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| | NIH Guide: AGING MUSCULOSKELETAL AND SKIN EXTRACELLULAR MATRIX |
 | | The extracellular matrix is the medium through which mechanotransduction takes place, which is vital to the health of cartilage, bone and muscle. | | | Research is needed on interdependent aging changes in bone, skin, muscle, and cartilage, and the role of extracellular matrix in these changes. | | | Objectives and Scope This PA is intended to encourage basic research into aging effects on extracellular matrix and how those changes in extracellular matrix composition and organization contribute to the altered function seen with aging in the musculoskeletal system and skin. |
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http://grants.nih.gov/grants/guide/pa-files/PA-03-167.html
(3694 words)
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| | Rednova NEWS Extracellular Matrix Protects Pancreatic [Beta]-Cells Against Apoptosis: Role of Short- and Long-Term ... |
| | The MAP kinase ERK pathway is involved in I[kappa]B[alpha] overexpression induced by the 804G matrix. | | | In the present study, we examined whether the 804G matrix could rescue primary pancreatic [beta]-cells from apoptosis, and we investigated the intracellular pathways involved. | | | The 804G matrix protects pancreatic [beta]-cells from apoptosis under three different conditions: "standard" culture conditions, after serum deprivation, and in response to the cytokine IL-1[beta]. |
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http://www.rednova.com/modules/news/tools.php?tool=print&id=78182
(6179 words)
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| | Amazon.ca: Books: Cellular Organelles and the Extracellular Matrix |
| | The second part of the volume is concerned with the extracellular matrix. | | | It sets out to show that a vast body of new knowledge of the extracellular matrix is available to us. | | | As for fibronectins, they seem to link the matrix with the cytoskeleton by interacting with integrins. |
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http://www.amazon.ca/exec/obidos/ASIN/1559388048
(536 words)
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| | ARS Publication request: Melanin in the Extracellular Matrix of Germlings of Botrytis Cinerea |
| | We conclude that melanin is an important component of the extracellular matrix of germlings of B. cinerea. | | | This could be important because it is felt that melanins are able to protect delicate biological structures from various environmental stresses such as ultraviolet light. | | | Publication request: Melanin in the Extracellular Matrix of Germlings of Botrytis Cinerea |
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http://ars.usda.gov/research/publications/Publications.htm?seq_no_115=152118
(269 words)
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| | Matrix, matrix background, extracellular matrix |
| | The matrix, and its close relative the determinant, are extremely important... | | | A matrix is a concise and useful way of uniquely representing and working... | | | Matrix has the experience, knowledge and resources to offer an unparalleled selection of fully integrated solutions for your laboratory. |
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http://www.funfind.net/matrix.html
(1350 words)
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| | Matrix - Wikipedia, the free encyclopedia |
| | Matrix (IT), a group of data which forms the "essence" of an application. | | | Look up Matrix on Wiktionary, the free dictionary | | | Extracellular matrix, any material part of a tissue that is not part of any cell. |
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http://en.wikipedia.org/wiki/Matrix
(275 words)
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| | Extracellular matrix |
| | ‘Cell interactions with the extracellular matrix (ECM) and with neighbouring cells trigger numerous responses that have essential roles in the regulation of their behaviour and fate. | | | So, the life of a cell seems to involve intense and complex crosstalk with the matrix.’ | | | Tales from the crypt[ic] sites of the extracellular matrix. |
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http://ipmc.epfl.ch/page53083.html
(369 words)
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| | EXTRACELLULAR MATRIX (ECM) |
| | fibrillin, which is an integral constituent of the non-collagenous microfibrils of the extracellular matrix. | | | These reactive aldehydes form specific cross-links between two chains thereby, stabilizing the staggered array of the collagens in the fibril. | | | The extracellular matrix (ECM) is a complex structural entity surrounding and supporting cells that are found within mammalian tissues. |
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http://web.indstate.edu/thcme/mwking/extracellularmatrix.html
(782 words)
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| | EXTRACELLULAR MATRIX ASSEMBLY IN DIATOMS (BACILLARIOPHYCEAE) |
| | The fact that this matrix is absent from CF/CPD prepared material suggests that this contribution to biofilm formation may have been underestimated or overlooked in previous investigations of establishment of the biofilm consortium. | | | When motile cells (2 h following inoculation and observed by light microscopy) were examined with cryo-FESEM, a ribbon-like material was observed in close association with the raphe valve and the substratum. | | | Fine structure of the apochlorotic diatom Nitzschia alba Lewin and Lewin. |
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http://www.bio.mtu.edu/~mrgretz/www/publications/ecm_assy4.htm
(6091 words)
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| | Basic Sciences - Extracellular Matrix Pathology |
| | The research goal of the Extracellular Matrix Pathology Section, LP, CCR, NCI is to further our understanding of the mechanisms of cell-extracellular matrix interactions which regulate cell behavior during tumor progression and angiogenesis. | | | These experiments will aid in further refinement of our understanding of TIMP biology. | | | These processes require remodeling of the extracellular matrix that occurs in a spatially and temporally controlled fashion. |
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http://home.ncifcrf.gov/ccr/lop/Research/extracellular
(1566 words)
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| | Extracellular Matrix (BIOE464) |
| | I also spent several days covering biochemical assays and techniques that can be used to quantify or identify extracellular matrix. | | | Development of an Undergraduate Bioengineering elective in Extracellular Matrix | | | There will be an emphasis on cells and cell-matrix interactions, matrix distributions in connective tissues and organs, techniques for measurement and modeling, changes with growth and aging, and tissue/matrix degradation including enzyme kinetics. |
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http://www.ruf.rice.edu/~bioewhit/courses/bioe464/home.html
(502 words)
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| | Z306231 Extracellular Matrix A Practical Approach |
| | This book is a compendium of the biochemical, immunological, and molecular biological techniques and approaches used to study both extracellular matrix macromolecules and their function in vertebrates. | | | Molecular biological approaches for studying extracellular matrix production | | | Techniques for the study of fibronectin and tenascin |
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http://www.sigmaaldrich.com/catalog/search/ProductDetail?ProdNo=Z306231&Brand=SIGMA
(243 words)
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| | The Extracellular Matrix |
| | [View] The matrix is principally collagen, and the fibers are all oriented parallel to each other. | | | The matrix of bone contains collagen fibers and mineral deposits. | | | Fascia is fibrous connective tissue that binds muscle together and binds the skin to the underlying structures. |
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http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/E/ECM.html
(752 words)
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| | [No title] |
| | Studies on the components of the extracellular matrix have expanded recently and greatly increased our understanding of their biological functions and roles in development and in disease. | | | Extracellular Matrix and Bone Morphogenetic Proteins in Cartilage and Bone Development and Repair (S.Vukicevic, W.M. Paralkar, and A.H. Reddi). | | | Of particular interest is the "promiscuity" of some of these receptors in their interaction with more than one matrix protein and even |
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http://www.shop.com/op/aprod-p20748940
(365 words)
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| | Developmental Biology Online: Building the Egg's Extracellular Matrix |
| | The sea urchin extracellular matrix is not a simple structure, either. | | | This extracellular matrix is sometimes called the hyaline layer. | | | Fertilization not only activates the egg and provides a new assortment of genes for the developing organism, it also provides the embryo with an extracellular matrix that is extremely important in coordinating cell stability and migration during cleavage and gastrulation. |
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http://www.devbio.com/article.php?ch=7&id=73
(515 words)
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| | Reproductive Biology and Endocrinology Full text Extracellular matrix: Forum introduction |
| | Support for this notion has been derived from correlative studies demonstrating large changes in the composition and distribution of extracellular matrix components during tissue development, differentiation and in response to hormone/growth factor/cytokine influences. | | | The extracellular matrix (ECM) is now appreciated as a key regulator of cell and tissue behavior [1,2]. | | | Blobel CP: Functional and biochemical characterization of ADAMs and their predicted role in protein ectodomain shedding. |
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http://www.rbej.com/content/2/1/1
(844 words)
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| | GEArray Q Series Human Extracellular Matrix & Adhesion Molecules Gene Array |
| | Zieske JD (2001) Extracellular Matrix and Wound Healing Curr Opin Ophthalmol 12 : 237-41. | | | (2000) The Extracellular Matrix Can Regulate Vascular Cell Migration, Proliferation, and Survival: Relationships to Vascular Disease. | | | Schonherr E, Hausser HJ (2000) Extracellular Matrix and Cytokines: a Functional Unit. |
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http://www.superarray.com/gene_array_product/HTML/HS-010.html
(523 words)
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| | Hypertension Online Slides - nephron, mesangium, extracellular matrix |
| | These functional changes lead to structural changes in the glomerular basement, expansion of the mesangial and interstitial matrix, ultimately resulting in sclerosis of both glomerular and tubular elements. | | | The mesangial cells and their surrounding non-cellular matrix, the mesangial matrix, provide a structure to support the delicate glomerular capillaries. | | | More detail about the mechanisms by which this process is thought to occur can be found in the description of the previous slide. |
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http://www.hypertensiononline.org/slides2/slide01.cfm?q=nephron
(1376 words)
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| | Developmental Biology Online: The Specificity of the Extracellular Matrix |
| | The microcarriers alone did not stimulate migration from either wild-type or mutant crests (Figure 2A, B). | | | Before the molecular analysis of the migratory pathway of the neural crest cells was possible, a series of ingenious experiments demonstrated that the extracellular matrix regulated neural crest cell migration.Some of the best evidence for the importance of extracellular matrices in directing neural crest cell migration comes from studies of mutant salamanders. | | | The microcarriers containing wild-type extracellular matrix, however, were able to stimulate neural crest migration from both the mutant and wild-type crests (Figure 2E, F), demonstrating the importance of the extracellular matrix in neural crest cell migration. |
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http://www.devbio.com/article.php?ch=13&id=132
(440 words)
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| | The extracellular matrix |
| | The principal collagen of skin and bone - i.e. | | | Not only do some tissues need to be strong and resistant to stretching, some are needed to be elastic in nature - recoil. | | | They help to organize the matrix and cell attachments to the matrix. |
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http://campus.murraystate.edu/academic/faculty/David.Canning/WEBFILES/321ECM.html
(1247 words)
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| | E0641 Extracellular Matrix Protocols |
| | art methods for probing the extracellular matrix (ECM), its mechanisms of assembly and how it influences cell behavior. | | | These highly detailed biochemical, biophysical, genetic, molecular biological, and cell biological techniques have been optimized for study of ECM structure and assembly, mechanisms of cell–ECM interactions, and molecular genetics of ECM proteins and defects in human disease. | | | Protein Interactions, Tissue Engineering of Cartilage, Tissue Recombinants to Study Extracellular Matrix Targeting |
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http://www.sigmaaldrich.com/catalog/search/ProductDetail?ProdNo=E0641&Brand=SIGMA
(366 words)
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| | ASIP Symposium: Extracellular Matrix and Signalling |
| | Description: Extracellular matrix exerts profound effects on tissue homeostasis and regulates the ability of cells to migrate, proliferate and generate an angiogenic response. | | | Presentation Title: Extracellular matrix and breast cancer: relation of tissue structure to function. | | | Dr. Bissell will discuss the central role of extracellular matrix and integrins in the control of cell proliferation, apoptosis and cancer. |
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http://asip.uthscsa.edu/EB99/TUE_AM.html
(170 words)
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| | Center for Extracellular Matrix Biology |
| | The extracellular matrix (ECM) is a biologically active tissue composed of a complex mixture of macromolecules, that in addition to serving a structural function, also profoundly affects the cellular physiology of an organism. | | | The ECM not only affects the behavior of cells of the host organism, but also can serve as a substrate for the attachment and colonization of pathogenic microorganisms. | | | Eukaryotic cell adhesion, migration, proliferation and differentiation are examples of biological processes influenced by the composition and structural organization of surrounding extracellular matrices. |
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http://www.tamu.edu/cemb
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| | Matrix Metalloproteinase-Mediated Extracellular Matrix Protein Degradation in Human Pulmonary Emphysema |
| | The aim of this study was to investigate the extracellular degrading proteolytic cascade proteins referred to as matrix metalloproteinase-1 (MMP-1), MMP-2, MMP-9, membrane-type matrix metalloproteinase-1 (MT1-MMP), tissue inhibitors of matrix metalloproteinase-1 (TIMP-1), TIMP-2, neutrophil elastase, and [alpha]1-antitrypsin in human pulmonary emphysema. | | | The data suggest that the MT1-MMP/MMP-2/TIMP-2 system plays a significant role in the MMP-mediated extracellular matrix degradation and tissue remodeling of emphysematous lungs, and thus may contribute to the weakening of lung parenchyma and lead to the formation of emphysema. | | | Matrix Metalloproteinase-Mediated Extracellular Matrix Protein Degradation in Human Pulmonary Emphysema |
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http://info.med.yale.edu/labinvest/abstracts/98months/9809sept/0998_006.html
(424 words)
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| | Ask A Scientist - Extracellular matrix in animals |
| | The term "extracellular matrix" (ECM) is used to refer to all the "stuff" found outside of cells inside a multicellular organism. | | | How does the structure of the extracellular matrix in animals determine its functions? | | | Usually, circulating fluids like blood and lymph are not considered to be ECM, since the word "matrix" evokes the image of a network—the network of structural proteins common to most extracellular material. |
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http://www.hhmi.org/askascientist/answers/molecular/ans_005.html
(708 words)
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| | CAMRC - Links to Cell Adhesion & Extracellular Matrix Related Sites |
| | Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases | | | This is a comprehensive guide to leukocyte adhesion, rolling and transmigration through endothelium, and includes discussion of the adhesion molecules involved in these processes. | | | A summary of information that is designed to "supplement" that in your book. |
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http://main.uab.edu/camrc/show.asp?durki=49745
(340 words)
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| | World of MS - About MSIF - Extracellular matrix |
| | In the central nervous system, specific molecules in the extracelluar matrix affect the growth of nerve fibres and may be involved in myelination. | | | The extracellular matrix is the material that surrounds cells. | | | World of MS - About MSIF - Extracellular matrix |
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http://www.ifmss.org.uk/en/about_msif/glossary/extracellular.html
(54 words)
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| | Extracellular Matrix Components |
| | This extract can be prepared from any tissue, normal or diseased, and contains essentially all the tissue collagens and any matrix component that is cross-linked to the collagens such as the fibronectins or laminins. | | | There are two major classes: lateral matrix and basal matrix. | | | The extracellular matrix is quite complex and is chemically tissue-specific. |
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http://www.med.unc.edu/~cgibd/Extracellular.html
(790 words)
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| | Regulation Of The Expression Of Extracellular Matrix Molecules During Wound Healing |
| | The processes of cell migration and extracellular matrix production are vital for wound healing to occur. | | | Faculty Research by Name: A B C D E F G H I J K L M N O P R S T U V W X Y Z | | | During the wound healing process, the expression of the extracellular matrix protein fibronectin and its cell surface receptor are dramatically increased on the cells that are migrating to cover the wounded area. |
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http://research.medicine.wustl.edu/ocfr/Research.nsf/c517b7f273394130862567970055bff2/08bdb3d0110648f58625679e00543585?OpenDocument
(190 words)
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| | Hydrogel thin film containing extracellular matrix components (US20020086423A1) |
| | A hydrogel thin film containing an extracellular matrix components, which is a thin film comprising a hydrate of a vitrified matrix gel containing an extracellular matrix components. | | | A hydrogel thin film containing an extracellular matrix components such as thin-film collagen hydrogel thin film, which is useful for a cell culture substratum and for preventing organ adhesion, can be easily prepared, and is excellent in expediency. | | | The thin film of the invention comprises a hydrate of a vitrified gel containing an extracellular matrix components, which can be integrated with a retainer as required. |
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http://www.delphion.com/details?pn=US22086423A1
(154 words)
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| | Powell's Books - The Extracellular Matrix Factsbook by Shirley. Ayad |
| | The authors are members of the Wellcome Trust Centre for Cell-Matrix Research in the School of Biological Sciences, Manchester University. | | | Provides information on molecular structure, isolation, primary structure, structural and functional sites, gene structure, database accession numbers, and entry-specific references. | | | Entries provide information on molecular structure, isolation, primary structure, structural and functional sites, gene structure, database accession numbers, and key references. |
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http://www.powells.com/cgi-bin/biblio?inkey=62-0120689111-3
(513 words)
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| | McMahan Lab |
| | Anglister, L. and McMahan, U.J. Extracellular matrix components involved in neuromuscular transmission and regeneration. | | | In: The Role of Extracellular Matrix in Development, ed. | | | McMahan, U.J. and Slater, C.R. The influence of basal lamina on the accumulation of acetylcholine receptors at synaptic sites in regenerating muscles. |
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http://mcmahan.stanford.edu/resume.php?person=jack
(1495 words)
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| | The Extracellular Matrix |
| | Deduce the major consequences of defects in collagen formation on the functions of the extra cellular matrix | | | Give examples of how cells interact with the extra cellular matrix | | | List the factors that could affect collagen synthesis and affect wound healing |
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http://staff.um.edu.mt/acus1/Extracellular.htm
(502 words)
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| | Extracellular Matrix |
| | 3:00 PM Tagging of matrix proteins for tracer and dynamic studies in bone |
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http://iadr.confex.com/iadr/2002SanDiego/techprogram/session_253.htm
(205 words)
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