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| | AIDS Fact Sheet: Efavirenz (Sustiva) |
 | | Efavirenz is a drug used for antiviral therapy. | | | To prove that the results are false, you would have to identify the drug that you are taking. | | | Your doctor will need to increase your dosage of indinavir, amprenavir, or atazanavir. |
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http://www.aids.org/factSheets/432-Efavirenz-Sustiva.html
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| | Efavirenz |
| | Efavirenz is a form of antiviral therapy for treating HIV-1. | | | For this reason it is imperative that the patients informs their doctor of all the drugs they are taking. | | | There have been reports of clinically significant drug interactions between efavirenz and indinavir and saquinanivr. |
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http://www.stanford.edu/group/virus/pox/2000/efavirenz.html
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| | Aidsmap Efavirenz - overview |
| | Efavirenz is equivalent to or more effective than protease inhibitors (PIs) when used in first-line therapy with two nucleoside analogue reverse transcriptase inhibitors (NRTIs). | | | Maintenance therapy with a two-drug combination of efavirenz and tenofovir (Viread) also promises to be an effective strategy in patients having achieved virologic suppression with an induction HAART regimen (Girard 2004). | | | There is evidence to suggest that efavirenz penetrates the cerebrospinal fluid (CSF) and that it may be effective against HIV in the brain. |
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http://www.aidsmap.com/en/docs/1AB59848-1DD6-4826-B54F-F29701248B35.asp
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| | Higher efavirenz concentrations determine the response to viruses carrying non-nucleoside reverse transcriptase ... |
| | After replacing nevirapine by efavirenz, a significant virological response was recorded in 20 (41.7%), 23 (48%) and 20 (41.7%) patients at weeks 12, 24 and 48, respectively (intent-to-treat analysis). | | | It should be pointed out that in our study there were no discontinuations of therapy as a result of efavirenz-related adverse effects, although two individuals complained of dizziness and one of vivid dreams plus insomnia. | | | In summary, therapeutic drug monitoring of nevirapine plasma concentrations at the time of the first viral rebound could help to identify those patients who may benefit from interventions focused on improving drug adherence or alternatively to attempt a rescue intervention based on efavirenz. |
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http://www.natap.org/2004/HIV/100604_12.htm
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| | Efavirenz - Drugs & Vitamins - Drug Library - DrugDigest |
| | Efavirenz is used in combination with other drugs to treat the HIV virus. | | | Efavirenz can interact with a large number of other drugs. | | | Make sure to discuss all of your medicines with your health care prescriber before starting efavirenz or any other new medicine. |
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http://www.drugdigest.org/DD/DVH/Uses/0,3915,756Efavirenz,00.html
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| | Sustiva (efavirenz) - Drug Summary |
| | Effect of Efavirenz on the Pharmacokinetics of the Lipid-lowering Statin Drugs Simvastatin, Atorvastatin and Pravastatin | | | A Genotypic Score for Efavirenz Hypersusceptibility Is Associated with Virologic Response to EFV + Indinavir +/- Abacavir in Nucleoside-experienced Patients | | | First-line Therapy with Efavirenz or Nevirapine is Effective in Patients with Advanced HIV Infection, and the Incidence of Rash in the Nevirapine Group Is Significantly Higher in Women with Higher CD4 Counts |
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http://www.hivandhepatitis.com/hiv_and_aids/sustiva1.html
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| | EFAVIRENZ |
| | During the first weeks of therapy with efavirenz, the most common side effects of efavirenz are | | | It is extremely important that you take efavirenz and your other antiretroviral medications exactly as directed. | | | The following medications should not be given together with efavirenz: |
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http://depts.washington.edu/actu/drugs/efavirenz.htm
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| | Managing Sustiva (efavirenz) Side Effects |
| | PK parameters (mean AUC, Cmin, and trough) of efavirenz are not affected by concomitant use of SSRIs in a retrospective review of patients in Study 006. | | | Educate the patient regarding why efavirenz was chosen so that he or she can understand and appreciate the need to continue therapy | | | Informing the patient of the nature and likelihood of side effects is likely to improve adherence and improve patient satisfaction with the antiretroviral regimen and enhance a trusting relationship with the healthcare provider. |
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http://www.hivandhepatitis.com/hiv_and_aids/sustivasideeffects1print.html
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| | Efavirenz Drug Information |
| | Some examples of medicines that affect the CNS are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; medicine for depression; medicine for anxiety; prescription pain medicine or narcotics; barbiturates; medicine for attention deficit and hyperactivity disorder; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. | | | Efavirenz will not keep you from spreading HIV to other people. | | | People who receive this medicine may continue to have some of the problems usually related to AIDS or HIV disease. |
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http://www.drugs.com/cons/Efavirenz.html
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| | Efavirenz & AZT/3TC Did Not Cause Limb Fat Loss in ACTG 364 |
| | I served as the original patient community representative on this study, when it was being organized. | | | This study provides evidence that the subsequent decreases in limb fat are related to use of particular antiretroviral drugs. | | | Objective: To determine if particular components of antiretroviral drug regimens are associated with greater insulin resistance, dyslipidemia, and peripheral lipoatrophy. |
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http://www.natap.org/2005/HIV/101905_01.htm
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| | Drug Interactions with Efavirenz |
| | There was a 16% increase in the AUC and no change in the Cmax of efavirenz. | | | There was no change in the AUC or Cmax of efavirenz. | | | The IC50 for nelfinavir was 2.5 µM. This suggests that there is the potential for clinical drug interactions. |
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http://www.hiv-druginteractions.org/drug/nnrt/efa_inter.htm
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| | MedlinePlus Drug Information: Efavirenz |
| | Efavirenz works by slowing the spread of HIV in the body. | | | Efavirenz does not prevent you from spreading HIV to other people. | | | Talk to your doctor about the possible risks of using this medication for your condition. |
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http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a699004.html
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| | The Body: AIDS Trestment NewsOctober 2, 1998 |
| | Efavirenz had already been available through a large expanded-access program (over 14,000 people worldwide), but only for patients who could not be treated effectively with approved drugs. | | | Because resistance can develop rapidly, it is especially important to avoid running out of medicines or otherwise interrupting treatment unnecessarily. | | | If a woman does become pregnant while taking the drug, she should notify her physician immediately. |
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http://www.thebody.com/atn/304.html
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| | EFAVIRENZ |
| | Efavirenz does not cure HIV nor does it prevent HIV transmission. | | | It is important that your physician or pharmacist knows about other drugs you are taking, even medications you can buy without a prescription. | | | Consult your doctor or pharmacist before taking any medications to treat the rash. |
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http://www.tthhivclinic.com/efavirenz.htm
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| | Nevirapine is better than efavirenz at raising ’good’ cholesterol |
| | Although the increase was higher with nevirapine, this does not prove that nevirapine is better at reducing the risk of heart disease and strokes, says Carr. | | | Two of the most commonly prescribed drugs for treating HIV (antiretroviral drugs)--nevirapine and efavirenz--can both raise levels of the "good type" of cholesterol (HDL cholesterol), but nevirapine raises it higher than efavirenz, according to a new study by van Leth and colleagues published in the launch issue of PLoS Medicine. | | | None of the patients had been on any antiretroviral drugs before. |
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http://www.innovations-report.com/html/reports/medicine_health/report-34993.html
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| | The Body Pro: Efavirenz (EFV, Sustiva, Stocrin) |
| | Lack of Clinically Relevant Drug-Drug Interactions Between Tenofovir DF and Efavirenz, Indinavir, Lamivudine and Lopinavir/Ritonavir in Healthy Subjects — October 29, 2001 | | | Quality of Life, Emotional Status, and Adherence of HIV-1-Infected Patients Treated With Efavirenz Versus Protease Inhibitor-Containing Regimens — April 15, 2002 | | | The so-called "COOL Study" examined this novel two-drug regimen in patients who had already achieved viral suppression on traditional, three-drug HAART. |
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http://www.thebodypro.com/treat/sustiva.html
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| | FDA APPROVES NEW DRUG TO TREAT HIV, AIDS |
| | During clinical trials, approximately 27 percent of patients treated with efavirenz experienced a skin rash, compared to 17 percent of patients in control groups. | | | Efavirenz should be discontinued in patients with these more severe symptoms. | | | Reports of delusions and severe acute depression have also occurred, predominantly in patients with a history of mental illness or substance abuse. |
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http://www.fda.gov/bbs/topics/NEWS/NEW00654.html
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| | Efavirenz [ HIV / AIDS Treatment Information ] |
| | Efavirenz [ HIV / AIDS Treatment Information ] | | | Where can I learn more about clinical trials that are using Sustiva? | | | View PDF View Tips & Tricks on Taking Sustiva (efavirenz) En español (in Spanish) |
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http://www.projectinform.org/fs/efavirenz.html
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| | Simple Facts Sheets: efavirenz (Sustiva) |
| | Other drugs in this class are nevirapine (Viramune) and delavirdine (Rescriptor). | | | Sustiva (also known as efavirenz) is a new anti-HIV drug in the class called non-nucleoside reverse transcriptase inhibitors (NNRTIs). |
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http://www.aegis.com/factshts/network/simple/efav.html
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| | The Hindu Business Line : Aurobindo Pharma gets US approval for Efavirenz |
| | Efavirenz is a key anti-retro viral (ARV) for AIDS therapy. | | | AUROBINDO Pharma Ltd on Sunday announced that it has received approval from the US Food and Drug Administration for Efavirenz tablets, 600 mg, which it claims is the first generic approval given to it ahead of the rest of the industry. | | | Efavirenz represents a significant opportunity in Africa for Aurobindo under the PEPFAR (the President's Emergency Plan for AIDS relief) programme. |
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http://www.thehindubusinessline.com/2005/07/04/stories/2005070401170500.htm
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| | Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine -- Richter et al. 308 (1): 189 -- ... |
| | Ward BA, Gorski JC, Jones DR, Hall SD, Flockhart DA, and Desta Z (2003) The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. | | | Hidestrand M, Osxarson M, Salamen JS, Nyman L, Pelkonen O, Turpeinen M, and Ingelman-Sundberg M (2001) CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes. | | | Hesse LM, von Moltke LL, Shader RI, and Greenblatt DJ (2001) Ritonavir, efavirenz and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion. |
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http://www.jpet.org/cgi/content/full/308/1/189
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| | AEGiS-RITA!: NRTI: EFAVIRENZ (Sustiva) - March 2000 |
| | A dose increase in lopinavir may be necessary for protease experienced patients but not for protease naïve patients when combining lopinavir with efavirenz. | | | Approval of efavirenz was based on 2 clinical trials in which the response was measured as time to treatment failure. | | | The Panel on Clinical Practices for the Treatment of HIV Infection classifies efavirenz as a "strongly recommended" NNRTI. |
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http://www.aegis.com/pubs/rita/2000/ri000313.html
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| | Gilead -- Gilead Provides Update on Development of Fixed-Dose Regimen of Truvada® (Emtricitabine and Tenofovir ... |
| | It is important that patients be aware that individual HIV medications must be taken as part of combination regimens, and that they do not cure HIV infection or prevent passing HIV to others. | | | (efavirenz) for the treatment of HIV did not demonstrate bioequivalence to the individual products dosed separately. | | | Guidelines issued by the U.S. Department of Health and Human Services (DHHS) list the combination of emtricitabine, tenofovir disoproxil fumarate and efavirenz as one of the preferred non-nucleoside reverse transcriptase inhibitor (NNRTI)-based treatments for use in appropriate patients that have never taken anti-HIV medicines before. |
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http://www.gilead.com/wt/sec/pr_741632
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| | News - FTC-Tenofovir-Efavirenz Regimen Appears More Effective in Suppressing HIV Than AZT-3TC-Efavirenz: Presented at ... |
| | Efavirenz, the drug used in both regimens, is a non-nucleoside reverse transcriptase inhibitor. | | | Not only did the new regimen outperform the Combivir regimen in controlling HIV replication, Dr. Pozniak said it also proved to be associated with fewer adverse effects. | | | Doctors set out to show that once-daily treatment with tenofovir (Viread), emtricitabine (Coviracil, also known as FTC), and efavirenz (Sustiva) was equivalent to the combination of Combivir (the combination of zidovudine and lamivudine) and Sustiva. |
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http://www.docguide.com/news/content.nsf/news/8525697700573E188525704C005CF88F
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| | Efavirenz. |
| | Clinically significant drug interactions have been reported with efavirenz and indinavir and saquinavir. | | | Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) which shows good inhibitory activity against HIV-1. | | | In vitro and in vivo data suggest that the resistance profile of efavirenz overlaps with that of the NNRTIs nevirapine and delavirdine. |
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http://www.aegis.com/aidsline/1999/may/a9950136.html
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| | Sustiva Indications, Dosage, Storage, Stability - Efavirenz - RxList Monographs |
| | SUSTIVA (efavirenz) in combination with other antiretroviral agents is indicated for the treatment of HIV-1 infection. | | | Dosing at bedtime may improve the tolerability of nervous system symptoms (see WARNINGS: Nervous System Symptoms,PRECAUTIONS: Information for Patients, and ADVERSE REACTIONS). | | | ACTG 364 is a randomized, double-blind, placebo-controlled, 48-week study in NRTI-experienced patients who had completed two prior ACTG studies. |
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http://www.rxlist.com/cgi/generic/efaviren_ids.htm
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| | Sustiva Online, Description, Chemistry, Ingredients - Efavirenz - RxList Monographs |
| | Efavirenz (EFV) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1). | | | (efavirenz) is a human immunodeficiency virus type 1 (HIV-1) specific, non-nucleoside, reverse tran-scriptase inhibitor (NNRTI). | | | EFV activity is mediated predominantly by noncompetitive inhibition of HIV-1 reverse tran-scriptase (RT). |
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http://www.rxlist.com/cgi/generic/efaviren.htm
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| | Low-level resistance and minority populations |
| | This study randomised 212 NNRTI-naïve and 269 NNRTI-experienced patients to efavirenz, abacavir, adefovir and amprenavir plus either a second PI or placebo. | | | Minor resistant variants were sought using single genome PCR and sequencing in a subgroup of patients who were failing treatment without evidence of resistance, and variants encoding NNRTI resistance were identified by single genome sequencing in 6/10 NNRTI-experienced and in 1/8 NNRTI-naive patients. | | | A second assay used to measure the frequency of efavirenz resistance (yeast-based chimeric Ty1/HIV-RT assay) detected efavirenz resistance in 8/10 (range of frequencies 10.9% - 0.8%) and 2/8 (0.6% and 0.3%). |
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http://www.i-base.org.uk/pub/htb/v4/htb4-7/Low.html
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| | Aurobindo gets USFDA approval for Efavirenz- The Economic Times |
| | This antiretroviral drug is used in combination with other antiretroviral agents for the treatment of HIV-1 infection. | | | Efavirenz is in the class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs), which helps keep the AIDS virus from reproducing in cells. | | | MUMBAI: Aurobindo Pharma Ltd has received tentative approval from the USFDA for Efavirenz tablets, an anti retro viral (ARV) drug used for the treatment of HIV-1 infection. |
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http://economictimes.indiatimes.com/articleshow/1152694.cms
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| | Merck & Co., Inc. Grants License for HIV/AIDS Drug Efavirenz to South African Company, Thembalami Pharmaceuticals, in ... |
| | Efavirenz is a non-nucleoside reverse transcriptase inhibitor used in combination therapy for the treatment of HIV infection, sold by MSD under the trademark STOCRIN®. | | | With the support of MSD's product supply partner, Bristol-Myers Squibb, Merck is offering Thembalami a royalty-free license to help further the goal of improving access to HIV/AIDS care and treatment for the people of Southern Africa, consistent with Merck's non-profit pricing of STOCRIN for South Africa and the SADC region. | | | The leading source of corporate responsibility and sustainability, press releases, reports and news. |
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http://www.csrwire.com/article.cgi/2882.html
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| | Men's Sexual Health |
| | In a recent study, Dr. Shafer followed newly diagnosed patients taking their first HIV drugs. | | | Results show a combination of AZT, Lamivudine and Efavirenz -- or EFV -- controlled the virus longer with fewer side effects. |
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http://www.menssexhealth.com/ms/news/8009834/main.html
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| | [Ip-health] Reuters: Merck Grants South Africa License for Generic Efavirenz |
| | Efavirenz, licensed to Merck by developer BristolMeyersSquibb in Europe, Middle East and Africa, was named by U.S. researchers in December as one part of the "best" regimen of antiretroviral drugs along with GlaxoSmithKline's AZT and lamivudine. | | | Under terms of a preliminary offer, Thembalami Pharmaceuticals Ltd, a joint venture between Adcock Ingram and India's Ranbaxy Laboratories, will provide generic efavirenz in the Southern African Development Community, which includes some of the countries worst hit by the worldwide AIDS epidemic. | | | http://www.hivandhepatitis.com/recent/developing/040904e.html Merck Grants South Africa License for Generic Efavirenz Andrew Quinn, Reuters 04/09/04 US drug maker Merck and Co Inc. plans to license a South African firm to make and sell a generic version of efavirenz (Sustiva), a key antiretroviral AIDS drug, the company said on Wednesday. |
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http://lists.essential.org/pipermail/ip-health/2004-April/006248.html
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| | EFAVIRENZ a Commonly Used Medication |
| | gross abnormalities reported in monkeys, such as anencephaly, anopthalmia, cleft palate, receiving standard doses of efavirenz; until further information is available, it would be best not to use in women of child-bearing potential, and it should not be used in pregnant women or women trying to become pregnant* |
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http://www.hivdent.org/drugs/EFAVIRENZ.htm
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| | Efavirenz (Sustiva) Approved by the FDA - Information on Sustiva |
| | If you have further questions about Sustiva or any other subject you can contact NATAP and me through the email at top of front page on web site or by calling 212 219-0106 or 888-26-NATAP. | | | As you may know the FDA approved Sustiva last week. | | | Efavirenz (Sustiva) Approved by the FDA - Information on Sustiva |
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http://www.natap.org/1998/sustiva.html
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