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| | Acetaminophen and codeine phosphate tablets are indicated for the relief of mild to moderately severe pain. | | | Dosage should be adjusted according to severity of pain and response of the patient. | | | If the mother has received narcotic analgesics during labor, newborn infants should be observed closely for signs of respiratory depression. |
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| | Therefore, even though the cause of the pain may remain, less pain is actually felt. | | | When taken together with other drugs that have a sedative effect on the central nervous system, for example, alcohol, sleeping drugs, antidepressant drugs and antihistamines, drowsiness is likely to be increased. | | | Codeine is also sometimes used to treat diarrhoea because of it's constipating side effect, however this is not a recommended use. |
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| | Codeine Pharmacology |
| | Codeine is an opioid (methylmorphine) with a relatively limited analgesic effect; it does not cause significant respiratory depressions but has good antitussive properties. | | | In most humans 10% of a codeine dose is transformed to morphine through demethylation in the liver. | | | This explains the analgesic effect that is absent in individuals with the respective genetic traits ("slow debrisoquine metabolism"). |
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