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| | THE MERCK MANUAL, Sec. 2, Ch. 15, Hyperlipidemia |
 | | Niacin is most effective when combined with cholestyramine in the severe heterozygote with familial hypercholesterolemia. | | | Different lipoprotein patterns in different affected members of the same family are often found. | | | Dietary changes usually should be tried for at least 6 mo before determining that a drug is also needed. |
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http://www.merck.com/pubs/mmanual/section2/chapter15/15c.htm
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| | Treatment of Familial Hypercholesterolemia and Other Genetic Dyslipidemias |
| | Because most patients treated in all long-term controlled trials did not have familial hypercholesterolemia, it is not logical to assume that the results will be comparative. | | | Developing new interventions, such as HDLC-raising drugs [14] and recombinant scavenger lipoprotein [15**], provide big hopes for improved therapies in the near future. | | | Heterozygotes have ASCVD by or before age 55, quite often in the third or fourth decade of life, unless vigorously treated [3*]. |
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http://www.treatment-options.com/article.cfm?KeyWords=&PubID=CM06-4-1-02&Type=Article
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| | EZETIMIBE/SIMVASTATIN (MDXexchange) |
| | Combination therapy with simvastatin and ezetimibe was more effective than simvastatin therapy alone in reducing low-density lipoprotein cholesterol (LDL- C) in patients with homozygous familial hypercholesterolemia. | | | Illingworth DR & Bacon S: Treatment of heterozygous familial hypercholesterolemia with lipid-lowering drugs. | | | Phase 1 was an open-label, lead-in phase of 6 to 14 weeks in which subjects with HoFH (by genotyping or clinical criteria) received 40 milligrams (mg) of either atorvastatin or simvastatin; phase 2 was a randomized, double-blind study over 12 weeks. |
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http://www.micromedex.com/products/updates/drugdex_updates/de/ezetimibe.html
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| | ENLmedical.com: Conditions And Concerns: Medical Encyclopedia: Familial hypercholesterolemia |
| | In families with a history of familial hypercholesterolemia, genetic counseling may be of benefit, especially if both parents are affected. | | | The incidence of familial hypercholesterolemia is 7 out of 1000 people. | | | Call your health care provider or go to the emergency room if you have crushing chest pain or other warning signs of myocardial infarction. |
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http://www.enlmedical.com/article/000392.htm
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| | Type IIa Familial Hypercholesterolemia With Hypoplastic Aortic Root |
| | Saku K., et al., Combined therapy with probucol and pravastatin in hypercholesterolemia. | | | Management of familial hypercholesterolemia improved considerably with HMG-CoA reductase inhibitors. | | | We evaluated the therapy modalities and small aortic root problems in this report. |
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http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijtcvs/vol7n1/aortic.xml
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| | Lipids Online Slides: ldl, LDL-C, FH, familial hypercholesterolemia |
| | On physical exam, this woman has xanthomas on the extensor tendons of both hands, which are very suggestive of the heterozygous form of familial hypercholesterolemia (FH). | | | These measurements may be helpful in refining the clinical decision of when and how to combine lipid-altering drug treatments but is not necessary at this stage to decide on initiating LDL-C reducing medications such as statins. | | | This combination has reduced her LDL-C 57%, which achieves the desired goal of |
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http://www.lipidsonline.org/slides/slide01.cfm?q=ldl&pg=28
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| | SparkNotes: Lipids and Coronary Heart Disease: Familial Hypercholesterolemia |
| | Genetic counseling is also a critical component of management of these patients and their families. | | | The more severe homozygous phenotype is characterized by similar findings, but at an even earlier age. | | | Home : Other Subjects : Health Study Guides : Lipids and Coronary Heart Disease : Familial Hypercholesterolemia |
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http://www.sparknotes.com/health/lipids/section6.rhtml
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| | Familial Hypercholesterolemia |
| | Gene therapy is expected to cure the homozygous FH patients and help remove the heterozygous patients from an early long-term drug therapy. | | | As the result of the lack of activity, the LDL particles are not recycled and are circulating in the bloodstream, a condition of hypercholesterolemia. | | | The heterozygous patients are generally treated in the same way as patients with hypercholesterolemia. |
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http://community.middlebury.edu/~chem/chemistry/students/ho/fh.html
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| | Familiar Hypercholesterolemia - West Virginia |
| | Your family medical history of heart disease is important, because it helps to determine whether or not you may have FH. | | | Discuss your family medical history with your health care provider. | | | FH or Familial Hypercholesterolemia is an inherited disorder which causes cholesterol levels to be elevated. |
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http://www.wvdhhr.org/bph/oehp/hp/cardio/fh.htm
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| | Familial Hypercholesterolemia - Compare Prices & Reviews at Smarter |
| | The National Heart, Lung and Blood Institute is actively seeking patients with familial hypercholesterolemia to receive free evaluation as part of clinical research studies. | | | Answers to your questions about familial hypercholesterolemia and more. | | | Your use of this Web site constitutes acceptance of the Smarter.com Privacy Policy and Terms & Conditions |
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http://www.smarter.com/books-1/product/familial_hypercholesterolemia-586737
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| | LIPOSORBER® LDL Apheresis - Treatment Option for Familial Hypercholesterolemia |
| | The information on this site does not replace your doctor's advice; only your doctor can assess the benefits and risks of therapy to determine whether LDL Apheresis using the LIPOSORBER® system is right for you. | | | Familial Hypercholesterolemia) for whom diet has been ineffective and maximum drug therapy (such as Statins) has either been ineffective or not tolerated: | | | LIPOSORBER® LDL Apheresis - Treatment Option for Familial Hypercholesterolemia |
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http://www.liposorber.com
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| | Cecil Textbook of Medicine : /> |
| | Click here for important legal information about Cecil Textbook of Medicine. | | | In the future, it is hoped that gene therapy may lead to correction of the primary genetic defect. | | | Peripheral vascular disease and cerebral vascular disease are also increased, although not as much as CAD. |
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http://www.merckmedicus.com/ppdocs/us/common/cecils/chapters/211_004.htm
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| | ROSUVASTATIN / CRESTOR® |
| | Rosuvastatin is a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which is used for the treatment of hypercholesterolemia. | | | Therapy should be temporarily withheld in any patient with an acute, serious condition suggestive of myopathy or predisposing to the development of renal failure secondary to rhabdomyolysis (e.g., sepsis, hypotension, major surgery, trauma, severe metabolic, endocrine, and electrolyte disorders, or uncontrolled seizures). | | | Clinical trials have also demonstrated the effectiveness of rosuvastatin in significantly reducing LDL-C levels in patients with homozygous familial hypercholesterolemia and in significantly reducing TG levels in patients with hypertriglyceridemia (Fredrickson Type IIb and IV). |
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http://www.micromedex.com/products/ptquik/samples/Rosuvastatin.htm
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| | Hypercholesterolemia - Wikipedia, the free encyclopedia |
| | In patients without any other risk factors, moderate hypercholesterolemia is often not treated. | | | The treatment depends on the type of hypercholesterolemia. | | | It is not a disease but a metabolic derangement that can be secondary to many diseases and can contribute to many forms of disease, most notably cardiovascular disease. |
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http://en.wikipedia.org/wiki/Hypercholesterolemia
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| | Familial Hypercholesterolemia |
| | Gourt :: Health :: Conditions and Diseases :: Genetic Disorders :: Familial Hypercholesterolemia | | | Yahoo Health: An overview of familial hypercholesterolemia including, symptoms, treatment and prevention. | | | The content of this directory is based on the Open Directory and has been modified by Gourt.com |
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http://www.gourt.com/Health/Conditions-and-Diseases/Genetic-Disorders/Familial-Hypercholesterolemia.html
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| | Lipids Online Slides: ldl, treatment practice, secondary prevention |
| | The ACP guidelines assume that diet and exercise will have no effect on lipid levels, and that every patient screened will be treated with drugs. | | | An objection raised against screening for and treating hypercholesterolemia is that all patients will be treated indiscriminately regardless of risk. | | | In the same retrospective study, however, treatment was shown to be targeted mostly to high-risk patients with CHD risk factors. |
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http://www.lipidsonline.org/slides/slide01.cfm?q=ldl&pg=28
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| | Whitehead Institute - Hypercholesterolemia |
| | Familial hypercholesterolemia (FH) is an autosomal dominant trait, meaning that a child born to an affected parent has a 50 percent chance of inheriting the gene. | | | It could allow one to screen for drugs or identify therapies that enable the defective receptor to fold properly," says Dr. Peter Kim of the Whitehead Institute for Biomedical Research and the Howard Hughes Medical Institute (HHMI). | | | "Knowing that a protein folding defect is at the root of familial hypercholesterolemia may allow scientists to design better therapies. |
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http://www.wi.mit.edu/news/archives/1996/pk_0828.html
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| | Healthopedia.com - Familial Hypercholesterolemia (Type IIa Hyperlipoproteinemia) |
| | You are here : Healthopedia.com > Medical Encyclopedia > Diseases and Conditions > Familial Hypercholesterolemia | | | Familial hypercholesterolemia is an inherited disease that causes high cholesterol levels. | | | Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. |
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http://www.healthopedia.com/familial-hypercholesterolemia
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| | Hypercholesterolemia, familial |
| | Clinical Outcome of Patients with Familial Hypercholesterolemia and Coronary Artery Disease Undergoing Partial Ileal Bypass Surgery |
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http://www.gfmer.ch/genetic_diseases_v2/gendis_detail_list.php?cat3=124
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| | Familial Hypercholesterolemia - High Cholesterol |
| | Familial Hypercholesterolemia (FH) is an inherited disorder that causes very high cholesterol levels and greatly increases the chance of having a heart attack early in life. | | | Cholesterol levels can be checked at birth, but the National Cholesterol Education Program (NCEP) guidelines suggest children in a FH family be checked at age two. | | | Heart attacks usually occur in men when they are 40-55 years old and in women when they are 50-65 years old. |
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http://www.medped.org/MEDPED-What-is-FH.html
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| | Familial hypercholesterolemia, Eastern North Carolina, NC |
| | A person with familial hypercholesterolemia does not have enough of the cells that remove low-density lipoprotein (LDL, or "bad") cholesterol from the blood. | | | The severity of this disorder depends on whether the person has inherited one or two copies of the faulty gene that causes it. | | | Healthwise disclaims any liability for the decisions you make based on this information. |
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http://www.uhseast.com/136029.cfm
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| | LDLR Locus |
| | This site has been designed to facilitate communication and convenient availability of information for researchers analysing the LDLR gene in FH. | | | A mutation number will be give and it is hoped to be made equivalent to a refereed journal (possible hard copy in a journal). | | | The low density lipoprotein receptor (LDLR) gene in familial hypercholesterolemia |
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http://www.ucl.ac.uk/fh
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