|
| |
| | Postgraduate Medicine: A practical workup for eosinophilia |
 | | Eosinophilia may be associated with respiratory symptoms, often asthmatic in nature, together with pulmonary infiltrates that are detectable on chest films (12). | | | Striking eosinophilia can occur in patients who have eosinophilic gastroenteritis, often accompanied by a history of atopy, and may cause abdominal pain without specific features or diarrhea and intestinal obstruction. | | | However, a more practical approach is to consider the degree of eosinophilia along with the clinical setting in which it was discovered (2,6,7). |
|
http://www.postgradmed.com/issues/1999/03_99/brigden.htm
(3326 words)
|
|
| |
| | Clinical and Molecular Allergy Full text Eosinophilia in a patient with cyclical vomiting: a case report |
| | commented on the reduction of eosinophilia with montelukast but the absence of any symptomatic relief in a patient with eosinophilic gastroenteritis [52]. | | | It frequently involves the skin, peripheral nerves and lungs with associated peripheral eosinophilia. | | | Cutaneous lesions occur over pressure areas, petechiae, purpura, and peripheral neuropathy is found in the majority of patients. |
|
http://www.clinicalmolecularallergy.com/content/2/1/7
(5437 words)
|
|
| |
| | eMedicine - Eosinophilia-Myalgia Syndrome : Article by Nicole Quartarolo, MD |
| | Serotonin overproduction by carcinoid tumors is associated with myalgias and arthralgias in addition to sclerodermalike skin changes. | | | This phase lasts weeks to months and is followed by a chronic phase characterized by sclerodermoid skin changes, neuropathy, neurocognitive deficits, continued myalgia, and muscle cramps. | | | This condition usually begins in the proximal muscle groups, such as those in the shoulders, the buttocks, and the thighs; then, myalgia becomes incapacitating. |
|
http://www.emedicine.com/derm/topic891.htm
(4431 words)
|
|
| |
| | Editorial |
| | Mayeno and colleagues may be well on their way toward affirming that our scientific world continues to shrink when neither time nor distance deters investigators who have the will to persevere. | | | The investigators in Japan did not identify other likely candidates in their studies. | | | The article by Mayeno and co-workers in this issue of the Proceedings does not address this possibility, but the authors tackle problems such as determining- the chemical structure of peak UV-5 and the epidemiologic relationship of the peak with the Eosinophilia-Myalgia Syndrome. |
|
http://www.nemsn.org/Articles/editorial.htm
(1542 words)
|
|
| |
| | Diseases Similar to Scleroderma (EF, EMS, Scleromyxedema...) |
| | Only a better and more complete understanding of the various mechanisms involved will enable this interesting new therapy to be made more effective and selective. | | | Stone-hard areas of skin are observed from birth or in early childhood. | | | The presence of lichen sclerosus, morphea, septal fibrosis, and fasciitis suggests that the sclerosis can start at and affect any level of the skin. |
|
http://www.sclero.org/medical/symptoms/associated/similar/a-to-z.html
(2530 words)
|
|
| |
| | The Effects of Trazodone with L-Tryptophan on Sleep-disordered Breathing in the English Bulldog -- VEASEY et al. 160 ... |
| | Modulation of neonatal rat hypoglossal motoneuron excitability by serotonin. | | | SIGRID C. and JOAN C. Center for Sleep and Respiratory Neurobiology; Division of Pulmonary and Critical Care, Department of Medicine, School of Medicine; Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania | | | Before initiating human trials of this combination therapy for the OSAHS, there are unresolved concerns with the safety of |
|
http://www.ajrccm.org/cgi/content/full/160/5/1659
(6395 words)
|
|
| |
| | Zebra Card SK-003: postexertional skin thickening |
| | Unusual thickening of the skin is no longer a zebra, or at least it wasn't in the late 1980s and early 1990s. | | | Studied the patients in one psychiatrist's practice in South Carolina. | | | Scleroderma-like skin thickening is part of this syndrome. |
|
http://www.zebracards.com/SK-003.html
(458 words)
|
|
| |
| | Eosinophilia-Myalgia Syndrome FAQ |
| | A: Myalgia is muscle pain, often accompanied by weakness. | | | For instance, someone with asthma might experience a rise in eosinophils during an attack or during allergy season. | | | FM patients have many overlapping medical symptoms with EMS patients, and one is muscle pain. |
|
http://www.eosinophilia-myalgia.net/faq.htm
(3663 words)
|
|
| |
| | PHIL\web page\l-tryptophan |
| | characterized by peripheral eosinophilia, myalgias, and a variety of | | | These observations underscore the need for careful application of | | | Eosinophilia myalgia syndrome (EMS) is a toxin-induced illness that |
|
http://biosci.cbs.umn.edu/~pregal/tryptophan.html
(4827 words)
|
|
| |
| | Untitled Document |
| | During the acute phase, EMS is characterized by flu-like constitutional symptoms, intense muscle pain (myalgia) and an increase in blood eosinophil counts. | | | Later, the syndrome is often characterized by skin rash and fasciitis, which may resemble scleroderma or eosinophilic fasciitis. | | | The skin and other organs may be infiltrated by inflammatory cells, including eosinophils, and the connective tissue is often inflamed and fibrotic. |
|
http://www.musc.edu/rheumatology/FAQs/FAQ-Eosin-Myal.html
(203 words)
|
|
| |
| | Eosinophilia-Myalgia Syndrome Symptoms |
| | Myofascial Pain Syndrome (or sometimes now called Chronic Myofascial Pain or CMP; Trigger Point pain) | | | Swelling (edema) of the face or extremities or other areas of the body, such as the arms | | | Eosinophilic Fasciitis and Eosinophilia-Myalgia Syndrome (symptoms of each) |
|
http://www.eosinophilia-myalgia.net/symptoms.htm
(1194 words)
|
|
| |
| | FDA/CFSAN "Dear Colleague" Letter on Legal and Regulatory Background on L-Tryptophan (February 2, 1990) |
| | As a follow up to my January 17, 1990, letter to you on L-tryptophan, I would like to bring you up to date with further developments and to provide a clarification of some of the legal and regulatory background on L-tryptophan. | | | These include nine deaths, one of which has been confirmed as being clearly associated with the taking of L-tryptophan. | | | As editorial by the CDC appeared in the Annals of Internal Medicine, "Interim Guidance on the Eosinophilia-Myalgia Syndrome," Volume 12, Number 2, January 15, 1990. |
|
http://www.cfsan.fda.gov/%7Edms/ds-ltr2.html
(566 words)
|
|
| |
| | American Family Physician: Eosinophilia-myalgia syndrome - Tips from Other Journals |
| | Four patients have recovered fully, while the others remain stable or are slowly recovering. | | | Martin and associates describe the clinical spectrum of eosinophilia-myalgia syndrome in 20 patients. | | | Pneumonitis and myocarditis developed in one patient, neuropathy culminating in respiratory failure occurred in one, encephalopathy in one and fibrosis around the common bile duct in one patient. |
|
http://www.findarticles.com/p/articles/mi_m3225/is_n6_v42/ai_9214412
(347 words)
|
|
| |
| | Directory - Health: Conditions and Diseases: Blood Disorders: Eosinophilia |
| | Yahoo Groups : Eosinophilia Myalgia Syndrome · iweb · cached · Information for those wishing to learn more about issues relating to EMS. | | | NetDoctor · iweb · cached · Facts about eosinophilia including what it is, how and when it occurs, symptoms, diagnosis and treatment. | | | Acute Pulmonary Eosinophilia: Loeffler's Syndrome · iweb · cached · Adam.com defines this disorder, its causes, incidence and risk factors. |
|
http://www.incywincy.com/default?p=441501
(140 words)
|
|
| |
| | Epidemiologic Notes and Reports Eosinophilia-Myalgia Syndrome -- New Mexico |
| | The surveillance case definition should be considered provisional and subject to change as knowledge of EMS evolves. | | | Clinical epidemiology of toxic-oil syndrome: manifestations of a new illness. | | | LT supplements are used by some persons for disorders such as insomnia, depression, and premenstrual syndrome (7). |
|
http://www.cdc.gov/mmwr/preview/mmwrhtml/00001497.htm
(911 words)
|
|
| |
| | Unintentional Provings - Dr P. Souk-Aloun |
| | Troubles appear in the hour that follows the meal, with headache, nausea, redness and heat of the superior part of the body, pains in the region of heart; rarely, one observes some asthma crises. | | | Used in some cancer treatments, Interferon give frequently astheny, a influenza-like syndrom (with chills, myalgias, arthralgias and headaches), anorexia and loss of libido. | | | The Cannabis, well-known soft drug is not so "soft" for predisposed persons, at which it provokes the apparition of psychiatric syndromes described for a long time by physicians of the countries having a customary use of this plant (Maghreb) (8): |
|
http://www.homeoint.org/books/soukrexp/provin.htm
(1863 words)
|
|
| |
| | Clinical Trial: L-5-HTP-related EMS |
| | This study is designed to learn more about EMS that develops in patients taking L-5-hydroxytryptophan. | | | Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan. | | | The L-tryptophan-related eosinophilia myalgia syndrome (EMS), characterized by eosinophilia, myalgias, myositis, scleroderma-like skin fibrosis and fasciitis, occurred in 1989 in over 1500 patients who had ingested L-tryptophan for sleep disturbances and depression. |
|
http://clinicaltrials.gov/show/NCT00001918
(469 words)
|
|
| |
| | Arch Intern Med -- Abstract: Rigorous New Approach to Constructing a Gold Standard for Validating New Diagnostic ... |
| | Arch Intern Med -- Abstract: Rigorous New Approach to Constructing a Gold Standard for Validating New Diagnostic Criteria, as Exemplified by the Eosinophilia-Myalgia Syndrome, October 22, 2001, Hertzman et al. | | | Phillip A. Hertzman, MD Daniel J. Clauw, MD Joseph Duffy, MD Thomas A. Medsger, Jr, MD Alvan R. Feinstein, MD Arch Intern Med. | | | Rigorous New Approach to Constructing a Gold Standard for Validating New Diagnostic Criteria, as Exemplified by the Eosinophilia-Myalgia Syndrome |
|
http://archinte.ama-assn.org/cgi/content/abstract/161/19/2301
(230 words)
|
|
| |
| | Chest: Pulmonary manifestations of the eosinophilia-myalgia syndrome associated with tryptophan ingestion.@ HighBeam ... |
| | However, previous reports have not described the results of longitudinal pulmonary function, exercise testing, high-resolution computerized tomographic (HRCT) scanning of the chest, or detailed... | | | Chest: Pulmonary manifestations of the eosinophilia-myalgia syndrome associated with tryptophan ingestion.@ HighBeam Research | | | Pulmonary manifestations of the eosinophilia-myalgia syndrome associated with tryptophan ingestion. |
|
http://highbeam.com/library/doc0.asp?docid=1G1:12765414&refid=ink_tptd_mag
(176 words)
|
|
| |
| | Notes on the Tryptophan Disaster |
| | Books, magazine articles, and many manufacturers promoted it with claims that it was useful against insomnia, pain, depression, PMS, and overweight, even though it had not been proven safe and effective for any of these purposes. | | | A hitherto rare disorder, EMS is a debilitating disease characterized by severe muscle and joint pain, weakness, swelling of the arms and legs, fever, skin rash, and an increase of eosinophils (certain white blood cells) in the blood. | | | On-line HPLC-tandem mass spectrometry analysis of contaminants of L-tryptophan associated with the onset of the eosinophilia-myalgia syndrome. |
|
http://www.quackwatch.com/01QuackeryRelatedTopics/DSH/trypto.html
(2183 words)
|
|
| |
| | Hot Peppers Can Fight the Sleepy Effects of Holiday Dinners |
| | Known as "L-Tryptophan," it was widely used as a natural way to treat insomnia, depression, PMS. | | | Then in 1990, the U.S. Food and Drug Administration banned L-tryptophan supplements after an outbreak of "Eosinophilia-myalgia," a syndrome that causes chronic muscle pain and even death. | | | In fact, more than 5,000 users got sick, and more two dozen died all due to poor manufacturing techniques. |
|
http://www.prweb.com/releases/2004/11/prwebxml181177.php
(1599 words)
|
|
| |
| | Toxic Myopathies |
| | Slow resolution over years (60%): Myalgias; Skin changes | | | Occasional patients with severe residual weakness or myalgia | | | Syndrome development: Subacute (2 weeks) to chronic (3 months) |
|
http://www.neuro.wustl.edu/neuromuscular/mother/myotox.htm
(330 words)
|
|
| |
| | Eosinophilia-Myalgia: Advocacy, Information, Support |
| | Faith Rumph's Story: Eosinophilia-Myalgia Syndrome (My story on www.sclero.org Web site) | | | Status of Pain in 37 Patients with Eosinophilia-Myalgia Syndrome (all pain, not just spasms) Don't forget you can also access all medical reports and other information on the Information Page. | | | To help persons with Eosinophilia-Myalgia Syndrome (EMS) and others who have an interest in EMS to become advocates for EMS awareness and research; to share information about EMS with patients, doctors, and the public; to foster various methods of support for people with EMS, their families, friends, and caregivers. |
|
http://www.eosinophilia-myalgia.net
(998 words)
|
|
| |
| | THE MERCK MANUAL, Sec. 11, Ch. 136, Eosinophilic Disorders |
| | Acquired and congenital immune disorders, often with eczema, may be associated with eosinophilia. | | | Eosinophilic drug reactions may be asymptomatic or associated with a variety of syndromes, including interstitial nephritis, serum sickness, cholestatic jaundice, hypersensitivity vasculitis, and immunoblastic lymphadenopathy. | | | Eosinophilia may be primary or secondary to an underlying disorder (see Table 136-1). |
|
http://www.merck.com/pubs/mmanual/section11/chapter136/136b.htm
(532 words)
|
|
| |
| | NBC's `Medical Investigation' evolves to survive |
| | McDonough says he goes home each night and studies medical journals "to see exactly what I'm saying." | | | "Here's some," he says, his blue eyes sparkling with a sort of grim satisfaction as he points to an upcoming line: "Contaminated L-tryptophans can cause eosinophilia-myalgia syndrome..." | | | Get 50% off home delivery of the Chronicle for 12 weeks! |
|
http://www.sfgate.com/cgi-bin/article.cgi?f=/news/archive/2005/01/31/entertainment1627EST0317.DTL
(672 words)
|
|
| |
| | Eosinophilia-myalgia syndrome - Wikipedia, the free encyclopedia |
| | Similar to regular eosinophilia, it causes an increase in eosinophil granulocytes in the patient's blood. | | | Eosinophilia-myalgia syndrome is an incurable and sometimes fatal flu-like neurological condition that was caused by contaminated L-tryptophan supplements. | | | The bacterial culture used to synthesise tryptophan had recently been genetically engineered to increase tryptophan production: unfortunately, with the higher tryptophan concentration in the culture medium, the purification process had also been modified to reduce costs, and a purification step that used charcoal absorption to remove impurities had been omitted. |
|
http://en.wikipedia.org/wiki/Eosinophilia-myalgia_syndrome
(174 words)
|
|
| |
| | FDA/CFSAN "Dear Colleague" letter regarding the Research on Eosinophilia-Myalgia Syndrome and Current Regulatory Status ... |
| | While not all patients may exhibit eosinophilia, many patients go on to experience peripheral edema -- both pitting and nonpitting, as well as features of peripheral neuropathy, myocarditis, pneumonitis, fasciitis, or a scleroderma-like syndrome. | | | Therefore, any new symptom or condition observed in EMS patients should be evaluated for potential relationship to the progression of EMS. | | | EMS was originally described in 1989 as a symptom complex associated with the ingestion of LT. Although the majority of the individuals originally described developed significant eosinophilia (>1000/mm) and debilitating muscle pain, it is now recognized that the syndrome may encompass a wide range of symptoms that may change over time. |
|
http://www.cfsan.fda.gov/~dms/ds-ltr3.html
(1656 words)
|
|
| |
| | Home Page |
| | Hence many doctors shrug off victims' complaints and attribute their symptoms to fibromyalgia (a chronic condition also involving acute muscle pain not verifiable by laboratory tests), Chronic Fatigue Syndrome, Lupus, Arthritis, Fasciitis, and other auto-immune or neuromuscular disorders with similar symptoms. | | | NEMSN is also committed to encouraging research to improve treatment for L-tryptophan induced EMS and to increasing awareness of the cause and effects of the disease and other similar auto-immune disorders. | | | Three women sought medical help for a mysterious, undiagnosable condition whose symptoms were marked by debilitating muscle pain and a high Eosinophilia count (a type of white blood cell that is usually found when a toxin or parasitic infection is present). |
|
http://www.nemsn.org
(451 words)
|
|
| |
| | FDA/CFSAN "Dear Colleague" letter on L-Tryptophan and Eosinophilia-Myalgia Syndrome (January 17, 1990) |
| | Most patients have shown an improvement after the L-tryptophan supplements were discontinued, while in other patients, the disease continued unchanged or progressed. | | | The course of the illness has not been completely defined; it may progress to a scleroderma-like syndrome or to an ascending polyneuropathy. | | | Myalgia (often incapacitating) and fatigue are the most characteristic symptoms. |
|
http://www.cfsan.fda.gov/~dms/ds-ltr1.html
(959 words)
|
|
| |
| | Eosinophilia |
| | Eosinophilia is not a disease, but rather, refers to an especially high number of eosinophil cells in the blood. | | | In a child, increased eosinophil levels is a normal response to allergens, infections and other substances foreign to the body's immune system. |
|
http://www.mayoclinic.org/peds-whitecell-rst/eosinophilia.html
(62 words)
|
|
| |
| | Tryptophan, 5-HTP, and the Eosinophilia-Myalgia Syndrome |
| | Thanks to well-timed supplements of tryptophan or 5-HTP, millions of people have bolstered their brain's usual supply of serotonin, relieving their depression, chronic pain and other conditions, with few or no side effects. | | | It resembles a chronic autoimmune disease, with aching joints and muscles, elevated white blood cells (eosinophils), fever, skin rash and fibrosis (hardening), swollen limbs, weakness and such long-term complications as lung disease (including pulmonary hypertension) and cognitive impairment. | | | Eosinophilia, scleroderma-like lesions, and even primary pulmonary hypertension have made rare appearances before and since. |
|
http://www.mts.net/~baumel/ems.html
(442 words)
|
|
| |
| | Netwd Health Directory: Eosinophilia |
| | Facts about eosinophilia including what it is, how and when it occurs, symptoms, diagnosis and treatment. | | | Information for those wishing to learn more about issues relating to EMS. |
|
http://www.netwd.com/diseases/blood-disorders/eosinophilia.html
(162 words)
|
|
| |
| | Update: Eosinophilia-Myalgia Syndrome Associated with Ingestion of L-Tryptophan -- United States, through August 24, ... |
| | Many persons may have forms of EMS that are either less severe or in which the constellation of clinical findings does not include the intense eosinophilia or severe myalgias initially identified as the hallmarks of epidemic EMS. | | | Update: eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan--United States. | | | As in other diseases with multiple connective tissue manifestations, a set of clear-cut diagnostic criteria with both high sensitivity and specificity may be difficult or impossible to establish. |
|
http://www.cdc.gov/mmwr/preview/mmwrhtml/00001738.htm
(717 words)
|
|
| |
| | Eosinophilia Myalgia Syndrome |
| | The Eosinophilia Myalgia Syndrome Research Advisory Council solicits research proposals that address the etiology, pathology, or treatment of EMS. | | | Applicants must submit an outline of the objectives and scope of their research proposal that is 1,500 words or less prior to submission of a formal application. |
|
http://vpr2.admin.arizona.edu/rso/01100510.htm
(57 words)
|
|
| |
| | Eosinophilia-Myalgia Syndrome - [Support Group] - Quest Diagnostics Patient Health Library |
| | For evidence-based information on diseases, conditions, symptoms, treatment and wellness issues, continue searching this site. | | | Mutual support for persons with eosinophilia myalgia syndrome (EMS) caused by using L-tryptophan, and their families. | | | Eosinophilia-Myalgia Syndrome - [Support Group] - Quest Diagnostics Patient Health Library |
|
http://www.questdiagnostics.com/kbase/shc/shc29ems.htm
(216 words)
|
|
| |
| | Eosinophilia-Myalgia SyndromeEosinophilia-Myalgia Syndrome |
| | The symptoms of eosinophilia-myalgia syndrome include inflammation or pain in affected skin, muscles, nerve, blood vessel, lung, heart and other organs. | | | Researchers believe the syndrome develops in people who have ingested products containing the amino acid l-tryptophan. | | | The first step in treating eosinophilia-myalgia is to discontinue use of any products containing |
|
http://www.mayoclinic.org/peds-whitecell-rst/eosinophilia-m.html
(84 words)
|
|
| |
| | Tryptophan Summary |
| | Over time many other symptoms developed in patients that led in some cases to death and in many other cases to serious long term disability. | | | The disease caused by this toxic product was called eosinophilia myalgia syndrome or EMS, because the initial symptoms were elevated numbers of blood cells called eosinophils and myalgia (muscle pain). | | | Based on these points, we conclude that it is highly likely that genetic engineering was the determining factor in generating this toxin. |
|
http://www.holisticmed.com/ge/trypt.html
(1207 words)
|
|
| |
| | Eosinophilia-Myalgia Syndrome - Patient UK |
| | Rare condition consisting of marked eosinophilia combined with severe myositis with tissues infiltrated with eosinophils (without evidence of infection or neoplasia). | | | Eosinophilia-Myalgia Syndrome - Patient UK PatientPlus articles are written for doctors and so the language can be technical. | | | Some patients develop memory problems or mild expressive dysphasia. |
|
http://www.patient.co.uk/showdoc/40001913
(394 words)
|
|
| |
| | Tryptophane and eosinophilia myalgia syndrome, was Re: insomnia |
| | Tryptophane and eosinophilia myalgia syndrome, was Re: insomnia | | | Tryptophane and eosinophilia myalgia syndrome, was Re: insomnia Sonja van Baardwijk | | | Tryptophan got pulled from a lot of places sometime around 1990. |
|
http://www.mail-archive.com/brin-l@mccmedia.com/msg21675.html
(66 words)
|
|
| |
| | CNN - Report: Contamination found in L-tryptophan supplement - August 31, 1998 |
| | WASHINGTON (CNN) -- For the second time in a decade, researchers say they have found possibly harmful contamination in a popular supplement sold in health food stores to promote sleep, prevent headaches and aid in weight loss. | | | Gleich told a briefing Monday that they are not aware of any current cases of illness associated with products currently on the market. | | | "This latter compound is freely available over the counter and is being recommended to overcome 'serotonin deficiency syndrome' as well as obesity, headaches and insomnia," they wrote in the findings. |
|
http://www.cnn.com/HEALTH/9808/31/tryptophan
(651 words)
|
|
| |
| | FDA/CFSAN - Information Paper on L-tryptophan and 5-hydroxy-L-tryptophan |
| | Background on L-tryptophan and 5-hydroxy L-tryptophan and the eosinophilia myalgia syndrome | | | This illness is associated with the use of dietary supplements containing L-tryptophan. | | | FDA took action to limit the availability of dietary supplements containing the amino acid that is the biological precursor of L-5-hydroxytryptophan, that is, L-tryptophan, because of the association between dietary supplements containing L-tryptophan and the 1989 epidemic outbreak of eosinophilia-myalgia syndrome (EMS) in the United States. |
|
http://vm.cfsan.fda.gov/~dms/ds-tryp1.html
(937 words)
|
|
| |
| | Food Standards Agency - COT statement On Tryptophan And The Eosinophilia-Myalgia Syndrome |
| | COT statement On Tryptophan And The Eosinophilia-Myalgia Syndrome | | | The COT was asked to assess the available data on the eosinophilia-myalgia syndrome and to consider the risks posed by the addition of isolated tryptophan to foods, including dietary supplements. | | | > Homepage > Science and Research > Scientific committees > Committee on Toxicity (COT) > COT statements > COT statements 2004 > COT statement On Tryptophan And The Eosinophilia-Myalgia Syndrome |
|
http://www.food.gov.uk/science/ouradvisors/toxicity/statements/cotstatements2004branch/cotstatements2004tryptophan
(88 words)
|
|
| |
| | International Notes Eosinophilia-Myalgia Syndrome -- Canada |
| | As of May 14, 1990, 10 confirmed cases of eosinophilia-myalgia syndrome (EMS) in Canada have been reported to the Laboratory Centre for Disease Control (LCDC), and other possible cases are under investigation. | | | All 10 cases have been linked to use of L-tryptophan (LT)-containing pills. |
|
http://www.cdc.gov/mmwr/preview/mmwrhtml/00001622.htm
(385 words)
|
|
| |
| | EOSINOPHILIA-MYALGIA SYNDROME WAS CAUSED BY CONTAMINATED TRYPTOPHAN - Journal Watch (General) |
| | It may well be that genetic or other environmental factors were also necessary for EMS to develop. | | | Ever since tryptophan tablets were linked to the outbreak of eosinophilia-myalgia syndrome (EMS) in 1989-90, many observers have assumed that the manufacturing process must have introduced a contaminant. | | | Belongia EA et al An investigation of the cause of the eosinophilia- myalgia syndrome associated with tryptophan use N Engl J Med 1990 Aug 9; 323:357-365. |
|
http://general-medicine.jwatch.org/cgi/content/full/1990/817/1
(229 words)
|
|
|
