|
| |
| | Archives of Pathology & Laboratory Medicine: Factor XIII polymorphisms and venous thromboembolism |
 | | Another casecontrol study examined 122 patients with deep vein thrombosis and 99 patients with pulmonary embolism in comparison with 254 healthy subjects with no personal or family history of venous thromboembolism. | | | In a logistic regression model including relevant clinical variables, there was a significant association of the Leu allele with risk of venous thromboembolism. | | | Methods.-Review of the medical literature using computerized databases and secondary sources identified through reviews of bibliographies. |
|
http://www.findarticles.com/p/articles/mi_qa3725/is_200211/ai_n9155738
|
|
| |
| | Clotting Factor Deficiencies |
| | However, considerable controversy surrounding factor use remains, especially with regard to the age of onset of such therapy and the cost. | | | Primary prophylactic therapy has been shown to reduce the incidence of arthropathy. | | | First-generation recombinant products (Bioclate, Helixate, Kogenate, Recombinate) have demonstrated efficacy in clinical trials; however, they continue to carry a theoretic risk of viral transmission because of the added human albumin necessary for factor stabilization. |
|
http://www.clevelandclinicmeded.com/diseasemanagement/hematology/clotting/clotting.htm
|
|
| |
| | NHF Bleeding Disorders Information Center Factor XIII Deficiency |
| | Without replacement therapy, patients in later life frequently sustain superficial bruising, epistaxes, hematoma in muscles and joints, and intracranial hemorrhage. | | | The reason is that factor XIII—fibrin stabilization factor—is necessary for clot formation and wound healing. | | | Factor XIII deficiency is a severe bleeding disorder usually associated with trauma. |
|
http://www.hemophilia.org/bdi/bdi_types11.htm
|
|
| |
| | Human blood coagulation factor XIII |
| | The human blood coagulation factor XIII A -subunit dimer structure, as determined by our X-ray crystallography efforts. | | | The zymogen, factor XIII, has been used in our published crystallization studies to date. | | | Additionally, factor XIIIa performs other cross-linking functions which promote wound healing. |
|
http://www.bmsc.washington.edu/projects/fxiii.html
|
|
| |
| | [No title] |
| | Factor XIII was present in extracellular matrix in cultured chondrocytes and in association with articular cartilage matrix vesicles. | | | Brefeldin caused no change in extracellular matrix factor XIII levels. | | | Understanding the processing and secretion of factor XIII in articular cartilage may lead to the development of novel therapies for osteoarthritis. |
|
http://www.blackwellpublishing.com/isth2003/abstract.asp?id=39503
|
|
| |
| | OHC : Factor XIII Deficiency |
| | Factor XIII deficiency results in a life-long bleeding tendency in homozygotes, and this is associated with poor wound healing. | | | Surgical procedures may be covered with a single infusion of concentrate (50-70 units/kg immediately before surgery) in view of the long half-life of the product. | | | The relative importance of the 'a' subunit is emphasized by the fact that in the great majority of clinical cases of factor XIII deficiency only the 'a' subunit is found to be functionally abnormal, but a bleeding disorder due to deficiency of 'b' subunits has been described. |
|
http://www.medicine.ox.ac.uk/ohc/xiii.htm
|
|
| |
| | tBLOG - Factor XIII Deficiency |
| | The last week before I am treated however, I need to be more cautious, as my factor level drops to a very low point. | | | This disease however, can be acquired over time, but it can not be transmitted from one person to another. | | | Like I said before most doctors donât even know much or anything about Factor XIII Deficiency, so it is especially important to have some knowledge of this disorder when surgery will be necessary. |
|
http://nstewart.tblog.com
|
|
| |
| | Homepage for David C. Teller |
| | The human blood coagulation factor XIII A -subunit dimer structure, as determined by our X-ray crystallography efforts. | | | The journal (Seminars in Thrombosis and Hemostasis) should be available in the medical school of your local university. | | | Factor XIII is a calcium-dependent transglutaminase and covalently crosslinks blood clots in the final stage of the coagulation process. |
|
http://www.bmsc.washington.edu/people/teller
|
|
| |
| | eMedicine - Factor XIII : Article by Rajalaxmi McKenna, MD, FACP |
| | Simple immediate ancillary measures of ice, pressure, ace wrap, immobilization of the affected joint, and avoidance of NSAIDs must not be forgotten. | | | During pregnancy, monthly replacement was found to be effective in preventing miscarriages (Burrows, 2000). | | | In contrast to the extreme variability in FFP, PLAS+SD contains no leukocytes, and physiologic inhibitor levels are mostly within reference range, with the exception of a moderate reduction in the levels of |
|
http://www.emedicine.com/med/topic3491.htm
|
|
| |
| | Factor XIII |
| | The assay is based on the method described by Kohler et al. | | | In patients with severe factor XIII deficiency the effect of substitution therapy was determined with Pefakit | | | Acquired deficiency of factor XIII is a common finding in patients with tumours, liver disease, septicemia, asparaginase therapy, severe burns or after surgery |
|
http://www.kordia.nl/pentapharm/Factor%20XIII.html
|
|
| |
| | Increased Factor XIII B and decreased Factor XIII A subunit antigen levels in insulin resistant South Asian patients ... |
| | To determine Factor XIII measures in South Asian stroke subjects 3 months post ischaemic stroke in comparison with South Asian subjects free from clinically detectable stroke. | | | Factor XIII A subunit was correlated to systolic blood pressure and body mass index (BMI) in patients and not correlated to any features of insulin resistance in controls. | | | Increased Factor XIII B and decreased Factor XIII A subunit antigen levels in insulin resistant South Asian patients with ischaemic stroke. |
|
http://www.basp.ac.uk/kain2.htm
|
|
| |
| | Factor XIII Deficiency |
| | In affected individuals, the blood fails to clot appropriately, resulting in poor wound healing. | | | The disease may also be acquired in association with other disorders such as Sickle Cell Disease or Henoch-Schonlein Purpura. | | | Internal bleeding may occur; approximately 25 percent of affected individuals experience bleeding in the brain (intracranial hemorrhage). |
|
http://www.bchealthguide.org/kbase/nord/nord66.htm
|
|
| |
| | The Seattle Times: Business & Technology: Biotech sells rights to drug candidate |
| | He said ZymoGenetics appeared to be able to handle all four drugs in development. | | | But there could be a downside: ZymoGenetics could miss out on a market for Factor XIII potentially worth more than $100 million a year, if the drug can treat the 100 American patients with genetic deficiencies of the protein, and the much larger numbers who might need it after trauma or heart surgery. | | | That's because it is not based on leading-edge science — it is a genetically-engineered version of an established drug derived from human blood. |
|
http://seattletimes.nwsource.com/html/businesstechnology/2002054052_zymo05.html
|
|
| |
| | [No title] |
| | This stabilizes the fibrin clot, making it resistant to the lytic action of plasmin. | | | These screening tests are typically normal in patients with Factor XIII deficiency. | | | Factor XIII also promotes the cross-linking of alpha-2-antiplasmin to fibrin, increasing the resistance to fibrin degradation. |
|
http://medic.med.uth.tmc.edu/hcprof/00001049.htm
|
|
| |
| | Life-threatening Haemorrhage after Circumcision |
| | The case highlights the importance of seeking a family history of bleeding disorders before surgery in the neonatal period, particularly if the parents are consanguineous. | | | Congenital factor XIII deficiency is a severe bleeding disorder that is inherited as an autosomal recessive trait. | | | The condition is commonly due to absence of the factor XIII-A subunit protein in the plasma. |
|
http://www.cirp.org/library/complications/killick1
|
|
| |
| | Forbes.com: ZymoGenetics in Deal With Novo Nordisk |
| | RhThrombin is in mid-stage trials while the two other drugs are in early clinical studies, the company said. | | | The company said it will put the resources devoted to the rFactor XIII protein into the development of three other proteins: the TACI-Ig treatment for autoimmune diseases, the IL-21 cancer treatment and rhThrombin to control bleeding associated with surgery. | | | Drug developer ZymoGenetics Inc. said Tuesday that it is licensing a blood-clotting protein to Novo Nordisk A/S to focus resources on other drug candidates. |
|
http://www.forbes.com/home_asia/feeds/ap/2004/10/05/ap1576493.html
|
|
| |
| | loewymemorial |
| | Most recently, his isopeptidase research focused on the disruption of the neurofibrillary tangles in the brain that cause symptoms of dementia in Alzheimer's disease and to the characterization of isopeptidase activity in biological tissues. | | | Ariel also developed purification techniques that are still used today, which enabled the production of factor XIII for treatment of clotting disorders.. | | | His continuing work revealed for the first time the enzymatic nature of factor XIII and he characterized its transglutaminase crosslinking function. |
|
http://www.fibrinogen.org/loewymemorial.html
|
|
| |
| | Bleeding Disorders |
| | Inherited factor VII deficiency is a chronic, life-long disorder. | | | A deficiency in any of these factors can lead to bleeding problems, each with its own symptoms and treatments. | | | For example, some people with low levels of factor VII do not have bleeding problems. |
|
http://www.accredohealth.net/hhs/bleeding_disorders/other.html
|
|
| |
| | FACTOR XIII DEFICIENCY CASE REPORTS PEDIATRIC ONCALL |
| | It has been reported in patients with prolonged treatment with isoniazid, penicillin or diphenylhydantoin. | | | Factor XIII may be decreased to about 50% in these diseases. | | | Factor XIII concentrates, fresh-frozen plasma (FFP) and cryoprecipitate are all effective. |
|
http://www.pediatriconcall.com/fordoctor/casereports/factor.asp
|
|
| |
| | Factor XIII Deficiency : BPL (Bio Products Laboratory) |
| | Replacement therapy in Factor XIII deficiency has proved to be generally straightforward, owing to the low levels of Factor XIII required to control bleeding. | | | Throughout life, a Factor XIII deficient individual can experience many superficial bleeds, such as bruises and tissue bleeding, although joint bleeds are generally rare. | | | Only Factor XIII deficiency is associated with a high risk of intracranial haemorrhage. |
|
http://www.bpl.co.uk/public/therapy_areas/coagulation/factor_xiii.asp
|
|
| |
| | Factor XIII - Wikipedia, the free encyclopedia |
| | This has no clear enzymatic activity, and may serve as a carrier for the A subunit. | | | This page was last modified 13:53, 12 May 2005. | | | Factor XIII deficiency may occur very rarely, and can cause a severe bleeding tendency. |
|
http://en.wikipedia.org/wiki/Factor_XIII
|
|
| |
| | Haematologic Technologies - Factor XIII |
| | Factor XIII is found both extracellularly in plasma and intracellularly in platelets, megakaryocytes, monocytes, placenta, uterus, liver and prostrate tissues. | | | Factor XIII is the zymogenic form of the glutaminyl-peptide g-glutamyl transferase factor XIIIa (fibrinoligase, plasma transglutaminase, fibrin stabilizing factor, E.C. Factor XIII is unique among transamidases in that it is a zymogen in vivo (2). | | | The concentration of factor XIII in plasma (A2B2) is approximately 30 mg/ml (8). |
|
http://www.haemtech.com/Zymogens/Factor_XIII.htm
|
|
| |
| | Factor XIII deficiency - OhioHealth |
| | Factor XIII is a clotting factor that is important for normal clotting and wound healing. | | | This means that a child must inherit two defective genes — one from each parent — to develop the disease. | | | It may be broadly considered a form of hemophilia. |
|
http://www.ohiohealth.com/healthreference/reference/06BF3901-8341-48F7-987DFDDDB89A9FBF.htm?category=questions
|
|
| |
| | CATHOLIC ENCYCLOPEDIA: Pope Leo XIII |
| | With regard to the Kingdom of Italy, Leo XIII maintained Pius IX's attitude of protest, thus confirming the ideas he had expressed in his pastoral of 1860. | | | Under Leo the religious orders developed wonderfully; new orders were founded, older ones increased, and in a short time made up for the losses occasioned by the unjust spoliation they had been subjected to. | | | He desired complete independence for the Holy See, and consequently its restoration as a real sovereignty. |
|
http://www.newadvent.org/cathen/09169a.htm
|
|
| |
| | Liver Degeneration Scientific Abstracts |
| | In this study, a search was therefore made for nucleotide mutations in the basic core promoter (BCP) and amino-acid substitutions in the precore/core region of HBV infecting patients with CAH or with acute hepatitis. | | | Furthermore, plasma BCAA with their keto-analog level, Factor XIII and opsonic activity were determined in another group of patients who received full strength load of BCAA immediately after subtotal or total gastrectomy, in a controlled prospective randomized double-blinded manner. | | | Around 5-10% of adults infected with hepatitis B virus (HBV) develop a chronic liver disease such as chronic active hepatitis (CAH), and it is unclear whether the clinical outcome depends solely on the immune response or whether viral factors also play a role. |
|
http://www.digestive-health-info.com/Liver-Degenerative-Disease-A.htm
|
|
| |
| | Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions changes structure for ... |
| | Yee,V.C., Le Trong,I., Bishop,P.D., Pedersen,L.C., Stenkamp,R.E. and Teller,D.C. (1996) Structure and function studies of factor XIIIa by X-ray crystallography. | | | Yee,V.C., Pedersen,L.C., Le Trong,I., Bishop,P.D., Stenkamp,R.E. and Teller,D.C. (1994) Three-dimensional structure of a transglutaminase: human blood coagulation factor XIII. | | | The structure factors and the coordinates of zymogen and the |
|
http://embojournal.npgjournals.com/cgi/content/full/21/9/2055
|
|
| |
| | factor deficient |
| | is drawn from a human donor demonstrating a specific inhibitor to factor VIII. | | | Factor I Deficient plasma is drawn from a human donor with afibrinogenemia and has very low levels of fibrinogen. | | | Plasmas should be used as factor VIII controls. |
|
http://www.kingbiomed.com/factor_deficient.htm
|
|
| |
| | Fibrinogen test |
| | Factor I is fibrinogen, while factor II (fibrinogen's immediate precursor) is called prothrombin. | | | Fibrinogen (Factor I) is a protein that originates in the liver. | | | The active form of the factor then activates several molecules of the next factor in the series, and so on, until the final step, when fibrinogen is converted into fibrin. |
|
http://www.healthatoz.com/healthatoz/Atoz/ency/fibrinogen_test.jsp
|
|
| |
| | factor VIII 96: ISTH |
| | Progress report on the ETRO survey of factor XIII deficient patients. | | | factor XIII deficiencies reviewing their own results and the data | | | coagulation factor XIII (FXIII) that has been put in its final form is |
|
http://www.med.unc.edu/isth/SSC/96minutes/thir.htm
|
|
| |
| | MedlinePlus: Hemophilia |
| | New Recombinant Antihemophilic Factor Licensed (Food and Drug Administration) | | | Factor XII Deficiency (Hageman Factor) (National Hemophilia Foundation) | | | Factor VII Deficiency (Proconvertin or Stable Factor) (National Hemophilia Foundation) |
|
http://www.nlm.nih.gov/medlineplus/hemophilia.html
|
|
| |
| | Factor XIII A subunit Antibody Search - Biocompare |
| | You may broaden your search for "Factor XIII A subunit" by refining your antibody search criteria in the Antibody Search box below. | | | Your search for "Factor XIII A subunit" antibody returned 1 antibodies. | | | Sheep Anti-Human Factor XIII, A subunit Antibody, Unconjugated |
|
http://www.biocompare.com/matrixsc/3194/2/6/30248/Factor+XIII%2C+A+subunit.html
|
|
| |
| | ZymoGenetics gets $77M licensing deal from Novo Nordisk - 2004-10-05 |
| | ZymoGenetics (NASDAQ: ZGEN) has been developing recombinant Factor XIII for the treatment of bleeding complications associated with congenital and acquired Factor XIII deficiencies. | | | The Food and Drug Administration recently gave ZymoGenetics clearance to proceed with clinical trials. | | | Seattle-based ZymoGenetics Inc. said it will license the worldwide rights to its experimental recombinant Factor XIII portfolio to Danish biotech giant Novo Nordisk A/S for as much as $77 million. |
|
http://www.bizjournals.com/seattle/stories/2004/10/04/daily10.html
|
|
| |
| | NHF October 5, 2004 ZymoGenetics Licenses Recombinant Factor XIII to Novo Nordisk |
| | ZymoGenetics Licenses Recombinant Factor XIII to Novo Nordisk | | | Users are prohibited from modifying, copying, distributing, transmitting, displaying, publishing, selling, licensing, creating derivative works, or using any information available on or through the site for commercial or public purposes. | | | ZymoGenetics has announced an agreement to give exclusive worldwide rights of its factor XIII (FVIII) portfolio and related intellectual property to Novo Nordisk. |
|
http://www.hemophilia.org/News/medicalnews/mn_10_05_04.htm
|
|
| |
| | Inactivated Proteins |
| | Peak '2' fibrinogen contains measurable amounts of factor XIII activity because the factor XIII B subunits bind to gamma chains and bring catalytic A subunits along with them. | | | Peak 1' fibrinogen molecules each contain two copies of the platelet-binding gamma-A chain C-terminal sequence and are ideal substrates for factor XIII assay. | | | Peak '1' fibrinogen contains mostly intact A-alpha subunit chains, is free of plasminogen, factor XIII, fibronectin, and other non-fibrinogen protein contaminants. |
|
http://www.enzymeresearch.com/newproducts.html
|
|
| |
| | Factor XIII Activity Assay |
| | Factor XIII deficiency is rare, and levels must be below 10% in order for bleeding symptoms to appear. | | | Centrifuge blue-stopper tube within 1 hour of collection, separate plasma and test or quick-freeze at -70°C. Specimen Accepted | | | Normal: presence of a clot for > 24 hours |
|
http://peir.path.uab.edu/coag/printer_71.shtml
|
|
|
