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Topic: Ferritin



  
 s010413a - Iron-Deficiency Anemia - Serum Ferritin Diagnosis
Whether ferritin is also the best predictor of response to iron therapy, cannot be determined on the basis of the present data.
Although reduced serum ferritin in anemic individuals is good evidence of iron deficiency, a significant proportion of anemic iron-deficient patients is missed by this procedure rendering it less useful than other, less expensive laboratory methods.
All 19 patients with low serum ferritin had iron deficiency as assessed on bone marrow examination, whereas six patients with low or absent bone marrow iron stores had serum ferritin within normal range.
http://www.emory.edu/WHSCL/grady/amreport/litsrch00/s010413a.html   (7138 words)

  
 [No title]
The measurement of ferritin in serum is useful in determining changes in body iron storage, and is non-invasive with relatively little patient discomfort.
Intended use For the quantitative determination of Human Ferritin concentration in human serum.
Under normal conditions, this may represent 25% of the total iron found in the body.
http://www.rapidtest.com/Ferritin_1601.doc   (1325 words)

  
 Initial Serum Ferritin Levels in Patients with Multiple Trauma and the Subsequent Development of Acute Respiratory ...
The mechanisms responsible for the increased serum ferritin are unknown.
Serum ferritin levels on admission correlated with a measurement of the degree of initial trauma injury as assessed by the
ferritin levels, there was a considerable overlap in the ferritin
http://ajrccm.atsjournals.org/cgi/content/full/159/5/1506   (2614 words)

  
 Anthracyclines Induce Accumulation of Iron in Ferritin in Myocardial and Neoplastic Cells: Inhibition of the Ferritin ...
Terman A and Brunk UT (1998) On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes.
ferritin is probably critical for important physiological processes
ferritin has been investigated, there is little information regarding
http://molpharm.aspetjournals.org/cgi/content/full/63/4/849   (7568 words)

  
 Ferritin-IRE-Paper
In contrast to yolk ferritin, it is expressed at a very moderate level.
Fer2 is present in both sexes where it is expressed in equal amounts in most, probably all of the tissues (Schüßler et al., 1995b; Winnen et al., 1995).
Sequence studies of the 5' UTRs, gel retardation assays, and hybridization experiments show that both ferritin mRNAs of S.
http://www.uni-duesseldorf.de/WWW/MathNat/Parasitology/ire_pap.htm   (4312 words)

  
 Nitrogen monoxide-mediated control of ferritin synthesis: Implications for macrophage iron homeostasis -- Kim and Ponka ...
The results are means ± SD of triplicate determinations in a typical experiment performed.
SD of triplicate determinations in a typical experiment from
http://www.pnas.org/cgi/content/full/99/19/12214   (4133 words)

  
 Proteomic approach to coronary atherosclerosis shows ferritin light chain as a significant marker: evidence consistent ...
Proteomic approach to coronary atherosclerosis shows ferritin light chain as a significant marker: evidence consistent with iron hypothesis in atherosclerosis -- You et al.
Statistical analysis determined that the ferritin light chain
Association between body iron stores and the risk of acute myocardial infarction in men.
http://physiolgenomics.physiology.org/cgi/content/full/13/1/25   (3628 words)

  
 Ferritin
If you have bleeding or clotting problems, or if you take blood-thinning medication, tell your health professional before your blood is drawn.
Too much iron in body organs (such as the pancreas or heart) can affect the organ's function.
For more information, see the medical test Bone Marrow Aspiration and Biopsy.
http://www.webmd.com/hw/womens_conditions/hw6212.asp   (798 words)

  
 Beryllium Journal Articles Related Chelation and Ferritin
Comparative study of the ability of ferritin or apoferritin to bind Cd2+, Zn2+, Cu2+, and Be2+ was conducted by using a gel equilibrium technique, Centifree micropartition technique, and microcentrifuge desalting technique.
During iron release ferritin produces free radicals which are involved in phosphoprotein inactivation, lipid peroxidation and, possibly, the general aging process.
http://dim.com/~mhj/Beryllium_chelation-1965-1999.htm   (2688 words)

  
 Ferritin, Serum
Ferritin determinations are not reliable in infants on iron therapy.
Grail A, Hancock BW, and Harrison PM, "Serum Ferritin in Normal Individuals and in Patients With Malignant Lymphoma and Chronic Renal Failure Measured With Seven Different Commercial Immunoassay Techniques," J Clin Pathol, 1982, 35(11):1204-12.
Elevated serum ferritin levels in patients with cancer is associated with a poor prognosis which may be due in part to deleterious biological effects of tumor ferritins on lymphocyte and granulocyte function.
http://www.labcorp.com/datasets/labcorp/html/chapter/mono/ri020300.htm   (665 words)

  
 Serum ferritin and risk of myocardial infarction in the elderly: the Rotterdam Study -- Klipstein-Grobusch et al. 69 ...
Serum ferritin and risk of myocardial infarction in the elderly: the Rotterdam Study -- Klipstein-Grobusch et al.
http://www.ajcn.org/cgi/content/full/69/6/1231?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&titleabstract=ferritin&fulltext=ferritin&searchid=QID_NOT_SET&stored_search=&FIRSTINDEX=&fdate=1/1/1993   (3375 words)

  
 Secretion of Ferritin by Rat Hepatoma Cells and Its Regulation by Inflammatory Cytokines and Iron -- Tran et al. 90 ...
Ferritin concentrations in human serum have been measured in many different physiologic states and are routinely used to assess body iron stores.
At the end of each experiment, the medium was aspirated off for analysis of albumin and ferritin in the medium, and for LDH activity.
Serum ferritin concentrations are elevated in inflammatory conditions, and we wondered whether serum ferritin might be an acute phase reactant responsive to certain cytokines.
http://www.bloodjournal.org/cgi/content/full/90/12/4979   (5904 words)

  
 Transcriptional Regulation of the Mouse Ferritin H Gene. INVOLVEMENT OF p300/CBP ADAPTOR PROTEINS IN FER-1 ENHANCER ...
mechanism and biological meaning of the increase in ferritin associated
observations may help to explain the response of ferritin H to
The E1A mutants that retained the ability to associate
http://www.jbc.org/cgi/content/full/274/11/7501   (5553 words)

  
 Ascorbic Acid Enhances Iron-induced Ferritin Translation in Human Leukemia and Hepatoma Cells -- Toth et al. 270 (6): ...
S]methionine experiments and the immunoprecipitaion measurements of ferritin content are substantial.
Detailed analysis of the IRE, including site-directed mutants, along with in vitro translation experiments are needed to define absolutely the role of this structure in mediating the ascorbate response.
This region of the 5`-UTR regulates ferritin translation in response to cytokines such as interleukin-1(45).
http://www.jbc.org/cgi/content/full/270/6/2846   (5476 words)

  
 Bathsheba Grossman - Ferritin Crystal
At any given moment 70% of your body's iron is in the blood's hemoglobin, a few percent in the muscles as myoglobin, and the rest safely stored in ferritin.
For anyone who loves life science, the Ferritin Crystal offers a look into biomolecular structure: a research-quality model of an essential, universal, and beautiful protein.
Early in the lives of cells, ferritin works to gather iron into its hollow core, to release it later as the cells make new iron proteins for respiration, photosynthesis, and other key processes.
http://www.bathsheba.com/crystalsci/ferritin   (257 words)

  
 ORGENTEC Diagnostika GmbH
During therapy with iron, ferritin values indicate the actual iron storage.
The determination of serum ferritin is an important parameter for diagnosis and therapy control of the iron-deficiency.
Ferritin measurements are recommended for risk groups, like blood donors, pregnant women, hemodialysis patients and infants.
http://www.orgentec.com/cgi-bin/cj/messigent.pl?company=73&zoneid=212&pk=1355&action=show&tmplid=1   (120 words)

  
 Heme controls antioxidants and iron in ferritin
Until now, scientists were convinced that the only way to develop new therapies for treating iron overload was to focus on iron metabolism.
"Our research shows that ferritin mRNA is sensitive to iron, ferritin DNA is sensitive to antioxidants like sulforphane and heme coordinates both DNA and mRNA," said Korry Hintze, a postdoctoral fellow at Children's Hospital Oakland Research Institute and co-author of the study.
Iron had practically no effect, but with heme or sulforphane much "reporter" was produced.
http://www.medicalnewstoday.com/medicalnews.php?newsid=31891&nfid=rssfeeds   (623 words)

  
 Association of Increased Levels of Heavy-Chain Ferritin with Increased CD4+ CD25+ Regulatory T-Cell Levels in Patients ...
Hann H., Levy H. M., Evans A. Serum ferritin as a guide to therapy in neuroblastoma.
and liver disease, conditions in which ferritin is disproportionately
Elevated levels of ferritin have been reported in patients with
http://clincancerres.aacrjournals.org/cgi/content/full/9/7/2551   (4836 words)

  
 News - Increased Serum Ferritin Common in Hypertensive Men
Patients with hemochromatosis, other conditions that may induce secondary iron overload, or serum ferritin increase unrelated to body iron stores were excluded.
Increased serum ferritin, a possible risk factor for hepatic cirrhosis and atherogenesis, is common in hypertensive men.
The metabolic abnormalities and serum ferritin were frequently positively correlated, the researchers reported.
http://www.docguide.com/news/content.nsf/news/8525697700573E1885256C15001C6AB7   (422 words)

  
 Ferritin Crystal Cataracts in Hereditary Hyperferritinemia Cataract Syndrome -- Brooks et al. 43 (4): 1121 -- ...
Schematic representation of IRE-IRP status in various clinical conditions, including the consequences of changes in IRE-IRP on ferritin translation and physiology.
were subjected to ophthalmic examination, serum ferritin assay,
Ferritin is found in the lens, where it may have a role in iron
http://www.iovs.org/cgi/content/full/43/4/1121   (3904 words)

  
 Specific repression of beta -globin promoter activity by nuclear ferritin -- Broyles et al. 98 (16): 9145 -- ...
It is not possible to do this experiment
supershift is specific for ferritin epitopes and for this DNA-protein
Binding of ferritin chains from human heart and liver to the distal promoter of the human
http://www.pnas.org/cgi/content/full/98/16/9145   (4035 words)

  
 Ferritin - Wikipedia, the free encyclopedia
Serum ferritin levels are measured in patients as part of the iron studies workup for anemia.
Ferritin is also used as a marker for iron overload disorders, such as haemochromatosis and porphyria in which the ferritin level may be abnormally raised.
As ferritin is also an acute-phase reactant, it is often elevated in the course of disease.
http://en.wikipedia.org/wiki/Ferritin   (262 words)

  
 Low Serum Ferritin Level Rules Out Advanced Liver Disease in Hemochromatosis -- 138 (8): I-30 -- Annals of Internal ...
These patients may have had severe disease and may not be typical
Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.
1500 µg/L. Only one patient had a serum ferritin level
http://www.annals.org/cgi/content/full/138/8/I-30   (554 words)

  
 Ferritin definition - Medical Dictionary definitions of popular medical terms
Mutations in the ferritin light chain are responsible for a disease called the hyperferritinemia-cataract syndrome characterized by cataracts (opacities in the lens of the eye) and high levels of ferritin in the blood.
Ferritin definition - Medical Dictionary definitions of popular medical terms
Liver and spleen ferritin consists of 24 subunits of 2 kinds, the heavy and the light subunit.
http://www.medterms.com/script/main/art.asp?articlekey=3410   (324 words)

  
 MedlinePlus Medical Encyclopedia: Ferritin
The lower the ferritin level, even within the "normal" range, the more likely a patient is iron deficient.
Additional conditions under which the test may be performed:
This is a test to measure the amount of ferritin in the blood.
http://www.nlm.nih.gov/medlineplus/ency/article/003490.htm   (620 words)

  
 Iron Metabolism and Iron Regulation
Excessive ferritin leads to an organ-damaging condition known as iron overload.
Too little ferritin leads to anemia, a condition characterized by insufficient levels of red blood cells or hemoglobin.
As cells die and are reabsorbed into the body, iron regulation processes redirect ferritin released from dead cells—particularly red blood cells—to the bone marrow.
http://www.about-blood-disorders.com/iron-disorders/metabolism.php   (641 words)

  
 Ferritin and Hemosiderin
All ferritins are composed of 24 apoferritin monomers which associate to form a spherical particle.
The structure of these molecules is very similar to those of animals and plants.
Interestingly, such control is at the level of translation.
http://arbl.cvmbs.colostate.edu/hbooks/molecules/ferritin.html   (549 words)

  
 Kamiya Biomedical Company - Clinical Diagnostics - Ferritin
Kamiya Biomedical Company - Clinical Diagnostics - Ferritin
http://www.kamiyabiomedical.com/03ClinicalDiagnosticsProducts/01Immunoassays/Reagents/KAI076.php   (32 words)

  
 Ferritin: The Test Sample
Ferritin and hemosiderin are present primarily in the liver but also in the bone marrow, spleen, and skeletal muscles.
Ferritin is a protein inside of cells that stores iron for later use by your body.
In healthy people, most iron is stored as ferritin (an estimated 70% in men and 80% in women) and smaller amounts are stored as hemosiderin.
http://www.labtestsonline.org/understanding/analytes/ferritin/sample.html   (173 words)

  
 Physican Discount Affiliate Program - Vitacost
Ferritin and LDL show a synergistic adverse association with cardiovascular disease and death.
Serum ferritin causes LDL lipid peroxidation and is a strong risk predictor for progression of atherosclerosis.
(Should never be given as a supplement unless ferritin levels are depleted.) Increases in iron intake increase coronary heart disease risk up to 360%.
http://www.vitacost.com/science/physguide.html   (1827 words)

  
 Regulation of translation
Translation of ferritin mRNA is regulated so that ferritin is only made when free iron is present, needing sequestration.
An RNA structural element, the IRE, present in the 5' untranslated region of ferritin mRNA is sufficient to confer iron-regulated translation on other mRNAs.
Similar protein-RNA interactions have totally different effects depending on the context of the RNA target of binding (compare the ferritin example with transferrin receptor mRNA stability regulation).
http://opbs.okstate.edu/~melcher/mg/MGW2/MG2442.html   (292 words)

  
 InterPro: IPR009078 Ferritin/ribonucleotide reductase-like
Ferritin is a multisubunit protein with a hollow interior, which contains a mineral core of hydrated ferric oxide, thereby ensuring its solubility in an aqueous environment [ 1 ].
This family contains ferritin and other ferritin-like proteins such as bacterioferritin (cytochrome b1) that binds haem between two subunits, non-haem ferritin, dodecameric ferritin homologue (DPS) that binds to and protects DNA, and the N-terminal domain of rubrerythrin that is found in many air-sensitive bacteria and archaea [ 2 ].
Jin S. Kurtz D.M. Liu Z.J. Rose J. Wang B.C. X-ray crystal structures of reduced rubrerythrin and its azide adduct: a structure-based mechanism for a non-heme diiron peroxidase.
http://www.ebi.ac.uk/interpro/IEntry?ac=IPR009078   (2831 words)

  
 Brain Ferritin Iron as a Risk Factor for Age at Onset in Neurodegenerative Diseases -- BARTZOKIS et al. 1012 (1): 224 ...
Key Words: iron • ferritin • risk factor • age at onset • aging • Alzheimer's disease • Parkinson's disease • dementia • sex • gender • brain development • myelin • oligodendrocytes • degeneration • amyloid • tau •
Brain Ferritin Iron as a Risk Factor for Age at Onset in Neurodegenerative Diseases -- BARTZOKIS et al.
Brain Ferritin Iron as a Risk Factor for Age at Onset in Neurodegenerative Diseases
http://www.annalsnyas.org/cgi/content/abstract/1012/1/224   (439 words)

  
 Holistic Health Encyclopedia - L
The liver can store a quart of extra blood when there is excess blood volume and supply it to the body when required, such as when a person exercises heavily or has a substantial blood loss.
Kupffer cells of the liver are macrophages that filter out about 99% of harmful bacteria in blood coming from the intestines before they can otherwise enter the general circulation.
The liver also stores vitamins A, B12, D, E, and K for long times, and ferritin, a liver protein, stores iron by bonding to it and releasing it for the production of red blood cells.
http://www.myholistic.com/glossary/L.php3   (6915 words)

  
 Ferritin antibodies from RDI Divison of Fitzgerald Industries Intl
Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
-see below 1 polyclonal and 4 monoclonals against ferritin
These clones have been derived from hybridization of SP2/0 myeloma cells with spleen cells of a Balb/c mice immunised with purified human ferritin
http://www.researchd.com/miscabs/ferritin.htm   (360 words)

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