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Topic: Extracellular



  
 NIH Guide: AGING MUSCULOSKELETAL AND SKIN EXTRACELLULAR MATRIX
The extracellular matrix is the medium through which mechanotransduction takes place, which is vital to the health of cartilage, bone and muscle.
Objectives and Scope This PA is intended to encourage basic research into aging effects on extracellular matrix and how those changes in extracellular matrix composition and organization contribute to the altered function seen with aging in the musculoskeletal system and skin.
Research is needed on interdependent aging changes in bone, skin, muscle, and cartilage, and the role of extracellular matrix in these changes.
http://grants.nih.gov/grants/guide/pa-files/PA-03-167.html   (3694 words)

  
 Extracellular Electrophysiology
What’s worse is that these conditions have to do with the state of the neuron and therefore may occlude from view the function of the neuron in particular states.
This is important if the conductivity of the tissue isn’t constant throughout because it can lead to sham sources and sinks at the interface between layers (Petsche et al., 1984).
While the precise source of these fluctuations isn’t fully understood, it’s clear that this non-synaptic activity can greatly affect the recorded field potential (Buzsaki and Traub, 1997).
http://osiris.rutgers.edu/~smm/extracellular_eclectrophysiology.htm   (3227 words)

  
 Extracellular Cyclic AMP and Adenosine Appearance in Adipose Tissue of Sus scrofa: Effects of Exercise -- Carey et al. ...
Extracellular Cyclic AMP-Adenosine Pathway in Isolated Adipocytes and Adipose Tissue
Evidence for an endogenous cAMP-adenosine pathway in the rat kidney.
cortex of conscious rats demonstrated that basal levels of extracellular
http://www.ebmonline.org/cgi/content/full/229/10/1026   (3547 words)

  
 Role of Adenosine A1 Receptors in Modulating Extracellular Adenosine Levels -- Andresen et al. 291 (1): 76 -- Journal ...
Effects of 10 nM DPCPX on extracellular levels of adenosine in normal rat cardiac fibroblasts and in rat cardiac fibroblasts coincubated with 200 ng/ml pertussis toxin or 1 µM AMPCP.
Effects of 10 nM DPCPX on extracellular levels of adenosine in control rat cardiac fibroblasts and in cardiac fibroblasts treated with 10 µM isoproterenol.
Effect of incubation time with DPCPX (10 nM) on extracellular levels of adenosine in rat cardiac fibroblasts.
http://jpet.aspetjournals.org/cgi/content/full/291/1/76   (2818 words)

  
 Role of the extracellular cAMP-adenosine pathway in renal physiology -- Jackson and Dubey 281 (4): 597 -- AJP - Renal ...
The extracellular cAMP pathway not only is present in the brain parenchyma but is also expressed in the cerebral vasculature.
Role of the extracellular cAMP-adenosine pathway in renal physiology -- Jackson and Dubey 281 (4): 597 -- AJP - Renal Physiology
Role of the extracellular cAMP-adenosine pathway in renal physiology
http://ajprenal.physiology.org/cgi/content/full/281/4/F597   (6771 words)

  
 Increased cerebral extracellular adenosine and decreased PGE2 during ethanol-induced inhibition of FBM -- Watson et al. ...
Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis.
Regional cerebral glucose phosphorylation and blood flow after insertion of a microdialysis fiber through the dorsal hippocampus in the rat.
Effect of maternal ethanol ingestion on fetal breathing movements, gross body movements, and heart rate at 37 to 40 weeks' gestational age.
http://jap.physiology.org/cgi/content/full/86/4/1410   (6771 words)

  
 Extracellular pH Responses in CA1 and the Dentate Gyrus During Electrical Stimulation, Seizure Discharges, and ...
Sykova E, and Svoboda J. Extracellular alkaline-acid-alkaline transients in the rat spinal cord evoked by peripheral stimulation.
Sykova E, Jendelova P, Simonova Z, and Chvatal A. and pH homeostasis in the developing rat spinal cord is impaired by early postnatal X-irradiation.
There is evidence that neuronal excitability can be influenced by extracellular pH.
http://jn.physiology.org/cgi/content/full/83/6/3519   (3870 words)

  
 Extracellular Dopamine and Amphetamine After Systemic Amphetamine Administration: Comparison to the Behavioral Response ...
Extracellular Dopamine and Amphetamine After Systemic Amphetamine Administration: Comparison to the Behavioral Response -- Kuczenski et al.
Extracellular Dopamine and Amphetamine After Systemic Amphetamine Administration: Comparison to the Behavioral Response
Sato, S. and Koshiro, A.: Pharmacokinetic analysis of chlorpromazine in rat serum, cerebrospinal fluid and striatum.
http://jpet.aspetjournals.org/cgi/content/full/282/2/591   (3402 words)

  
 ARS Publication request: Melanin in the Extracellular Matrix of Germlings of Botrytis Cinerea
We conclude that melanin is an important component of the extracellular matrix of germlings of B. cinerea.
This could be important because it is felt that melanins are able to protect delicate biological structures from various environmental stresses such as ultraviolet light.
Publication request: Melanin in the Extracellular Matrix of Germlings of Botrytis Cinerea
http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=152118   (269 words)

  
 Extracellular Domain of the Transforming Growth Factor-beta Receptor Negatively Regulates Ligand-independent Receptor ...
We conclude therefore that in the absence of ligand, the extracellular
Luciferase activities were assayed as described under "Experimental Procedures." The results are representative of at least three separate experiments.
36), supporting the notion that both the extracellular and cytoplasmic
http://www.jbc.org/cgi/content/full/274/41/29220   (4283 words)

  
 Probing the extracellular release site of the plasma membrane calcium pump -- Xu et al. 278 (5): 965 -- AJP - Cell ...
The Na pump is in the same family as the PMCA and, in contrast to the
Recent exciting developments suggest that the Na pump has an extracellular high-field access channel.
These results are similar to those obtained on the Na pump in the absence of extracellular Na
http://ajpcell.physiology.org/cgi/content/full/278/5/C965   (5054 words)

  
 Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril ...
channels and the first extracellular domain is sufficient to determine
degree to which the extracellular domains affect paracellular
In contrast, chimeras expressing the first or both extracellular
http://ajpcell.physiology.org/cgi/content/full/284/6/C1346   (5764 words)

  
 Search Results for extracellular - Encyclopædia Britannica
Collagen is of commercial as well as medical interest because leather is the dense collagen of the dermis of animal skins preserved and toughened by the process called tanning.
Tissue in the body that maintains the form of the body and its organs...
The polysaccharides, or glycans, of the extracellular matrix are responsible for its gellike quality and for organizing its components.
http://www.britannica.com/search?query=extracellular&submit=Find&source=MWTAB   (327 words)

  
 EXTRACELLULAR MATRIX (ECM)
fibrillin, which is an integral constituent of the non-collagenous microfibrils of the extracellular matrix.
These reactive aldehydes form specific cross-links between two chains thereby, stabilizing the staggered array of the collagens in the fibril.
The ECM is often referred to as the
http://web.indstate.edu/thcme/mwking/extracellularmatrix.html   (782 words)

  
 Physical State of the Extracellular Matrix Regulates the Structure and Molecular Composition of Cell-Matrix Adhesions ...
Extracellular matrix (ECM) microstructural composition regulates local cell-ECM biomechanics and fundamental fibroblast behavior: a multidimensional perspective
Abbreviations used: ECM, extracellular matrix; FAK, focal adhesion kinase; FC, focal contact; FN, fibronectin; pTyr, phosphotyrosine.
Physical State of the Extracellular Matrix Regulates the Structure and Molecular Composition of Cell-Matrix Adhesions
http://www.molbiolcell.org/cgi/content/full/11/3/1047   (5712 words)

  
 Extracellular - Wikipedia, the free encyclopedia
The term 'extracellular' is often used in reference to the extracellular fluid (ECF) which composes about 15 litres of the average human body.
It is used in contrast to intracellular (inside the cell).
In cell biology, molecular biology and related fields, the word extracellular means "outside the cell".
http://en.wikipedia.org/wiki/Extracellular   (125 words)

  
 Another dimension to calcium signaling: a look at extracellular calcium -- Hofer 118 (5): 855 -- Journal of Cell Science
future investigation of the physiological roles of extracellular
However, we still know relatively little about how these changes
extracellular depletion or accumulation of the cation upon stimulation
http://jcs.biologists.org/cgi/content/full/118/5/855   (5392 words)

  
 Extracellular Calcium Sensing and Extracellular Calcium Signaling -- Brown and MacLeod 81 (1): 239 -- Physiological ...
ligands in the extracellular matrix; and 3) Src family kinases
the extracellular ends of the TMDs, deeper within the TMDs, or
The extracellular, ligand-binding domains of the family C GPCRs are structurally related to those of the bacterial periplasmic
http://physrev.physiology.org/cgi/content/full/81/1/239   (10056 words)

  
 Extracellular cAMP inhibits proximal reabsorption: are plasma membrane cAMP receptors involved? -- Bankir et al. 282 ...
pathway and provide evidence that extracellular cAMP plays an
As presented in this review, a great body of evidence
It is conceivable that cGMP, the second messenger of ANP and nitric oxide, may also behave as an extracellular mediator because,
http://ajprenal.physiology.org/cgi/content/full/282/3/F376   (8385 words)

  
 Spike Amplifiers
Gerhardt, G.A. and M.R. Palmer (1987) Characterization of the Techniques of Pressure Ejection and Microiontophoresis Using In-Vivo Electrochemistry.
Signals picked up by extracellular electrodes are in the microvolt range and they need to be amplified to be able to be processed in more
Microiontophoresis is most often used in conjunction with extracellular recording of neuronal firing.
http://members.aol.com/kations/iontophoresis/spikeamps.html   (826 words)

  
 Basic Sciences - Extracellular Matrix Pathology
The research goal of the Extracellular Matrix Pathology Section, LP, CCR, NCI is to further our understanding of the mechanisms of cell-extracellular matrix interactions which regulate cell behavior during tumor progression and angiogenesis.
These processes require remodeling of the extracellular matrix that occurs in a spatially and temporally controlled fashion.
Mission Statement of the Extracellular Matrix Pathology Section:
http://home.ncifcrf.gov/ccr/lop/Research/extracellular   (1566 words)

  
 Extracellular Calcium
As opposed to the traditional view that extracellular calcium exists at a stable concentration, we explore the hypothesis that calcium concentrations may change.
One extracellular species, calcium, holds a prominent position as one of the most important messengers known in the brain.
Instead, it seems as though the tissue is engineered so that external calcium levels are meant to fluctuate dramatically; given the functional importance of external calcium, we are led to the strong suspicion that external calcium fluctuations are an important class of information-bearing signal in the nervous system.
http://nba.uth.tmc.edu/homepage/eagleman/calcium.html   (981 words)

  
 GEArray Q Series Human Extracellular Matrix & Adhesion Molecules Gene Array
Zieske JD (2001) Extracellular Matrix and Wound Healing Curr Opin Ophthalmol 12 : 237-41.
(2000) The Extracellular Matrix Can Regulate Vascular Cell Migration, Proliferation, and Survival: Relationships to Vascular Disease.
Schonherr E, Hausser HJ (2000) Extracellular Matrix and Cytokines: a Functional Unit.
http://www.superarray.com/gene_array_product/HTML/HS-010.html   (523 words)

  
 Amazon.com: The Extracellular Matrix Factsbook (Factsbook): Books: Shirley Ayad,Ray Boot-Handford,Martin Humphries,Karl ...
The purpose of this book is to collate and present key facts relating to the diverse group of macromolecules that assemble to form the extracellular matrix.
I found this to be a very thorough reference across a broad range of extracellular matrix proteins.
In particular, identifying which critical ECM proteins to add back to 3D cell culture conditions to re-approximate the in vivo milieu.
http://www.amazon.com/exec/obidos/tg/detail/-/0120689111?v=glance   (781 words)

  
 Cellml.org - Extracellular And Intracellular Calcium Effects On Pancreatic Beta-Cells
The mechanisms underlying these affects are not well understood.
She studies the extracellular calcium effect using a mathematical model which includes seven currents across the plasma membrane and two calcium fluxes across the membrane of the endoplasmic reticulum (ER) (see Figure 1 below).
Extracellular And Intracellular Calcium Effects On Pancreatic Beta-Cells
http://www.cellml.org/examples/repository/chay_model_1997_doc.html   (357 words)

  
 Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading -- KJÆR 84 (2): 649 ...
Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading -- KJÆR 84 (2): 649 -- Physiological Reviews
Extracellular matrix (ECM) placed in tendon tissue as well as
Skeletal muscle (bovine semitendinosus muscle) extracellular network shown by scanning electron micrographs after removal of skeletal muscle protein.
http://physrev.physiology.org/cgi/content/full/84/2/649   (9207 words)

  
 Developmental Biology Online: The Specificity of the Extracellular Matrix
The microcarriers alone did not stimulate migration from either wild-type or mutant crests (Figure 2A, B).
Before the molecular analysis of the migratory pathway of the neural crest cells was possible, a series of ingenious experiments demonstrated that the extracellular matrix regulated neural crest cell migration.Some of the best evidence for the importance of extracellular matrices in directing neural crest cell migration comes from studies of mutant salamanders.
The microcarriers containing wild-type extracellular matrix, however, were able to stimulate neural crest migration from both the mutant and wild-type crests (Figure 2E, F), demonstrating the importance of the extracellular matrix in neural crest cell migration.
http://www.devbio.com/article.php?ch=13&id=132   (440 words)

  
 Extracellular matrix - Wikipedia, the free encyclopedia
The integrins transmit mechanical stimuli from the ECM to the cytoskeleton.
Extracellular matrix is the defining feature of connective tissue.
In biology, extracellular matrix (ECM) is any material part of a tissue that is not part of any cell.
http://en.wikipedia.org/wiki/Extracellular_matrix   (159 words)

  
 Extracellular Superoxide Dismutase Polymorphism in Mice -- Pierce et al. 23 (10): 1820 -- Arteriosclerosis, Thrombosis, ...
Extracellular superoxide dismutase in the vascular system of mammals.
Vascular expression of extracellular superoxide dismutase in atherosclerosis.
Extracellular superoxide dismutase (SOD3): tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene.
http://atvb.ahajournals.org/cgi/content/full/23/10/1820   (3601 words)

  
 An Extracellular Protease of Streptococcus gordonii Hydrolyzes Type IV Collagen and Collagen Analogues -- Juarez and ...
Identification and characterisation of two extracellular proteases of Streptococcus mutans.
through the hydrolysis of gelatin by cell-associated or extracellular
of the protein to the extracellular millieu is likely a consequence
http://iai.asm.org/cgi/content/full/67/1/271   (5018 words)

  
 The Functionality of Extracellular Diffusion in Electrical Neural Processing
Agnati further proposes that extracellular pathways diffusely connect neurons [4] [5].
Because this not a characteristic of AR and AECS responses, this characteristic is attributed to the differencing of extracellular and synaptic potentials.
These results support the premise that extracellular potential resulting from ECD produces a nonsynaptic pathway connecting synaptic cartridges.
http://www.ewh.ieee.org/tc/nnc/edu/research/reports-2000/haines2000.html   (3960 words)

  
 International Society for Fibrinolysis and Proteolysis
Members of this family may play a role in controlling vital processes, like apoptosis, angiogenesis and tumor metastasis by cleavage of critical substrates such as growth factors, hormones or extracellular matrix (see: Yousef and Diamandis, 2002).
A study (Julie et al.,2000) quantified mRNA levels for many extracellular proteases and extracellular matrix proteins in a rat carotid artery injury model.
The inhibitor binds to the extracellular matrix and may modulate, positively or negatively, the invasive and metastatic properties of tumor cells.
http://www.fibrinolysis.org/NewFiles/Proteins.html   (1873 words)

  
 Extracellular definition - Medical Dictionary definitions of popular medical terms
Extracellular definition - Medical Dictionary definitions of popular medical terms
Please consult your healthcare provider before beginning any course of supplementation or treatment.
MedicineNet Home > MedTerms medical dictionary A-Z List > Extracellular
http://www.medterms.com/script/main/art.asp?articlekey=24384   (131 words)

  
 Human Extracellular Water Volume Can Be Measured Using the Stable Isotope Na234SO4 -- Hamadeh et al. 129 (3): 722 -- ...
McCullough A. J., Mullen K. D., Kalhan S. Measurements of total body and extracellular water in cirrhotic patients with and without ascites.
The volume of human extracellular water (ECW) may be estimated
S]sulfate and bromide as reported by different research groups
http://www.nutrition.org/cgi/content/full/129/3/722   (2591 words)

  
 The Extracellular Matrix
While it is true that all living things are made of cells, that is only part of the story.
Most of the cells in multicellular organisms are surrounded by a complex mixture of nonliving material that makes up the extracellular matrix (ECM).
All epithelial cells as well as some other types (e.g., smooth muscle cells) are attached to a basal lamina (also known as the basement membrane) [View].
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/E/ECM.html   (752 words)

  
 Extracellular Recordings - Research Application
Single unit experiments record the changes in potential caused by the generation of an action potential (extracellular spike recordings; Figure 1).
The Extracellular Recording System provides a complete solution for researchers wanting to measure extracellular activity and includes:
The triggering option within Chart and Scope is extremely useful for synchronizing recordings with a stimulus, while the analog or digital outputs on the PowerLab may be used to control a third-party stimulator.
http://www.adinstruments.com/research/rapps/xtracellular.html   (1182 words)

  
 Extracellular Peptidase Activity Tunes Motor Pattern Modulation -- Wood and Nusbaum 22 (10): 4185 -- Journal of ...
Extracellular peptidase activity cleaves neuroactive peptides, and it is a major mechanism for functional inactivation of
Zappulla JP, Wickham L, Bawab W, Yang X-F, Storozhuk MV, Castellucci VF, DesGroseillers L (1999) Cloning and characterization of Aplysia neutral endopeptidase, a metallo-endopeptidase involved in the extracellular metabolism of neuropeptides in Aplysia californica.
Extracellular recordings were used to determine the mean
http://www.jneurosci.org/cgi/content/full/22/10/4185   (7040 words)

  
 Extracellular nature of Redox signaling
Similarly, extracellular active oxygen species may also directly influence platelet (l67-I71) and fibrocyte (63,172) function.
"Since SOD and catalase (which probably do not penetrate into cells) ameliorate the toxicity of such agents in vivo, a significant fraction of their toxicity may be due to extracellular production of oxygen metabolites, in line with the relative paucity of defense mechanisms in the extracellular space."
http://www.nitrone.com/84/extracellular.htm   (237 words)

  
 The Extracellular Matrix Factsbook:0120689111:Ayad, Shirley; Boot-Handford, Ray; Ayad, Shirley:eCampus.com
Entries provide information on molecular structure, isolation, primary structure, structural and functional sites, gene structure, database accession numbers, and key references.
The Second Edition of The Extracellular Matrix Facts-Book has been completely revised, updated and expanded by over 50 percent.
It contains over 85 entries on the diverse group of macromolecules that assemble to form the extracellular matrix.
http://www.ecampus.com/bk_detail.asp?isbn=0120689111&referrer=yah04   (77 words)

  
 Extracellular Matrix & Adhesion Molecules Arrays gene array
The Extracellular Matrix (ECM) and Cell Adhesion GEArray DNA Microarrays and RT² Profiler PCR Arrays are designed to determine the expression profile of a special group of genes, including matrix metalloproteinases (MMPs), integrins, proteases and protease inhibitors, all of which are involved in cell-cell and cell-substratum interactions.
For more information, see the technology overviews for the
Extracellular Matrix & Adhesion Molecules Arrays gene array
http://www.superarray.com/extrac.php   (84 words)

  
 Cell Adhesion & Extracellular Matrix - Virtual Library of Biochemistry & Cell Biology
The Worthington Tissue Dissociation Guide - Introduction to the general characteristics of extracellular matrices associated with various types of tissues.
The Interactive Fly: Evolutionarily Conserved Pathways: Extracellular Matrix - "Functional conservation of extracellular matrix proteins and cell surface receptors." (Society for Developmental Biology)
Kimball's Biology Pages: Extracellular Matrix - Connective tissue and composition of the ECM.
http://www.biochemweb.org/adhesion_ecm.shtml   (539 words)

  
 Extracellular calcium acts as a "third messenger" to regulate enzyme and alkaline secretion -- Caroppo et al. 166 (1): ...
We found that in intact gastric mucosa, the changes in extracellular
only in intracellular Ca, but also in local extracellular
The fact that numerous cell types possess an extracellular
http://www.jcb.org/cgi/content/abstract/166/1/111   (369 words)

  
 Holistic Health Encyclopedia - E
This is because, glutamate, as a neurotransmitter, exists in the extracellular fluid only in very, very small concentrations --- no more than 8 to 12uM.
Defenders of MSG and aspartame use, usually say: How could a substance that is used normally by the brain cause harm?
When the concentration of this transmitter rises above this level, the neurons begin to fire abnormally.
http://www.findhealer.com/glossary/E.php3   (7235 words)

  
 Extracellular Signals
Published by Garland Publishing, a member of the Taylor & Francis Group.
Each cell type displays a set of receptor proteins that enables it to respond to a corresponding set of signal molecules produced by other cells.
An animal cell depends on multiple extracellular signals.
http://www.accessexcellence.org/AB/GG/extraSigs.html   (124 words)

  
 diabetes - Columbia Encyclopedia® article about diabetes
In general, insulin acts to reduce extracellular (including blood plasma) levels of glucose by interacting in some way yet unknown with various cell membranes.
Insulin was one of the first products to be manufactured using genetic engineering.
http://columbia.thefreedictionary.com/diabetes   (1225 words)

  
 Definition of extracellular - Merriam-Webster Online Dictionary
: situated or occurring outside a cell or the cells of the body digestion> enzymes>
For More Information on "extracellular" go to Britannica.com
Get the Top 10 Search Results for "extracellular"
http://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=extracellular   (88 words)

  
 MU IPG Faculty: Arun Chatterjee
Bacterial products important for plant diseases: extracellular enzymes.
Encyclopedia of Plant and Crop Sciences, Marcel Dekker, Inc, 98-100.
http://www.plantgroup.org/achatterjee.html   (565 words)

  
 Upstate - Product #06-457 - Anti-Fms/CSF-1 R, extracellular domain ( 06457 )
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extracellular domain of human c-fms gene product (CSF-1 or M-CSF receptor)
Upstate - Product #06-457 - Anti-Fms/CSF-1 R, extracellular domain (06457)
http://www.upstate.com/browse/productdetail.asp?ProductID=06-457   (129 words)

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