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| | s030406b - Factor VIII Inhibitors - Acquired or Induced |
 | | Abstract: A multicenter prospective study of recombinant activated factor VII (rFVIIa) given by continuous infusion (CI) to treat severe hemorrhages and to handle surgical procedures was carried out. | | | Acquired factor VIII inhibitors in the nonhemophiliac: historical perspectives, and future approaches. | | | Finally, this symposium will speculate on the potential application of innovative approaches to inhibitor therapy, based on results from numerous provocative studies on the nature of the human immune response. |
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http://www.emory.edu/WHSCL/grady/amreport/litsrch02/s030406b.html
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| | Coagulation Factor Assays |
| | Factors XI and XII have the longest half-lives and therefore are often the last to be affected. | | | Deficiencies of factor(s) VIII, IX, XI, and/or XII (intrinsic pathway) | | | Each laboratory should determine its own chromogenic factor X therapeutic range. |
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http://www.mgh.harvard.edu/labmed/lab/coag/handbook/CO001100.htm
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| | Factor VIII & IX |
| | In quite many patients, a lowered factor VIII:C has been found by the chromogenic method as compared to the one-stage technique. | | | Barrowcliffe and himself, presented data on a study on rFVIII full-length and a BDD factor VIII under true field conditions. | | | Recent experiments elucidated that if the APTT reagent, Dapttin, was utilised in the one-stage factor VIII:C assay, the discrepancy seemed to abolish. |
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http://www.med.unc.edu/isth/SSC/00sscminutes/00fviiiix.htm
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| | eMedicine - Factor VIII : Article by Rajalaxmi McKenna, MD, FACP |
| | Prompt and early therapy for acute bleeding episodes, with appropriate replacement with factor concentrate to achieve adequate levels of FVIII, immobilization of acutely affected joints, and adequate pain relief with narcotic analgesics is essential. | | | Patients and families have become self-sufficient with the application of sterile home infusion techniques, with prompt replacement of the missing factor at the earliest evidence of pain and/or possible bleeding rather than having to spend hours waiting for care in crowded emergency departments. | | | This has also improved quality of life by minimizing the time spent in hospital emergency departments, providing rapid and early therapy for acute bleeding, achieving a prompt reduction in pain due to early specific correction of the factor deficiency and joint immobilization, and allowing concomitant provision of appropriate narcotic and nonnarcotic analgesics. |
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http://www.emedicine.com/med/topic981.htm
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| | MedlinePlus Drug Information: Antihemophilic Factor (Recombinant) |
| | Your health care provider may tell you to stop your infusion if you have a mechanical problem (such as a blockage in the tubing, needle, or catheter); if you have to stop an infusion, call your health care provider immediately so your therapy can continue. | | | This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. | | | if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking antihemophilic factor (recombinant), before any surgeries or procedures. |
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http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a694027.html
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| | Clotting Factor Deficiencies |
| | However, considerable controversy surrounding factor use remains, especially with regard to the age of onset of such therapy and the cost. | | | Primary prophylactic therapy has been shown to reduce the incidence of arthropathy. | | | First-generation recombinant products (Bioclate, Helixate, Kogenate, Recombinate) have demonstrated efficacy in clinical trials; however, they continue to carry a theoretic risk of viral transmission because of the added human albumin necessary for factor stabilization. |
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http://www.clevelandclinicmeded.com/diseasemanagement/hematology/clotting/clotting.htm
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| | OHC : Porcine Factor VIII |
| | Most important of all, transmission of viral infections has never been a problem with porcine factor VIII despite the fact that the product is not subjected to any specific virucidal process. | | | This transient phenomenon is very unlikely to be of clinical relevance, although caution should be exercised in treating HIV-infected patients with pre-existing thrombocytopenia. | | | Perhaps such work will lead to the introduction of even more effective therapeutic materials in the future, suitable for the treatment of patients with high-titre antibodies. |
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http://www.medicine.ox.ac.uk/ohc/porcine.htm
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| | HIV & AIDS - Factor VIII, HIV and AIDS in Haemophiliacs: An analysis of their relationship |
| | This fact is of such pivotal significance it is essential to review the mechanism of HIV infection as reported by leading HIV researchers. | | | In this review, the association between the Acquired Immune Deficiency Syndrome (AIDS) and haemophilia has been carefully examined, especially the data that have been interpreted as indicating transmission of the human immunodeficiency virus (HIV) to the recipients of purportedly contaminated factor VIII preparations. | | | Furthermore, haemophiliacs with thrombocytopenia "usually need treatment with drugs as zidovudine, corticosteroids or immunoglobulins, which interfere with the immune system" (Mannucci et al., 1992). |
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http://www.virusmyth.net/aids/data/ephemophilia.htm
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| | Clinical Trial: Cooperative Study of Factor VIII Inhibitors |
| | Because of lack of information on the natural course of patients with Factor VIII inhibitors, the relative efficacy of various modes of therapy was not established. | | | This method of therapy attracted wide popularity, but the success was greatly debated. | | | It was intended at the very outset of the Factor VIII study that therapeutic trials involving patients with inhibitors would not be a prime function, but that such studies would be monitored if necessary. |
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http://clinicaltrials.gov/ct/show/NCT00000582?order=8
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| | August / September1998 - Acquired Inhibitors to Factor VIII |
| | These hemorrhages are refractory to local measures, may be worsened by surgical intervention, and are poorly responsive to clotting factor concentrates. | | | Copies of the Transfusion Medicine Update can be obtained by calling Deborah Small at (412)209-7320; or by e-mail: dsmall@itxm.org | | | Anti-VIII autoantibodies may be associated with autoimmune disorders, lymphoproliferative disorders, pregnancy, or drugs: however, in the majority of cases, there is no associated disease. |
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http://www.itxm.org/TMU1998/tmu8-98.htm
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| | Factor VIII Activity |
| | Factor VIII is an acute phase reactant and can be elevated in a number of clinical conditions. | | | Factor VIII is an acute phase reactant with levels that rise during periods of acute stress, following surgery, and in inflammatory conditions. | | | Factor VIII levels can be elevated in a number of clinical conditions including: carcinoma, leukemis, liver disease, renal disease, hemolytic anemia, diabetes mellitus, deep vein thrombosis, and myocardial infarction. |
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http://www.labcorp.com/datasets/labcorp/html/chapter/mono/cf000600.htm
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| | Immunoaffinity purification of factor VIII. |
| | The development of factor VIII concentrates has greatly facilitated hemophilia care and has made the home care of hemophilia possible. | | | Its role in the treatment of patients who have already been infected with HIV is less clear. | | | Early clinical studies have demonstrated that these products are effective in treating bleeding episodes and that the risk of viral infection with HIV or hepatitis viruses is low. |
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http://www.aegis.com/aidsline/1989/oct/M89A0116.html
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| | von Willebrand Disease |
| | Your child's doctor will take a family medical history to determine if other relatives have a bleeding disorder. | | | Although the condition can be made worse by taking aspirin and other nonsteroidal anti-inflammatory drugs, the symptoms might be so mild that the person isn't ever diagnosed. | | | This medication is given intravenously (into the vein). |
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http://kidshealth.org/parent/medical/heart/vwd.html
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| | Philip J. Fay Faculty Page |
| | Ongoing studies in our laboratory include physical and biochemical analyses of factor VIII structure and inter-subunit interactions. | | | We are particularly interested in study of the activated form of the cofactor, factor VIIIa, which consists of a labile heterotrimeric structure. | | | Little is known about the mechanism by which this is achieved. |
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http://dbb.urmc.rochester.edu/bcbp/members/faculty/fay_Philip.html
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| | Factor VIII gearing up for competition! - FileFront Gaming Forums |
| | Our North American based guild is made up of mature gamers who value teamwork, skill, competing, and above all our commitment to each other. | | | New players are welcome, we don't have "tryouts" because we believe if someone is willing to learn, they can be taught whatever skills they need. | | | Factor VIII has adopted the philosophy of "Life first, gaming second." With this in mind, we have become more than just the pixelated representations on the battlefield and are comrades off the field of battle as well. |
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http://forums.filefront.com/showthread.php?t=119638
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| | Factor IX - Wikipedia, the free encyclopedia |
| | Factor IX is inactive unless activated by factor XIa (of the contact pathway) or factor VIIa (of the tissue factor pathway). | | | Over 100 mutations of factor IX have been described; some cause no symptoms, but many lead to a significant bleeding disorder. | | | Deficiency of factor IX causes Christmas disease (hemophilia B). |
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http://en.wikipedia.org/wiki/Factor_IX
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| | Human Anti-hemolytic Factor, Factor VIII for Hemophilia, 360 |
| | Human anti-hemophilic factor (AHF) maintenance therapy as needed to maintain trough levels at 1% or greater in patients with severe Hemophilia A (AHF activity less than 1% of normal). | | | Reviewed 8/99 to include coverage for human anti-hemophilic factor (AHF) for treatment and/or management of bleeding episodes in surgical patients with mild hemophilia (AHF activity 5%-30%) or moderately severe hemophilia (AHF activity 1%-5%) and for treatment of moderate to severe Von Willebrand& disease in appropriate settings, for example, major surgery, trauma. | | | Human anti-hemophilic factor (AHF) for treatment and/or management of bleeding episodes in surgical patients with mild hemophilia (AHF activity 5%-30%) or moderately severe hemophilia (AHF activity 1%-5%). |
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http://www.bluecrossma.com/common/en_US/medical_policies/360.htm
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| | Safety ADVATE |
| | Contact your doctor if you are not able to prevent or control bleeding episodes with your regular doses of prescribed Factor VIII therapy. | | | The most common related Adverse Reactions observed during the ADVATE clinical studies include: strange taste in mouth, headache, dizziness and flushing. | | | If you experience any of these symptoms, stop the infusion immediately and promptly contact your doctor. |
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http://www.advate.com/content/difference/safety.html
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| | Treatment - Boston Hemophilia Center - Clinical Services - Children's Hospital Boston |
| | Individual treatment plans are created for hemophiliacs with inhibitors. | | | Hemophilia B, caused by a deficiency of factor IX, is treated with intravenous infusion of plasma-derived or synthetic recombinant factor IX. | | | This approach leads to more rapid treatment and decreases the number of hospital visits that are necessary, allowing people with the illness to live more normal and active lives. |
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http://www.childrenshospital.org/clinicalservices/Site1971/mainpageS1971P16.html
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| | Hemophilia A Description and Treatment |
| | This is done by a process called "factor replacement therapy." One method is to inject replacement factor VIII directly into their blood, a process called "infusion." Some people with the mild type of hemophilia A may be infused with the chemical DDAVP (desmopressin acetate) or use a nasal spray containing highly concentrated DDAVP. | | | Hemophilia A is a deficiency of factor VIII. | | | About 85% of people with hemophilia have hemophilia A. People with hemophilia A need to increase the level of factor VIII in their blood. |
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http://www.zlbbehring.com/zb/n25237/PFDiseaseCatProd2.htm
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| | A Molecular Model for the Triplicated A Domains of Human Factor VIII Based on the Crystal Structure of Human ... |
| | A molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin | | | A Molecular Model for the Triplicated A Domains of Human Factor VIII Based on the Crystal Structure of Human Ceruloplasmin -- Pemberton et al. | | | Clinical and molecular characterization of 6 patients affected by severe deficiency of coagulation factor V: broadening of the mutational spectrum of factor V gene and in vitro analysis of the newly identified missense mutations |
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http://www.bloodjournal.org/cgi/content/abstract/89/7/2413
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| | AccessMedicine - HARRISON'S ONLINE: Factor VIII Deficiency—Hemophilia A |
| | Topics Discussed: acquired immunodeficiency syndrome; aspirin; carrier detection; cryoprecipitate; dental care; desmopressin; factor viii; factor viii antibody; gene therapy; genetic counseling; hemarthrosis; hematuria; hemophilia a; hemorrhage, central nervous system, and cerebrovascular accidents; hepatitis; hiv; surgical aspects. | | | Sections: Pathogenesis and Clinical Manifestations, Treatment, Complications, Genetic Counseling and Carrier Detection. | | | "The antihemophilic factor (AHF), or factor VIII coagulant protein, is a large (265-kDa), single-chain protein that regulates the activation of factor X by proteases generated in the intrinsic coagulation pathway (Figs. |
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http://www.accessmedicine.com/content.aspx?aID=66656
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| | Factor VIII Activity Assay |
| | Because factor VIII is an acute phase reactant, a single elevated result may not alone indicate a risk of thrombosis. | | | Factor VIII deficiency is also seen in some cases of von Willebrand disease. | | | Factor VIII deficiency is associated with mild to severe bleeding. |
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http://peir.path.uab.edu/coag/article_59.shtml
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| | Factor VIII Deficiencies |
| | However, these two are under clinical trials currently and may be associated with increased risk of thrombosis. | | | Please note that this is non-specific because things like a lupus anticoagulant or treatment with heparin can also cause prolongation of the aPTT in the absence of any factor inhibitors. | | | This association has several functions including protecting FVIII from proteolysis, enhancing FVIII synthesis, and concentrating FVIII at the site of active hemostasis. |
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http://medinfo.ufl.edu/year2/coag/viiidef.html
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| | factor VIII - definition of factor VIII in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus ... |
| | A factor in the clotting of blood, a deficiency of which is associated with hemophilia A. Also called antihemophilic factor, antihemophilic globulin, antihemophilic globulin A, proserum prothrombin conversion accelerator. | | | This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. | | | factor VIII - definition of factor VIII in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia. |
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http://medical-dictionary.thefreedictionary.com/Factor+VIII
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| | Factor VIII - Coatest Factor VIII |
| | Human factor VIII can be packaged and functionally expressed in an adeno-associated virus background: applicability to haemophilia A gene therapy. | | | Hemophilia A mutations associated with 1-stage/2-stage activity discrepancy disrupt protein-protein interactions within the triplicated A domains of thrombin-activated factor VIIIa. | | | The classic chromogenic kit for the determination of factor VIII activity in human plasma, blood fractions and purified preparations. |
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http://www.factorviiikits.com/coatest_fviii.htm
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| | Human Factor 8 (VIII) & VIIIc antibodies from Research Diagnostics Inc |
| | Not for use in or on humans or animals or for diagnostics. | | | The VIIIc is non covalently bound to VIII RAg and is eluted from the complex and shown to be free of VIII RAG. | | | Application: immunoassays of factor VIII:C and Factor VIII:C vWF complex and in neutralization studies where antibodies are required to inhibit the activity of factor VIII. |
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http://www.researchd.com/miscabs/factor8.htm
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| | Factor VIII & IX |
| | Mikaelsson summarized three studies on the characterization of recombinant factor VIII with and without B-domain, and high purity plasma-derived factor VIII, demonstrating equivalence of activity measured by chromogenic assay and antigen content. | | | The final report on the Registry of Factor VIII and IX Concentrates was presented by Dr. C. | | | Barrowcliffe reported on the SSC/5 "Field Type" Collaborative Study on Concentrates, one involving F VIII, the other involving F IX, and proposed a further exercise by October 1998. |
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http://www.med.unc.edu/isth/SSC/98minutes/FactorVIII&IX.html
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