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| | PA-03-049: CHEMICAL SCREENS FOR NEW INDUCERS OF FETAL HEMOGLOBIN (SBIR/STTR) |
 | | The induction of fetal hemoglobin by hydroxyurea, currently approved for treatment of SCD patients in acute vaso-occlusive crisis, is based on that principle (though it has still not been conclusively proven that the therapeutic effect of hydroxyurea is mediated through fetal hemoglobin induction). | | | The ultimate long-term objective will be to bring new fetal hemoglobin inducers to clinical practice to improve upon drugs such as hydroxyurea, the only FDA-approved drug for treatment of sickle cell disease. | | | Hydroxyurea is thought to work in part through fetal hemoglobin induction, but does not benefit all patients. |
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http://grants.nih.gov/grants/guide/pa-files/PA-03-049.html
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| | Smoking during pregnancy has been linked to a variety of adverse pregnancy outcomes |
| | Hemoglobin adducts originally were suggested as a biochemical monitor of carcinogen exposure and a measure of genotoxic risk by Ehrenberg, Osterman-Golkar and others [Ehrenberg 1977; Ehrenberg 1992; Osterman-Golkar 1983; Segerback 1978; Tornqvist 1986]. | | | The investigators are aware of a recent report in the literature on the use of cotinine as an indicator of smoke exposure (Haufroid V, 1998) which reviews the effectiveness and practicality of cotinine as a reliable indicator of tobacco smoke exposure. | | | Globin will be prepared by removing the heme from hemoglobin using acidified acetone conditions. |
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http://www.louisville.edu/medschool/pharmacology/smoking.html
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| | Engscientific Blood Bank Page |
| | This procedure, a modification of the Kleihauer Technique, is based on the resistance of fetal hemoglobin to acid conditions. | | | These procedures are based upon the resistance of fetal hemoglobin to acid conditions. | | | This is done with the new Kleihauer technique rather than the new Clayton technique. |
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http://www.engscientific.com/blood.html
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| | Public Informaion on Sickle Cell Anemia ~ Reasons for Variation |
| | Emond et al showed that fetal hemoglobin levels could lead to male imptoence and painful erections through priaprism. | | | In Bailey et al experiment researchers observed the relationship between Jamaicans who had fetal hemoglobin levels and early signs of sickle cell anemia. | | | 22% to 26.8% is the mean hemoglobin level among Saudi Arabian patients. |
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http://www.shodor.org/~aamoaten/possiblesolutionsforsicklecell.html
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| | Hemoglobin Overview |
| | Most variant hemoglobins function normally, and are only found through specialized research techniques. | | | The goal is to provide sufficient background to make this Web site useful to people unfamiliar with the area. | | | The Principles and Practice of Medicine, Appleton, Century, Croftis |
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http://sickle.bwh.harvard.edu/hemoglobin.html
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| | Myoglobin and Hemoglobin |
| | The predominant fetal hemoglobin in afflicted individuals is a tetramer of | | | In addition, the quaternary structure of hemoglobin leads to physiologically important allosteric interactions between the subunits, a property lacking in monomeric myoglobin which is otherwise very similar to the | | | An example of this technique is shown in the Figure below. |
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http://web.indstate.edu/thcme/mwking/hemoglobin-myoglobin.html
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| | Hemoglobin - Wikipedia, the free encyclopedia |
| | The contacts tend to be hydrophobic but are important in the allosteric interactions. | | | When inspired air contains CO levels as low as 0.02% headache and nausea occur; if the CO concentration is increased to 0.1%, unconsciouness will follow. | | | Mutations in the globin chain are associated with the haemoglobinopathies, such as sickle-cell anemia and thalassemia. |
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http://en.wikipedia.org/wiki/Hemoglobin
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| | Welcome to The American Sickle Cell Anemia Association |
| | Some researchers are focusing on identifying drugs that will increase the level of fetal hemoglobin in the blood. | | | Two approaches to gene therapy are being explored. | | | The ultimate cure for sickle cell anemia may be gene therapy. |
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http://www.ascaa.org/ftreat.htm
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| | Ask A Scientist - Fetal hemoglobin |
| | Scientists think that the higher oxygen affinity of fetal hemoglobin facilitates the transport of oxygen from mother to fetus. | | | Therefore, it is said to have higher oxygen affinity. | | | If at a given concentration of oxygen the mother's hemoglobin is more likely to unload oxygen while the fetus's hemoglobin is more likely to bind oxygen, then the oxygen is transferred from the mother to the fetus. |
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http://www.hhmi.org/askascientist/answers/general/ans_027.html
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| | Significance of fetal hemoglobin-containing erythroblasts (F blasts) and the F blastF cell ratio in myelodysplastic ... |
| | In this study, using an immunohistochemical ssDNA assay, which is sensitive and specific to early stages of apoptosis, we observed significantly increased apoptosis in patients with MDS compared with controls. | | | An apparent paradox in MDS is that patients with this disease show peripheral cytopenia despite normal or high cellularity in their bone marrows. | | | Monoclonal antibody-based methods for quantitation of hemoglobin: application to evaluating patients with sickle cell anemia treated with hydroxyurea. |
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http://www.nature.com/leu/journal/v16/n8/full/2402536a.html
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| | Fetal hemoglobin - Wikipedia, the free encyclopedia |
| | Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia (original 1995 study) | | | Combination therapy with hydroxyurea and recombinant erythropoietin â”rather than treatment with hydroxyurea aloneâ”has been shown to further elevate hemoglobin F levels and to promote the development of HbF-containing F-cells [1]. | | | These invariably lead to so-called painful vaso-occlusive episodes, which are a hallmark of the disease. |
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http://en.wikipedia.org/wiki/Fetal_hemoglobin
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| | GenomicsHuGENetReviewsHb S Allele and Sickle Cell Disease |
| | The Agency for Health Care Policy and Research (AHCPR) has recommended hemoglobin electrophoresis, isoelectric focusing and high-performance liquid chromatography as accurate methods for newborn screening ( 2). | | | This association is most likely related to the fact that the mean hemoglobin concentrations and the mean fetal hemoglobin levels differ among the haplotypes ( 15), both which have been shown to be correlated with clinical expression of sickle cell disease ( 10, 16). | | | Increased levels of fetal hemoglobin (Hb F) are associated with a less severe clinical course of sickle cell disease ( 16). |
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http://www.cdc.gov/genomics/hugenet/reviews/sickle.htm
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| | Fetal Hemoglobin Test AHealthyMe.com |
| | Reference values vary from laboratory to laboratory but are generally found within the following ranges: | | | The determination of fetal hemoglobin is an aid in evaluating low concentrations of hemoglobin in the blood (anemia), as well as the hereditary persistence of fetal hemoglobin, and a group of inherited disorders affecting hemoglobin, among which are the thalassemias and sickle cell anemia. | | | A disorder characterized by a reduced blood level of hemoglobin, the oxygen-carrying pigment of blood. |
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http://www.ahealthyme.com/topic/topic100586822
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| | New Hope for People with Sickle Cell Anemia (FDA Consumer Reprint) |
| | Your organs become more damaged when they are chronically not receiving enough blood and oxygen." | | | Because hydroxyurea is already on the market for other uses, it was unnecessary for FDA to issue a Treatment IND (investigational new drug) to make the drug available to patients with sickle cell anemia. | | | The symptoms of a painful crisis may be relieved by giving patients fluids and painkillers, said Lilia Talarico, M.D., director of the division of gastrointestinal and hematologic drug products in FDA's Center for Drug Evaluation and Research. |
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http://www.fda.gov/fdac/features/496_sick.html
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| | Chromosome Analysis, Prenatal Cordocentesis and Fetal Hemoglobin |
| | Standard G-banded karyotyping and isoelectric focusing of hemoglobin to confirm fetal derivation of the sample | | | Rapid analysis of fetal chromosomes, used most frequently following the determination of fetal abnormalities by ultrasound | | | Specimen frozen; clotted specimen; specimen determined to be maternal in origin |
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http://www.labcorp.com/datasets/labcorp/html/chapter/mono/510313.html
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| | ARUP: Fetal Hemoglobin Determination for Fetomaternal Hemorrhage |
| | For additional interpretive data see Fetal Hemoglobin in "ARUP's Guide to Clinical Laboratory Testing" | | | For routine fetal hemoglobin (Hb F) testing, please order Hemoglobin Evaluation with Reflex to Electrophoresis and/or HPLC (0050610). | | | This test should only be used to detect and quantify the extent of fetomaternal hemorrhage, in pregnant or post-partum women who need to be assessed for RhoGAM |
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http://www.arupcs.com/guides/ug/tests/0096026.jsp
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| | nih book chap 26 Fetal Hemoglobin |
| | Less pain, increase in Hb F to 15-20 percent, increased hemoglobin level if severely anemic, | | | Hb F of 6.8 percent increased to 19.8 percent | | | If no major toxicity, escalate dose every 6-8 weeks until the desired endpoint is reached. |
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http://www.scinfo.org/nihnewchap26.htm
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| | triButyrate® and Thalassemia/Sickle Cell Anemia Research |
| | The painful episodes associated with the disease are fewer among patients who have a naturally higher level of fetal hemoglobin, which normally diminishes as people age. | | | Since then clinical studies have been conducted on the effect of Sodium Phenylbutyrate combined with other drugs on Thalassemia and Cooley's Anemia. |
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http://www.tributyrate.com/html/thalassemia_sca.php
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| | University of South Alabama Cell Biology and Neuroscience Faculty Betty S. Pace |
| | The main objective of my research has been the identification of new agents with fetal hemoglobin inducibility for the treatment of patients with sickle cell disease. | | | Elevated levels of fetal hemoglobin are known to inhibit the intracellular polymerization of hemoglobin S and to prevent vaso_occlusive complications in patients with sickle cell disease. | | | Yang, Y., Baliga, B.S., and Pace, B.S.: Characterization of in vitro BFU_E colony growth and fetal hemoglobin production in response to hydroxyurea: an analysis of the relationship to in vivo fetal hemoglobin induction. |
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http://southmed.usouthal.edu/com/scb/pace.htm
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| | Hemoglobin Synthesis |
| | For more information, see "Hemoglobin: molecular, genetic, and clinical aspects", Bunn and Forget, Saunders, 1986. | | | With the exception of the first 10 to 12 weeks after conception, fetal hemoglobin is the primary hemoglobin in the developing fetus. | | | Two dimers combine to form a hemoglobin tetramer, which is the functional form of hemoglobin. |
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http://sickle.bwh.harvard.edu/hbsynthesis.html
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| | Fetal Hemoglobin |
| | The hemolysate is subjected to an alkali solution and all hemoglobins except HbF are denatured. | | | The alkaline denaturation method relies on the resistance to denaturation by alkali effect of HbF compared to HbA. |
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http://mahsa-yaran.com/prod03.htm
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| | Alpha Thalassemia - Health and Medical Information produced by doctors - MedicineNet.com |
| | Between these two extremes, impairment of 2 or 3 alpha-chain genes results in a span of syndromes with varying degrees of anemia and, hence, varying degrees of disease. | | | Fetal hemoglobin (Hb F) is the predominant hemoglobin of the developing fetus. | | | Thus, in the case of hemoglobin, there are stunning series of changes (called switches) from one type of hemoglobin to another as development progresses from the embryo to the fetus to the newborn, etc. |
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http://www.medicinenet.com/alpha_thalassemia/page2.htm
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| | FETAL BLOOD AND CIRCULATION |
| | and nutrients from the placenta to the fetal body. | | | If not corrected, it can lead to irreversible degenerative changes in the.heart and lungs. | | | The concentration of hemoglobin in fetal blood is about 50 % greater than in maternal blood. |
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http://www.cayuga-cc.edu/people/facultypages/greer/biol204/heart4/heart4.html
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| | NEJM -- Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea |
| | These results strongly suggest that S-phase-specific cytotoxic/cytostatic drugs increase fetal hemoglobin by a mechanism that does not involve inhibition of DNA methylation. | | | Immediately after phlebotomy was initiated, there was a rise in the level of F cells, which stabilized at an average value of 13 per cent in one animal and 20 per cent in the other during a two-month control period. | | | Fetal hemoglobin gradually rose from undetectable values before bleeding to 3 per cent in one animal and 5 per cent in the other. |
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http://content.nejm.org/cgi/content/short/310/14/869
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| | fetal hemoglobin - yourDictionary.com - American Heritage Dictionary |
| | The predominant form of hemoglobin in a fetus and a newborn. | | | Normally present in small amounts in an adult, it may be abnormally elevated in certain forms of anemia. | | | fetal hemoglobin - yourDictionary.com - American Heritage Dictionary |
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http://www.yourdictionary.com/ahd/f/f0091700.html
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| | Fetal Hemoglobin |
| | Fetal hemoglobin does not bind 2,3-DPG as well as normal hemoglobin. | | | Fetal PO2 is lower than adult PO2 for a given oxygen saturation value. | | | Fetal hemoglobin curve is shifted to the left binding oxygen more tightly than normal hemoglobin. |
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http://www.jlenterprise.com/hb.html
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