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| | Department of Pediatrics Robert W. Wilmott, M.D. ,IMMUNO Professor & Chair Saint Louis University School of Medicine |
 | | The purpose of the Section of Hemostasis and Thrombosis in the Division of Hematology/Oncology is to provide multidisciplinary care and to facilitate clinical research for patients with the chronic disorders of inherited coagulopathies, thrombophilia, and HIV exposure/infection. | | | A team approach utilizing a specialized staff of nurses, social workers, physical therapists, and physicians work with patients and their families to promote independence, understanding and prevention of long term disabilities. | | | Special services include a Comprehensive Hemophilia Clinic which provides the multidisciplinary care for patients with chronic disorders of inherited coagulopathies, and the HIV/AIDS clinic which provides comprehensive care including pediatrician/hematologist, immunologist and nursing coordination for the individual patient’s care. |
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http://pediatrics.slu.edu/index.phtml?page=hemostasisdiv&cat=divisions
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| | Hematopathology Fellowship, Department of Laboratory Medicine at Yale |
| | The program takes advantage of the rich environment in both anatomic and clinical pathology at these institutions with a special emphasis on integrating all aspects of clinical practice, teaching and research with the other academic activities in Pathology and Laboratory Medicine at Yale. | | | The basic "how-to" of procedures is also taught during this initial set of rotations - this includes, for example, doing bone marrow aspirates and biopsies on the floor and interviewing patients with coagulopathies (both during the heme/coag and flow/molecular rotations). | | | In each rotation, the role of the pathologist as consultant is the focus of learning - trainees communicate results of studies directly to other clinicians, albeit during this initial period of time that communication is often carried out in the presence of the pathology attending. |
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http://info.med.yale.edu/labmed/residency_fellowships/hematopath_fellowship.html
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| | [No title] |
| | The ACT test is a test of the intrinsic clotting pathway and is sensitive to severe platelet deficiencies. | | | In dogs with a coagulopathy this time is often increased. | | | Activated coagulation times of whole blood in normal dogs and dogs with coagulopathies. |
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http://www.nwlabs.co.uk/tp9-coagulation-timehtml.html
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| | Guidelines for the Management of Bleeding |
| | Most coagulopathies of primary or secondary hemostasis are acquired due to an underlying systemic disorder. | | | Perform these tests in the absence of anticoagulant therapy but when bleeding suggests a coagulopathy. | | | Useful when anticoagulant therapy has been ruled out and when bleeding suggests a coagulopathy. |
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http://peir.path.uab.edu/coag/article_222.shtml
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| | Research Activities, June 2001: Outcomes/Effectiveness Research: Nearly one-third of stroke patients receive blood ... |
| | In this study, for example, these tests were ordered for patients who already had other indications for anticoagulation (blood-thinning) therapy with warfarin or for patients with contraindications to receiving warfarin. | | | Young patients with ischemic stroke are more likely to have a coagulopathy, even though this still accounts for only 10 to 15 percent of stroke cases in this group. | | | Nearly one-third of stroke patients receive blood coagulation testing when the result is unlikely to influence treatment |
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http://www.ahrq.gov/research/jun01/601RA10.htm
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| | Prothrombin Time |
| | Thus, it is indicated to perform an assessment of the clotting pathways prior to invasive procedures in an animal with hepatic pathology. | | | The intrinsic pathway is evaluated with the APTT test. | | | Coagulopathies and Hepatic Disease: The clotting factors are acute phase reactant proteins that are manufactured in the liver. |
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http://www.vetmed.wsu.edu/courses_vm546/content_links/Clinical_Pathology/Lab_Tests/ospt.htm
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| | Bleeding Web - the bleeding information source |
| | Patients with antithrombin III deficiency should receive full therapeutic heparin therapy for the entire pregnancy, irrespective of their thromboembolic history. | | | These conditions are also associated with intrauterine growth retardation and preeclampsia. | | | Postpartum therapy with either heparin or warfarin is required in all cases. |
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http://www.bleedingweb.com/artsumdisplayc.asp?num=5
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| | Brazil (Brasilia) |
| | Intensive therapy), monitoring by hematologists training in coagulopathies. | | | Laboratory Activities/Research: Our laboratory is dedicated to patients with hemorrhagic congenital coagulopathies, but is not yet involved in research. | | | Out patient department - Comprehensive treatment with a Multidisciplinary team: Haematology; Orthopaedic, Clinical (adult and child), nurse issues, physiatry, Dental issues, physiotherapy and therapeutic fitness education. |
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http://www.wfh.org/ShowDoc.asp?Rubrique=26&Document=337
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| | Research Activities, August 2002: Heart Disease and Stroke: Educating neurologists about coagulation tests could ... |
| | More details are in "Physician knowledge and practices in the evaluation of coagulopathies in stroke patients," by Drs. | | | Educating neurologists to optimize diagnostic testing for coagulopathies in stroke patients will most likely require reminder systems, educational outreach, and other strategies, says Cheryl D. Bushnell, M.D., M.H.S., and Larry B. Goldstein, M.D., of Duke University Medical Center. | | | Blood coagulation disorders (coagulopathies) are a rare but recognized cause of stroke. |
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http://www.ahrq.gov/research/aug02/0802RA8.htm
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| | :: Bonfils Blood Center :: www.bonfils.org :: |
| | History: "Coagulopathies" uses the decision-making structure of the earlier "Platelets in Transfusion Medicine" module. | | | Cases and content material relating to the assessment and management of hemostasis disorders have been substituted for the material in Module 2. | | | A summary of student actions is presented after each case, and extensive provisions are made for student self-evaluation. |
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http://www.bonfils.org/bonfils.php?section=about&page=research&drill=tmep2#module_2
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| | Thoracic surgery |
| | Patients who have blood-clotting problems (coagulopathies), and who have had previous standard thoracic surgery may not be good candidates for video-assisted thoracic surgery (VATS). | | | Blunt chest trauma, reflux esophagitis, esophageal cancer, lung transplantation, lung cancer, and emphysema are just a few of the many clinical indications for thoracic surgery. | | | Because VATS requires the collapse of one lung, potential patients should have adequate respiratory function to maintain oxygenation during the procedure. |
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http://www.healthatoz.com/healthatoz/Atoz/ency/thoracic_surgery.jsp
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| | Asprin For Prevention - HealthIsNumberOne.com |
| | Asprin is not for patients with stomach ulcers, bleeding problems (coagulopathies) and certain other problems. | | | Risks and benefits should be discussed with your family physician. |
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http://www.healthisnumberone.com/libasprin.htm
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| | Coagulation Disorders |
| | The classic coagulation cascade is composed of two basic parts, an intrinsic pathway and an extrinsic pathway (Fig. | | | The origin of ICH in these patients was coagulopathic, but the coagulopathy was very different from that in patients with leukostasis. | | | Coagulopathies are another major cause of ICH in cancer patients and are most often seen in those with leukemia. |
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http://www.vaccinetruth.org/coagulation_disorders.htm
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| | Beaumont Hospitals - Transfusion Medicine |
| | The Blood Banking/Transfusion Medicine Fellowship, started in 1978, is a twelve-month ACGME-accredited program intended to prepare an American Board of Pathology eligible or certified pathologist for practice in hospital-based, academic or blood center Transfusion Medicine. | | | The fellow develops expertise in community hospital Blood Banking through a busy FDA-registered autologous blood collection program, clinical apheresis service and consultation service for transfusion support and evaluation of patients with coagulopathies. |
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http://www.beaumonthospitals.com/pls/portal30/cportal30.webpage?l_recent=gme_fel_transfuse
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| | OSTEONECROSIS |
| | One of the major aims of the Center for Osteonecrosis Research and education is to conduct basic science experiments pertaining to the pathogenesis of this disease process. | | | As recent reports in the medical literature have provided evidence that patients with osteonecrosis may have defects in their blood clotting system, we currently screen all of our osteonecrosis patients for coagulopathies. | | | Larger numbers of patients and matched control subjects are needed to define the association between coagulopathies and osteonecrosis. |
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http://hipuniverse.homestead.com/files/jhavn.htm
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| | Refortan (HES 200/0,5; 6%) |
| | Prescribed for: Therapy and prophylaxis hypovolemic and of other origin shock, including haemoragic, traumatic, septic and after combustion. | | | Contraindications: congestive cardiac insufficiency, renal diseases with oliguria or anuria not associated with hypovolemia, severe coagulopathies, intracerebral haemorrhage; hyper hydration or serious dehydration; hyper sensibility to the drug. | | | The dose is settled individually in dependence of the pacient’s condition and age. |
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http://www.refortan.md/index.php?domen_id=57&lang=en&sessia=&username_medicina=
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| | [No title] |
| | The use of recombinant factor VIIa may be a valuable therapeutic option in children with severe acquired coagulopathies since it provides a good hemostatic efficacy and probably few adverse side-effects. | | | Besides this well recognized therapy rFVIIa is used to control bleedings caused by a variety of diseases like thrombocytopathies, liver disease, during liver transplantation or cardiac surgery. | | | In contrast to rising experience obtained by ongoing clinical trials in adults, poor data exit for the use of rFVIIa in acquired coagulopathies in childhood. |
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http://www.blackwellpublishing.com/isth2003/abstract.asp?id=8233
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| | PetPlace.com - Article: Hematemesis (Vomiting Blood) |
| | It is best to determine the underlying cause, and treat the specific problem, rather than attempting only symptomatic therapy. | | | Coagulopathies or bleeding disorders should be considered, especially if there is evidence of bleeding from other body sites as well. | | | The most common causes are usually diseases or disorders of the upper gastrointestinal tract, although in some cases, clotting disorders (coagulopathies) may result in bleeding even though the gastrointestinal tract is essentially healthy. |
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http://www.petplace.com/articles/artPrinterFriendly.asp?conID=22398
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| | New Drugs for Hemorrhage and HIT |
| | Few human studies of factor VIIa exist, and most of those that have been done included only patients with preexisting coagulopathies. | | | Factor VIIa has been used as a treatment for hemophilia for years; it has been shown to be effective in patients with other coagulopathies. | | | Most evidence to support the use of factor VIIa in trauma patients is anecdotal, consisting of testimonials and case reports. |
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http://www.pulmonaryreviews.com/may03/pr_may03_newdrugs.html
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| | Medical Support of the US Army in Vietnam |
| | To see a patient suddenly begin to bleed profusely from every orifice and wound just as heroic surgery appeared to be successful was a dramatic experience. | | | Fortunately the number of patients suffering from coagulation problems was small, but the threat after massive, transfusions and surgery was ever present. | | | Since coagulopathies usually occur in combinations and rarely in the pure form, study under field conditions is almost impossible. |
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http://www.ehistory.com/vietnam/books/medsup/0123.cfm
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| | eMedicine - Spinal Hematoma : Article by Charles E Rawlings III, MD |
| | Diagnosis and treatment follow those of any spinal cord AVM—a subject too broad for this article. | | | In these patients, treatment was not only surgical but also involved the correction of the coagulopathy by reversing the effects of coumadin. | | | Schenk and Wisoff, in separate reports, detail cases in which patients suffered a spinal cord hematoma secondary to their intrinsic coagulopathies. |
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http://www.emedicine.com/med/topic2890.htm
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| | PathMax: Award--June 2000 |
| | Part 3 contains a list of coagulopathies and their mechanisms and suggested therapies. | | | The winner demonstrates an integrated approach to web-based coagulopathy education in an intuitive, well-designed interface. | | | In all, the suite works as a dynamic textbook and is useful for the day to day workup of coagulopathies as well as a board study tool. |
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http://www.pathmax.com/awardjun2000.html
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| | COMMON PERIOPERATIVE ACQUIRED COAGULOPATHIES Surgery PLAB AIPPG USMLE |
| | : COMMON PERIOPERATIVE ACQUIRED COAGULOPATHIES and Surgery ! | | | Hemodilution: Dilutional coagulopathy can complicate fluid resuscitation from trauma or major perioperative hemorrhage, or it may be from elective normovolemic hemodilution induced during perioperative use of blood/cell saver. | | | PT most useful test in detecting coagulopathy secondary to liver disease. |
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http://www.aipge.com/article605.html
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| | VECCS - Journal Article Abstracts |
| | Thrombotest (PIVKA) Test Results in 25 Dogs with Acquired and Hereditary Coagulopathies | | | The most common vitamin K-responsive coagulopathy is anticoagulant rodenticide intoxication, although vitamin K deficiency may also occur with malnutrition and intestinal malabsorption, extended oral antibiotic therapy, and hepatic disease. | | | Abnormalities of coagulation may be acquired or inherited, however, acquired causes of abnormal coagulation constitute the majority of cases seen in clinical practice. |
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http://veccs.org/public/journal/abstracts.cfm?abstractID=39&...
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| | Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations |
| | Energy Citations Database (ECD) Document #6481987 - Sensitivity and specificity of fluid-blood levels for coagulopathy in acute intracerebral hematomas | | | Sensitivity and specificity of fluid-blood levels for coagulopathy in acute intracerebral hematomas | | | Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link. |
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http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=6481987
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| | Medical hemostasis in experimental liver resection with antifibrinolytic therapy Cihan Alper, Yilmaz Erdal - Indian J ... |
| | Perioperative or postoperative coagulopathies can be caused by the surgical procedure itself, by the pre-existing coagulopathy of the patient, accompanying pathologies, administered medications, hypothermia and dilutional effects. | | | Instead of being treated with medical hemostasis, stress and coagulopathic conditions caused by parenchymatous organ injuries due to blunt traumas may result in unnecessary surgical interventions. | | | In patients undergoing prolonged surgical procedures, in those with trauma [1] and hemorrhage, bleeding resulting from disturbances of coagulation cascade and factor deficiencies has been observed. |
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http://www.indianjsurg.com/article.asp?issn=0972-2068;year=2004;volume=66;issue=4;spage=227;epage=231;aulast=Cihan
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| | Program_PM |
| | Transfusion triggers, component therapy for coagulopathies, transfusion risks, blood salvage. |
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http://www.anesthesia.org/winterlude/wl98/Program_PM.htm
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| | MEDIC: CLINICAL HANDBOOK: Acute Intermittent porphyria |
| | In patients who do not have coagulopathies or are not on anticoagulant therapy the use of hematin can be considered. | | | Autonomic manifestations such as hypertension and tachycardia have been controlled with the use of propanolol. | | | If started early in the attack it may have benefit through the lowering of porphyrin precursor excretion. |
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http://medic.med.uth.tmc.edu/path/00000805.htm
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| | Oncaspar Side Effects, and Drug Interactions - L-asparaginase - RxList Monographs |
| | Excluding hypersensitivity reactions, the most frequently occurring known L-asparaginase related toxicities and adverse experiences reported for the 174 patients in clinical studies were chemical hepatotoxicities and coagulopathies, the majority of which did not result in any significant clinical events. | | | Overall, the adult patients treated with ONCASPAR® had a somewhat higher incidence of known L-asparaginase toxicities, except for hypersensitivity reactions, than the pediatric patients treated with ONCASPAR®. |
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http://www.rxlist.com/cgi/generic2/pegaspargase_ad.htm
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| | WSAVA 2001 - Coagulopathies—SOTAL |
| | Coagulopathies may be associated with single or multiple sites of bleeding characterized by cavity bleeding such as hematoma, hemarthrosis, hemomediastinum, and hemoperitoneum and —thorax, but gastrointestinal hemorrhage and bruising may also occur. | | | Hemorrhagic presentations may suggest certain hemostatic disorders and practical tests are available to characterize the bleeding tendency. | | | Signs of other underlying diseases may be recognized. |
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http://www.vin.com/VINDBPub/SearchPB/Proceedings/PR05000/PR00103.htm
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| | Labfax Disease Investigation 5 - Investigation of Coagulopathies |
| | The age of onset, breed, history of previous episodes, relation to surgical procedures or trauma, drug therapy, access to toxins and any familial history of haemorrhagic episodes should be recorded. | | | Coagulopathies in dogs most commonly present as a bleeding tendency. | | | Coagulopathies due to platelet disorders (primary haemostasis) commonly present with multiple pettechiation or ecchymoses (skin, mucosal surface or gingiva), epistaxis, melaena, haematuria, retinal/intraocular haemorrhage, bleeding after venupuncture or prolonged bleeding from incisions. |
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http://www.nwlabs.co.uk/di5-coag.htm
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| | The Fluoroquinolone Toxicity Research Foundation |
| | Complications arising from antibiotic use are of interest to neurosurgeons because many neurosurgical patients are treated for infection. | | | In this report, the authors describe three patients with spine disorders who developed coagulopathies after treatment with levofloxacin, an antibiotic commonly used by neurosurgical services. | | | Three patients with spine disorders developed urinary tract infections (UTIs) for which they received a 3-day course of oral levofloxacin. |
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http://www.fqresearch.org/blood_2.htm
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| | Glasgow ePrints Service - Dental management considerations for the patient with an acquired coagulopathy. Part 1: ... |
| | Dental management considerations for the patient with an acquired coagulopathy. | | | Current teaching suggests that many patients are at risk for prolonged bleeding during and following invasive dental procedures, due to an acquired coagulopathy from systemic disease and/or from medications. | | | Making changes in anticoagulant drug regimens are often unwarranted and/or expensive, and can put patients at far greater risk for morbidity and mortality than the unlikely outcome of postoperative bleeding. |
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http://eprints.gla.ac.uk/archive/00000176
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| | Leah Teragawa-Choi |
| | Whether all trauma patients suffer from coagulopathies is debatable. | | | There is evidence coagulopathies play a role in acute respiratory distress syndrome (ARDS) and multiple organ failure (MOF) following trauma. | | | ARDS and MOF may be sequelae of disseminated intravascular coagulopathies (DIC). |
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http://www.umdnj.edu/snjmsweb/Main/Summer/LEAH_TERAGAWA_CHOI.html
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| | Liberto Pechet - Faculty - Pathology - UMass Medical School |
| | As a clinician, I am most interested in patients with lymphoproliferative disorders, and with coagulopathies. | | | I am both a practicing hematologist and a hematology laboratorian with boards in clinical pathology for hematology. | | | In the laboratory, I am particularly interested in various aspects of quality assurance. |
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http://www.umassmed.edu/pathology/faculty/Pechet.cfm
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| | Coagulopathies |
| | To become familiar with the clinical conditions resulting in coagulopathies | | | To become familiar with the clinical presentations of coagulation disorders | | | To become familiar with the treatment principles of coagulopathies |
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http://www.vetmed.lsu.edu/oncology/Thrombocytopenia/tsld029.htm
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| | Hematologic Complications of HIV Infection |
| | This review explores the causes of isolated or trilineage cytopenias and coagulopathies; the utility of bone marrow biopsy examination; and the role of colony-stimulating factors as therapeutic agents in patients with HIV disease. | | | Hematologic complications of HIV infection are common and challenge physicians treating patients at all stages of HIV disease [1,2]. | | | Ineffective hematopoiesis, infiltrative diseases of the bone marrow, nutritional deficiencies, peripheral destruction of blood cells secondary to splenomegaly or immune dysregulation, and drug effects all contribute to the variety of hematologic abnormalities seen in these patients. |
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http://www.cancernetwork.com/journals/oncology/o9605b.htm
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| | UCLA Department of Medicine - wfsection-Deep Venous Thrombosis and Pregnancy |
| | Inherited coagulopathies are among the major causes of thromboembolism; these disorders are thought to be responsible for approximately half of all DVT. | | | In addition, many patients with an identifiable acquired or transient provoking risk factor should also be screened for inherited coagulopathies since 50% of the DVT in patients with thrombophilia are provoked by a recognized risk factor. | | | The risk of maternal thrombosis is further increased 8 fold in patients with a hereditary coagulopathy compared to women without such an abnor-mality. |
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http://www.med.ucla.edu/modules/wfsection/article.php?articleid=71
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| | Liver Disease Assays |
| | These assays are available from the UAB Coagulation Service to detect and monitor liver disease and the coagulopathies associated with liver disease. |
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http://peir.path.uab.edu/coag/article_156.shtml
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| | iknowledgenow.com |
| | Knowledge of the possible causes of hemorrhage with special reference to clotting deficits is the key to rational and effective treatment of these patients. | | | Detection of petechia or ecchymosis is commonly associated with thrombocytopenia or thrombocytopathia. | | | Once a coagulopathy has been identified, treatment can be designed to provide what is needed to control bleeding. |
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http://www.iknowledgenow.com/search.cfm?keywordlist=Bleeding
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| | HEMEX Laboratories |
| | We offer a full range of clinical testing, interpretation, pathologist review, and consultation to assist clinicians in the diagnosis and treatment of a wide range of coagulopathies and hematological disorders. |
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http://www.hemex.com
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| | Transjugular Liver Core Biopsy: Indications, Results, and Complications |
| | In a small number of patients severe complications may occur. | | | CONCLUSION: In patients with coagulopathies, transjugular liver biopsy is a viable alternative for hepatic tissue evaluation with a good sample quality. | | | MATERIALS AND METHODS: Eighty-five consecutive patients (57 males, 28 females) with various liver disorders (cirrhosis [30], hepatitis [12], acute hepatopathy [34], orthotopic liver transplantation [8], hepatocellular carcinoma [1]), coagulopathies (n=71) and/or ascites (n = 46) were referred to our department for a transjugular liver biopsy. |
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http://www.natap.org/2003/nov/113003_16.htm
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| | Listserve For EmergencyMedical Practioners: Re: [EMED-L] A coupl |
| | A 24 hour delay on antibiotic therapy in getting a CSF sample in suspected bacterial meningitis may preclude identification of the organism but will still allow you to confirm a sisgnificant inflamatory response by observing polymorphonuclear cells. | | | With respect to LP if its bacterial memingitis that is suspected I would treat empirically with antibiotics admit the patient and let the medicine service correct the coagulopathy to the point were an LP can be done safely. | | | I have seen to epidural spinal bleeds leading to permanent plegia and so you will forgive me for ignoring the literature on this if it says otherwise. |
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http://www.ucsf.edu/its/listserv/emed-l/18820.html
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| | nosocomial hepatitis |
| | Those patients had marked coagulopathies, and transmission to the sixth patient most probably occurred through environmental contamination by patients or through cross-contamination between patients through staff. | | | A sixth patient died in August 1986 (second generation), after his initial admission in June that coincided with the terminal hospitalizations of three first-generation patients. | | | The unusually high mortality rate (5 of 6) in this outbreak has not been definitely explained. |
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http://www.hepatitisdoctor.com/nosocomial%20hepatitis.html
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