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| | G-protein-coupled receptor - Wikipedia, the free encyclopedia |
 | | GPCRs are present in a wide variety of physiological processes. | | | This pervasive involvement in normal biological processes has the consequence of involving GPCRs in many pathological conditions, which has led to GPCRs being the target of 40 to 50% of modern medicinal drugs. | | | These systems are responsible for control of many automatic functions of the body such as blood pressure, heart rate and digestive processes. |
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http://en.wikipedia.org/wiki/G_protein_coupled_receptor
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| | A further aspect of the present invention is a method of assessing GPCR pathway activity upon exposure of the test cell to a test ligand. | | | A further aspect of the present invention is a method of assessing GPCR pathway activity in the presence of a test kinase. | | | A further aspect of the present invention is a method of assessing GPCR pathway activity in the presence of a test G-protein. |
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http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=01/59451.010816&ELEMENT_SET=DECL
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| | Cell Signaling |
| | A recently-reported (Feb 2002) phase 2 study, found that almost 90% of the CML patients treated with the drug showed no further progression of their disease. | | | Tumor Necrosis Factor-α Receptors and the NF-κB Pathway | | | Tumor Necrosis Factor-alpha (TNF-α) Receptors and the NF-κB Pathway |
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http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/CellSignaling.html
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| | Heterodimeric Opioid G-Protein Coupled Receptor |
| | Additional research is resolving the mechanisms by which the opioid system influences the cardiovascular system, the immune system and other physiologic processes. | | | There is a significant clinical need for the development of new, more selective, drugs that interact with the opioid system for the analgesic uses and for several other diseases where the opioid receptors interact with other receptors. | | | Understanding possible differences in the affinity and efficacy of various agonists and antagonists for the various forms of these receptors and their differential ability to transmit signals will help explain the differences in the physiological responses induced and will be instrumental in identifying and developing novel therapeutic compounds and formulations. |
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http://www.med.nyu.edu/oil/tech/therapeutics/topioid.html
(316 words)
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| | A Novel G-Protein-Coupled Neuronal Receptor Active in Neurosecretion |
| | It was therefore hypothesized that its effects involve a novel mechanism of activation of neurosecretion which does not depend on a classical calcium-signaling pathway. | | | Alexandre G. Petrenko, Ph.D. The Skirball Institute of Biomolecular Medicine | | | The identification of the molecule via which a-latrotoxin mediates neurotransmitter release would shed light on the critical problem in neurobiology, the nature of biochemical machinery responsible for regulation of synaptic vesicle release at presynaptic nerve terminals, and allow the development of drugs that could modulate neurotransmitter release in various diseases. |
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http://www.med.nyu.edu/oil/tech/biotech/bpetrnk.html
(547 words)
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| | G-protein coupled receptor |
| | ...stage drug development company that uses a proprietary drug discovery technology and approach to develop drugs for G-protein coupled receptor (GPCR) and ion... | | | ChemDiv and Euroscreen Form Strategic Alliance for GPCR Drug... | | | ...of three product candidates currently in the clinic, all of which were internally discovered utilizing computer-based G-Protein Coupled Receptor (GPCR) models... |
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http://www.mongabay.com/igapo/biotech/G-protein_coupled_receptor.html
(665 words)
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| | Domain swapping in G-protein coupled receptor dimers |
| | This is in contrast to the work of Hebert (1996) on the | | | Much of the evidence involves functional rescue experiments which may or may not apply to the normal receptors, these are denoted FR. | | | Mutation of Tyr 205 in the neurokinin NK-1 receptor results in loss of (this is thought to be an external residue though the authors do not identify it as such). |
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http://www.essex.ac.uk/bs/staff/reync/ds/dimer.html
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| | GeneCard for MRGPRD |
| | Identification of a G protein-coupled receptor specifically responsive to beta-alanine. | | | Shinohara T. Hinuma S. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. | | | Function: May regulate nociceptor function and/or development, including the sensation or |
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http://www.genecards.org/cgi-bin/carddisp.pl?gene=MRGPRD
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| | GeneCard for P2RY13 |
| | Antibodies from Abcam (GPCR GPR86), each with their Abpromise | | | Takeda S. Mitaku S. P2Y(13): identification and characterization of a novel Galphai-coupled ADPreceptor from human and mouse. | | | P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+stem and progenitor cells. |
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http://www.genecards.org/cgi-bin/carddisp.pl?gene=P2RY13
(718 words)
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| | GPCR Subfamily Classifier |
| | We have omitted several GPCR subfamily SVM classifiers from the system because they contain only one known member and this is insufficient to train good quality models. | | | All training data for the GPCR subfamily SVM classifiers was taken from the GPCRDB information system, a curated database of GPCRs developed by Gert Vriend and Florence Horn. | | | Hierarchical index of all GPCR subfamily training sets used to build the classifiers. |
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http://www.soe.ucsc.edu/research/compbio/gpcr-subclass
(334 words)
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| | GPCRDB home page |
| | Other information relevant to GPCRs (GPCR related links, references,...). | | | GPCR family pages'; return true">alignments and other sequence-derived data sorted per family | | | Information on G proteins have been removed from the GPCRDB and are now available (24-May-05) via the GPCRIPDB (GPCR interacting partners DB) along with the RAMP proteins. |
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http://www.gpcr.org/7tm
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| | www.gpcr.org |
| | Visit this site to get some information on the MCSIS methodology. | | | The GPCRIPDB: a Molecular-Specific Information System for GPCR Interacting Partners (G proteins & RAMPs) (created May, 23 2005) | | | The GPCRDB: a Molecular-Specific Information System for G Protein-Coupled Receptors (created in 1994) |
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http://www.gpcr.org
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| | Kinetics of G-protein-coupled receptor signallingand desensitization |
| | The kinetics of G-protein-coupled receptor activation and deactivation has, so far, been measured only | | | agonist (measured as conformational change in the receptor), the kinetics of G-protein activation (measured | | | methods based on fluorescence resonance energy transfer to quantify the kinetics of receptor activation by |
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http://biowww.net/detail-646.html
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