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 | | A non pharmacological stimulation of ocytocine secretion, as we have recently demonstrated in a preliminary study, related to hypnosis, could induce a beneficial inhibition of corticotrop axis and needs further rigorous experimental approach. | | | This has been demonstrated not only in pharmacological (perfusion) but also in physiological (lactation) conditions. | | | The neurohypophysial peptide oxytocin (OT), besides it well known uterotonic and milk ejection activity, share also an inhibitory action on corticotrope activity. |
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http://www.altor.org/0700-99/a0723.htm
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| Â | Haussmann et al., September 2000 |
| | Pigs' behaviors were recorded at 6 and 8 wk of age. | | | Pituitary corticotrope and somatotrope cell numbers and adrenal cortex-to-medulla area ratios (CORT:MED) were also determined. |
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http://www.asas.org/jas/abs/2000/sep2399.htm
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| Â | CENTIGRAY.COM - Resources for the Radiation Oncology Professional |
| | Notably there have been no visual sequelae or further loss of anterior pituitary function in this heavily pretreated group. | | | This cohort comprised 13 patients with somatotrope adenomas, four with corticotrope adenomas, one with a lactotrope adenoma, and three with nonfunctioning pituitary adenomas (median follow-up: 33 months, range: 3-72 months). | | | SMART has proven effective, safe, and rapidly acting. |
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http://www.sroc.net/pituitary.htm
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| Â | Systemic Pathology: Test #3 |
| | CORTICOTROPE ADENOMA : Has a higher chance of becoming malignant than the other adenomas. | | | They occur in non-tumorous corticotrope cells, but they may also occur in the corticotrope adenoma itself. | | | Cushing's Disease (see adrenal gland later) is defined as hypercorticism caused by an overproduction of ACTH. |
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http://www.geocities.com/doctor_uae/syspath3.htm
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| Â | Stress |
| | Among these other secretagogues, the physiological importance of AVP in the regulation of the stress response should be highlighted, because of the colocalization and corelease of CRH and AVP in mpPVN (86) and because of the synergistic effects of both peptides on the corticotropes. | | | This genomic feedback operates at the level of the pituitary corticotrope by controlling POMC gene expression (10) as well as at the brain level. | | | These steroids possess extremely broad actions mediated by specialized receptors affecting expression and regulation of genes throughout the body, and readying the organism for the changes in energy and metabolism required for coping (60). |
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http://www.acnp.org/G4/GN401000073/CH073.html
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| Â | T OKABE AND OTHERS |
| | These results strongly suggest that nur77 antagonizes the negative feedback effect of glucocorticoid on the synthesis and secretion of ACTH in pituitary corticotropes. | | | This suggests that nur77 plays an important role in the pituitary gland in the biological adaptation to overcome stress. | | | Nur77, a member of the steroid receptor superfamily, antagonizes negative feedback of ACTH synthesis and secretion by glucocorticoid in pituitary corticotrope cells |
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http://journals.endocrinology.org/joe/156/joe1560169.htm
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| Â | Endotext.com - Pediatric Endocrinology, Pituitary Tumors in Childhood |
| | LHX3 is expressed in the developing Rathke's pouch and is required for the development of most anterior pituitary cell types, including the somatotrope, the thyrotrope, the lactotrope and the gonadotrope (but notably not the corticotrope). | | | Mutation of PROP1, therefore, results in the deficiency of GH, TSH, PRL, FSH and LH although some individuals with PROP1 mutations have been described with ACTH deficiency(21). | | | Essential for the early development of the anterior pituitary, including the somatotrope, thyrotrope, lactotrope and the gonadotrope (but not the corticotrope) |
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http://www.endotext.com/pediatrics/pediatrics1/pediatrics1a.htm
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| Â | Nat'l Academies Press, Clinical Applications of Mifepristone (RU486) and Other Antiprogestins: (1993), B10. Uses of RU ... |
| | CRH secretion is increased by a variety of stimuli, many of which can be considered biologic stressors: states of chronic and acute psychological or physical stress are presumed to increase CRH secretion (Chrousos and Gold, 1992). | | | By contrast, patients with other causes of Cushing's syndrome (in whom hypercortisolism presumably suppressed activity of normal ACTH-producing pituitary corticotropes) showed no response to RU 486 (Bertagna et al., 1986~. | | | Patients with Cush- ing's disease, in whom an ACTH-producing pituitary tumor retains many of the normal physiologic regulatory mechanisms, responded to RU 486 with increased cortisol levels. |
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http://www.nap.edu/books/0309049490/html/229.html
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| Â | Beta-adrenergic stimulation of cFOS via protein kinase A is mediated by cAMP regulatory element binding protein ... |
| | corticotrope cells, but the molecular mechanisms of these effects are not | | | Beta-adrenergic stimulation of cFOS via protein kinase A is mediated by cAMP regulatory element binding protein (CREB)-dependent and tissue- specific CREB-independent mechanisms in corticotrope cells -- Boutillier et al. | | | Beta-adrenergic stimulation of cFOS via protein kinase A is mediated by cAMP regulatory element binding protein (CREB)-dependent and tissue- specific CREB-independent mechanisms in corticotrope cells |
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http://intl-dev.biologists.org/cgi/ijlink?linkType=ABST&journalCode=jbc&resid=267/33/23520
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| Â | MGI_3.02 - References Query Results (Details) |
| | Molecular genetic analyses reveal that Lhx4 and Prop1 have overlapping functions in early pituitary development. | | | Double mutants exhibit delayed corticotrope specification and complete failure of all other anterior pituitary cell types to differentiate. |
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http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2389279
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| Â | Corticotrope |
| | Corticotropes are cells in the anterior pituitary which produce | | | Sorry, no screened links relevant to Corticotrope were found. | | | You can click on this message to see their list of those items. |
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http://omniknow.com/essays/Corticotrope.html
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| Â | UCSD Graduate Program in Neurosciences: Richard L. Hauger |
| | CRF receptors expressed in anterior pituitary corticotropes undergo downregulation during chronic stress. | | | Moreover, I have found that vasopressin also enhanced the ability of CRF to downregulate CRF receptors in the anterior pituitary. | | | In past research, I have determined that CRF receptors in the central nervous system of rats and cynomolgous monkeys are widely distributed in neocortical areas of late phyllogenetic acquisition, limbic areas (e.g., the amygdaloid nuclei, bed nucleus of the stria terminalis, septal nuclei, and nucleus accumbens), and in certain brain stem regions. |
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http://medicine.ucsd.edu/neurosci/the-faculty/hauger.html
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| Â | Biomolecular Chemistry 704 |
| | Briefly explain why this patient exhibits signs of virilization despite the fact that there is no steroid hydroxylase deficiency. | | | Patient I does not show signs of virilization, whereas patient II does show evidence of virilization, e.g., facial hair, voice deepening and increased muscle mass. | | | D. Also from the information provided in part A, you deduce that patient II suffers from a corticotrope tumor. |
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http://www.bmolchem.wisc.edu/teachinglab/fall704/module5/pjbmod5a8-13.htm
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| Â | MEDICOpolis: MEDROnet: Corticosteroids Use in Medicine:#1: General Info: Physiology |
| | Within the corticotrope, a large precursor, pro-opiomelanocortin, is synthesized and then processed into smaller, biologically active fragments. | | | Many types of stressful stimuli provoke secretion of corticotropin, and plasma may increase to 10 times the normal value. | | | -endorphin are secreted simultaneously by the human corticotrope []. |
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http://www.medicopolis.net/MEDRONET/TEXTBOOK/03Physiology.htm
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| Â | [No title] |
| | Growing evidence implicates elevated HPA function and CRF-mediated neurotransmission in human anxiety and depression. | | | of its selective stimulation of the corticotrope cells of the | | | The hormonal response to stress is triggered by increased CRF secretion from the paraventricular neurons of the hypothalamus |
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http://jpet.aspetjournals.org/cgi/content/full/301/1/322
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| Â | Science Blog -- Discovery Of Cell Sites May Shed Light On How Bodily Systems Interact |
| | The research, directed by Keith Kelley, a University of Illinois animal scientist and immunologist, led to a color snapshot of a direct link between the body's immune and endocrine systems. | | | Previous theory held that they were on corticotrope cells, makers of stress hormones. | | | First, the receptors were found on cells in the pituitary gland, and, second, they were on somatotrope cells, which make growth hormone. |
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http://www.scienceblog.com/community/older/1996/A/199600548.html
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| Â | APStracts 4:0095R, 1997. |
| | This effect was mimicked by the D1-like agonists SKF38393 and 6-chloro APB, indicating that the D1-like receptor activity is responsible for the enhancement of the di/mono ratio. | | | The apparent loss of sensitivity of the MSH cells to inhibitory concentrations of dopamine, therefore, must be caused by the activation of the D1-like receptors and not by changes in the activity of the D2-like receptor proper. | | | Stimulatory concentrations of dopamine not only quantitatively but also qualitatively enhanced the corticotropic activity of the released [alpha]-MSH, as indicated by the elevated ratio of di- and mono-acetyl [alpha]-MSH. |
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http://www.uth.tmc.edu/apstracts/1997/regulatory/March/95r.html
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