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| | [No title] |
 | | The results shown in Figure 7 are the mean of experiments performed in duplicate. | | | Peptides linked to malignant conditions have been characterised (Brossart, 1998 Cancer Res. | | | (T-M) This analysis was carried out on Mel 1 cells treated with biotin-conjugated 225.28s, avidin, and biotin-conjugated HLA-A2/gag. |
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http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=99/64464.991216&ELEMENT_SET=DECL
(5093 words)
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| | T Cell Development |
| | Bone marrow chimeras demonstrate that bone marrow-derived APC are most important for negative selection. | | | Negative selection to self antigen has been studied in mice expressing an endogenous superantigen. | | | Which of the following is NOT associated with negative selection? |
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http://microvet.arizona.edu/Courses/MIC419/Tutorials/Tcelldevelopment.html
(3818 words)
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| | HON Allergy Glossary T-Cell |
| | The basic concept of suppressor T-cells is a cell-type that specifically suppresses the action of other cells in the immune system, notably B-cells and T-cells, thereby preventing the establishment of an immune response. | | | Another fact that renders the study of this cell-type difficult is the lack of a specific surface marker. | | | A lymphocyte (white blood cell) that develops in the bone marrow, matures in the thymus and expresses what appear to be antibody molecules on their surfaces but, unlike B-cells, these molecules cannot be secreted. |
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http://www.hon.ch/Library/Theme/Allergy/Glossary/t_cell.html
(221 words)
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| | Michael J. Bevan |
| | Amazingly, many tissue-specific antigens are ectopically, or promiscuously, expressed in the thymus to mediate central tolerance. | | | More recently, this model has been replaced by one in which the antigen-presenting cell (most likely a dendritic cell) is the essential go-between for CD4-mediated assistance in the cytotoxic T cell response. | | | This begins in the thymus when T cells with dangerously high affinity for self-antigen are deleted or negatively selected in a process referred to as central tolerance. |
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http://www.hhmi.org/research/investigators/bevan.html
(1035 words)
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| | HIV T Cell Immunity |
| | The final goal of the study is to identify parameters that are able to augment the immune responses. | | | One goal of the study is the construction of coxsackie/HIV recombinants which will elicit HIV-specific T helper and T cytotoxic responses. | | | The results obtained from this work will provide the framework for developing appropriate recombinants for testing in a non-human primate model in a later study. |
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http://www.wadsworth.org/educate/hiv.htm
(293 words)
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| | Modeling the cytotoxic T cell response (ResearchIndex) |
| | Immunologists are interested in manipulating and enhancing the CTL response to these diseases, whether by vaccination or drug therapy, but the process can be difficult and ad hoc.... | | | Abstract: This work describes a computer model of the immune system s response to infection, specifically the cytotoxic T lymphocyte (CTL) response. | | | CTLs play an important role in the control of infectious agents, and they are essential components of our defense against HIV, cancer, and other diseases of great public interest. |
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http://citeseer.ist.psu.edu/694732.html
(215 words)
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| | Cytotoxic T cell - Wikipedia, the free encyclopedia |
| | This Fas-Fas ligand interaction is the main route to dispose of unwanted T lymphocytes during their development. | | | A second way to induce apoptosis is through an interaction between cell-surface molecules on the T | | | The vast majority of T cells express alpha-beta TCRs, but some T cells in epithelial express beta-gamma TCRs, which recognize non-protein antigens. |
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http://en.wikipedia.org/wiki/Cytotoxic_T_cell
(419 words)
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| | Definition of cytotoxic T cell - NCI Dictionary of Cancer Terms |
| | Certain cytokines can also be given to a patient to help form cytotoxic T cells in the patient's body. | | | T cells can be separated from other blood cells, grown in the laboratory, and then given to a patient to destroy tumor cells. | | | The Nation's Investment in Cancer Research FY 2007 |
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http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=45664
(73 words)
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| | Zoology 214 Lecture 52: December 7, 2001 |
| | We can’t just fuse normal body cells together to produce the new organism | | | Depending if we’re talking about a cell-mediated immune response or a humoral immune response, either B cells or cytotoxic T cells will also have encountered the same antigen being presented by the macrophage | | | The fused cell would have twice the number of chromosomes as the parents |
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http://www.humboldt.edu/~bao3/214lectures/214Lecture52.htm
(963 words)
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| | CD8 T cell populations in anti-HIV gag cytotoxic T cell activity. |
| | Analysis of in vitro cultured cells showed that CTL activity was found only in patients cells in which a significant increase in %CD8 CD45RO+ and HLA-DR+ cells (P less than 0.005) had occurred. | | | Autologous EBV transformed B cell lines infected with a vaccinia-HIVgag construct were incubated in vitro with cultured patient cells. | | | The state of the art may have changed since the publication date. |
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http://www.aegis.com/aidsline/1992/dec/M92C4864.html
(504 words)
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| | THE ROLE OF a4 INTEGRIN/FIBRONECTIN INTERACTIONS IN ALLOSPEClFIC CYTOTOXIC T CELL ACTIVATION AND HOMING--INITIAI ... |
| | Interaction between integrin adhesion molecules and their ligands are believed to be important in both processes. | | | The purpose of this study was to develop a model in which T cell activation and homing could be monitored independently in vivo We then tested the mode, using a peptide inhibitor of 4 integrin/fibronectin (FN) interactions thought to specifically inhibit T cell homing without affecting activation. | | | To study allorejection in vivo, we used an adoptive transfer model of allograft rejection. |
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http://www.a-s-t.org/abstracts98/abs431.htm
(528 words)
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| | BioCarta - Charting Pathways of Life |
| | Distinct types of T cells are characterized and their activities determined by the proteins they express on their cell surface. | | | Communication with and interaction with other cell types is essential for cytotoxic T cell function. | | | There are two mechanisms by which activated cytotoxic T cells kill cells presenting specific antigen. |
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http://www.biocarta.com/pathfiles/h_tcytotoxicPathway.asp
(323 words)
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| | CD8 |
| | This is the most effective effector function of Tc cells. | | | Their action is specific, since they act only on those cells that express their receptor. | | | They perform their function by inducing Apoptosis in those cells that express their specific antigen:MHC I complex. |
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http://sprojects.mmi.mcgill.ca/immunology/cd8_text.htm
(979 words)
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| | [No title] |
| | class I molecules expressed on all cells in the body, used to stimulate cytotoxic T cell lysis. | | | The absence of these other signals may make the cell tolerant for that antigen. | | | for cytotoxic T cell can be any other cell in the body |
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http://www.pitt.edu/~wsaund/lect14.htm
(696 words)
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| | Cytotoxic T cell Activation, Immunology bookcase, Dalhousie University |
| | These cells are characterized by the presence of the CD8 marker on their surface, and an antigen-specific T cell receptor which recognizes antigens in the context of MHC class I. The main role of the cytotoxic T cell, as the name suggests, is to kill other cells. | | | The requirement for MHC class I on the target cell means that the Tc cell is very important in recognizing and destroying self-cells that have been altered or infected. | | | This ensures that only the cells recognizing the antigen will become activated. |
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http://pim.medicine.dal.ca/tcact.htm
(202 words)
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| | Immune System 23 |
| | This will display the main subject of that particular page. | | | A cytotoxic T cell recognizes antigens such as virus proteins,which are produced within a cell, in combination with a class I self-marker protein. | | | Then, when the mature cytotoxic T cell encounters its specific target antigen combined with a class I marker protein—for instance, on a body cell that has been infected with a virus—it is ready to attack and kill the target cell. |
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http://www.transferfactorresearch.com/immune23.html
(162 words)
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| | Cytotoxic T cell responses to intracellular pathogens. |
| | The identification of two mechanisms of lysis induced by cytotoxic T lymphocytes--the granule exocytosis pathway and the Fas-FasL interaction--have provided new insight into the role of cytotoxic T lymphocyters in immunity to infection. | | | Host defense against intracellular pathogens is thought to require cytotoxic T cells. | | | Recent studies have investigated the impact of host cell lysis and cytokine production by cytotoxic T lymphocytes on the fate of intracellular pathogens. |
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http://www.aegis.com/aidsline/1999/feb/A9920977.html
(294 words)
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| | CD8 - Wikipedia, the free encyclopedia |
| | CD8 (cluster of differentiation 8) is a glycoprotein which serves as a co-receptor that is expressed on the surface of cytotoxic T cells. | | | This page was last modified 14:31, 3 April 2006. | | | CD8 consists of an α and a ß chain, which both resemble an immunoglobulin-like domain that is connected to the membrane by a thin stalk. |
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http://en.wikipedia.org/wiki/CD8
(118 words)
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| | Cytotoxic T Lymphocyte |
| | Cytotoxic T lymphocytes (CTL) recognize surface markers on other cells in the body that label those cells for destruction. | | | In this way, CTLs help to keep virus-infected or malignant cells in check. | | | A longer, larger, silent version of the above clip may be purchased and downloaded for classroom use as part of the "Immune System Collection". |
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http://www.cellsalive.com/ctl.htm
(103 words)
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| | Drug Discovery & Development |
| | Researchers are tweaking murine models, while others are touting newer models such as zebrafish, but integration may be the key. | | | Use of this website is subject to its terms of use. | | | Effective Strategies for Whole Genome Amplification of Single Cell DNA |
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http://dddmag.com/scripts/Glossary.asp?RPTID=KWSRCH&...&SEARCHWORD=T+cell
(181 words)
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| | National Cancer Institute - Dictionary of Cancer Terms |
| | For example, typing "lung" and choosing "Contains" will find terms like "isolated lung perfusion" and "non-small cell lung cancer" in addition to terms that start with "lung" (e.g., "lung metastases"). | | | Use "Contains" when you want to find all terms in the dictionary that include a word or set of letters. |
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http://www.cancer.gov/Templates/db_alpha.aspx?print=1&cdrid=45664
(138 words)
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| | Stalking the AIDS Virus: Cytotoxic T Cell Research Quarterly Fall 2003 Los Alamos National Laboratory |
| | Although only one viral epitope is recognized by a given cytotoxic-T-cell receptor, an individual's immune system potentially responds to dozens of different epitopes; in addition, different epitopes will be recognized by the immune systems of different individuals. | | | HLA proteins are thus indispensable in the process by which HIV-infected cells are identified and killed. | | | After recognizing an HLA/viral-epitope combination with a receptor of complementary shape, the cytotoxic T cell will kill the infected helper. |
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http://www.lanl.gov/quarterly/q_fall03/tcell.shtml
(134 words)
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| | Figure Pop Up - Modern Pathology |
| | CD8 immunostaining reveals positive reactivity in the cytoplasmic membranes of the neoplastic cells (Case 2; large cell type) (original magnification, 680 | | | Nodal CD8 Positive Cytotoxic T-Cell Lymphoma: A Distinct Clinicopathological Entity |
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http://www.nature.com/modpathol/journal/v15/n11/fig_tab/3880668f6.html
(49 words)
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