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| | immuno_CTL.htm |
 | | Positive cytotoxic T lymphocyte recall and cytokine (interferon-gamma and tumor necrosis factor alpha) responses were detected for all peptides, all were recognized in the context of more than one HLA class I molecule, and at least 12 of the 17 were recognized in the context of all HLA alleles studied. | | | The common allele of a variable HLA-B7-restricted epitope in the circumsporozoite protein behaved as an altered peptide ligand (APL) with respect to CTL cognate for a rarer allelic variant of this epitope, suggesting that APL antagonism may occur in natural CTL responses to P. falciparum. | | | These data validate the concept of HLA supertypes at the biological level, show that highly degenerate peptides are almost always recognized as epitopes, and demonstrate the feasibility of developing a universally effective vaccine by focusing on a limited number of peptide specificities. |
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http://odomarle.free.fr/page_keywords/immuno_CTL.htm
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| | 64464.991216&ELEMENT_SET=DECL |
| | Cytotoxic T cells of various specificities within a host immune system are also able to recognise and trigger an immunological response against a cell exhibiting an HLA class I molecule which is of a different allotype from the HLA class I molecules of the host cells. | | | Each cytotoxic T cell expresses a number of cell surface recognition receptors, which recognition receptors all possess precise specificity for a particular"foreign"peptide sequence, which recognition receptors are adapted to bind to HLA class I molecules expressed on the surface of cells scanned by the T cell. | | | The results shown in Figure 7 are the mean of experiments performed in duplicate. |
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http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=99/64464.991216&ELEMENT_SET=DECL
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| | T Cell Development |
| | Bone marrow chimeras demonstrate that bone marrow-derived APC are most important for negative selection. | | | Negative selection to self antigen has been studied in mice expressing an endogenous superantigen. | | | Which of the following is NOT associated with negative selection? |
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http://microvet.arizona.edu/Courses/MIC419/Tutorials/Tcelldevelopment.html
(3818 words)
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| | T lymphocyte, Primary Sclerosing Cholangitis Literature |
| | Kamal MA, Jusko WJ 2004 Interactions of prednisolone and other immunosuppressants used in dual treatment of systemic lupus erythematosus in lymphocyte proliferation assays. | | | Cunard R, DiCampli D, Archer DC, Stevenson JL, Ricote M, Glass CK, Kelly CJ 2002 WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivo. | | | Laffitte E, Revuz J 2004 Thalidomide: an old drug with new clinical applications. |
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http://www.psc-literature.org/Tlymph.htm
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| | Lymphocytes |
| | Positive selection means enhancing development of certain T lymphocytes | | | Memory lymphocytes form the basis for strong secondary immune responses | | | CTL are usually not stimulated to a significant degree |
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http://www.outlinemed.com/demo/allergy/6643.htm
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| | HON Allergy Glossary T-Cell |
| | The basic concept of suppressor T-cells is a cell-type that specifically suppresses the action of other cells in the immune system, notably B-cells and T-cells, thereby preventing the establishment of an immune response. | | | Another fact that renders the study of this cell-type difficult is the lack of a specific surface marker. | | | A lymphocyte (white blood cell) that develops in the bone marrow, matures in the thymus and expresses what appear to be antibody molecules on their surfaces but, unlike B-cells, these molecules cannot be secreted. |
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http://www.hon.ch/Library/Theme/Allergy/Glossary/t_cell.html
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| | projektesfb432.htm |
| | Furthermore, an impaired expression of MHC class I molecules is often associated with a deficient functional expression of specific components of the complex MHC class I antigen processing and presentation pathway which results in impaired processing of T cell epitopes as well as reduced sensitivity of tumor cells against tumor reactive cytotoxic T lymphocytes. | | | Retroviral transduction of human T lympocytes with wild-type and partially humanized mouse-derived TCR leads to the equipment of the otherwise tolerant T cell repertoire with effective cytotoxic T lymphocytes (CTL) with high avidity for a wide range of A2.1-positive tumors and leukemias. | | | We believe that mainly thereby we will come to a better understanding of pathways leading to anti-tumor immunity and possibly to the development of more effective immunotherapies. |
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http://www.sfb432.uni-mainz.de/projektesfb432.htm
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| | Michael J. Bevan |
| | More recently, this model has been replaced by one in which the antigen-presenting cell (most likely a dendritic cell) is the essential go-between for CD4-mediated assistance in the cytotoxic T cell response. | | | It was thought that helper T cells and cytotoxic T cells were brought close together by recognizing their antigen on the same cell, and that help was provided by cell-cell contact or the short-range provision of cytokines. | | | Amazingly, many tissue-specific antigens are ectopically, or promiscuously, expressed in the thymus to mediate central tolerance. |
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http://www.hhmi.org/research/investigators/bevan.html
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| | HIV T Cell Immunity |
| | One goal of the study is the construction of coxsackie/HIV recombinants which will elicit HIV-specific T helper and T cytotoxic responses. | | | To generate T cytotoxic cell responses, HIV sequences will be expressed in infected cells but will not be incorporated into progeny virions. | | | The final goal of the study is to identify parameters that are able to augment the immune responses. |
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http://www.wadsworth.org/educate/hiv.htm
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| | Modeling the cytotoxic T cell response (ResearchIndex) |
| | Abstract: This work describes a computer model of the immune system s response to infection, specifically the cytotoxic T lymphocyte (CTL) response. | | | Immunologists are interested in manipulating and enhancing the CTL response to these diseases, whether by vaccination or drug therapy, but the process can be difficult and ad hoc.... | | | CTLs play an important role in the control of infectious agents, and they are essential components of our defense against HIV, cancer, and other diseases of great public interest. |
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http://citeseer.ist.psu.edu/694732.html
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| | lecture22 |
| | Thus, cytotoxic T cells having the same T receptor as the helper T cells are begin to increase in number. | | | Only those cytotoxic T cells that are already bound to an antigen/MHC combination can respond to the chemical signals from the helper T cells, however. | | | Cytotoxic T cells bind briefly to the antigen presenting cells and secrete lethal compounds that cause them to destroy themselves and any virus pieces inside. |
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http://www.uwyo.edu/bio1000skh/lecture22.htm
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| | Medmicro Chapter 50 |
| | Activation of cytotoxic and other T lymphocytes may be one of the earliest manifestations of an immune response. | | | Cytotoxic T lymphocytes can recognize and destroy virus-infected cells, and this recognition is virus specific and major histocompatibility complex (MHC) restricted. | | | These cytotoxic T cells are specific not only for the viral antigen but also for self major histocompatibility antigens and will lyse virus-infected cells only if these cells also express the correct major histocompatibility complex (MHC) gene products. |
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http://gsbs.utmb.edu/microbook/ch050.htm
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| | Anti-human CD8 antibodies from Research Diagnostics Inc |
| | Not supplied for use in human diagnostic or therapeutic procedures | | | The monoclonal antibody reacts with T lymphocytes with surpressor-cell activity in pokeweel mitogen- stimulated immunoglobulin production, as was shown in separation experiments (i.e."panning"). | | | The monoclonal antibody reacts with T lymphocytes with suppressor-cell activity in pokeweed mitogen- stimulated immunoglobulin production, as was shown in separation experiments (i.e. |
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http://www.researchd.com/rdicdabs/cd8.htm
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| | Cytotoxic T cell - Wikipedia, the free encyclopedia |
| | Cytotoxic T cells are activated when their TCR binds to an MHC class I molecule presenting viral antigen, which can occur on any nucleated or neoplastic cell. | | | This Fas-Fas ligand interaction is the main route to dispose of unwanted T lymphocytes during their development. | | | A second way to induce apoptosis is through an interaction between cell-surface molecules on the T |
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http://en.wikipedia.org/wiki/Cytotoxic_T_cell
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| | Definition of cytotoxic T cell - NCI Dictionary of Cancer Terms |
| | Certain cytokines can also be given to a patient to help form cytotoxic T cells in the patient's body. | | | T cells can be separated from other blood cells, grown in the laboratory, and then given to a patient to destroy tumor cells. | | | The Nation's Investment in Cancer Research FY 2007 |
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http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=45664
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| | Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression - Nature Medicine |
| | Qualitative and quantitative analysis of human cytotoxic T lymphocyte responses to HIV-1 proteins. | | | Jacobson, S., Shida, H., McFarlin, D.E., Fauci, A.S. and Koenig, S. Circulating HTLV-1 pX-specific CD8+ cytotoxic T lymphocytes in patients with HTLV-1 associated neurologic disease. | | | Slobod, K.S. and Allen, J.E. Parainfluenza type 1 virus-infected cells are killed by both CD8+ and CD4+ cytotoxic T cell precursors. |
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http://www.nature.com/doifinder/10.1038/nm0495-330
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| | B Cells and T Cells |
| | Knockout mice that cannot make γδ T cells are slower to heal injuries to their skin. | | | Not only does the patient become hypersusceptible to pathogens that give all of us grief but also to microorganisms, especially viruses and fungi, that normally inhabit our tissues without harming us. | | | Their response does seem to be quicker than that of αβ T cells. |
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http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/B/B_and_Tcells.html
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| | Recent Publications |
| | Differential processing of HLA A2-trestricted HIV-1 cytotoxic T lymphocyte epitopes. | | | Cytotoxic T Lymphocyte Responses to HIV: Control and Escape. | | | Giangrande, R.E. Phillips and A.J. McMichael (1997) Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two HLA-identical siblings with HLA-A*0201 are influenced by epitope mutation. |
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http://www.jr2.ox.ac.uk/ndm/andy/Recent_Publications.htm
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| | CD8 T cell populations in anti-HIV gag cytotoxic T cell activity. |
| | CD8 T cell populations in anti-HIV gag cytotoxic T cell activity. | | | Analysis of in vitro cultured cells showed that CTL activity was found only in patients cells in which a significant increase in %CD8 CD45RO+ and HLA-DR+ cells (P less than 0.005) had occurred. | | | Autologous EBV transformed B cell lines infected with a vaccinia-HIVgag construct were incubated in vitro with cultured patient cells. |
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http://www.aegis.com/aidsline/1992/dec/M92C4864.html
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| | THE ROLE OF a4 INTEGRIN/FIBRONECTIN INTERACTIONS IN ALLOSPEClFIC CYTOTOXIC T CELL ACTIVATION AND HOMING--INITIAI STUDIES IN THE 2C T-CELL RECEPTOR TRANSGENIC. |
| | The 2C T cell receptor transgenic provides a purified alloreactive CD8+ cytotoxic T cell (CTL) population (B6 background) with specificity for the Class 1 MHC (Ld) of the BALB/c mouse. | | | Interaction between integrin adhesion molecules and their ligands are believed to be important in both processes. | | | The purpose of this study was to develop a model in which T cell activation and homing could be monitored independently in vivo We then tested the mode, using a peptide inhibitor of 4 integrin/fibronectin (FN) interactions thought to specifically inhibit T cell homing without affecting activation. |
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http://www.a-s-t.org/abstracts98/abs431.htm
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| | ref.php?id=25 |
| | The human leukocyte antigen B44-restricted cytotoxic T lymphocyte response was observed in three of five patients with chronic hepatitis C and a human leukocyte antigen B44 molecule but in neither of two hepatitis C virus-negative healthy individuals with human leukocyte antigen B44 molecules. | | | We studied the cytotoxic T lymphocyte response to the putative nucleocapsid protein of hepatitis C virus in patients with chronic hepatitis C. Cytotoxic T lymphocytes specific for hepatitis C virus nucleocapsid protein were generated from peripheral blood lymphocytes by means of repeated stimulation with a synthetic hepatitis C virus nucleocapsid protein peptide. | | | The results demonstrate the presence of hepatitis C virus-specific cytotoxic T lymphocytes in the peripheral blood of patients with chronic hepatitis C and provide a strategy to study the role of cytotoxic T lymphocytes in the viral clearance and the pathogenesis of hepatitis C virus infection. |
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http://www.ibmh.msk.su/hcvmap/ref.php?id=25
(528 words)
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