| | COUP-TF Upregulates NGFI-A Gene Expression through an Sp1 Binding Site -- Pipaón et al. 19 (4): 2734 -- Molecular and Cellular Biology |
| | Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc. | | | Gene silencing by chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional corepressors, nuclear receptor-corepressor (N-CoR) and silencing mediator for retinoic acid receptor and thyroid hormone receptor (SMRT). | | | Estrogen-induced retinoic acid receptor alpha 1 gene expression: role of estrogen receptor-Sp1 complex. |
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http://mcb.asm.org/cgi/content/full/19/4/2734
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| | L-N WEI AND OTHERS |
| | The regulation of mouse cellular retinoic acid binding protein-I (CRABP -I) gene expression by the retinoids and thyroid hormones was examined, by using a ß-galactosidase (lacZ) reporter gene and a CRABP-I specific antibody, in transgenic mouse embryos and a mouse embryonal carcinoma cell line P19. | | | In this study, transgenic mice and transformed P19 EC cells carrying this fusion gene were generated in order to study the expression as well as its regulation by retinoids and thyroid hormones in embryos and EC cells. | | | Regulation of the mouse cellular retinoic acid-binding protein-I gene by thyroid hormone and retinoids in transgenic mouse embryos and P19 cells |
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http://journals.endocrinology.org/joe/155/joe1550035.htm
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| | GO Bibliography |
| | Gene family analysis of the Arabidopsis pollen transcriptome reveals biological implications for cell growth, division control, and gene expression regulation. | | | Genetic expression profiles during physiologic and pathologic cardiac hypertrophy and heart failure in rats. | | | Fatty acid metabolism pathway play an important role in carcinogenesis of human colorectal cancers by Microarray-Bioinformatics analysis. |
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http://www.geneontology.org/GO.biblio.html
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| | ISIS News no.3 index |
| | Thus, GURT technologies involve multiple feats of precise gene stacking, inserting the gene stacks into plants in exactly the configurations constructed, and subsequent to that, precise regulation in the transgenic plant(s), and exactly predictable response of the recombinase to the external chemical stimulus. | | | Adopting such a principle will change our whole approach to environmental policies and to regulation. | | | The major consequences of the horizontal transfer of transgenic DNA are the spread of antibiotic resistance marker genes among bacteria and the generation of new bacteria and new viruses that cause diseases from the many bacterial and viral genes used. |
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http://www.i-sis.org.uk/i-sisnews3.htm
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| | tumour suppressor gene -- Encyclopædia Britannica |
| | Tumour suppressor genes, like proto-oncogenes, are involved in the normal regulation of cell growth; but unlike proto-oncogenes, which promote cell division and differentiation, tumour suppressors restrain them. | | | Illustrated information on techniques involved in gene therapy. | | | The RB gene is associated with retinoblastoma, a cancer of the eye that affects 1 in every 20,000 infants. |
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http://www.britannica.com/eb/article-9003104
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| | Mutant Gene Linked to Obsessive Compulsive Disorder - |
| | Analysis of DNA samples from patients with obsessive compulsive disorder (OCD) and related illnesses suggests that these neuropsychiatric disorders affecting mood and behavior are associated with an uncommon mutant, malfunctioning gene that leads to faulty transporter function and regulation. | | | By examining the serotonin transporter gene's mutation and flawed regulation in individuals with OCD, the new research provides insights on transporter function and on the consequences of the variant, which may lead to tests to identify and treat mental illness. | | | NIMH, NIDA, an NIAAA are part of the National Institutes of Health (NIH), the Federal Government's primary agency for biomedical and behavioral research. |
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http://www.specialneeds.net/disabilities/mutant-gene-linked-to-obsessive-compulsive-disorder.html
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| | Abl |
| | Resistance has been attributed to up-regulation of Bcr-Abl gene expression as well as a variety of acquired point mutations in the Abl kinase domain. | | | This gene fusion event results in a constitutively active Abl activity which is critical to the pathogenesis of chronic myelogenous leukemia (CML). | | | More recently, resistance to Gleevec® has been observed in the clinic and the molecular basis investigated. |
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http://www.upstate.com/features/abl.asp
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| | Evolution: Glossary |
| | His current research involves analysis of gene regulation and patterning in the early Drosophila embryo; studies of embryonic development in the tunicate, Ciona intestinalis, focused on the specification of the notochord and tail muscles; and a critical test of classical models for the evolutionary origins of the chordate body plan. | | | In general, "homeotic" genes are genes that control the development of organisms, and "homeogenes" or "homeobox genes" are the subset of homeotic genes that contain "homeoboxes". | | | The double set of genes and chromosomes of the normal diploid cells is reduced during meiosis to a single haploid set in the gametes. |
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http://www.pbs.org/wgbh/evolution/library/glossary
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| | NIH - Glossary |
| | Proteins are essential to the structure, function, and regulation of the body. | | | a gene-hunting technique that traces patterns of heredity in large, high-risk families, in an attempt to locate a disease-causing gene mutation by identifying traits that are co-inherited with it. | | | an inherited disease of infancy characterized by profound mental retardation and early death; it is caused by a recessive gene mutation. |
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http://www.accessexcellence.org/AE/AEPC/NIH/gene27.html
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| | WHGD Topics from the Director's Report, September 1997 |
| | Ganapathy and his research team has recently published reports that demonstrate that tyrosine phosphorylation is an essential component in the signaling pathways participating in the regulation of the human serotonin transporter gene expression. | | | Regulation of the transporter gene expression also appeared to be modulated by a neuro-protective agent, aurin tricarboxylic acid (ATA) and epidermal growth factor (EGF) as both agents increased the transporter activity in JAR human placental choriocarcinoma cells. | | | A defective clearance of serotonin from the maternal circulation due to dysfunctional serotonin expression in the placenta may play a role in the pathogenesis of intra-uterine growth retardation. |
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http://www.nida.nih.gov/WHGD/WHGDDirRep9.html
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| | Responses - Homeobox Gene |
| | Several of the genes with altered regulation were themselves muscle-specific transcription factors (responsible for activating other muscle genes). | | | All of this evidence points toward a problem at the very top of the muscle gene cascade, and homeobox-containing genes tend to be in such positions. | | | If muscle gene expression is being scrambled, this in turn could lead to muscle cell death. |
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http://www.mdausa.org/experts/question.cfm?id=556&disease=61
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| | Dr. E. Premkumar Reddy - Professor of Biochemistry, Chairman, Department of Biochemistry, Director, Fels Research Institute |
| | We have, in the past few years, focused on three genes, c-myb, c-myc and c-abl, which are intimately associated with human cancers and seem to play an important role in the regulation of growth and differentiation of hematopoietic cells. | | | To further delineate the regulatory mechanisms associated with the regulation of c-myb gene expression, we have studied the role of nuclear factors that interact with c-myb gene regulatory sequences. | | | The role of this gene in hematopoiesis, and the effects of oncogenes on its induction is currently being studied using in vitro cell culture systems such as 32Dcl3 cell line and in vivo gene-knockout techniques. |
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http://www.temple.edu/biochemistry_medical/Dr.EReddyResrch.html
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| | Gene ABL |
| | All three hybrid proteins have increased protein kinase activity compared to ABL: 3BP1 (binding protein) binds normal ABL on SH3 domain,which prevents SH1 activation; with BCR/ABL, the first (N-terminal) exon of BCR binds to SH2, hidding SH3 which, as a consequence, cannot be bound to 3BP1; thereof, SH1 is activated; oncogenesis | | | Regulation of cell death by the Abl tyrosine kinase. | | | NH2-term Helix Loop Helix from ETV6(TEL) fused to Tyr Kinase from ABL COOH-term; localised in the cytoskeleton. |
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http://www.infobiogen.fr/services/chromcancer/Genes/ABL.html
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| | Gene Technology Bill 2000 (Bills Digest 11 2000-01) |
| | The regulation of gene technology is primarily the responsibility of the Ministry of Agriculture, Forestry and Fisheries (MAFF). | | | The Regulator is responsible for the decisions on particular applications, is subject to guidance at a general level from the Ministerial Council, and is ultimately responsible to Parliament. | | | Gene technology is extremely precise in that a single foreign gene can be introduced to target host cells which then decode the new gene along with all the natural genes in their DNA. |
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http://www.aph.gov.au/library/pubs/bd/2000-01/01bd011.htm
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| | Evolutionary developmental biology - Open Encyclopedia |
| | These researchers argue that the combinatorial nature of transcriptional regulation allows a rich substrate for morphological diversity, since variations in the level, pattern, or timing of gene expression, may provide more variation for natural selection to act upon, than changes in the gene product alone. | | | In contrast, changes in gene regulation, is a "second-order" effect of genes, resulting from the interaction and timing of the genetic network, as distinct from the functioning of the individual genes in the network | | | The discovery of the homeotic Hox gene family in vertebrates in the 1980s, allowed researchers in developmental biology to empirically assess the relative roles of the above two factors, with respect to their importance in the evolution of morphological diversity. |
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http://open-encyclopedia.com/Evolutionary_developmental_biology
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| | evolutionary developmental biology: Information From Answers.com |
| | In contrast, changes in gene regulation, is a "second-order" effect of genes, resulting from the interaction and timing of the genetic network, as distinct from the functioning of the individual genes in the network. | | | These researchers argue that the combinatorial nature of transcriptional regulation allows a rich substrate for morphological diversity, since variations in the level, pattern, or timing of gene expression, may provide more variation for natural selection to act upon, than changes in the gene product alone. | | | The discovery of the homeotic Hox gene family in vertebrates in the 1980s, allowed researchers in developmental biology to empirically assess the relative roles of the above two factors, with respect to their importance in the evolution of morphological diversity. |
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http://www.answers.com/topic/evolutionary-developmental-biology
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| | DDT and Its Metabolites Alter Gene Expression in Human Uterine Cell Lines through Estrogen Receptor-Independent Mechanisms |
| | Differential spatiotemporal regulation of lactoferrin and progesterone receptor genes in the mouse uterus by primary estrogen, catechol estrogen, and xenoestrogen. | | | Effects of sex hormones on oncogene expression in the vagina and on development of sexual dimorphism of the pelvis and anococcygeus muscle in the mouse. | | | Conversely, AP-1-mediated gene expression is ablated when Jun or Fos family members associate with co-repressors such as silencing mediator of retinoic acid and thyroid hormone receptor, which is known to interact with Sin3 and recruit histone deacetylases, condensing chromatin and terminating transcription (9). |
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http://ehp.niehs.nih.gov/members/2002/110p1239-1245frigo/frigo-full.html
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| | Anger Gene |
| | Although this report did acknowledge that research in this area is still early, it is claimed that those who are more prone to anger can be identified based upon this particular genetic characteristic. | | | This figure was generated based upon information presented by Ohara et al. | | | According to Dr. Redford’s Williams’ research, central nervous system (CNS) serotonin function is involved in the regulation of potentially health damaging behavioral characteristics such as anxiety, depression, hostility and social isolation. |
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http://www.bio.davidson.edu/Courses/genomics/2004/Cobain/angergene.html
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