Corneal endothelium - Medicow
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Topic: Corneal endothelium


  
 Fuch's Dystrophy
If corneal blisters develop, soft bandage contact lenses can provide some pain relief.
Corneal edema may develop to the point were the surface epithelium forms blisters that intermittently rupture, causing sharp pain - a condition termed '
Statistically, half of the members of a family may be affected ; however, the expression of severity is variable and visual acuity may or may not be disturbed.
http://www.wa-eyemd.org/W_Fuch's_corneal_dystrophy.htm

  
 Corneal Endothelial Microscopy
Corneal endothelial microscopy is considered medically necessary as a pre-operative test before intra-ocular surgery (i.e., cataract surgery) in order to identify individuals at risk for post-surgical corneal decompensation for individuals who meet the criteria listed below.
Corneal endothelial microscopy is used by ophthalmologists as a predictor of success of ocular surgery or certain other ocular procedures.
Always seek the advice of your physician or other qualified health care provider if you have questions regarding a medical condition or treatment.
http://www.bcbst.com/MPManual/Corneal_Endothelial_Microscopy.htm

  
 Non-ulcerated corneal discorneal
If a corneal ulcer is present, it will be treated with topically applied antibiotics and atropine to prevent infection and relieve pain.
Oral Rimadyl® may be given for pain relief to dogs with corneal ulcers.
The reason that success rates have been low includes the fact that the dog's cornea vascularizes more readily that the human cornea which promotes rejection (vascularization and scarring) of the graft.
http://home.flash.net/~anmleyz/cornea.htm

  
 Aquaporin Deletion in Mice Reduces Corneal Water Permeability and Delays Restoration of Transparency after Swelling -- ...
B, left, time course of corneal thickness of individual eyes in response to exposure of the external surface to hypotonic saline.
Perhaps the most interesting observation in these experiments was the significant impairment in corneal recovery in AQP1 null
As discussed above, these phenomena might be explained by acute
http://www.jbc.org/cgi/content/full/277/21/19139

  
 Value of two mortality assessment techniques for organ cultured corneal endothelium: trypan blue versus TUNEL technique ...
Integrity of epithelium and endothelium in organ-cultured human corneas.
Value of two mortality assessment techniques for organ cultured corneal endothelium: trypan blue versus TUNEL technique -- Gain et al.
Our study, like Albon's, is on whole corneas, allowing easy
http://bjo.bmjjournals.com/cgi/content/full/86/3/306

  
 eMedicine - Corneal Edema, Postoperative : Article by Michael Taravella, MD
Bandage contact lenses may be useful as an adjunct to medical treatment for the temporary relief of corneal pain and discomfort.
It is very important to identify and counsel patients at risk for developing corneal edema at the time of cataract or other intraocular surgery.
Directly touching the endothelium during cataract surgery with instruments, nuclear fragments, or the intraocular lens should be avoided.
http://www.emedicine.com/oph/topic64.htm

  
 Mechanisms of Mitotic Inhibition in Corneal Endothelium: Contact Inhibition and TGF-{beta}2 -- Joyce et al. 43 (7): ...
Age is clearly an important factor in the ability of human corneal
kinetics of p27kip1 expression in neonatal rat corneal endothelium.
in the endothelium of neonatal rat cornea by immunolocalization
http://www.iovs.org/cgi/content/full/43/7/2152

  
 Age-related changes in the corneal endothelium of the rat.
Age-related changes in the corneal endothelium of the rat.
These age-related changes correspond closely to those reported in the human cornea from approximately age 20 to age 70 years.
The corneal endothelium may be found useful as an index of physiological aging in these and other mammals.
http://www.arclab.org/medlineupdates/abstract_7140858.html

  
 [No title]
The development of improved systems for the clinical specular microscopy in vivo has strongly contributed to the study and to the comprehension of the physiopathology of the corneal endothelium [1-2].
This is in the aim to grant to the doctor an effective procedure able to supply the required real time support in clinical diagnostic.
MORPHY has been developed to give a real-time easy-to-use tool to the doctor in order to deal with an useful support in clinical diagnostic.
http://www.cirlab.uniroma2.it/cnn/cnn_morphy.html

  
 Expression and localization of Na+-HCO3- cotransporter in bovine corneal endothelium -- Sun et al. 279 (5): 1648 -- AJP ...
These images were acquired with the same exposure time and printed using the same contrast and brightness settings.
Therefore, we conclude that pNBC is present in the basolateral
RT-PCR analysis for pNBC was positive in endothelium and
http://ajpcell.physiology.org/cgi/content/full/279/5/C1648

  
 Cornea
Various refractive eye surgery techniques change the shape of the cornea in order to reduce the need for glasses or otherwise improve the refractive state of the eye.
Corneal stroma (also substantia propria); a thick, transparent middle layer responsible for most of the focusing that the cornea performs.
Corneal endothelium : a simple squamous or low cuboidal epithelium, an inner lining acting as a barrier to prevent water inside the eyeball from moving into and hydrating the cornea, which would lead to blurred vision.
http://www.sciencedaily.com/encyclopedia/cornea

  
 Fluorophotometry and the Cornea
A new method for determining corneal epithelial barrier to fluorescein in humans.
Rogova NA, Badalova EIU, Krupko LA. Scanning photometry in the dynamics of experiment keratitis.
Comparative study of three methods of evaluation of the corneal endothelium in pseudophakic patients: fluorophotometry, specular microscopy and pachymetry.
http://www.ocumetrics.com/cornea.shtml

  
 bcec
Recent experiments focus on the study of the Na pump and factors that alter pump number and function.
Corneal transplantation is the only available method for restoring sight when the endothelium is sufficiently compromised.
Under pathological conditions, water balance may be disrupted resulting in corneal swelling, opacity, and if not reversed, blindness.
http://bioweb.wku.edu/faculty/Crawford/bcec.html

  
 MORPHOMETRIC ANALYSIS OF HUMAN CORNEAL ENDOTHELIUM BY MEANS OF SPATIAL POINT PATTERNS
Keywords : Spatial point processes; corneal endothelium; point pattern descriptors; early diagnosis.
Images of this type of tissue can be characterized by two types of points: cell centroids and triple points associated with the apical intersections as it was proposed by Díaz.
This paper presents a method for detecting abnormalities in spatial arrangements of cells within any tissue that can be described by different sets of relevant points.
http://ejournals.wspc.com.sg/ijprai/16/1602/S0218001402001605.html

  
 Fluid and ion transport in corneal endothelium: insensitivity to modulators of Na+-K+-2Cl- cotransport -- Riley et al. ...
cotransporter in the corneal endothelium, we examined both physiological
Rb by the endothelium of the incubated cornea was increased 25%
The effects of changing the osmolality of the superfusing solutions are shown in Fig.
http://ajpcell.physiology.org/cgi/content/full/273/5/C1480

  
 Targeted gene transfer to corneal endothelium in vivo by electric pulse
Department of Ophthalmology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
This targeted gene transfer method appears to have great potential for use in gene therapy for ocular diseases.
gene therapy; corneal endothelium; electroporation; wound healing; lacZ; viral vector
http://www.nature.com/cgi-taf/DynaPage.taf?file=/gt/journal/v5/n10/abs/3300725a.html

  
 Leung, Mol Vis 2000; 6:15-23.
The retrocorneal fibrous membrane (RCFM), first described by Fuchs in 1901 [1], has been observed in various clinical conditions associated with disease and damage to the corneal endothelium [2-4].
This in vivo study confirms our in vitro model of endothelial mesenchymal transformation, in which corneal endothelial cells are transformed to fibroblasts that are responsible for fibrosis.
Since corneal endothelium was not present in the previous work [22], a direct comparison of the two studies may hamper the information obtained from these studies.
http://www.molvis.org/molvis/v6/a4

  
 Gray's Anatomy - The Tunics of the Eye - Yahoo! Reference
Lymphatic vessels have not yet been demonstrated in it, but are represented by the channels in which the bundles of nerves run; these channels are lined by an endothelium.
Some of the fibers of this trabecular tissue are continued into the substance of the iris, forming the pectinate ligament of the iris; while others are connected with the forepart of the sclera and choroid.
This furrow has been named by Arthur Thomson 145 the sulcus circularis corneæ; it is bounded externally by the trabecular tissue already described as forming the inner wall of the sinus venosus scleræ.
http://messenger.yahooligans.com/reference/gray/225.html

  
 FDA Approves Implanted Lens to Correct Nearsightedness
One potential concern raised by the study was the loss of endothelial cells in the corneas of patients who received the implants.
At this point, it is not known whether this loss will continue at the same rate, or what the long-term effect of this device on the cornea's health might be.
To minimize any potential long-term effects of the device on the corneal endothelium, FDA is requiring the labeling for the new lens to specify that it should be used only on patients whose corneal endothelial cells are dense enough to withstand some loss over time.
http://www.medicalnewstoday.com/medicalnews.php?newsid=13397

  
 Endothelium Dystrophy Fuchs Corneal Dystrophy Information
This is not "medical advice" but only an average person who has Fuchs' Corneal Dystrophy relating what she has learned from the disease she has.
That's why many people with Fuchs' Corneal Dystrophy are "blinded" by car headlights at night, and have difficulty identifying people when the light is behind the person they're viewing.
I know that the usual reaction to being diagnosed with such a relatively unknown eye disease is shock, panic, and the strong desire for information about it.
http://www.fuchsinformation.cornealdystrophy.com/

  
 1999 Training and Research Programs in Vision Science
Our laboratory is using cell and molecular biology techniques to study the molecular basis for this limited division to determine whether proliferation could be transiently stimulated as a treatment for some forms of corneal endothelial dysfunction.
Identification of the PKC isoforms that stimulate proliferation of corneal endothelial cells and determination of their specific regulatory effects are early steps leading to possible pharmacologic stimulation of division in human corneal endothelium.
Currently a tissue culture model of rat corneal endothelial cells is being used for evaluation of the activity of specific PKC isoforms on relative proliferative activity.
http://www.eri.harvard.edu/htmlfiles/training/joyce.html

  
 Immunolocalization of electrogenic sodium-bicarbonate cotransporters pNBC1 and kNBC1 in the rat eye -- Bok et al. 281 ...
A-F : immunolocalization of pNBC1 in rat corneal epithelium and stroma.
There are several cell types in the eye where functional electrogenic sodium-bicarbonate cotransport has been reported.
Light - evoked changes in extracellular pH in frog retina.
http://ajprenal.physiology.org/cgi/content/full/281/5/F920

  
 Corneal Endothelium and Trabecular Meshwork Lab
In both the cell types (i.e., trabecular meshwork and corneal endothelial), common focus is on the convergence of various signal transduction pathways which result in the regulation of actin cytoskeleton through phosphorylation of regulatory light chain of Myosin II (abbreviated as MLC).
In the corneal endothelium, we hypothesize that MLC phosphorylation decreases the barrier integrity at the posterior surface of the cornea and thereby impedes the stromal hydration control.
We are currently involved in two main research projects:
http://research.opt.indiana.edu/Labs/CornealEndothelium

  
 Lysosomal Ca2+ Stores in Bovine Corneal Endothelium -- Srinivas et al. 43 (7): 2341 -- Investigative Ophthalmology & ...
The dye-loaded cornea was then trephined, and the resultant
This study demonstrates the presence of Ca stores in lysosomes
corneal endothelial cells that had been previously shown only
http://www.iovs.org/cgi/content/full/43/7/2341

  
 Calcium Influx Factor from Cytochrome P-450 Metabolism and Secretion-like Coupling Mechanisms for Capacitative Calcium ...
A, CalyA and BFA treatment significantly attenuated CCE.
The effects of rearranging the actin cytoskeleton on CCE
In the current study, the secretion-like coupling and CIF models were examined using a combinatorial approach in corneal endothelial
http://www.jbc.org/cgi/content/full/277/19/16559

  
 Quantitative evaluation of the corneal endothelium in the mouse after grafting -- Plskova et al. 88 (9): 1209 -- ...
Results: In control corneas, more than 90% of the posterior
Conclusion: In corneal allografts there is progressive loss
Quantitative evaluation of the corneal endothelium in the mouse after grafting -- Plskova et al.
http://www.bjophthalmol.com/cgi/content/abstract/88/9/1209

  
 Faculty Publications 96
Joyce, N.C., Navon, S.E., Roy, S., and Zieske, J.D.: Expression of cell cycle-associated proteins in human and rabbit corneal endothelium in situ.
Fini, M.E., Parks, W.C., Rinehart, W.B., Girard, M.T., Matsubara, M., Cook, J.R., West-Mays, J.A., Sadow, P.M., Burgeson, R.E., Jeffrey, J.J., Raizman, M.B., Krueger, R.R., and Zieske, J.D.: Role of matrix metalloproteinases in failure to re-epithelialize after corneal injury.
Ksander, B.R.: Introduction of J. Wayne Streilein 1996 recipient of the Proctor medal.
http://www.schepens.org/faculty_publications_96.htm

  
 nutritional supplements and vitamins from Wassen
Riley M. V., Physiologic neutralisation mechanisms and the response to corneal endothelium to hydrogen peroxide, CLAO J, 1990, Vol.
http://www.wassen.com/profres1/nutritional-supplements-Visio-Max.htm

  
 Immunology and Uveitis Service Publications Book Chapters
Lack of Blood Group Antigen A on Human Corneal Endothelium.
In: Brightbill FS, editor, Corneal Surgery: Theory, Technique and Tissue, 3
Principles and Practice of Ophthalmology: Section XVII, Chapter 332, 2
http://www.uveitis.org/medical/pubs/chapters.html

  
 Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney -- Fang et al. 542 (1): 63 -- The Journal of ...
Additional comments follow, after which general issues with regard to aquaporin-mediated CO transport are discussed.
The exchange of CO between the air-space and erythrocytes in alveolar capillaries involves CO movement across the alveolar epithelium and endothelium, and the erythrocyte membrane, as well as CO diffusion through the lung interstitium and serum.
, J. Effect of AQP1 expression level on CO permeability in bovine corneal endothelium.
http://jp.physoc.org/cgi/content/full/542/1/63

  
 Energy Citations Database (ECD) Document #6725254 - Mechanisms of allograft rejection of corneal endothelium
Energy Citations Database (ECD) Document #6725254 - Mechanisms of allograft rejection of corneal endothelium
http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=6725254

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