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| | Serotonin and dopamine system interactions in the reinforcing properties of psychostimulants: A research strategy |
 | | Amphetamine and fenfluramine are therapeutic drugs and are frequently given to naive patients as part of outpatient therapy with little evidence of iatrogenic dependence (Schuster, 1989). | | | Fenfluramine: amphetamine congener that fails to maintain drug-taking behavior in the rhesus monkey. | | | MDMA is discriminated as amphetamine in d-amphetamine trained rats (Glennon et al., 1988), pigeons (Evans and Johanson 1986), and rhesus monkeys, (Kamien et al., 1986) but also as fenfluramine in fenfluramine-trained rats (Schechter 1986). |
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| | Active and ongoing behavior therapy with professionals trained in behavior modification techniques was an integral part of the study. | | | During this time, behavioral and dietary therapy along with exercise and medical monitoring were on-going. | | | The average weight of the remaining group of 59 was 9.4 kg (~21 lbs) less than when they started the study 156 weeks before. |
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| | Q&A About Fen/Dexfen Withdrawal, 9/15/97 (FDA) |
| | Because valve disease is not usually associated with drug use, it is not normally screened for in human clinical testing of drugs. | | | Wyeth-Ayerst, the US manufacturer of both Pondimin (fenfluramine) and Redux (dexfenfluramine) has said that it will not reintroduce these medications regardless of the outcome of the studies. | | | However, we encourage those people who have taken fenfluramine or dexfenfluramine to contact their physician and discuss the appropriate follow-up, even after stopping their medicine. |
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http://www.obesity-news.com/fenfaq.htm
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| | Fenfluramine Anorexients and Anesthesia |
| | However, neither the clinical information presented in the case report nor the design of the drug interaction experiment were adequate to answer the question of whether or not a interaction exists (11). | | | Although, pulmonary artery pressures were not measured and post mortem examination did not note morphological signs consistent with chronic pulmonary hypertension, the possibility that unrecognized pulmonary hypertension contributed to the fatal outcome in the patient described by Bennett and Eltringham cannot be excluded. | | | Although the aforementioned hypothesis seems plausible, it must be emphasized that it is not yet clear if a drug interaction truly exists between anesthetics and fenfluramines. |
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| | SIGHTINGS: |
| | Fenfluramine studies that examine serotonin as a possible factor in violence are especially important to drug companies such as Eli Lilly who making drugs like Prozac which affect serotonin. | | | Now that fenfluramine has been withdrawn from the market, it is not known if the investigators will attempt to obtain a research exception for its future use or if they will continue the studies with other dangerous drugs and intrusive physical interventions. | | | Yet it was already known by 1989 that fenfluramine has no positive effect on the behavior of children, even by NIMH standards. |
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| | Drug Alert - weight loss, anti-obesity drugs - fenfluramine |
| | While fenfluramine is an old and well-studied drug and there is evidence that it may make a modest contribution to appetite and weight-management in long-term treatment situations, new evidence of a significant health problem related to its use makes the drug look very unattractive. | | | Our view is that short-term treatment with fenfluramine is not likely to contribute to long-term reduction in body weight and the risk of fatal pulmonary hypertension, while small, argues strongly against using this drug. | | | Meanwhile, supporters point out that thousands of people here and abroad have taken the drug, so there is widespread experience with it." |
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| | Serotonin is one of your brain's most sedating, satiating and relaxing neurotransmitters. | | | However, serotonin reuptake inhibitors are simply not as effective as Fenfluramine. | | | Fenfluramine, on the other hand, stimulates serotonin release. |
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| | FenPhenAla's Home Page 2 |
| | Fenfluramine and the other drug that makes up the fen-phen regimen, phentermine, have been on the market for more than two decades. | | | Often, no physical examination was done for patients when they were initially put on the drugs or any time later. | | | The authors concluded that patients who have taken the drugs for more than three months are 20 times more likely to develop PPH. |
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| | Psychiatry, SSRI's, Prozac, Paxil, Zoloft, Luvox, Effexor, Serzone, Anafranil, Fenfluramine, Fen-phen, Redux, ... |
| | If you are being given psychiatric SSRI drugs such as prozac, paxil, zoloft, luvox, effexor, serzone, anafranil, fenfluramine, fen-phen and redux, you must read this book. | | | Withdrawal from psychiatric drugs should be done gradually and under medical and clinical supervision. | | | Why are people being given psychiatric drugs such as ssri's, prozac, paxil, zoloft, luvox, effexor, serzone, anafranil, fenfluramine, fen-phen and redux? |
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| | Serotonin: It's Possible to Have Too Much of a Good Thing/Brainstorms December 1997 |
| | Although there have been no reports of long-lasting or permanent serotonin depletion in brains of human fenfluramine users, or any proven changes in behavior, this possibility has always been a nagging concern for the long-term safety of fenfluramine use. | | | So far, there is no rationale or empiric observations to create any concern that the SSRIs cause cardiac problems similar to those associated with fenfluramine. | | | Brainstorms aims to provide updates of novel concepts emerging from the neurosciences that have relevance to practitioners. |
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| | Weight and Balance -- Diet Pills and Flying |
| | Phendimetrazine is not a replacement for Fenfluramine; rather, it is another central nervous system stimulant. | | | Some doctors, concerned about the liability of prescribing Fenfluramine, prescribe Phentermine and Phendimetrazine (phen/phendi) instead. | | | Pursuant to the Guide for Aviation Medical Examiners, when item 17 (medications) is checked yes: |
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http://www.cami.jccbi.gov/AAM-400A/FASMB/FAS9703/weight.htm
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| | CNN - Valvular heart disease associated with fenfluramine-phentermine - June 8, 1997 |
| | Fenfluramine is a sympathomimetic amine that has an anorectic action mediated through activation of serotonergic pathways in the brain. | | | Patient 1: A 41-year-old woman (body mass index, 39.6 kg/m2) was referred to the Mayo Clinic for mitral valve surgery 3 months after a systolic murmur was first noted. | | | Although serotonin levels were not measured in our patients, we postulate the combination of fenfluramine and phentermine may potentiate the effect or concentration of circulating serotonin and result in valvular injury similar to that seen in patients with carcinoid syndrome or in those taking ergot preparations. |
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http://www.cnn.com/HEALTH/9707/08/fenphen.report/index.html
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| | BioMed Central Full text Risk of valvular heart disease associated with use of fenfluramine |
| | Some recent reviews conclude that the risks associated with fenfluramine and dexfenfluramine are similar, real but modest for aortic valve disease, and barely detectable for mitral valve disease; phentermine appears not to be associated with increased risk [ 17-20 ]. | | | In some studies, control subjects were derived from patients assigned to placebo in a formal randomized trial of fenfluramine or dexfenfluramine. | | | Data provided in this study can be used to estimate the relative contribution of exposure to fenfluramines to overall incidence of echocardiographically defined, FDA-positive AR and MR. |
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http://www.biomedcentral.com/1471-2261/3/5
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| | EUROECHO: No Increase In Cardio Physical Findings Using Fenfluramine |
| | "The study represented a unique opportunity to evaluate patients years after their participation in a placebo-controlled study with fenfluramine," Dr. Davidoff said. | | | TRIESTE, ITALY -- Dec. 10, 1998 -- Study results presented today at the annual EUROECHO meeting showed no statistically significant increase in heart valve regurgitation or cardiovascular physical findings and outcomes when patients previously treated with fenfluramine or placebo for approximately three months were compared. | | | Fenfluramine was frequently prescribed as part of the diet drug combination known as phen-fen. |
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| | Cardiac Valvulopathy Associated with Exposure to Fenfluramine or Dexfenfluramine: U.S. Department of Health and Human ... |
| | Practitioners should use their best judgment, based on the individual patient's history, clinical presentation, and current valvular or pulmonary hypertension status, to determine the need for additional echocardiographic follow-up. | | | Although valvular lesions were observed on both sides of the heart, a left-sided valve was affected in all cases. | | | Although the degree to which patients with these valvular lesions are at risk for developing endocarditis has not yet been determined, prudent medical management of these patients should include appropriate antimicrobial prophylaxis before certain invasive procedures and should be based on 1997 American Heart Association (AHA) recommendations for preventing bacterial endocarditis (6). |
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http://www.cdc.gov/mmwr/preview/mmwrhtml/00049815.htm
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| | Arch Intern Med -- Abstract: Echocardiographic Examination of Women Previously Treated With Fenfluramine: Long-term ... |
| | From the Section of Cardiology, Evans Department of Medicine, Boston University Medical Center, Boston, Mass (Drs Davidoff, Balady, and Mendes); Cancer Prevention Research Program and Women's Health Initiative, Fred Hutchinson Cancer Research Center, Seattle, Wash (Drs McTiernan, Rudolph, and Bowen); and Wyeth-Ayerst Research, Philadelphia, Pa (Drs Constantine and Davis). | | | Arch Intern Med -- Abstract: Echocardiographic Examination of Women Previously Treated With Fenfluramine: Long-term Follow-up of a Randomized, Double-blind, Placebo-Controlled Trial, June 11, 2001, Davidoff et al. | | | Echocardiographic Examination of Women Previously Treated With Fenfluramine |
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http://archinte.ama-assn.org/cgi/content/abstract/161/11/1429
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| | Fenfluramine Hydrochloride, Pondimin, Diet Pills, Weight Loss, Appetite Supressants, Prescription Drugs, Medications |
| | The mechanism of valve injury is uncertain but may be related to an alteration in circulating serotonin. | | | These reports have included dyspnea, chest pain, syncope, lower extremity edema, or a new heart murmur." | | | Fenfluramine Hydrochloride(Pondimin), Health Pamphlets, Health Link :"The manufacturer of the weight loss drug Pondimin (fenfluramine hydrochloride) have added a new warning regarding a potentially serious and unusual form of valvular heart disease which has been reported in patients taking this drug in combination with phenteramine. |
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| | HEALTH ADVISORY ON FENFLURAMINE/PHENTERMINE FOR OBESITY |
| | There is no conclusive evidence of a cause-effect relationship between use of the drugs and the development of valvular disease. | | | The drugs were approved individually more than 20 years ago for single-drug, short-term obesity therapy. | | | The agency encourages all health care professionals to report any cases of cardiac valvular disease or other serious toxicities associated with the use of fenfluramine, dexfenfluramine, or phentermine to the FDA's MEDWATCH program at 1-800-FDA-1088/fax 1-800-FDA-0178; or to the respective drug manufacturers. |
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| | Valvular heart disease and fenfluramine-phentermine |
| | Of these 19 patients, 10 presented with symptoms of CHF, 5 with chest pain or arrhythmia and 4 with only a murmur. | | | The serotoninergic drugs fenfluramine and its d-isomer dexfenfluramine as well as the adrenergic agonist phentermine have been increasingly prescribed for the treatment of obesity. | | | This is the first report of similar cardiac valvular problems in patients taking the combination of fenfluramine and phentermine. |
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http://www.journalclub.org/vol2/a53.html
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| | Aortic Valve Insufficiency - Fen-Phen, Pondimin |
| | Fenfluramine is contraindicated in patients with glaucoma or with hypersensitivity to fenfluramine or sympathomimetic amines. | | | Fenfluramine should be avoided in patients with psychotic illness. | | | Pondimin is contraindicated in patients with diagnosed pulmonary hypertension. |
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| | Therefore, the study does not address the issue of incidence or prevalence of valvulopathy. | | | Fenfluramine and its isomer, dexfenfluramine, are thought to act by affecting brain serotonin levels. | | | Patients and physicians are wondering which patients treated with fenfluramine, dexfenfluramine alone or in combination with phentermine should undergo echocardiography. |
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| | Effects of phentermine [ Adipex , Fastin , Ionamin , Duromine] and fenfluramine ( Pondimin ) on normal healthy ... |
| | Seven male and five female volunteers participated in an eight-session, double-blind study in which each subject received each of the following drug conditions: d-amphetamine (10 and 20 mg), phentermine (30 mg), fenfluramine (40 and 80 mg), phentermine (30 mg) with fenfluramine (40 mg), phentermine (30 mg) with fenfluramine (80 mg), and placebo. | | | ecent clinical reports indicate that combined administration of phentermine and fenfluramine may have useful effects in the treatment of drug abuse. | | | Phentermine reduced the apparently aversive effects of fenfluramine when the two drugs were given together. |
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| | FDA Warning on Chinese “Herbal” Diet Pills Containing Fenfluramine |
| | "Herbal Phen - Fen" Contaminated with Fenfluramine Linked to Deaths in Japan; Recalled / Banned in USA | | | Fenfluramine and another diet drug, Phentermine, were used in combination for weight loss until it was determined that the combination of drugs was linked to Valvulopathy, a serious and sometimes fatal heart disease. | | | Fenfluramine and a chemically similar drug, Dexfenfluramine, were removed from the market in 1997. |
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| | A.Tracy PhD. Psychiatry, SSRI's: prozac, paxil, zoloft, luvox, effexor, serzone, anafranil, fenfluramine, fen-phen, ... |
| | Anything which will raise the level of serotonin can bring on this hyperserotonergic condition. | | | FEATURES: Latest in medical research on serotonergic medications, information on America's drug history (including politics in medicine), sleep and sleep disorders, causes of depression and other mental illnesses, many first hand patient case reports, alternative solutions to these disorders and many additional reference materials. | | | The book includes new medical research that clearly defines the serious flaws in the hypothesis behind these new serotonin enhancing drugs. |
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| | CNN - Doctors say Fen-Phen causes heart disease - July 8, 1997 |
| | Added Dr. Donald Hensrud, a co-author of the report: "This new information adds a little bit more to the risk side of things." | | | Although both fenfluramine and phentermine are FDA-approved, their combination is not. | | | Fen-Phen is a combination of two drugs -- fenfluramine, an appetite suppressant, and phentermine, a mild stimulant. |
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http://www.cnn.com/HEALTH/9707/08/fen.phen.pm
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| | Fen-Phen Index 11/00-10/01 |
| | Wyeth-funded study shows no injury from fenfluramine, Iss. | | | AHP has settled 85 percent of opt-out cases, Iss. | | | European court orders removal of diet drugs, Iss. |
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| | drugINTEL newsletter - Yellow Card Report Card — Fenfluramine Ephedra |
| | Pharmacia exports custom generic HIV drugs for use in third world countries | | | The European Court of First Instance overturned the withdrawal of marketing authorization for fenfluramine and dexfenfluramine (Pondimin; Ponderal; Ponderax; Redux): see ruling. | | | Reporting adverse events in Britain - Yellow Card better than MedWatch but still considered inadequate |
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http://www.drugintel.com/news/a30127
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| | Echocardiography |
| | PATIENTS: 46 patients who used fenfluramine or dexfenfluramine for 14 days or more and had echocardiograms obtained before therapy. | | | BACKGROUND: Fenfluramine and phentermine have been individually approved as anorectic agents by the Food and Drug Administration (FDA). | | | BACKGROUND: Because uncontrolled echocardiographic surveys suggested that up to 30% to 38% of users of fenfluramine and dexfenfluramine had valvular disease, these drugs were withdrawn from the market. |
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http://www2.umdnj.edu/~shindler/fen-phen.html
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| | Setola V, Hufeisen SJ, Grande-Allen KJ, Vesely I, Glennon RA, Blough B, Rothman RB, Roth BL (2003) ... |
| | Fenfluramine, norfenfluramine, dihydroxyergotamine, pergolide and methysergide were all more potent human 5HT2B agonists than MDMA or MDA. | | | This report describes a series of in vitro studies of 5HT2B activity of fenfluramine, MDMA (racemic and both R-(-)- and S-(+)-MDMA) and other drugs, and in vitro studies of human heart cell growth arising after 5HT2B receptor stimulation. | | | Findings indicate that because they may stimulate heart cell growth, drugs that are 5HT2B agonists may also pose a risk for valvular heart disease. |
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| | January/February 1999 OMR -- Supplement: Meridia Survey Results |
| | This is not possible with Meridia, and Knoll's warning against using Meridia in conjunction other CNS stimulants or depressants, makes it less likely that this medication could be properly adjusted for patients who feel nervous or sleepy. | | | Meridia, as a reuptake inhibitor only, is not as potent as phen/fen was, and clinical studies show much more modest weight loss with Meridia than with phen/fen (5-10 percent versus 15.9 percent). | | | The dose of Meridia can be increased or decreased within a small range, but if patients experience nervousness or sleepiness, raising the dose will mostly likely increase the side effect, and lowering the dose may reduce efficacy considerably. |
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http://www.obesity101.com/mersur.htm
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| | d-Fenfluramine Reduces Binge Eating - Journal Watch Psychiatry |
| | Since patients were told not to diet or expect weight loss during the study, the absence of weight loss in the treated group suggests that patients' expectations play a prominent role in d- fenfluramine's efficacy as a weight-loss drug. | | | This controlled study examined the efficacy of d- fenfluramine in 28 obese patients with binge eating disorder. | | | However, some clinicians use this medication for binge eating disorder and bulimia nervosa in the absence of controlled efficacy data. |
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http://psychiatry.jwatch.org/cgi/content/full/1997/101/1
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| | Fenfluramine - Wikipedia, the free encyclopedia |
| | Fenfluramine is a drug that was part of the Fen-Phen anti- | | | This page was last modified 16:43, 22 May 2005. | | | It is designed to increase the level of the neurotransmitter |
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| | (S)-fenfluramine |
| | All of these reactions have been achieved without any loss of chirality. | | | Independent research, using the epoxidation method of Sharpless [9, 35] lead us too to the alcohol (S)- 3 which we tried to convert into fenfluramine (S)- 1 using a different method. | | | Further, it is no longer necessary to bother with the regioselectivity of the nucleophilic attack on the epoxide, which allows the usage of the simplest method for the preparation of the aminoalcohols: ethylamine in ethanol. |
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| | Fen Phen 2005 Update: Premier Wyeth Diet Drug Settlement Site |
| | During the period from March to August 1997, the Mayo clinic in Rochester, Minnesota observed and reported an association between the use of fenfluramine and/or dexfenfluramine and valvular heart disease ("VHD"). | | | Epidemiological studies have also established that fenfluramine and dexfenfluramine cause a fatal disease known as primary pulmonary hypertension ("PPH"). | | | In 1997, under pressure from the Food and Drug Administration (FDA), concerned medical authorities and injured Fen Phen patients who had filed lawsuits, American Home Products ("AHP"), the manufacturer of the diet drugs Pondimin (fenfluramine) and Redux (dexfenfluramine), took the drugs off the market. |
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| | Fen-Phen Information |
| | With the withdrawal of fenfluramine and dexfenfluramine from the US market, many people have asked what they should do if they have taken these drugs. | | | As fenfluramine and dexfenfluramine are no longer marketed in the U.S. and have no current FDA labels, we refer you to the medical literature to stay up-to-date on the emerging research on this topic. | | | In order to try to provide guidance, based on the best information known at present, the Centers for Disease Control and Prevention, the Food and Drug Administration, and the National Institutes of Health (all components of Department of Health and Human Services) collaborated with experts within the medical community to develop interim recommendations for patients. |
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| | Pondimin Online, Description, Chemistry, Ingredients - Fenfluramine - RxList Monographs |
| | Pondimin (fenfluramine hydrochloride) is an anorectic drug for oral administration. | | | RxList only refers patients to online pharmacies certified by VIPPS, Verified Internet Pharmacy Practice Sites, a program administered by the National Association of Boards of Pharmacy which ensures that member pharmacies offering online prescription services are bona fide, fully licensed, and demonstrate "competent Internet/interstate pharmacy practices." | | | Fenfluramine HCl has the following chemical name: N-ethyl-alpha-methyl-3-(trifluoromethyl) benzeneethanamine hydrochloride. |
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| | treated for obesity with a combination of fenfluramine and phentermine. | | | FDA today alerted physicians to reports of valvular heart disease in women | | | combination of fenfluramine and phentermine for management of obesity, to be |
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| | FenPhenCental |
| | PPH can loosely be defined as a disease resulting in increased pulmonary artery pressure, caused by Pondimin or Redux ingestion, in the absence of any other significant contributing factor. | | | Primary pulmonary hypertension is generally the most serious and potentially deadly of the injuries caused by the fenfluramines. | | | Benjamin is involved in a related battle, with the PMC seeking sanctions against him for a lawsuit he filed in New York state court accusing the PMC of malpractice for its alleged failure to develop a case for the neurotoxicity of fenfluramine and dexfenfluramine. |
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| | Serotonin Transporters, Serotonin Release, and the Mechanism of Fenfluramine Neurotoxicity -- BAUMANN et al. 914 (1): ... |
| | RICHARD B. Medications Development Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA | | | Serotonin Transporters, Serotonin Release, and the Mechanism of Fenfluramine Neurotoxicity | | | Serotonin Transporters, Serotonin Release, and the Mechanism of Fenfluramine Neurotoxicity -- BAUMANN et al. |
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