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| | Bullous disorders due to hereditary or acquired desmosome or hemidesmosome impairment. A short survey |
 | | In the current literature our readers frequently encounter information on desmosome and hemidesmosome components, which are mentioned as the main targets or pathogenetic factors in bullous skin disorders. | | | The authors believe that clinicians should be familiar with the newest development in basic sciences concerning the pathogenetic role of desmosome and hemidesmosome. | | | Bullous skin disorders especially pemphigus and bullous pemphigoid presented unsurpassed therapeutic problems to dermatologists until the late fifties, when corticosteroids were introduced. |
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http://www.mf.uni-lj.si/acta-apa/acta-apa-01-2/1-2-01.html
(2336 words)
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| | DSP - desmoplakin |
| | The relationship between the location of PF antigen and other constitutive desmosomal proteins, desmocollin, desmoplakin and plakoglobin, in normal human skin was investigated using a double immunogold labelling technique. | | | These experiments suggested that the DP carboxyl-terminal domain is involved either directly or indirectly in linking IF with the desmosome. | | | This enhanced serine phosphorylation coincided with the increase in the protein solubility, suggesting that phosphorylation of desmoplakin may be a mechanism by which PKC mediates desmosome disassembly. |
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http://www.ihop-net.org/UniPub/iHOP/gi/87813.html
(3746 words)
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| | PNN - pinin, desmosome associated protein |
| | The objective of the present study is to evaluate the effects of peripheral parenteral nutrition (PNN) in a homogeneous group of patients who had not had surgery, and to determine whether the deterioration of the nutritional state can be avoided while keeping the advantages of the administration of a peripheral route. | | | These synonyms are used for gene PNN (pinin, desmosome associated protein): DRS, pinin, SDK3. |
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http://www.ihop-net.org/UniPub/iHOP/gi/91148.html
(455 words)
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| | pop up template parts |
| | which is a rather painful condition characterized by the formation of large blisters on the skin, is caused by a breakdown of desmosomal structures. | | | This may account for their ability to metastasize. | | | This is the only type of junction seen in the stratified squamous epithelium of the skin. |
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http://fig.cox.miami.edu/~cmallery/150/frames/thumbs/junc/desmosome.content2.html
(213 words)
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| | Definition of lipitor,leukemia,sense,allotrope,secondary structure,desmosome,bacterium,kinetic energy,vocal ... |
| | Medical term desmosome Define desmosome Meaning of desmosome What does desmosome mean? | | | Explanation of lipitor, leukemia, sense, allotrope, secondary structure, desmosome, bacterium, kinetic energy, vocal cord, exoskeleton | | | Definitions of lipitor, leukemia, sense, allotrope, secondary structure, desmosome, bacterium, kinetic energy, vocal cord, exoskeleton |
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http://www.english-test.net/pcat/vocabulary/words/118/pcat-definitions.php
(1070 words)
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| | Desmosome - Wikipedia, the free encyclopedia |
| | These patients are often be found to have antibodies that bind to the desmosomal cadherins and disrupt the desmosomes. | | | If the desmosomes connecting adjacent epithelial cells of the skin are not functioning correctly, layers of the skin can pull apart and allow abnormal movements of fluid within the skin, resulting in blisters and other tissue damage. | | | Blistering diseases such as Pemphigus Vulgaris can be due to genetic defects in desmosomal proteins or due to an autoimmune response. |
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http://en.wikipedia.org/wiki/Desmosome
(274 words)
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| | [No title] |
| | the desmosome is a very extraordinarily complex structure, and they exist between all epithelial cells - not just in the skin. | | | first is the desmosome, the intercellular bridges you can see on light microscopy. | | | these are strange words, but when you get into clinics, you will see dz where animals are making auto-Ab against parts of the desmosome, so you need to know this. |
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http://www.hillary.net/school/fall.97/syspath/syspath.lec.10.16.97
(2025 words)
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| | ASCO - Abstracts - PubMed Abstract View |
| | Although the effects of some of these mutant genes have been analysed by targeted disruption experiments in mouse models, little is known about the cell and tissue changes in affected human patients. | | | These changes were more advanced in skin from patients with Dp mutations. | | | METHODS: We analysed palm and nonpalm skin sections from four SPPK patients with Dp mutations and one patient with a Dsg1 mutation with respect to tissue and subcellular morphologies, and correlated the in vivo and in vitro findings. |
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http://www.asco.org/ac/1,1003,_12-002865-00_18-0015149499,00.asp?SearchNames=
(563 words)
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| | Abstract |
| | Over the last eight years, several naturally occurring human gene mutations in structural components of desmosomes, cell-cell adhesion junctions found in skin, heart and meninges, have been reported. | | | Of note, as well as compromising tissue integrity, many of the resulting phenotypes have been associated with visible changes in hair. | | | Collectively, the data demonstrate the surprising effects inherited desmosome gene/protein pathology may have on hair growth and development. |
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http://www.kjm.keio.ac.jp/past/54/2/72.html
(152 words)
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| | Anchoring Junctions |
| | There are a number of variant forms of classical desmosomes. | | | Additionally, in tissues such as intestinal epithelium, desmosomes are seen that form adhering bands rather than spots. | | | For instance, hemidesmosomes are seen in a number of tissues where cells interact with basal laminae and in cultured cells where they anchor the cell to the culture dish. |
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http://arbl.cvmbs.colostate.edu/hbooks/cmb/cells/pmemb/ajunctions.html
(206 words)
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| | Regulation of desmosome assembly in MDCK epithelial cells: coordination of membrane core and cytoplasmic plaque domain ... |
| | Results show distinct differences in the sedimentation profiles of these proteins, suggesting that they are not associated in the Triton X-100-soluble pool of proteins; this was also supported by the observation that DGI and DPI/II could not be coimmunoprecipitated in a complex with each other from sucrose gradient fractions. | | | Furthermore, DPI/II and DGI were found to be associated with different elements of cytoskeleton; DPI/II were located along cytokeratin intermediate filaments, whereas DGI appeared to be associated with microtubules. | | | The regulatory role of cytoskeletal elements in the intracellular organization and assembly of the cytoplasmic plaque and membrane core domains, and their integration into desmosomes on the plasma membrane is discussed. |
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http://www.pdg.cnb.uam.es/UniPub/iHOP/gp/6904154.html
(273 words)
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| | Stephen P. Sugrue, Ph.D. |
| | This phosphoprotein of 150 kDa, which we call 08L, is localized to the periphery of desmosomes. | | | Functional studies of the 08L protein, which will initially be carried out in transient expression systems, will allow us to study the assembly of 08L to the desmosome and resolve the relationship of 08L with other adhesion related molecules, including cadherins, desmogleins, and integrins. | | | Our working hypothesis is that 08L is not integral to the desmosome structure but may be a regulatory protein involved in assembly of the intermediate filament-desmosome complex. |
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http://www.med.ufl.edu/anatomy/sugrue.html
(877 words)
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| | Animal Parasitology |
| | A thin layer of host cell cytoplasm envelops the parasite, which may be derived from fused microvilli. | | | Developmental stages occur between the microvilli and are attached to epithelial cells. | | | During penetration of host cells by sporozoites or merozoites, an electron-dense layer forms at the point of attachment and is morphologically reminiscent of a desmosome. |
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http://www.ksu.edu/parasitology/625tutorials/Crypto02.html
(139 words)
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| | desmosome - OneLook Dictionary Search |
| | Desmosome, desmosome : Dorland's Illustrated Medical Dictionary [home, info] | | | desmosome : The On-line Medical Dictionary [home, info] | | | desmosome : Stedman's Online Medical Dictionary, 27th Edition [home, info] |
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http://www.onelook.com/?w=desmosome
(115 words)
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| | Lecture Template |
| | The better term is "junctional complex" which also includes desmosomes. | | | Spot desmosome (macula adherens); disk-like junction scattered over the surface of the cell which is paired with a similar structure in adjacent cells. | | | Attach cells to each other and anchor them to the basal lamina |
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http://www.cbil.vcu.edu/dev/ecur/bigbee/cell.html
(2158 words)
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| | 5.4 |
| | Tighter junctions (~2 nm) called occluding junctions form nearly watertight seals in certain critical areas such as between the cells lining the digestive system. | | | The other principal class of anchoring junction is the spot desmosome, a buttonlike point of intercellular contact that rivets together certain types of epithelial tissue cells. | | | Nanorobots linked by narrow equatorial-band or wide whole-wall bumpers into nanotissues may perform similar feats, under continuous computer control. |
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http://www.nanomedicine.com/NMI/5.4.htm
(329 words)
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| | [No title] |
| | The antibody cross-reacts with targets in the skin Antibodies bind desmoglein-1 which is a component of the desmosome core, and disrupt its function in cell adhesion. | | | These cells release enzymes like elastase which break down BP 180 and other proteins int he area, leading to a loss of adhesion. |
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http://www.med.unc.edu/wms/firstaid/FirstAid2/osy-DermNotes.DOC
(1748 words)
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| | Nikon MicroscopyU Digital Video Gallery: Live-Cell Imaging - CV-1 Cell Motility |
| | Though most of these cell-cell junctions can also occur among other kinds of animal cells, tight junctions are characteristically formed only by epithelial cells. | | | Slowly the binucleated cell and the cell at the far end of the cell series migrate away from the two central cells, which appear to have formed junctions with one another along their overlapping margins. | | | Several different junction types may form between neighboring epithelial cells, including tight junctions, adherens junctions, desmosome junctions, gap junctions, and hemidesmosomes junctions. |
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http://www.microscopyu.com/moviegallery/livecellimaging/cv1/56k/cv1-56k2.html
(284 words)
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| | Human protein: Q63HM4 - Hypothetical protein DKFZp686P18250. EMBL Bioinformatic Harvester |
| | The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. | | | These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. | | | Alternative splicing results in two transcript variants encoding distinct isoforms. |
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http://harvester.embl.de/harvester/Q63H/Q63HM4.htm
(689 words)
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| | DESMOSOME |
| | Desmosomes are junctional complexes that are formed among opposing plasma membranes. | | | These can be found between the interdigitating cellular bridges in squamous cell carcinomas (green arrowheads) as well as in adenocarcinomas. | | | Each desmosome consists of an electron dense plate immediately underneath the plasma membrane (blue arrowheads) where tonofilaments converge (red arrowheads). |
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http://www.bioscience.org/atlases/tumpath/em/desmosom.htm
(91 words)
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| | Adhering junction (desmosome) |
| | This type of junction provides very tight contact between adjacent cells and allows the cells to fuction as a unit. | | | Belt desmosomes are attachment sites that circle the cell, and spot desmosomes are small points of attachment across the cell's surface. |
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http://www.cartage.org.lb/en/themes/Reference/dictionary/Biologie/A/216.html
(60 words)
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| | desmosome : Definition |
| | Search for desmosome in these other databases too |
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http://www.everythingbio.com/glos/definition.php?word=desmosome
(112 words)
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| | Cryo-electron microscopy of vitreous sections |
| | (B) Human desmosome at midportion of the viable part of forearm epidermis prepared by CEMOVIS. | | | (A) Desmosome from neonatal mouse epidermis prepared by freeze substitution (from He et al, 2003, from Figure 1B, with permission). |
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http://www.nature.com/emboj/journal/v23/n18/fig_tab/7600366f3.html
(180 words)
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| | Nikon MicroscopyU Digital Video Gallery: Live-Cell Imaging - LLC-MK2 Cell Motility |
| | A number of cell-cell junctions form between epithelial cells, including tight junctions, which are a special type of connection unique to the cell type. | | | Other junctions that may hold two LLC-MK2 or other epithelial cells together are adherens junctions, desmosome junctions, gap junctions, and hemidesmosomes junctions. | | | Though it is unclear exactly what type of junction binds them together, several LLC-MK2 cells are evidently connected in this time-lapse sequence. |
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http://www.microscopyu.com/moviegallery/livecellimaging/llcmk2/t1/llcmk2-dsl3.html
(277 words)
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| | Kate's Words - Desmosome |
| | A spot desmosome has roughly circular points of contact and a belt desmosome has continuous bands of contact extending round the cell. | | | At a desmosome, the cell membrane is thickened and the space between the cells is filled with various types of |
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http://www.earth.li/~kake/maths/mathbiol/Words/desmosome.html
(64 words)
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| | Investigation into a role for the primitive streak in development of the murine allantois -- Downs et al. 131 (1): 37 ... |
| | The arrow points to a desmosome between the two outer cells, whereas the arrowheads indicate electron densities, possibly adhesion plaques or glancing sections through desmosomes, at sites of contact between the outer cells and an inner cell. | | | (D) Ultrathin section through the distal region of a 4-somite pair (4-s) allantois contains an apparently mature spot desmosome between two outer cells. | | | (B) Ultrathin section contains a possible junctional complex between two cells (1,2) in the proximal region of an early allantoic bud (EB), consisting of a putative tight junction (left of asterisk), adhesion plaque (arrowhead), and spot desmosome (arrow). |
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http://dev.biologists.org/cgi/content/full/131/1/37/FIG3
(242 words)
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| | ExactAntigen jup -- antibodies, ELISA, siRNA, and recombinant proteins |
| | (1991) Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP). | | | component: catenin complex; cell-cell adherens junction; cytoskeleton; desmosome; nucleus | | | related topics: Cytoskeletal Proteins, Desmosomes, Cadherins, Cell Adhesion Molecules, Cell Adhesion, Precipitin Tests, Intermediate Filaments, Arrhythmogenic Right Ventricular Dysplasia, Adherens Junctions |
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http://www.exactantigen.com/monoclonal/jun/jup-antibody.html
(178 words)
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| | Microscopic Anatomy |
| | Alimentary Canal; Salivary gland; Human; H and E | | | dead tracts; demilune, serous; dendrite; dentin; dentin, interglobular; dentin, reparative; dentin, tertiary formation; dermis; desmosome; diapedesis; disk, intercalated; droplet, lipid; duct, alveolar; duct, bile; duct, collecting; duct, excretory; duct, intercalated; duct, interlobular; duct, intralobular; duct, striated; ducts of Bellini |
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http://www.med.fsu.edu/gsm/ma/index/dterms.htm
(585 words)
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