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| | Cisplatin (PIM 132) |
 | | Ototoxicity, as induced by cisplatin, is cumulative so therapy is contraindicated in patients with pre-existing hearing impairments. | | | Cisplatin is carcinogenic in animals so care must be exercised in regards to handling cisplatin and wastes associated with patients receiving cisplatin. | | | Breastfeeding is not recommended during cisplatin therapy due to potential risk to the infant (Briggs et al., 1990). |
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http://www.intox.org/databank/documents/pharm/cisplat/cisplat.htm
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| | Cisplatin - Wikipedia, the free encyclopedia |
| | This study found that cis-diamminedichloroplatinum(II) was the most effective out of this group, which started the medicinal career of cisplatin. | | | Cisplatin: The Invention of an Anticancer Drug by Andri Smith | | | Neurotoxicity (nerve damage) can be anticipated by performing nerve conduction studies before and after treatment. |
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http://en.wikipedia.org/wiki/Cisplatin
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| | Cisplatin and DNA repair in cancer chemotherapy |
| | The mechanisms by which cells develop resistance to cisplatin is an area of intense research because it is one of the major impediments to the clinical success of this drug. | | | Cisplatin is indicated as palliative therapy to be employed against: Metastatic testicular tumors - Most effective | | | There are two major limitations to Cisplatin therapy: |
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http://bioweb.wku.edu/courses/Biol588/Bishopl.html
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| | MedlinePlus Drug Information: Cisplatin (Systemic) |
| | Cisplatin is to be administered only by or under the immediate supervision of your doctor. | | | While you are being treated with cisplatin, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. | | | Before you begin treatment with cisplatin, you and your doctor should talk about the good this medicine will do as well as the risks of using it. |
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http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202143.html
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| | MedlinePlus Drug Information: Cisplatin |
| | Talk to your doctor about the possible risks of using this drug for your condition. | | | This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. | | | tell your doctor and pharmacist if you are allergic to cisplatin or any other platinum-containing compounds such as carboplatin (Paraplatin, CBDCA) or any other drugs. |
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http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a684036.html
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| | Cisplatin |
| | Cisplatin is a chemotherapy drug used to treat some forms of cancer. | | | People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status. | | | Silymarin has not yet been studied in humans treated with cisplatin. |
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http://www.a1nutritionproducts.com/health/Drug/Cisplatin.htm
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| | Cisplatin factsheet |
| | This fact sheet explains what Cisplatin is, how it is given and some of the possible side effects. | | | Strange taste: It is possible that your child may experience a strange taste whilst receiving cisplatin. | | | Your child may complain of aches and pains in their legs. |
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http://www.gosh.nhs.uk/factsheets/families/F990241
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| | cisplatin - [Medication] |
| | Your doctor will determine the correct amount and frequency of treatment with cisplatin depending upon the type of cancer being treated and other factors. | | | If for any reason an overdose of cisplatin is suspected, seek emergency medical attention or contact your healthcare provider immediately. | | | Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with cisplatin to monitor progress and side effects. |
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http://www.peacehealth.org/kbase/multum/d00195a1.htm
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| | Phase III Study of Pemetrexed in Combination With Cisplatin Versus Cisplatin Alone in Patients With Malignant Pleural ... |
| | Thodtmann R, Depenbrock H, Dumez H, et al: Clinical and pharmacokinetic phase I study of multitargeted antifolate (LY231514) in combination with cisplatin. | | | Samson MK, Wasser LP, Borden EC, et al: Randomized comparison of cyclophosphamide, imidazole carboxamide, and adriamycin versus cyclophosphamide and adriamycin in patients with advanced stage malignant mesothelioma: A Sarcoma Intergroup study. | | | does not overlap that of cisplatin (gastrointestinal, neurological, |
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http://www.jco.org/cgi/content/full/21/14/2636
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| | Cisplatin |
| | You may not be able to get pregnant or father a child after taking this medication. | | | Eye problems, such as blurred vision or loss of the ability to see colors. | | | Cisplatin is an intravenous (IV) medication usually given in a dose that is based on body surface area. |
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http://www.webmd.com/hw/cancer/tv6626.asp
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| | Methods of Treatment - Cisplatin - The Platinum Standard |
| | Cisplatin, like Gertrude Elion's 6-MP, is an example of an anticancer treatment that was discovered by serendipity, by following the curious puzzles that arise in scientific investigations. | | | Both cisplatin and carboplatin currently are used to treat testicular and ovarian cancer. | | | Cisplatin, as Rosenberg dubbed cis-diamminedichloroplatinum, was approved for use as a cancer drug in 1978. |
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http://chemheritage.org/EducationalServices/pharm/chemo/readings/cisplat.htm
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| | Product Label |
| | Cisplatin showed meaningful response rate in 7 studies as a sinle therapy for testicular tumors, in three studies as a combination therapy for testicular tumors and in two studies as a single or combination therapy for ovarian tumors. | | | FDA Oncology Tools Approval Summary for cisplatin for Metastatic testicular-in established combination therapy with other approved chemotherapeutic agents in patients with metastatic testicular tumors whoc have already received appropriate surgical and/or radiotherapeutic procedures. | | | Royal Morsdem Hospital study: 52 pts cisplatin alone RR 32%, cisplatin/hydration/mannitol 18% cr, 45% PR.. |
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http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=71
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| | News - Irinotecan/Cisplatin Combination Aids Lung Cancer Patients |
| | This is the finding of a multicentre study in Japan conducted by Kazumasa Noda and colleagues for the Japan Clinical Oncology Group. | | | Irinotecan plus cisplatin is an effective treatment for metastatic small-cell lung cancer. | | | There was a high response rate and a promising median survival time in an earlier phase two study of irinotecan plus cisplatin in patients with extensive small-cell lung cancer. |
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http://docguide.com/news/content.nsf/news/8525697700573E1885256B3D004EBB04
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| | ChemCases: Cisplatin - 17. Drug Resistance |
| | Even though cisplatin has proven to be a highly effective chemotherapeutic agent for treating various types of cancers, it has encountered the same fate as many other drugs used in cancer chemotherapy—namely, drug resistance. | | | Furthermore, in one case, a patient was treated with carboplatin, a close relative of cisplatin (see below); carboplatin was initially effective in treating the patient’s tumor, but resistance to this drug eventually occurred. | | | Therefore, it is beneficial for the cancer cell to develop mechanisms either to keep cisplatin out of the cell or to remove cisplatin from the cell; indeed, reducing cisplatin accumulation by cancer cells seems to be a major form of acquired resistance. |
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http://science.kennesaw.edu/~mhermes/cisplat/cisplat17.htm
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| | ChemCases: Cisplatin - 13. Recent Developments |
| | Once a successful drug has been discovered for the treatment of a particular disease or condition, researchers will often try to improve on that drug by synthesizing and studying related compounds, referred to as analogs or second-generation drugs. | | | Researchers believe that these third-generation drugs are more effective than cisplatin because they are taken up into the cell in greater concentrations than cisplatin. | | | It would be impossible to describe all of that research here, so we will focus on just two areas of continuing study: the development of second- and third-generation drugs in the cisplatin family, and the research on the cellular target of cisplatin. |
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http://science.kennesaw.edu/~mhermes/cisplat/cisplat13.htm
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| | cisplatin |
| | Cisplatin (cis-diamminedichloroplatinum(II)) is a DNA damaging anticancer drug used most successfully for the treatment of testicular tumors. | | | Reference: Zdravesky, Z.Z., Mello, J.A., Marinus, M.G. and Essigmann, J.M. Multiple pathways of recombination define cellular responses to cisplatin. | | | Finally, cisplatin was found to be a potent recombinogen in comparison to the therapeutically inactive trans isomer. |
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http://users.umassmed.edu/martin.marinus/cisplatin.html
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| | Cisplatin |
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