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| | UI study suggests genetics and gender affect human response to endotoxin |
 | | The study is the first to examine endotoxin response in nonsmoking, nonasthmatic and nonallergic individuals whose jobs do not put them in contact with the contaminant. | | | Overall, the research adds to the "growing acceptance" that endotoxin is an important component of environmental influences on asthma and other airway obstructions, he said. | | | Previous research, including studies led by David A. Schwartz, M.D., UI professor of internal medicine and a senior author for the current study, showed that the inhalation of dust containing endotoxin can cause problems for individuals with asthma or other lung conditions. |
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http://www.eurekalert.org/pub_releases/1999-09/UoI-Ussg-010999.php
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| | Ambient Endotoxin Concentrations in PM10 from Southern California |
| | Furthermore, although the health effects of indoor exposure to low-levels of endotoxin have been investigated, further research is needed to determine what role endotoxin in outdoor air plays in respiratory conditions, both alone and in combination with other pollutants. | | | Endotoxin in house dust is associated with asthma but not allergy [Abstract]. | | | This may not reflect indoor airborne endotoxin concentrations but provides a useful means for classification of subjects by endotoxin exposure in studies of childhood asthma. |
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http://www.ehponline.org/members/2004/6552/6552.html
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| | ScienceDaily: Bacteria In Household Dust May Trigger Asthma Symptoms |
| | A disease association analysis was performed to correlate endotoxin concentrations to specific health outcomes. | | | "This suggests that exposure to endotoxin increases asthma risk even in non-allergic individuals." | | | Knowing what triggers asthma, whether it is endotoxins or something else, may help a physician better prevent or treat symptoms. |
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http://www.sciencedaily.com/releases/2005/09/050907095650.htm
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| | Bacterial Endotoxins |
| | Most of our knowledge of the biological activities of endotoxins derives not from the study of natural disease but by challenge of experimental animals. | | | The physiological effects of endotoxin are thought to be mediated by Lipid A. | | | The biological activity of endotoxin is associated with the lipopolysaccharide (LPS). |
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http://www.bact.wisc.edu/Bact330/lectureendo.1
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| | Endotoxin-Like Reactions Associated with Intravenous Gentamicin -- California, 1998 |
| | The cardiovascular response of normal humans to the administration of endotoxin. | | | Endotoxin levels responsible for clinical reactions have been reported previously for dialysate or medications (7-9). | | | Physicians using ODD gentamicin should be aware that a patient may receive a level of endotoxin two to three times higher than that of TD gentamicin. |
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http://www.cdc.gov/mmwr/preview/mmwrhtml/00055322.htm
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| | Annual Report for Fiscal Year 1997 - DERT |
| | These findings prompted Dr. Schwartz to investigate the role of susceptibility to LPS as an important mechanism to understanding its pulmonary consequences. | | | There is evidence by others that endotoxin exposure may also cause asthma. | | | The systematic approach that has been developed by these investigators provides a template for the development and validation of other chemical specific biomarkers and their application to cancer or other chronic diseases. |
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http://www.niehs.nih.gov/dert/annrpt.htm
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| | Endotoxin Sampling Guide |
| | Sterile surgical gloves should be worn for all samples. | | | These must be specially treated to remove all endotoxins. | | | Since endotoxin levels may be significant in outside air, the latter may not be suitable for background levels, especially in environments known to have high levels of gram-negative bacteria (see above, 1 |
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http://www.emsltesting.com/endotoxin_sampling_guide.html
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| | Endotoxin Detection Products |
| | The LAL assay is the most sensitive and specific means available to screen human drugs, biologics, animal drugs, medical devices and raw materials for the presence of harmful levels of endotoxin. | | | KTA is a test for quantitative endotoxin values when measured with a multi-tube or microplate reader adapted with endotoxin measuring software. | | | Our optimized formulations provide increased sensitivity, greater linearity and superior interference-resistance qualities for our pharmaceutical and medical device customers. |
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http://www.advpr.com/products/micro/supplies/en0001_endotoxin_01.html
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| | Endotoxin - Wikipedia, the free encyclopedia |
| | In pharmaceutical production, it is necessary to remove all traces of endotoxin from drug product containers, as even small amounts of endotoxin will cause illness in humans (but not disease). | | | Studies of endotoxin over the next 50 years revealed that the actual molecule responsible for the effects of "endotoxin" was in fact lipopolysaccharide. | | | Humans are able to produce antibodies to endotoxins after exposure, but these are generally directed at the polysaccharide chain, and do not protect against a wide variety of endotoxins. |
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http://en.wikipedia.org/wiki/Endotoxin
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| | Frequently asked questions: Medical gloves and Endotoxin Testing. |
| | Therefore, even if a medical device has been sterilised, residual endotoxins may still be found on the device. | | | Endotoxins are toxic to most mammals, and produce the same range of biological effects in the animal host. | | | At present, there are no requirements in the UK or Europe for endotoxin levels on Natural Rubber Latex (NRL) medical gloves. |
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http://www.smtl.co.uk/MDRC/Gloves/Endotoxin-FAQ.html
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| | ESKIA EndoCAb Endotoxin-Core Antibody Home Page |
| | A number of studies in which we participated have confirmed abnormal levels and perturbations of normal levels of EndoCAb in a variety of clinical conditions, and have indicated a role for the EndoCAb assay in diagnosis, especially in predicting "at risk" clinical groups or cases. | | | We developed a relevant assay for endotoxin core antibody (EndoCAb), and showed that these antibodies are commonly present and readily detectable in plasma from healthy individuals, and established normal ranges for IgG, IgM and IgA classes of EndoCAb. | | | Use of MAbs in a lab study (LAL inhibition) to distinguish circulating endotoxin from clinical bacterial isolate |
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http://freespace.virgin.net/r.barclay
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| | endotoxin - Hutchinson encyclopedia article about endotoxin |
| | Endotoxins are typically produced by the Gram negative bacteria and can cause fever. | | | In biology, heat stable complex of protein and lipopolysaccharide that is produced following the death of certain bacteria. | | | They can also cause shock by rendering the walls of the blood vessels permeable so that fluid leaks into the tissues and blood pressure falls sharply. |
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http://encyclopedia.farlex.com/endotoxin
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| | Pfam 19.0 : Endotoxin_N |
| | Once activated the endotoxin binds to the gut epithelium and causes cell lysis by the formation of cation-selective channels, which leads to death. | | | This activated region of the delta endotoxin is composed of three structural domains. | | | The activated toxin is composed of three distinct domains: an N-terminal helical bundle domain involved in membrane insertion and pore formation; a beta-sheet domain involved in receptor binding; and a C-terminal beta-sandwich domain that interacts with the N-terminal domain to form a channel PUBMED:7490762, PUBMED:11468393. |
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http://pfam.wustl.edu/cgi-bin/getdesc?name=Endotoxin_N
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| | Specialists in Endotoxin and Glucan Detection and Glycobiology Reagents Associates of Cape Cod, Inc. |
| | ACC was the first manufacturer licensed by the FDA to manufacture LAL for use as a quality control test for endotoxin in the pharmaceutical and medical device markets. | | | For over 30 years, Associates of Cape Cod, Inc. (ACC) has been a leading global supplier of analyte detection products, including Limulus Amebocyte Lysate (LAL) for the detection and quantification of bacterial endotoxins. | | | A Rapid Endotoxin Test Specially Designed for Water and Dialysate Testing |
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http://www.acciusa.com
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| | Endotoxin Testing - Biocompare Buyer's Guide |
| | Up to 5 samples per plate can be analyzed. | | | Home » Molecular Biology » Molecular Biology Services » Endotoxin Testing | | | Description: Pyrogen/Endotoxin Free Certification for devices or liquids Certifying your products pyrogen-free will... |
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http://www.biocompare.com/molbio.asp?catid=2982
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