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| | Cross Talk between Peptide Growth Factor and Estrogen Receptor Signaling Systems |
 | | Estrogen induces insulin-like growth factor-I expression in the rat uterus. | | | This evidence suggests a role for the ER in mediating physiological actions of EGF in the reproductive tract in the absence of estradiol. | | | This type of model is also optimal for experiments in which the signal-transduction pathways that may mediate the growth factor interaction with the ER can be elucidated. |
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http://ehp.niehs.nih.gov/members/1995/Suppl-7/ignar-full.html
(4090 words)
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| | AbcBodybuilding |
| | Lanyon, L.E. Using functional loading to influence bone mass and architecture: Objectives, mechanisms, and relationship with estrogen of the mechanically adaptive process in bone. | | | HRT preserves increases in bone mineral density and reductions in body fat after a supervised exercise program. | | | Plowman SA, Liu NY, Wells CL. Body composition and sexual maturation in premenarcheal athletes and nonathletes. |
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http://www.abcbodybuilding.com/bonemechanics1.php
(4211 words)
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| | Ovarian cancer sheds tumor suppression with loss of estrogen receptor |
| | This disappearing act may help explain why ovarian cancers are often typically resistant to anti-estrogen drugs including Tamoxifen. | | | Specialty meetings, held throughout the year, focus on the latest developments in all areas of cancer research. | | | Tumors from 58 ovarian cancer patients contained less messenger RNA for the ER beta than found in ovarian samples from healthy patients, said Lazennec, whose team included scientists from France and Italy. |
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http://www.eurekalert.org/pub_releases/2004-08/aafc-ocs081304.php
(519 words)
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| | National Cancer Institute - Dictionary of Cancer Terms |
| | A procedure in which pulses of weak electrical current are sent through acupuncture needles into acupuncture points in the skin. | | | A drug that is being studied in the treatment and prevention of cancer. | | | A drug that is commonly used to treat arthritis. |
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http://www.cancer.gov/dictionary/db_alpha.aspx?expand=e
(5209 words)
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| | Estrogen Receptor Structures & Functions |
| | Simpson, ER and Davis SD (2000) "Another role highlighted for estrogens in the male: Sexual behavior". | | | Another example is tamoxifen, which was developed as an antiestrogen for the treatment of breast cancer and was subsequently shown to have estrogen-like effects on bone and the cardiovascular system. | | | Estrogen has been shown to influence the morphology and function of the secretory epithelial cells in rat prostates, making it likely that at least some of the effects of estrogens in vivo are direct rather than indirect. |
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http://www.bio.cmu.edu/Courses/BiochemMols/ER/ERIntro.html
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| | NGC - NGC Summary |
| | Co-administration of local vaginal estrogen therapy may be used for the relief of vaginal dryness in patients receiving raloxifene or tamoxifen therapy. | | | Individualized risk assessment should be performed to determine whether a patient is a candidate for breast cancer risk reduction by chemoprevention, unless she has ductal carcinoma in situ or lobular carcinoma in situ, in which case the benefit of chemoprevention already has been documented. | | | The use of tamoxifen for chemoprevention should be limited to 5 years. |
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http://www.guideline.gov/summary/summary.aspx?view_id=1&doc_id=3987
(773 words)
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| | Artemis -- March 2003 |
| | More recent studies have addressed the effect that Tamoxifen therapy has upon prevention of recurrences of ductal carcinoma in situ (DCIS). | | | Estrogen Receptor Status in Ductal Carcinoma In Situ Predicts Effectiveness of Tamoxifen Therapy. | | | Analysis of the data showed that for patients with estrogen receptor positive ductal carcinoma in situ, Tamoxifen therapy was effective; there was an approximately 50% reduction in both ipsilateral and contralateral new breast cancers. |
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http://www.hopkinsmedicine.org/breastcenter/artemis/200303/feature0.html
(672 words)
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| | Estrogen Receptor (alpha & Beta) antibodies from Research Diagnostics Inc |
| | RNA distribution studies have shown ERB is transcribed in human thymus, spleen, ovary and testis as well as rat ovary and prostate. | | | This material is both soluble functionally active because the baculovirus expression system used for its expression produces a recombinant proein with post-translational modifications similar to those found in mammalian cells. | | | However, a new estrogen binding receptor,referred to as ERB, has recently been cloned in rat and humans. |
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http://www.researchd.com/rdiabs/estrorec.htm
(1683 words)
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| | Estrogen Receptor Accessory Proteins: Effects on Receptor-DNA Interactions |
| | Environmental Health Perspectives (EHP) is a monthly journal of peer-reviewed research and news on the impact of the environment on human health. | | | Despite a wealth of information about the structure and composition of steroid receptors and their functional domains, little is known about the role of accessory proteins as mediators of receptor activity. | | | To better define the role of such proteins in estrogen receptor (ER) function, we have used immuno-affinity, steroid-affinity, and site-specific DNA-affinity chromatography to identify and characterize proteins that associate with human ER in extracts from MCF-7 cells and hER-expressing CHO (CHO-ER) cells. |
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http://ehp.niehs.nih.gov/docs/1995/Suppl-7/landel.html
(295 words)
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| | Estrogen Receptors |
| | Read recent research reviews on the risks of estrogen therapy for menopausal symptom relief. | | | The goal of anti-estrogen therapy is to deprive cancer cells of the estrogen that triggers their growth and multiplication. | | | Estrogen is a very important "key" for receptor sites throughout the body AND on some breast cancer cells. |
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http://www.breastcancer.org/tre_sys_hrt_howEstWrk.html
(348 words)
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| | mekentosj.com Science - Estrogen Receptor |
| | His work provided a foundation for the modern use of hormone therapy for the treatment and prevention of breast cancer. | | | Most estrogen receptor-positive breast cancers are fully dependent on this process for their growth, therefore these tumors are commonly treated with anti-estrogens that induce a conformational change in the receptor and prevent the recruitment of the cofactors essential for gene transcription. | | | As it turned out this receptor plays a key role in the development and maintenance of the sexual reproductive tissues, and therefore, as Beatson had discovered, in breast cancer as well. |
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http://www.mekentosj.com/science/er
(990 words)
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| | Healthopedia.com - Selective Estrogen Receptors (Designer Estrogens, SERMs) |
| | Women who take estrogen and do not have their uterus are not at risk for uterine cancer. | | | This reduces the risk of uterine cancer to the level of women who do not take estrogen at all. | | | It is often given together with a progestin as hormone replacement therapy after menopause. |
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http://www.healthopedia.com/selective-estrogen-receptors
(671 words)
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| | estrogen - definition of estrogen in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and ... |
| | Any of several natural or synthetic substances formed by the ovary, placenta, testis, and certain plants, that stimulate the female secondary sex characteristics, exert systemic effects such as the growth and maturation of long bones, and are used to treat disorders due to estrogen deficiency and to ameliorate cancers of the breast and prostate. | | | This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. | | | estrogen - definition of estrogen in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia. |
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http://medical-dictionary.thefreedictionary.com/estrogen
(125 words)
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| | Estrogen receptor -- Facts, Info, and Encyclopedia article |
| | ER status is used to determine sensitivity of (Cancer of the breast; one of the most common malignancies in women in the US) breast cancer lesions to (An antagonist for estrogen that is used in the treatment of breast cancer) tamoxifen and (additional info and facts about aromatase inhibitor) aromatase inhibitors. | | | The receptors exist in (A compound whose molecules are composed of two identical monomers) dimers, and there are two possible subunits (α and β). | | | Estrogen receptor -- Facts, Info, and Encyclopedia article |
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http://www.absoluteastronomy.com/encyclopedia/e/es/estrogen_receptor.htm
(108 words)
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| | PDB Molecule of the Month: Estrogen Receptor |
| | Estrogens are made in the ovaries and then delivered within seconds throughout the body in the blood, directing the growth from child to adult. | | | Estrogens pass directly into cells throughout the body, so the cell can use receptors that are in the nucleus, right at the site of action on the DNA. | | | These receptors each bind to a specific signaling molecule and then activate or repress their own set of 50-100 genes. |
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http://www.rcsb.org/pdb/molecules/pdb45_1.html
(455 words)
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| | Bioreagents.com: Estrogen Receptor Beta |
| | Estrogen receptor (ER) was first cloned in 1987 and has been shown to be expressed and transcriptionally active in a number of tissues including ovary, testis, prostate and brain. | | | RNA distribution studies have shown ER beta is transcribed in human thymus, spleen, ovary and testis as well as rat ovary and prostate. | | | PA1-311 has been successfully used in Western blot, immunohistochemistry, immunocytochemistry and gel shift procedures. |
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http://www.bioreagents.com/index.cfm/fuseaction/products.detail/CatNbr/PA1-311
(390 words)
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| | Estrogen receptor |
| | Lack of response of uterus and vagina to estradiol treatment | | | The mouse estrogen receptor (ER) has been cloned and found to have nine exons. | | | Eddy, T. Washburn, D. Bunch, E. Goulding, B. Glanden, D. Lubahn & K.S. Korach: Targeted Disruption of the Estrogen Receptor Gene in Male Mice Causes Alteration of Spermatogenesis and Infertility. |
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http://www.bioscience.org/knockout/estrgrec.htm
(96 words)
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| | PDB Molecule of the Month: Estrogen Receptor |
| | A list of all estrogen receptor structures in the PDB as of September, 2003, is available here. | | | Several amino acids on one side of this helix reach out and grip the edges of the base pairs, making sure that the DNA is of the appropriate sequence. | | | Four cysteine amino acids (shown in yellow here) surround each zinc ion (shown in green), forming a sturdy core that gives the domain a rigid structure. |
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http://www.rcsb.org/pdb/molecules/pdb45_3.html
(158 words)
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| | U.S. Department of Health and Human Services Breast Cancer Reference Collections Page |
| | Understanding Estrogen Receptors, Tamoxifen, and Raloxifen (National Cancer Institute, National Institutes of Health) | | | Understanding Breast Changes: A Health Guide for All Women (National Cancer Institute, National Institutes of Health) | | | Understanding Cancer: Estrogen Receptors/SERMs [Selective Estrogen Receptor Modulators] (National Cancer Institute, National Institutes of Health) |
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http://www.hhs.gov/breastcancer/reference.html
(679 words)
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| | Center for Environmental Biotechnology Publications |
| | Evaluation of polycyclic aromatic hydrocarbons in the activation of early growth response-1 and peroxisome proliferators activated receptors. | | | A yeast reporter strain expressing bacterial bioluminescence for rapid sensitive detection of estrogenic compounds. | | | Degradation of estrogens in dairy waste solids: Effects of acidification and temperature. |
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http://www.ceb.utk.edu/publications.html
(5397 words)
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| | Endocrine Disruptor BRD Page (Final) |
| | B4 - Standard Operating Procedure for the Rat Estrogen Receptor Equilibrium Exchange Assay | | | Notice to Reader: The BRDs contain data, a proposed list of substances, and minimum procedural standards that were reviewed by an independent Expert Panel in May 2002. | | | B5 - Protocol for the Estrogen Receptor Competitive Binding Assay Using Rat Uterine Cytosol |
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http://iccvam.niehs.nih.gov/methods/endodocs/ed_brd.htm
(884 words)
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| | Upstate - Product #07-662 - Anti-Estrogen-related Receptor α ( 07662 ) |
| | Click here to set your country preference and view prices. | | | Ovalbumin-conjugated, synthetic peptide corresponding to amino acids 339-364 of human Estrogen Receptor-Related α | | | MSDS: No Material Safety Data Sheet is required for this product. |
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http://www.upstate.com/browse/productdetail.asp?ProductID=07-662
(135 words)
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| | Xiaole Shirley Liu |
| | Carroll JS, Liu XS, Brodsky AS, Li W, Szary AJ, Meyer CA, Shao W, Hestermann EV, Geistlinger TR, Fox EA, Silver PA, Brown M. Chromosome-wide mapping of estrogen receptor binding reveals long-rnage combinatorial regulation. |
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http://genome.dfci.harvard.edu/xsliu
(575 words)
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