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| | MedlinePlus Drug Information: Desflurane (Inhalation-Systemic) |
 | | If you will be receiving a general anesthetic during surgery, your doctor will give you the medicine and closely follow your progress. | | | In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. | | | Your doctor will take your age into account when deciding on the right amount of desflurane for you. |
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http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202685.html
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| | Economic value of Desflurane in comparison to Isoflurane in Low Flow Anesthesia |
| | Patients were tracheal intubated and then in 20 patients the anesthesia was performed using Desflurane and oxygen/nitrous oxide and in 20 patients anesthesia was performed using Isoflurane and oxygen/nitrous oxide at about 1.3 MAC in both groups. | | | This is no real disadvantage, since fresh gas flows of more than 2 l/min have no clinical advantage in Desflurane use. | | | Using Desflurane in this fresh gas flows deems not clinically necessary. |
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http://gasnet.med.yale.edu/esia/1998/may/economic.html
(1566 words)
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| | Review Of Currently Used Inhalation Anesthetics |
| | Enflurane, isoflurane, desflurane, and sevoflurane produce skeletal muscle relaxation that is about twice as high than that associated with halothane. | | | Nitrous oxide does not relax skeletal muscle and may, especially in combination with opioids cause muscle rigidity. | | | Volatile anesthetics do not only potentate the action of neuromuscular blocking agents but also have muscle relaxants properties of their own. |
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http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ija/vol3n3/inhal2.xml
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| | DESFLURANE - (Organic Method #106) |
| | Desflurane was not included in Method 103 because it required different analytical conditions. | | | The average percent change was 0% for samples that were resealed with new septa and +0.6% for those that retained their punctured septa. | | | Acute exposure by ingestion may lead to unconsciousness or death. |
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http://www.skcinc.com/nioshdbs/oshameth/org106/org106.htm
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| | Drug Discovery & Development |
| | Previous research has shown that desflurane was neuroprotective during deep hypothermic circulatory arrest (DHCA), one of the modalities used during infant cardiac surgery. | | | Loepke says that, "If results in humans parallel our results in animal studies, desflurane or similar anesthetics could contribute to clinical improvements for children with heart conditions." Research continues to determine how desflurane actually protects the brain from ischemia in the surgical setting. | | | According to Andreas Loepke, MD, PhD, a pediatric anesthesiologist at The Children's Hospital and lead author of the study published in the December 2002 issue of Anesthesiology, the study's results show that desflurane seems to be protective during circulatory arrest as well as during low-flow cardiopulmonary bypass surgery. |
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http://www.dddmag.com/PRArchivebyIssue.aspx?RELTYPE=BRK&YEAR=2003&MONTH=03
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| | Newsletter |
| | Thus, the primary objective of this study is to determine the intraoperative and postoperative drug costs associated with desflurane anaesthesia compared to isoflurane anaesthesia in daycare patients undergoing arthroscopic menisectomy. | | | Our secondary objectives are to compare the postoperative adverse events associated with desflurane and isoflurane anaesthesia in the Post Anaesthetic Recovery Room (PAR), and to compare fitness for discharge scores from the PAR. | | | This unique opportunity to interact with anesthetists, surgeons, and nurses has provided an excellent opportunity to learn more about medicine first hand. |
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http://www.cpro.ubc.ca/OldCpro/newslettera99cost.html
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| | Physiologic Effects of Anesthesic and Analgesic Agents |
| | Autoregulation of cerebral blood flow in response to changes in arterial pressure is retained during 1 MAC isoflurane but not halothane. | | | Volatile inhalants cause dose-dependent and drug specific changes in pattern of breathing, response to hypercapnia, hypoxia and airway resistance. | | | During normocapnia, administration of greater than 0.6 MAC causes cerebral blood flow to increase even though cerebral oxygen requirements are reduced. |
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http://info.med.yale.edu/yarc/vcs/anesthesiaeffect.htm
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| | Sito dedicato allo studio ed alla divulgazione dell'anestesia inalatoria |
| | Desflurane MAC is decreased but recovery time is unaltered following premedication with midazolam (0 05 mg/kg). | | | Remifentanil as an adjuvant during desflurane anesthesia facilitates early recovery after ambulatory surgery. | | | Induction of anaesthesia with desflurane: a comparison of conventional (C) and vital capacity rapid inhalation induction (VCRII) techniques. |
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http://www.desflurane.it/12.html
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| | bibliographie l... |
| | Cerebral uptake and elimination of desflurane, isoflurane, and halothane from rabbit brain: an in vivo NMR study. | | | A prospective, randomized comparison of haemodynamic behaviour and treated haemodynamic side effects during remifentanil / propofol / oxygen, remifentanil / desflurane / oxygen, remifentanil / sevoflurane / oxygen and alfentanil / isoflurane / nitrous oxide anaesthesia for ENT surgery. | | | A prospective randomized comparison of postoperative patient comfort and satisfaction after remifentanil propofol / oxygen, remifentanil / desflurane / oxygen, remifentanil / sevoflurane / oxygen and alfetanil / isoflurane / nitrous oxide anaesthesia for ENT surgery. |
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http://www.sitanest.net/bibliohalo/l.htm
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| | Data Sheet |
| | Desflurane is one of a family of halogenated methylethylethers which is administered by inhalation producing a dose-related, reversible loss of consciousness and of pain sensations, suppression of voluntary motor activity, modification of autonomic reflexes and sedation of respiration and the cardiovascular system. | | | If added relaxation is required, supplemental doses of muscle relaxants may be used. | | | Nausea and vomiting have been observed in the postoperative period, common sequelae of surgery and general anaesthesia, which may be due to inhalational anaesthetic, other agents administered intraoperatively or post-operatively and to the patient's response to the surgical procedure. |
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http://www.medsafe.govt.nz/Profs/datasheet/s/Supraneliq.htm
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| | The Worldwide Anaesthetist : Journal Club 24 January 2001 |
| | 5% for desflurane) and recovery was marginally quicker with desflurane (by ~2 minutes); the incidence of PONV was similar, and small. | | | Seventy five ASA I to III patients had superficial surgical procedures, after baseline assessment (Visual analogue scores [VAS], for sedation, fatigue, comfort, pain and nausea). | | | Results: Forty percent of patients in the propofol group moved during surgery (v. |
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http://www.anaesthetist.com/anaes/jnl/2001/2001my23.htm
(1038 words)
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| | Desflurane ( Suprane ) |
| | Results from a few clinical studies indicate that emergence from desflurane is significantly earlier (by approximately equal to 2 to 6 minutes) than that from propofol anaesthesia, whereas other studies do not concur. | | | Haemodynamic stability during coronary artery surgery is as well maintained with desflurane as with isoflurane, and the drug does not worsen the adverse postoperative outcomes | | | Differences, if any, in the recovery of cognitive and psychomotor functions after desflurane or propofol anaesthesia remain unclear. |
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http://www.general-anaesthesia.com/desflurane.html
(419 words)
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| | ELECTROENCEPHALOGRAPHIC EFFECTS OF DESFLURANE DURING SURGICAL STIMULATION |
| | To obtain clinical relevant data, we examined the effect of desflurane on several univariate EEG parameters during surgery. | | | Cortical activity was monitored with a 3 lead EEG, which was analyzed to yield the median and the 95% quantile of the power spectrum (SEF 95) and the bispectral index (BIS; Aspect A-1000). | | | Between opening and closure of the peritoneum desflurane vapor settings were randomly varied between 0.5 and 1.6 MAC, as long as a clinically adequate depth of anesthesia was maintained. |
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http://www.meb.uni-bonn.de/kai/paper/hr1.htm
(313 words)
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| | IngentaConnect An assessment of desflurane for use during cardiac electrophysiol... |
| | IngentaConnect An assessment of desflurane for use during cardiac electrophysiol... | | | There were no other significant differences between fentanyl or desflurane techniques in terms of EPS measurements. | | | Desflurane reduced the mean arterial pressure (MAP) in all patients. |
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http://www.ingentaconnect.com/content/bsc/pa/2000/00000010/00000002/art00465
(276 words)
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| | DARE abstract952015 |
| | There are only minor clinically important differences between desflurane and isoflurane or propofol with respect to time to following commands and time to discharge. | | | Patients who received propofol were discharged to home a mean of 17 minutes (4 - 30 minutes) more quickly than patients who received desflurane. | | | The studies comparing desflurane to isoflurane differed in a number of ways; however, the results of the studies were still pooled. |
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http://nhscrd.york.ac.uk/online/dare/952015.htm
(521 words)
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| | Government and academic resources on DESFLURANE |
| | : Postoperative Recovery After Desflurane or Sevoflurane Anesthesia Among Morbidly Obese Patients: A Prospective, Randomized Study E. Strum, MD; J. enohradszky... | | | MedlinePlus Drug Information: Drugs beginning with D-Dh: USP DI - Deferoxamine (Systemic); Desflurane (Inhalation-Systemic) USP DI; Desipramine MedMaster USP DI - Antidepressants, Tricyclic (Systemic) | | | Awakening, clinical recovery, and psychomotor effects after desflurane and propofol anesthesia. |
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http://drugs.mongabay.com/ingredients/DESFLURANE.html
(585 words)
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| | SSM Online - News |
| | In a finding that may ultimately benefit children undergoing heart surgery as infants, researchers showed that a particular anesthetic medication improved neurological outcomes in animals that underwent cardiopulmonary bypass (CPB) under surgical conditions. | | | Dr Loepke added that, “If results in humans parallel our results in animal studies, desflurane or similar anesthetics could contribute to clinical improvements for children with heart conditions.” | | | The researchers remain uncertain about the process by which desflurane improved neurologic outcomes in their study, although they speculate that it may decrease the amount and effects of deleterious amino acids in the brain. |
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http://www.ssmonline.org/News/ViewRelease.asp?ReleaseID=2867
(471 words)
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| | Cardiovascular effects of desflurane after acute hemorrhage in dogs |
| | In this study, a team from Brazilia examined the cardiovascular effects of desflurane following acute hemorrhage in an experimental study of eight mixed breed dogs. | | | Cardiovascular effects of desflurane after acute hemorrhage in dogs | | | Desflurane induced significant changes in blood pressure and arterial pH when administered to dogs following acute hemorrhage. |
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http://www.vetcontact.com/en/art.php?a=152&t=
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| | TheMediWeb |
| | A concentration of 4-11% desflurane produces surgical anaesthesia in 2-4 minutes -Concentrations of up to 15% have been used in some clinical trials As mentioned above desflurane is not to be used for induction of anaesthesia in children | | | Desflurane is not recommended for use in neurosurgical patients due to limited experience. | | | Concentrations of 1-4% of desflurane in a mixture of nitrous oxide and oxygen havebeen used successfully in patients with chronic renal/hepatic impairment and duringrenal transplantation surgery. |
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http://www.themediweb.net/pharmacy/Desflurane.htm
(884 words)
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| | EEG Response During Stimulation Under Desflurane |
| | For up to 8% des, SEF 95, MPF, and BIS were about 2-3 times higher during surgical stimulation... | | | Surgical Stimulation Shifts EEG Concentration-Response Relationship of Desflurane | | | You do, of course, have to believe that a BIS of 50 is OK. There is plenty of data saying that it is, and no one here (small group) had recall. |
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http://www.unc.edu/~rvp/RP_Anesthesia/Articles/Ropcke-SurgStimEEGAndDes-Prasad.html
(310 words)
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| | ASA: Desflurane at High Concentrations Appears to Have More Adverse Events Than Sevoflurane |
| | Shankar pointed out that confounding factors -- such as the use of nitrous oxide with both drugs and a higher use of opioids with desflurane -- might have contributed to the earlier finding. | | | He concluded that desflurane irritates the airway enough so that its use could be a problem in some patients, especially at higher concentrations. | | | None of the sevoflurane patients had any of those reactions, Dr. Shankar said. |
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http://www.docguide.com/dg.nsf/PrintPrint/DC21F61F124E035485256F3A00680CB2
(486 words)
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| | eriksson |
| | Our results suggest that in order to achieve a propofol-like recovery profile in patients with a high likelihood of PONV, desflurane should be combined with a potent antiemetic (e.g., ondansetron). | | | The total incidence of PONV in the desflurane-only group was 80% (P < 0.01), compared to 40% and 20% in the desflurane group receiving ondansetron and the propofol group, respectively. | | | Control groups received a similar desflurane anesthetic (placebo) or a propofol-infusion-based (active control) anesthetic. |
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http://www.sivauk.org/Education/eriksson.htm
(254 words)
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| | WebMD Health - Patient Handout for Desflurane Inhalation |
| | WebMD Health - Patient Handout for Desflurane Inhalation | | | A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. | | | Important Note: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. |
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http://my.webmd.com/drugs/drug-9859-Desflurane+Inhalation.aspx?...+Inhalation
(230 words)
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| | Inhaled anaesthetics: desflurane and sevoflurane |
| | However, in contrast to desflurane, at concentrations exceeding 1 MAC sevoflurane has little or no respiratory irritant properties and may be used to rapidly induce anesthesia. | | | Neither anesthetic seems to materially affect heart rate at concentrations lower than MAC, but at higher concentrations desflurane, but not sevoflurane, may increase heart rate. | | | Thus, neither of these new anesthetics can be said to be ideal, but each may be a step in that direction. |
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http://www.ether.org/inhaled-anaesthetic.html
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| | Virtual Mass Spectrometry Laboratory |
| | Like sevoflurane, the amount of time that it takes for a patient to awaken from desflurane induced anesthesia is quite small. | | | The chemical is used with other inhalation anesthetics to produce balanced anesthesia due to the fact that it causes severe coughing when administered to the patient. |
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http://mass-spec.chem.cmu.edu/VMSL/genanes/desflurane.html
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| | Volatile Anaesthetics |
| | Desflurane has a biphasic effect on m1 signaling, enhancing at a low concentration but depressing at higher concentrations. | | | Halothane, enflurane, isoflurane, desflurane and sevoflurane, at clinical concentrations, significantly suppress voltage-gated sodium channels. | | | Owing to environmental concerns there may be no alternative but to use xenon even if it incurs an increase in cost. |
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http://www.anaesthetist.com/anaes/drugs/volatile.htm
(2791 words)
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| | Desflurane |
| | It has the most rapid onset and offset ofthe volatile anaesthetic drugs used for general anaesthesia. | | | Desflurane is a halogenated ether used for maintenance of general anaesthesia. |
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http://www.therfcc.org/desflurane-195918.html
(80 words)
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| | desflurane - General Practice Notebook |
| | Oxbridge Solutions Ltd® is an independent company owned by the authors which does not receive income from any other organisation or individual. | | | Desflurane is a relatively new inhalational ether-derived anaesthetic agent. |
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http://www.gpnotebook.co.uk/cache/2080768045.htm
(99 words)
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| | (Excerpt from WVU Newsletter) |
| | Thus the filling mechanism of the desflurane vaporizer is constructed as a closed system to avoid loss of the liquid agent. | | | The problem is that the o-rings on some bottles of desflurane slip off when they’re used. | | | Desflurane (Suprane) has a vapor pressure of 664 mmHg at 20°C. |
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http://www.hsc.wvu.edu/som/anesth/news/June_10_2002.htm
(1819 words)
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| | (S-207) DESFLURANE VAPORIZER PERFORMANCE IS AFFECTED BY XENON |
| | The respective median and range of the twelve dial settings of each series of measurement is shown in the table. | | | INTRODUCTION: The Desflurane Dräger Devapor vaporizer (Drägerwerk AG, Lübeck, Germany) which is technically based on the Tec 6 vaporizer (Ohmeda, Madison, WI) is calibrated to use air, oxygen and nitrous oxide as carrier gases (1). | | | RESULTS: Table-ratio between dial setting versus analyzed desflurane op[utput |
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http://www.iars.org/abstracts/abstracts/S190/S207.htm
(271 words)
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| | Glutamate Receptor-Mediated Hyperexcitability after Ethanol Exposure in Isolated Neonatal Rat Spinal Cord -- Wong et ... |
| | Fang Z, Ionescu P, Chortkoff B, Kandel L, Sonner J, Laster MJ and Eger EI II (1997b) Anesthetic potencies of n-alkanols: results of additivity studies suggest a mechanism of action similar to that for conventional inhaled anesthetics. | | | Erwin VG and Deitrich RA (1996) Genetic selection and characterization of mouse lines for acute functional tolerance to ethanol. | | | Fang Z, Gong D, Ionescu P, Laster MJ, Eger EI II and Kendig J (1997a) Maturation decreases ethanol minimum alveolar anesthetic concentration (MAC) more than desflurane MAC in rats. |
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http://www.jpet.org/cgi/content/full/285/1/201
(3945 words)
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