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| | Brain Scans Detect Earliest Stages Of Alzheimer's Disease |
 | | In the new study, Dr. de Leon and co-workers developed a new method of measuring the size of the entorhinal cortex based on structural landmarks (called gyri and sulci) which are visible on MRI. | | | In a new study published in the Jan. 2 issue of the journal Lancet, Dr. de Leon and co-workers report that they have measured the anatomical changes in a key memory center of the brain called the entorhinal cortex. | | | In the second part, the researchers used the landmark technique to distinguish patients with very mild Alzheimer's from healthy volunteers. |
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http://www.eurekalert.org/pub_releases/1999-01/NYUM-BSDE-010199.php
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| | Cogprints - Response Dynamics of Entorhinal Cortex in Awake, Anesthetized, and Bulbotomized Rats. <i>Brain ... |
| | [9]Chrobak, J.J. and G. Buzsaki, Gamma oscillations in the entorhinal cortex of the freely behaving rat, Journal of Neuroscience. | | | Pharmacological manipulations as well as surgical disconnection of the olfactory bulb serve to quell the background excitatory input incident to entorhinal cortex, resulting in evoked responses without characteristic oscillations and showing no signs of polysynaptic feedback. | | | Cogprints - Response Dynamics of Entorhinal Cortex in Awake, Anesthetized, and Bulbotomized Rats. |
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http://cogprints.org/1676
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| | APStracts 10:0117J, 2003. |
| | To investigate the potential associative function of the perirhinal cortex with respect to sensory and motivational stimuli and the influence of the association on the perirhinal/entorhinal/hippocampal neurocircuit, we prepared rat brain slices including the perirhinal cortex, entorhinal cortex, hippocampal formation, and amygdala. | | | The perirhinal cortex also interconnects with the amygdala, which plays an important role in various motivational and emotional behaviors. | | | The neural pathway from the perirhinal cortex to the entorhinal cortex is considered one of the main paths into the entorhinal-hippocampal network, which has a crucial role in memory processes. |
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http://www.uth.tmc.edu/apstracts/2003/jn/May/117j.html
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| | Distribution of calretinin-immunoreactivity in the rat entorhinal cortex: coexistence with GABA |
| | Distribution of calretinin-immunoreactivity in the rat entorhinal cortex: coexistence with GABA | | | The distribution patterns of calretinin-immunoreactivity in the entorhinal cortex is consistent with the partitioning of the rat entorhinal cortex into six subfields. | | | We characterized the inhibitory circuits in the rat entorhinal cortex by analyzing the distribution of calretinin-immunoreactivity and its colocalization with glutamate decarboxylase (GAD) and gamma-aminobutyric acid (GABA). |
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http://www.uku.fi/neuro/ab9768.htm
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| | Institut des Sciences Cognitives |
| | Anatomically, the critical zone is the media temporal lobe, a set of interconnected structures (amygdala, hippocampus, entorhinal cortex) located in the medial part of cerebral hemispheres. | | | Yet, emotions rely on a neural organization similar to that of other cognitive functions. | | | Amygdala lesions impair expression of emotions : aggressivity and fear reactions are reduced, whereas submissive behavior is increased with respect to normal. |
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http://www.isc.cnrs.fr/preslabo7en.htm
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| | MRI measures of entorhinal cortex vs hippocampus in preclinical AD. |
| | CONCLUSION: These findings are consistent with neuropathologic data showing substantial involvement of the entorhinal cortex in the preclinical phase of AD and suggest that, as the disease spreads, atrophic change develops within the hippocampus, which is measurable on MRI. | | | Hippocampal head size associated with verbal memory performance in nondemented elderly. | | | Comparative aspects of the olfactory portion of the entorhinal cortex and its projection to the hippocampus in rodents, nonhuman primates, and the human brain. |
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http://www.accelerated-learning-online.com/research/mri-measures-entorhinal-cortex-vs-hippocampus-preclinical-ad.asp
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| | Ramirez - Senior Theses |
| | GM1-Enhanced Recovery from Bilateral Entorhinal Cortex Lesions in Rats | | | The Effects of Ganglioside Administration on Behavioral Recovery after Unilateral Entorhinal Cortex Lesions | | | The Contribution of Septodentate Sprouting to the Recovery of Alternation Performance after Unilateral Entorhinal Cortex Lesions |
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http://www.davidson.edu/academic/psychology/Ramirezsite/RamirezTheses.htm
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| | Entorhinal cortex - Wikipedia, the free encyclopedia |
| | In the eyeblink reflex, the association of impulses from the eye and the ear occurs in the entorhinal cortex. | | | The entorhinal cortex (EC) is an important memory center in the brain. | | | EC as a whole, therefore, receives highly processed input from every sensory modality, as well as input relating to ongoing cognitive processes, though it should be stressed that, within EC, this information remains at least partially segregated. |
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http://en.wikipedia.org/wiki/Entorhinal_cortex
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| | Hyaluronan-associated adhesive cues control fiber segregation in the hippocampus -- Förster et al. 128 (15): 3029 ... |
| | Miller, B., Sheppard, A. M., Bicknese, A. and Pearlman, A. Chondroitin sulfate proteoglycans in the developing cerebral cortex: The distribution of neurocan distinguishes forming afferent and efferent axonal pathways. | | | of entorhinal fiber growth but did not affect the pathfinding | | | Effect of hyaluronidase treatment on the lamina-specific growth of entorhinal fibers in entorhino-hippocampal cocultures. |
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http://dev.biologists.org/cgi/content/full/128/15/3029
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| | entorhinal cortex from On-line Medical Dictionary |
| | The cytoarchitecturally well-defined area of multilaminate cerebral cortex on the medial aspect of the parahippocampal gyrus, immediately caudal to the olfactory cortex of the uncus. | | | The entorhinal cortex is the origin of the major neural fibre system afferent to the hippocampus, the so-called perforant pathway. | | | Previous: entoprocta, entoptic, entoptic pulse, entoretina, entorganism, entorhinal area |
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http://cancerweb.ncl.ac.uk/cgi-bin/omd?query=entorhinal+cortex
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| | Directory of open access journals |
| | Pre- or post-training entorhinal cortex lesions caused an impairment of performance in the shuttle avoidance task, which agrees with the previously described role of this area in the processing of memories acquired in successive sessions. | | | Lesions of the entorhinal cortex produce retrograde memory impairment in both animals and humans. | | | Here we report the effects of bilateral entorhinal cortex lesions caused by the stereotaxic infusion of N-methyl-D-aspartate (NMDA) in rats at two different moments, before or after the training session, on memory of different tasks: two-way shuttle avoidance, inhibitory avoidance and habituation to an open field. |
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http://www.doaj.org/abstract?id=24165&toc=y
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| | Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in ... |
| | Whereas it is not possible in the present study to assess how functional such neurons with altered physiology might be, it is nonetheless likely that these transitional neurons open new options for potential therapeutic interventions aimed at protecting neurons vulnerable to neurofibrillary degeneration. | | | The entorhinal cortex and hippocampus are the first cortical regions to be affected by the degenerative cellular process that leads to Alzheimer disease (AD) and display a limited degree of neuronal alterations in normal aging. | | | Several quantitative studies have reported a substantial loss of neurons in these regions and a parallel increase in the number of neurofibrillary tangles (NFTs). |
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http://www.arclab.org/medlineupdates/abstract_12528818.html
(328 words)
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| | [No title] |
| | Dickson C.T., and Vanderwolf C.H. (1990) Behavioral models of human amnesia and dementia: Hippocampal and amygdala ablation compared with serotonergic and cholinergic blockade in the rat. | | | Dickson C.T., Trepel C. and Bland B.H. (1994) Extrinsic modulation of theta field activity in the entorhinal cortex of the anesthetized rat. | | | (2000) Oscillatory activity in entorhinal neurons and circuits: Mechanisms and function. |
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http://www.psych.ualberta.ca/~cdickson/Selectedpub.htm
(227 words)
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| | Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations |
| | Autoradiographic study of the efferent connections of the entorhinal cortex in the rat | | | Energy Citations Database (ECD) Document #5441407 - Autoradiographic study of the efferent connections of the entorhinal cortex in the rat | | | Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link. |
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http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=5441407
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| | BioMed Central Abstract Evidence for proteolytic cleavage of brevican by the ADAMTSs in the dentate gyrus after ... |
| | Neural plasticity may occur more readily when these ECM complexes are broken down by endogenous proteases, the ADAMTSs (adisintegrin and metalloproteinase with thrombospondin motifs), that selectively cleave the lecticans. | | | The purpose of these experiments was to determine whether the production of brevican or the ADAMTS-cleaved fragments of brevican were altered after deafferentation and reinnervation of the dentate gyrus via entorhinal cortex lesion (ECL). | | | In the C57Bl6J mouse, synaptic density in the molecular layer of the dentate gyrus, as measured by synaptophysin levels in ELISA, was significantly attenuated 2 days (nearly 50% of contralateral) and 7 days after lesion and returned to levels not different from the contralateral region at 30 days. |
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http://www.biomedcentral.com/1471-2202/6/52/abstract
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| | Quantitative MRI of the entorhinal cortex in temporal lobe epilepsy |
| | The entorhinal cortex (Brodmann's area 28) is located at the anterior aspect of the parahippocampal gyrus ventral to the amygdala and the hippocampus. | | | In 11 of 36 patients, however, the entorhinal cortex volume was reduced by 25%. | | | The mean volumes of the entorhinal cortex on the focal side did not differ from controls. |
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http://www.uku.fi/neuro/ab0016.htm
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| | NDL - Response Dynamics in the Entorhinal Cortex |
| | We apply our dynamical-systems and engineering toolboxes to excitatory cells in the superficial medial entorhinal cortex (MEC). | | | Burton BG and White JA (2003) The role of cellular memory in the function of stellate cells in the rat entorhinal cortex. | | | Using a statistical approach, we are currently investigating to what extent this memory can affect the output patterns of the cell in response to simple modulated input. |
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http://www.bu.edu/ndl/ent.html
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| | From healthy aging to early Alzheimer's disease: in vivo detection of entorhinal cortex atrophy. |
| | From healthy aging to early Alzheimer's disease: in vivo detection of entorhinal cortex atrophy. | | | In an attempt to determine the earliest sites of involvement in mild and incipient Alzheimer's disease (AD), we compared entorhinal and hippocampal volume in (1) healthy elderly controls, (2) patients with very mild AD, and (3) elderly patients who were evaluated for cognitive complaints, but did not meet criteria for dementia. | | | The left EC was found to be smaller than the right in both young and healthy aged subjects. |
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http://www.arclab.org/medlineupdates/abstract_10911878.html
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| | Mark Stewart |
| | The entorhinal cortex is nearest the neocortex in its structure and the subiculum is nearest the structure of Ammon's horn. | | | We are investigating the mechanisms by which individual regions initiate seizure activity and the mechanisms by which such activity invades neighboring regions. | | | The capabilities of the other hippocampal and retrohippocampal regions are much more limited, but the inter-regional connectivity provides multiple access points for events generated in entorhinal cortex. |
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http://www.downstate.edu/pharmacology/stewart.htm
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| | Layton Center: Neuroimaging: Entorhinal Cortex Analysis |
| | Our results suggest that the entorhinal cortex volume has greater variability (see graph below) than the hippocampal body volume and therefore is not as powerful for detecting dementia as the hippocampus. | | | Our tracing method measures the bilateral entorhinal cortex volumes using standard T2 images and atlas-based boundaries. | | | The entorhinal cortex, shown below in red, is the layer of grey matter tissue on a specific subregion of the parahippocampal gyrus of the temporal lobe. |
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http://www.ohsu.edu/alzheimers/vol_entorhinal.htm
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| | Preserved number of entorhinal cortex layer II neurons in aged macaque monkeys. |
| | These results suggest that the circuit-specific decrease in N-methyl-D-aspartate receptor subunit 1 reported previously occurs in the absence of structural compromise of the perforant path, and thus may be linked to an age-related change in the physiological properties of this circuit. | | | Accordingly, disturbances in this circuit may contribute to age-related cognitive deficits. | | | The perforant path, which consists of the projection from the layer II neurons of the entorhinal cortex to the outer molecular layer of the dentate gyrus, is a critical circuit involved in learning and memory formation. |
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http://www.arclab.org/medlineupdates/abstract_9390783.html
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| | Dementia Tumor |
| | The entorhinal cortex was the only region explored that at baseline had lower metabolism in the subjects who declined. | | | Baseline PET in 12 subjects with MCI who in a follow up of 3 years developed progressive cognitive impairment (declining), compared to 13 subjects of similar age who did not | | | Illustration of the location of the entorhinal region from Killiany R et al. |
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http://www.unav.es/neurologia/WFNni/dementia_entor_pet.htm
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| | New Study Supports Use Of PET Scans In Early Diagnosis Of Alzheimer's Disease |
| | A study appearing in the March issue of The Journal of Nuclear Medicine identifies a new PET technique that may increase the already high accuracy of PET in diagnosing AD at a very early stage. | | | Researchers reported that AD-related processes leading to altered brain connections between the entorhinal cortex (EC) and both hemispheres of the brain can be clearly identified with 18F-FDG PET. | | | The EC is a small area located deep in the brain that plays a central role in memory functions, and is an early site for neuronal damage resulting in memory impairment in AD. |
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http://www.sciencedaily.com/releases/2004/03/040312085134.htm
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| | Graded persistent activity in entorhinal cortex neurons : Nature |
| | The entorhinal cortex in the parahippocampal region is crucially involved in the acquisition, consolidation and retrieval of long-term memory traces for which working memory operations are essential | | | Graded persistent activity in entorhinal cortex neurons : Nature | | | The most widely accepted hypothesis is that persistent activity is based on synaptic reverberations in recurrent circuits. |
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http://dx.doi.org/10.1038/nature01171
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| | Table of contents : Nature |
| | The entorhinal cortex, where neurons fire repeatedly when an animal's position coincides with the vertices of a grid of triangles, looks like a good bet. | | | Microstructure of a spatial map in the entorhinal cortex p801 |
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http://www.nature.com/nature/journal/v436/n7052/index.html
(1259 words)
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| | Escape Pod |
| | Emotion could screw up the reading, her own pheromones and toxins clogging up the massive olfactory bulb and entorhinal cortex that occupied most of her cranium. | | | She took a deep breath, pulling air through her huge nostrils, trying to calm herself. | | | Shari struggled to keep her own distaste under control. |
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http://www.escapepod.info
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| | Electrical activity of caudal neurosecretory neurons in seawater- and freshwater-adapted flounder: responses to ... |
| | Cazalis, M., Dayanithi, G. and Nordmann, J. The role of patterned burst and interburst interval on the excitation-coupling mechanism in the isolated rat neural lobe. | | | Larson, B. A., Bern, H. A., Lin, R. and Nishioka, R. A double sequential immunofluorescence method demonstrating the co-localisation of urotensins I and II in the caudal neurosecretory system of the teleost, Gillichthys mirabilis. | | | Klink, R. and Alonso, A. Muscarinic modulation of the oscillatory and repetitive firing properties of entorhinal cortex layer II neurons. |
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http://jeb.biologists.org/cgi/content/full/206/22/4011
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| | Upregulated Expression of Neurocan, a Nervous Tissue Specific Proteoglycan, in Transient Retinal Ischemia -- Inatani et ... |
| | McKeon, RJ, Jurynec, MJ, Buck, CR (1999) The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar J Neurosci 19,10778-10788 | | | Haas, CA, Rauch, U, Thon, N, Merten, T, Deller, T. (1999) Entorhinal cortex lesion in adult rats induces the expression of the neuronal chondroitin sulfate proteoglycan neurocan in reactive astrocytes J Neurosci 19,9953-9963 |
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http://www.iovs.org/cgi/content/full/41/9/2748
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