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Topic: Ganciclovir



  
 New Cardiomyopathy: Pilot Study of Intravenous Ganciclovir in a Subset of CFS
Antibody titers to HCMV and EBV in 18 CFS patients treated with intravenous ganciclovir.
After treatment with ganciclovir, the 13 patients from group A, but no patient from group B, returned to his or her premorbid activity.
Before the initiation of intravenous ganciclovir and, again, 6 months later, objective evaluations of the ability to work and the EI for each study patient were analyzed.
http://www.ncf-net.org/library/ganciclovir.htm   (3828 words)

  
 Project Inform's CMV [ HIV / AIDS Treatment Information ]
While no studies have compared cidofovir to other CMV therapies, such as ganciclovir or foscarnet, results from the studies that have been conducted are encouraging.
A growing number of researchers and physicians believe the most effective and least invasive way to treat CMV retinitis may be to use a localized therapy for the retinitis in combination with an oral therapy for protection throughout the rest of the body.
People without sight-threatening CMV retinitis may be able to use therapies that allow for a better quality of life such as initial therapy with intravenous drugs and subsequent maintenance with oral or local therapy.
http://www.projinf.org/fs/cmv.html   (6634 words)

  
 MedlinePlus Drug Information: Ganciclovir (Systemic)
Before you begin treatment with ganciclovir, you and your doctor should talk about the good this medicine will do as well as the risks of using it.
This is to make sure the medicine is fully absorbed into the body and will work properly.
It is very important that your doctor check you at regular visits for any blood problems that may be caused by this medicine.
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202255.html   (1565 words)

  
 Management of herpes virus infections following transplantation -- 45 (6): 729 -- Journal of Antimicrobial Chemotherapy
Ganciclovir pre-emptive therapy based on the CMV viraemia
A randomised study comparing ganciclovir and foscarnet for pre-emptive therapy of CMV infection in allogeneic SCT recipients.
ganciclovir therapy are not able fully to reconstitute the immune
http://jac.oxfordjournals.org/cgi/content/full/45/6/729   (8755 words)

  
 Resistance of Human Cytomegalovirus to Antiviral Drugs -- Erice 12 (2): 286 -- Clinical Microbiology Reviews
Ganciclovir susceptibilities and analysis of UL97 region in cytomegalovirus isolates from bone marrow recipients with CMV disease after antiviral prophylaxis.
to ganciclovir is associated with lack of therapeutic response
Susceptibility of human cytomegalovirus to cidofovir is unchanged after limited in vivo exposure to various clinical regimens of drug.
http://cmr.asm.org/cgi/content/full/12/2/286   (8525 words)

  
 AEGiS-CATIE: INFECTION FIGHTERS: Oral ganciclovir to prevent CMV
Doctors were more likely to prescribe bone marrow stimulants (G-CSF) for subjects receiving ganciclovir than those on placebo.
Researchers randomly assigned 486 subjects to receive ganciclovir 1 gram three times daily, and 239 others to receive fake drug (placebo).
Use of anti-HIV drugs and the anti-herpes drug acyclovir did not appear to affect the protection provided by ganciclovir.
http://www.aegis.com/pubs/catie/1996/CATE6906.html   (617 words)

  
 Impact of Prophylactic Immediate Posttransplant Ganciclovir on Development of Transplant Atherosclerosis : A Post Hoc ...
incidence of death or retransplantation at follow-up in ganciclovir
a subset analysis of the impact of ganciclovir in patients who
as a whole were similar in patients randomized to ganciclovir
http://circ.ahajournals.org/cgi/content/full/100/1/61   (4338 words)

  
 Simple Facts Sheets: ganciclovir implants
There may be ways to reduce the risk of CMV spreading to other parts of the body.
One group was treated with standard intravenous ganciclovir.
If you are having blurred vision or other problems with your eyes, it's important to see an ophthalmologist who is experienced in examining and treating people with HIV.
http://www.atdn.org/simple/implants.html   (775 words)

  
 Cytomegalovirus: Just the facts...
Antiviral drug therapy is now being evaluated in infants.
Vaccines are still in the research and development stage.
Ganciclovir treatment is used for patients with depressed immunity who have either sight-related or life-threatening illnesses.
http://www.absoluteastronomy.com/encyclopedia/c/cy/cytomegalovirus.htm   (2159 words)

  
 GANCICLOVIR Faq
Maintain your regular visits and inform your doctor of any new medical problems that develop while you are taking ganciclovir.
Therefore, inform your doctor and pharmacist about all of the medications you are taking, and do not start taking other medciations without discussing this first.
Ganciclovir is an antiviral medication used for the treatment of Cytomegalovirus (CMV) infection.
http://www.tthhivclinic.com/gcv.htm   (843 words)

  
 News - Valacyclovir as Effective as Ganciclovir in Renal Transplant Prophylaxis of Cytomegalovirus: Presented at ATC
Twelve patients who were given no drug treatment were defined as the "deferred therapy" arm.
At 1 year post-transplant, 67% of the deferred therapy group, 6% of the ganciclovir group, and 3% of the valacyclovir group had CMV disease (
Acute rejection in patients with delayed graft function was 53% in the 15 ganciclovir patients and 20% in the 7 valacyclovir patients.
http://www.docguide.com/news/content.nsf/news/8525697700573E1885256E9B004961C4   (532 words)

  
 Ganciclovir (Valcyte™/Cymevene®) reduces risk of cancer in kidney transplant patients
An analysis of patients with post-transplant lymphoproliferative disease (PTLD), cancer of the blood, showed that the cumulative length of ganciclovir treatment is significantly associated with a lower risk of developing PTLD, compared to those with no antiviral therapy.
Valcyte, a prodrug of Roche’s anti-CMV treatment, Cymevene (Cytovene in the US), was developed in response to the need for a more convenient and patient-friendly oral form of ganciclovir.
Ganciclovir, the active antiviral agent in Roche’s Valcyte and Cymevene drugs, is used to prevent cytomegalovirus (CMV) disease, a potentially fatal infection that can occur after a transplant and lead to the loss of the transplanted organ and patient death.
http://www.medicalnewstoday.com/index.php?newsid=8455   (901 words)

  
 Prevention of Cytomegalovirus Infection and Disease After Lung Transplantation : Results Using a Unique Regimen ...
IV ganciclovir therapy, initiated 3 to 4 weeks after transplantation,
Our study provides evidence that ganciclovir prophylaxis in
ganciclovir prophylaxis to most patients, if prophylaxis is
http://www.chestjournal.org/cgi/content/full/121/2/407   (3709 words)

  
 ADAP drugs: ganciclovir
The other end of the catheter remains outside your chest or has an injectable port just under the skin, providing access to your bloodstream so you can give yourself the drug.
Like other infections, the virus which causes this condition takes advantage of a weakened immune system.
Ganciclovir is a treatment for CMV (cytomegalovirus) infection.
http://www.atdn.org/access/drugs/ganc.html   (487 words)

  
 Clinical Trial: Comparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients With AIDS Who Have CMV ...
Cidofovir needs to be compared to ganciclovir to determine the best way to treat CMV retinitis.
Comparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients With AIDS Who Have CMV Retinitis
While cidofovir is effective in suppressing retinitis and prolonging time to progression, no studies have compared cidofovir to other therapies and its place in the treatment of CMV retinitis remains unexplored.
http://clinicaltrials.gov/show/NCT00000894   (586 words)

  
 AEGiS-GMHC: Improved Ganciclovir Regimens
In a subgroup receiving concomitant protease inhibitor treatment, incidence rates of new CMV were low in all groups.
Between May 1994 and July 1996, 377 patients were randomized to one of the three treatment groups.
For this reason, many patients consider using systemic medication, such as oral or IV ganciclovir, to prevent the spread of disease.
http://www.aegis.com/pubs/gmhc/1998/GM120105.html   (1300 words)

  
 Cell-Specific Induction of Sensitivity to Ganciclovir in Medullary Thyroid Carcinoma Cells by Adenovirus-Mediated Gene ...
GCV conditioned medium was changed each 36 h.
Perez-Cruet MJ, Trask TW, Chen S-H, Goodman JC, Woo SLC, Grossman RG, Shine HD 1994 Adenovirus mediated gene therapy of experimental gliomas.
Bovenberg RAL, Adema GJ, Jansz HS, Baas PD 1988 Model for tissue specific calcitonin/CGRP-I RNA processing from in vitro experiments.
http://endo.endojournals.org/cgi/content/full/141/5/1814   (5351 words)

  
 MedlinePlus Medical Encyclopedia: CMV - pneumonia
Calling your health care provider Return to top
The objective of treatment is to stop the replication of the virus within the body through the use of antiviral agents, such as ganciclovir or foscarnet.
Oxygen therapy and ventilatory support may initially be necessary to maintain oxygenation until the infection is brought under control.
http://www.nlm.nih.gov/medlineplus/ency/article/000664.htm   (531 words)

  
 Drug Shortage Bulletin: Ganciclovir Sodium Injection and Valganciclovir Tablets
Oral ganciclovir is also indicated as an alternative to intravenous ganciclovir for maintenance therapy of stable CMV retinitis in immunocompromised patients, including patients with AIDS.
Ganciclovir sodium for injection is labeled for the treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS).
Ganciclovir capsules are labeled for the prevention of CMV disease in patients at risk for CMV disease, including solid organ transplant recipients and patients with AIDS.
http://www.ashp.org/shortage/ganciclovir.cfm?cfid=21617612&CFToken=10380268   (717 words)

  
 [No title]
Cytovene should be used with caution in patients with a history of cytopenic drug reactions.
Abdominal pain, nausea, flatulence, pneumonia, paresthesia, and rash are the most frequently observed effects in clinical trials, but occur with equal or greater frequency than placebo controlled subjects.
Cytovene is the name for the drug ganciclovir, or ganciclovir sodium, put out by Roche Laboratories.
http://www.stanford.edu/group/virus/1999/thanatos/ganciclovir.html   (692 words)

  
 NEJM -- Oral Ganciclovir for Patients with Cytomegalovirus Retinitis Treated with a Ganciclovir Implant
Oral Ganciclovir for Patients with Cytomegalovirus Retinitis Treated with a Ganciclovir Implant
NEJM -- Oral Ganciclovir for Patients with Cytomegalovirus Retinitis Treated with a Ganciclovir Implant
VELEZ, G., WHITCUP, S. New developments in sustained release drug delivery for the treatment of intraocular disease.
http://content.nejm.org/cgi/content/abstract/340/14/1063   (1494 words)

  
 Ganciclovir resistance of AIDS-related CMV retinitis detectable in blood
The same alterations were identified in blood-derived CMV of 11 of the patients.
"For patients treated with the ganciclovir implant and oral ganciclovir, mutations might be more likely to occur in the blood and subsequently seed the eye," the researchers suggest.
Thirteen patients were found to harbor CMV with a ganciclovir resistance-conferring mutation or a polymorphism in the UL97 gene in the vitreous.
http://www.aidsmeds.com/news/20020412clin003.html   (353 words)

  
 GANCICLOVIR a Commonly Used Medication
ZDV may potentiate ganciclovir's bone marrow toxicity; nephrotoxic and bone marrow depressant drugs should be administered with caution due to possible additive effects.
Monitor for visual disturbances which may indicate progression of retinal CMV; regular opthalmology F/U is essential for early detection of disease reactivation.
Imipenerm-cilastatin + DHPG may result in seizures, and should not be used together unless benefit clearly outweighs risk.
http://www.hivdent.org/drugs/GANCICLOVIR.htm   (212 words)

  
 Expression of MRP4 Confers Resistance to Ganciclovir and Compromises Bystander Cell Killing -- Adachi et al. 277 (41): ...
Ganciclovir (9-(1,3-dihydroxy-2-propoxymethyl)guanine (GCV)) is widely used against cytomegalovirus infection in patients
reveal ganciclovir egress by MRP4 as a novel mechanism contributing
Our results demonstrate that cellular retention and accumulation of the guanine analog ganciclovir is strongly influenced
http://www.jbc.org/cgi/content/full/277/41/38998   (4309 words)

  
 Acyclovir, Ganciclovir, and Zidovudine Transfer into Rat Milk -- Alcorn and McNamara 46 (6): 1831 -- Antimicrobial ...
Acyclovir, Ganciclovir, and Zidovudine Transfer into Rat Milk
processes govern the transfer of both ganciclovir and zidovudine
for acyclovir, ganciclovir, and zidovudine were 5.1 ±
http://aac.asm.org/cgi/content/abstract/46/6/1831   (396 words)

  
 Vitrasert Online, Description, Chemistry, Ingredients - Ganciclovir - RxList Monographs
The Vitrasert Implant contains the antiviral drug ganciclovir.
Ganciclovir is a white to off-white crystalline powder with a molecular formula of C
The chemical name of ganciclovir is 9-[[2-hydroxy -1- (hydroxymethyl)ethoxy] methyl]guanine.
http://www.rxlist.com/cgi/generic2/vitrasert.htm   (122 words)

  
 Ganciclovir - definition of Ganciclovir in Encyclopedia
Embed a dictionary search in your own web page
http://encyclopedia.laborlawtalk.com/Ganciclovir   (41 words)

  
 ChemFinder.Com
2-Amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6H-purin-6-one; 2'-NDG; 2'-nor-2'-deoxyguanosine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)-methyl)guanine; Cymevan; Cymevene; Cytovene; DHPG; Ganciclovir; Ganciclovir sodium; Vitrasert;
http://chemfinder.cambridgesoft.com/result.asp?mol_rel_id=82410-32-0   (171 words)

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