|
| |
| | Fluoroquinolones |
 | | Taking fluoroquinolones with certain other drugs may affect the way the drugs work or may increase the chance of side effects. | | | Anyone who takes fluoroquinolones should let the physician know all other medicines he or she is taking. | | | Some fluoroquinolones may weaken the tendons in the shoulder, hand, or heel, making the tendons more likely to tear. |
|
http://www.chclibrary.org/micromed/00048540.html
|
|
| |
| | [No title] |
| | Campylobacter Risk Assessment The data on fluoroquinolone resistance levels, and the evidence leading to the conclusion that the use of fluoroquinolones in chickens is a significant cause of fluoroquinolone resistance in humans, establish an adverse effect on human health by fluoroquinolones. | | | Importance of Fluoroquinolines in Human Medicine Fluoroquinolones are considered to be one of the most valuable antimicrobial drug classes available to treat human infections because of their broad spectrum of activity, pharmacokinetics, safety, and ease of administration (Ref. 56). | | | Second, reports of studies conducted after approvals of fluoroquinolones for poultry in other countries had shown a relationship between the approval of fluoroquinolones for therapeutic use in food-producing animals and the development of fluoroquinolone resistance in Campylobacter in animals and humans. |
|
http://www.fda.gov/OHRMS/DOCKETS/98fr/103100a.htm
|
|
| |
| | Public Citizen Publications - Petition to Require a Warning on All Fluoroquinolone Antibiotics (HRG Publication #1399) |
| | Despite the fact that the fluoroquinolones are essentially second-line drugs, there being few clinical situations in which they would be the first choice to treat an infection, they are heavily promoted and are often used as first-line drugs in situations where an equally or more effective, less expensive and possibly safer antibiotic would be preferable. | | | In the subgroup of patients who were treated with fluoroquinolones, the incidence was 12 percent compared to none in those who had never received a fluoroquinolone antibiotic. | | | Doctors and the public must be warned to immediately discontinue use of fluoroquinolone antibiotics at the onset of tendon pain. |
|
http://www.citizen.org/publications/release.cfm?ID=6595
|
|
| |
| | The Fluoroquinolone Toxicity Research Foundation |
| | Judicious use of fluoroquinolones, as with any other drug therapy, requires adherence to cautionary advice provided in the prescribing information for the drug. | | | Cure rates achieved with fluoroquinolone therapy in uncomplicated and complicated UTI can exceed 90% and 80%, respectively. | | | Thus, it may be that it is only under specific conditions of sufficient CNS penetration, coupled with threshold antagonism of inhibitory pathways (GABA) and stimulation of excitatory pathways (NMDA, adenosine), that observable CNS symptoms are manifested. |
|
http://www.fqresearch.org/m26.htm
|
|
| |
| | Drug Information: Fluoroquinolones (Systemic) (Print Version) |
| | Fluoroquinolones may also be used for other problems as determined by your doctor. | | | These medicines may keep fluoroquinolones from working properly. | | | Glucose-6-phosphate dehydrogenase activity defect (problem with an enzyme that your body makes)â”If you have this condition and you take a fluoroquinolone, you could have problems with anemia. |
|
http://www.nlm.nih.gov/medlineplus/print/druginfo/uspdi/202656.html
|
|
| |
| | Review of Optometry May 1999 Therapeutic Drugs |
| | Fluoroquinolones have also demonstrated their effectiveness in post-refractive surgery. | | | Surgeons typically have patients instill topical fluoroquinolones prior to cataract surgery to prevent post-surgical infections such as endophthalmitis, which occurs in 0.12 percent of all such surgeries.13 Many surgeons will prescribe a fluoroquinolone two days before the procedure, or on the day of surgery in combination with NSAIDs and mydriatics. | | | This article explores how fluoroquinolones work and evaluates their effectiveness in treating bacterial keratitis, either alone or in combination with other antibiotics. |
|
http://www.revoptom.com/archive/issue/ro05f6.htm
|
|
| |
| | The Use of Fluoroquinolones in Animal Health |
| | With most therapeutic antimicrobials used to treat bacterial infection in animals there are related antimicrobials used in human medicine from the same family, so there are fluoroquinolones used in animal medicines and fluoroquinolones used in human medicines. | | | In this situation, the veterinary surgeon may decide that a course of a therapeutic antimicrobial is necessary. | | | (i) Fluoroquinolones can only be given under prescription by a veterinary surgeon: they are classified POM (Prescription Only Medicine) or MFS. |
|
http://www.noah.co.uk/issues/briefingdoc/18-fluoroquinolones.htm
|
|
| |
| | CDC - Fluoroquinolones Protective against Cephalosporin Resistance in Gram-negative Nosocomial Pathogens |
| | Interventional studies are required to determine whether replacing third-generation cephalosporins with fluoroquinolones will be effective in reducing cephalosporin resistance and the effect of such interventions on fluoroquinolone resistance. | | | Although good infection control practices are the most important measure in limiting the spread of resistance, other measures are required, including changes in antimicrobial drug—prescribing patterns through formulary modification and enhanced education of prescribers ( 5). | | | Our data, then, provide the impetus for further studies, including a prospective interventional trial to explore the overall protective efficacy of fluoroquinolones against multiresistant gram-negative pathogens. |
|
http://www.cdc.gov/ncidod/eid/vol10no1/02-0663.htm
|
|
| |
| | Optometric Management |
| | In considering acquired resistance to antibiotics or to fluoroquinolones, we should note that a recurrent theme in the systemic and ophthalmic literature emphasizes the importance of achieving high concentrations of the drugs in affected tissues. | | | Compared to previous generations of fluoroquinolones, they have an increased ability when topically applied to penetrate and maintain therapeutic levels in ocular tissues, thus improving their efficacy (Hwang). | | | The new fourth-generation fluoroquinolones bring to our armamentarium an important therapy in treating bacterial conjunctivitis and prophylaxis in corneal injury or pre-/post-surgical care. |
|
http://www.optometricmanagement.com/article.aspx?article=71180
|
|
| |
| | DUR Newsletter, August 2002, College of Pharmacy, Oregon State University |
| | However, concern regarding the development of fluoroquinolone resistance in certain key organisms has led most infectious disease experts to express caution regarding overuse of this class of drugs. | | | The key concerns are: 1) overuse of fluoroquinolones in the era of DRSP, and 2) the question of whether certain fluoroquinolones should be favored over others for treatment of S. | | | Since its description in 1967, penicillin resistance in Streptococcus pneumoniae has been steadily increasing and is an ongoing concern. |
|
http://pharmacy.oregonstate.edu/drug_policy/news/4_6/4_6.html
|
|
| |
| | La Consulta Semanal |
| | Most of the new quinolones are structurally dissimilar to the traditional fluoroquinolones and demonstrate activity against Helicobacter pylori (MIC=0.013 microg/ml). | | | At least for some of the newer fluoroquinolones a steep dose-response relationship of adverse effects seems to exist. | | | Mechanisms of action of antimicrobials: focus on fluoroquinolones. |
|
http://www.intermedicina.com/consultas/Cons_mar02.htm
|
|
| |
| | Fluoroquinolones: Focus on Safety |
| | The overall incidence is 2% to 3% in patients receiving fluoroquinolones. | | | If the use of fluoroquinolones is necessary in these patients, careful monitoring with an electrocardiogram and Holter monitor should be strongly considered. | | | Tendinitis and tendon rupture, mostly involving the Achilles tendon, have occurred in <1% of patients. |
|
http://www.pharmacytimes.com/article.cfm?ID=1541
|
|
| |
| | Cipro, related antibiotics over-prescribed, fueling microbe resistance |
| | The researchers found that fluoroquinolones were widely prescribed to patients discharged from the hospital, even when tests showed that narrow-spectrum antibiotics were appropriate. | | | Cipro and related drugs are the only antibiotics patients can take orally to combat Pseudomonas aeurginosa, the most common bacterium associated with cystic fibrosis, Guglielmo said. | | | A new study heightens concerns that Cipro and related broad-spectrum antibiotics known as fluoroquinolones are being over-prescribed, accelerating bacterial resistance to the drugs and reducing their ability to treat infections. |
|
http://www.eurekalert.org/pub_releases/2002-09/uoc--cra092502.php
|
|
| |
| | Fluoroquinolones Lawyers - Fluoroquinolones Attorneys - California Law Firm - Law Offices of Masry & Vititoe |
| | California Fluoroquinolones Injury Lawyer Disclaimer:The West Coast fluoroquinolones, fluoroquinolones side effects, fluoroquinolones warning, fluoroquinolones and tendonitis, pharmaceutical error, dangerous drugs, drug error, defective medical device, recalled product and/or other legal information offered herein by Personal Injury Attorneys Masry and Vititoe is not formal legal advice, nor the formation of an attorney client relationship. | | | Tendonitis and rupture of the shoulder, hand and Achilles tendons requiring surgical repair have been reported. | | | Any results set forth here were dependent on the facts of that particular case and the results will differ from case to case. |
|
http://www.masryvititoe.com/fluoroquinolones.shtml
|
|
| |
| | PEC Update, March 2004, Page 14: Oral Fluoroquinolones |
| | As a result of the contract, gatifloxacin was added to the Basic Core Formulary as a “workhorse” fluoroquinolone for the indications of community acquired pneumonia (CAP) and acute sinusitis. | | | MTFs will incur increased costs in this drug class if they take no action and utilization patterns do not change. | | | Levofloxacin should only be used in cases of medical necessity when a more cost effective fluoroquinolone will not meet patients’ clinical needs. |
|
http://www.pec.ha.osd.mil/Updates/0402web/Mar_04_Update_Page_14.htm
|
|
| |
| | THE MERCK MANUAL, Sec. 13, Ch. 153, Antibacterial Drugs |
| | The fluoroquinolones are currently contraindicated for use in children and pregnant women, but further research is ongoing. | | | Seizures are rare, but these drugs should be avoided in patients with convulsive or other CNS disorders. | | | Fluoroquinolones, except norfloxacin, are useful in pneumonia, skin and soft tissue infection, and osteomyelitis caused by susceptible bacteria. |
|
http://www.merck.com/mrkshared/mmanual/section13/chapter153/153g.jsp
|
|
| |
| | Fluoroquinolones and warfarin: suspected interactions |
| | In 15 of the reports, the INR had been stabilized with warfarin before the fluoroquinolone therapy was started. | | | Certain fluoroquinolones may enhance the effects of warfarin or its derivatives during concomitant administration of these drugs.2-6 The prothrombin time and INR should be monitored closely, especially in elderly patients, and the anticoagulant dose adjusted accordingly. | | | Fluoroquinolones are primarily used to treat respiratory and urinary tract infections, prostatitis, septicemia, and skin, soft-tissue, bone and joint infections.1-6 Cases of increased anticoagulant activity have been reported in patients taking warfarin concurrently with fluoroquinolones.7,8 |
|
http://www.pharma-lexicon.com/medicalnews.php?newsid=10352
|
|
| |
| | Unsafe at any dose |
| | Understanding the Adverse Drug Reactions Associated with Fluoroquinolone Therapy QUINOLONE ANTIBIOTICS TOXICITY. | | | "Physicians routinely fail to recognize, treat and report the adverse drug reactions associated with fluoroquinolone therapy despite the overwhelming evidence that such therapy may cause irreversible injury and death." | | | Alphabetical Listing of the Adverse Drug Reactions to the Fluoroquinolones with Definitions. |
|
http://www.fqresearch.org/post_marketing_reports.htm
|
|
| |
| | Increases in Fluoroquinolone-Resistant Neisseria gonorrhoeae Among Men Who Have Sex with Men --- United States, ... |
| | Fluoroquinolone therapy is used frequently because it is an inexpensive, oral, and single-dose therapy. | | | Fourteen of the 17 patients with QRNG for whom gonorrhea treatment history was available had been treated with ceftriaxone. | | | Clinicians must be vigilant in identifying treatment failures when fluoroquinolones are used, advise their patients about the importance of follow-up if symptoms persist, and be prepared to evaluate such cases by culture. |
|
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5316a1.htm
|
|
| |
| | Fluoroquinolones - Drug Interactions and Warnings |
| | Interactions between fluoroquinolones and drugs metabolised by the hepatic cytochrome P450 system affect the clearance of theophylline and caffeine. | | | You should not use this material to diagnose or treat a health condition or disease without consulting with your healthcare provider. | | | Drug interactions are limited; however, all fluoroquinolones interact with metal ion containing drugs (eg. |
|
http://www.personalhealthzone.com/drug_interactions/fluoroquinolones.html
|
|
| |
| | Mechanism of action of fluoroquinolones: the basics... |
| | Frequent side effects of fluoroquinolones: is there a SAR ? | | | From norfloxacin to the other 1st generation fluoroquinolones: ofloxacin | | | From norfloxacin to the other 1st generation fluoroquinolones: pefloxacin |
|
http://www.sbimc.org/1999/fall/tulkens-van-bambeke-slides
|
|
| |
| | Reports of Adverse Events with Fluoroquinolones |
| | FDA is asking prescribers and pharmacists to alert patients and other caregivers to the potential for tendinitis and tendon rupture while taking or after taking antimicrobial fluoroquinolones. | | | The Agency has taken steps to have the package insert revised for the following antimicrobial agents: ciprofloxacin, enoxacin, lomefloxacin, norfloxacin, and ofloxacin. | | | FDA Medical Bulletin * October 1996 * Volume 26 Number 3 |
|
http://www.fda.gov/medbull/oct96/adverse.html
|
|
|
