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| | A Human Dendritic Cell-Based Method to Identify CD4+ T-Cell Epitopes in Potential Protein Allergens |
 | | HLA-DR and -DQ types were analyzed for associations with responses to defined epitope peptides. | | | Environmental Health Perspectives (EHP) is a monthly journal of peer-reviewed research and news on the impact of the environment on human health. | | | Second, evidence from the literature suggests that as an immune response develops, T-cell epitope complexity increases. |
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http://www.ehponline.org/members/2003/5707/5707.html
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| | Visualization of Myelin Basic Protein (MBP) T Cell Epitopes in Multiple Sclerosis Lesions using a Monoclonal Antibody ... |
| | Direct Phenotypic Analysis of Human MHC Class I Antigen Presentation: Visualization, Quantitation, and In Situ Detection of Human Viral Epitopes Using Peptide-Specific, MHC-Restricted Human Recombinant Antibodies | | | T Cell Epitopes of Human Myelin Oligodendrocyte Glycoprotein Identified in HLA-DR4 (DRB1*0401) Transgenic Mice Are Encephalitogenic and Are Presented by Human B Cells | | | Visualization of Myelin Basic Protein (MBP) T Cell Epitopes in Multiple Sclerosis Lesions using a Monoclonal Antibody Specific for the Human Histocompatibility Leukocyte Antigen (HLA)-DR2-MBP 85-99 Complex -- Krogsgaard et al. |
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http://www.jem.org/cgi/content/abstract/191/8/1395
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| | Epitope - Wikipedia, the free encyclopedia |
| | Epitopes can be mapped using protein microarrays, and with the ELISPOT or ELISA techniques. | | | Genetic sequences coding for epitopes that are recognised by common antibodies can be fused to genes, thus aiding further molecular characterization of the gene product. | | | Exceptions are linear epitopes, which are determined by the amino acid sequence (the primary structure) rather than by the tertiary structure of a protein. |
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http://en.wikipedia.org/wiki/Epitope
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| | Molecular approaches to identifying allergenic epitopes. |
| | This dichotomy in the type of epitope that mediates clinical symptoms is believed to be due to the fact that food allergens must survive the GI tract to provoke allergic reactions whereas aeroallergens can be introduced intact to the nasal mucosa and lung epithelium. | | | Conformational epitopes appear to play a significant role in mediating clinical reactions of aeroallergens and linear epitopes play a major role in the etiology of allergic reactions to foods. | | | The structure of the allergenic proteins appears to play a significant role in defining those regions that become epitopes and which epitopes are immunodominant in an allergic patient population. |
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http://www.aaccnet.org/meetings/2001/Abstracts/a01ma158.htm
(217 words)
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| | T HELPER CELL EPITOPES (WO0046390A1) |
| | In particular, for antibody responses, epitopes need to be recognised by specific immunoglobulin (1g) receptors present on the surface of B lymphocytes. | | | For any peptide to be able to induce an effective antibody response it must contain particular sequences of amino acids known as epitopes that are recognised by the immune system. | | | In addition to these B cell epitopes, the immunogen must also contain epitopes that are presented by antigen presenting cells (APC) to specific receptors present on helper T lymphocytes, the cells which are necessary to provide the signals required for the B cells to differentiate into antibody producing cells. |
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http://www.delphion.com/details?pn=WO00046390A1
(361 words)
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| | CYTOTOXIC T-CELL EPITOPES (WO9524925A1) |
| | Minimalisation experiment to define the active epitope sequence within VTAVLLHEESMQGVQVHGSM. | | | The present invention also relates to the use of the epitopes in subunit vaccines. | | | The peptides were synthesised using the sequence of the B95.8 strain of EBV (Baer et al 1990). |
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http://www.delphion.com/details?pn=WO09524925A1
(421 words)
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