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Topic: Cholinergic



  
 Structure and Function of Cholinergic Pathways in the Cerebral Cortex, Limbic System, Basal Ganglia, and Thalamus of ...
Cholinergic pathways are phylogenetically ancient and anatomically ubiquitous.
Cortical cholinergic pathways are thus in a position to alter the neural impact of sensory experiences according to their behavioral significance.
The preferential concentration of cholinergic innervation in these parts of cortex may explain why cholinergic antagonists and cholinoactive drugs seem to have a preferential effect on memory, learning, and other limbic functions such as mood, reward, and aggressive behaviors (15, 77, 78).
http://www.acnp.org/g4/gn401000012/ch012.html   (5715 words)

  
 Urticaria, Cholinergic
Cholinergic Urticaria is a disorder of the immune system characterized by an immediate skin reaction (hypersensitivity) to heat, emotional stress, and/or exercise.
Hydroxyzine hydrochloride (Atarax) is the drug of choice for the treatment of Cholinergic Urticaria.
Cholinergic Urticaria is a specific form of Physical Urticaria.
http://hw.healthdialog.com/kbase/nord/nord249.htm   (1781 words)

  
 Effects of 60 Hz Magnetic Field on the Cholinergic System
The purpose of this research project is to study the effects of 60-Hz magnetic field exposure on neurological functions and behavior in the rat.
Since both cholinergic system and endogenous opioids play important roles in neurophysiological functions, and behavioral changes could lead to detrimental health effects, we will carry out experiments to further investigate and characterize our preliminary findings.
Data from preliminary experiments suggest that acute exposure to magnetic fields affects two neurochemical systems in the brain of the rat.
http://infoventures.com/emf/federal/rapid/nov95res/lai.html   (928 words)

  
 eMedicine - Urticaria, Cholinergic : Article by Jere D Guin, MD, FACP
Aspirin aggravated the condition in 52% of patients with cholinergic urticaria, which is similar to other forms of urticaria.
In cholinergic urticaria, whether skin lesions are provoked by passive heating of the body at rest (eg, saunalike conditions) or by active heating at a low ambient temperature is basically related to the thermoregulatory process.
Cholinergic dermographism comprises a localized distribution of typical tiny wheals that appear after stroking the skin of some patients with cholinergic urticaria.
http://emedicine.com/DERM/topic442.htm   (1981 words)

  
 The role of the septohippocampal cholinergic system in cognitive functions
The basic mechanisms by which the cholinergic therapy affects cognition are still poorly understood.
Therefore, the basis of the cholinergic therapy for AD is mainly symptomatic.
Cholinergic synapses in the rat brain: a correlated light and electron microscopic immunohistochemical study employing a monoclonal antibody against choline acetyltransferase.
http://www.uku.fi/neuro/54the.htm   (17634 words)

  
 Cholinergic Transmission
That is the result of a less obvious third effect in the eye, which is mediated by interruption of cholinergic tone to the ciliary muscle which controls the angle of refraction of the lens.
In the absence of more specific therapy, diazepam (ValiumR) can be used to control the delirium and convulsions.
Contraction of the ciliary muscle allows the lens to round up by its own elasticity to accommodate for near vision.
http://www.dartmouth.edu/~rpsmith/Cholinergic_Transmission.html   (11031 words)

  
 Evidence for Differential Reflex Regulation of Cholinergic and Noncholinergic Parasympathetic Nerves Innervating the ...
These increases in cholinergic tone were typically preceeded by rapidly developing but short-lived decreases in cholinergic tone.
cholinergic tone evoked by laryngeal capsaicin were exceedingly
cholinergic tone in the trachea was elevated by 50-100% in most
http://ajrccm.atsjournals.org/cgi/content/full/165/8/1076   (5092 words)

  
 Fetal Chlorpyrifos Exposure: Adverse Effects on Brain Cell Development and Cholinergic Biomarkers Emerge Postnatally ...
CPF has adverse effects on cholinergic synaptic function and behavior that are elicited even at exposures below the threshold for overt fetal or maternal toxicity, with a window of vulnerability extending from prenatal through neonatal stages (Dam et al.
Indeed, when animals given prenatal CPF were evaluated for behavioral performance in adolescence and adulthood, they displayed deficits in cognitive behaviors that depend specifically upon septohippocampal cholinergic function, and showed selective loss of the cholinergic components of working and reference memory (Levin et al.
Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways.
http://ehp.niehs.nih.gov/members/2003/5828/5828.html   (7778 words)

  
 The Cholinergic Hypothesis of Neuropsychiatric Symptoms in Alzheimer's Disease -- Cummings and Back 6 (2): 64 -- ...
Cholinergic therapies promise to be part of the armamentarium
Cholinergic deficits contribute to behavioral disturbance in patients with dementia
Relationships between the cholinergic deficits and the behavioral
http://ajgp.psychiatryonline.org/cgi/content/full/6/2/S64   (4437 words)

  
 A Review of Cholinergic Agents in the Treatment of Neurobehavioral Deficits Following Traumatic Brain Injury -- Griffin ...
Although cholinergic mechanisms of behavioral disorders in TBI
of cholinergic agents in treating cognitive, and possibly behavioral,
work to enhance cholinergic activity in the brain.
http://neuro.psychiatryonline.org/cgi/content/full/15/1/17   (4619 words)

  
 The cholinergic hypothesis of Alzheimer's disease: a review of progress -- Francis et al. 66 (2): 137 -- Journal of ...
lesioning of cholinergic pathways that lead to the hippocampus.
Effects of cholinergic and non-cholinergic drugs on visual discrimination and delayed visual discrimination performance in rats.
The basal forebrain-cortical cholinergic system: interpreting the functional consequences of excitotoxic lesions.
http://jnnp.bmjjournals.com/cgi/content/full/66/2/137   (6900 words)

  
 Cholinergic Excitation of Septohippocampal GABA But Not Cholinergic Neurons: Implications for Learning and Memory -- Wu ...
Markowska AL, Olton DS, Givens B (1995) Cholinergic manipulations in the medial septal area: age-related effects on working memory and hippocampal electrophysiology.
Visualization of septohippocampal cholinergic neurons in live rat brain slices using Cy3-192IgG, a selective marker of p75-receptor-expressing neurons in the MSDB.
and studied their response to cholinergic drugs using extracellular
http://www.neuroscience.org/cgi/content/full/20/10/3900   (6042 words)

  
 Impairment of reward-related learning by cholinergic cell ablation in the striatum -- Kitabatake et al. 100 (13): 7965 ...
tonic firing of cholinergic neurons is paused by sensory stimuli
ablation of striatal cholinergic neurons induces adaptive changes
conducted after the ninth session, WT and cholinergic cell-eliminated
http://www.pnas.org/cgi/content/full/100/13/7965   (3656 words)

  
 Abnormal Chemosensory Jump 6 Is a Positive Transcriptional Regulator of the Cholinergic Gene Locus in Drosophila ...
A, Cholinergic fluorescence is observed in neurons of the antennomaxillary complex of wild-type larvae (arrowhead) as well as neurons associated with external sensory organs.
types of cholinergic neurons such as peripheral sensory neurons
Third are neurons that express Acj6 but maintain cholinergic
http://www.jneurosci.org/cgi/content/full/22/13/5291   (6775 words)

  
 Alzheimer's Disease: Cholinergic Therapy and Beyond -- Sunderland 6 (2): 56 -- American Journal of Geriatric Psychiatry
CHOLINERGIC HYPOTHESIS IN AD While no "preventative" drugs currently exist for AD, it is
have entered the era of viable cholinergic therapies, and we
also been associated with a better response to cholinergic replacement
http://ajgp.psychiatryonline.org/cgi/content/full/6/2/S56   (2376 words)

  
 Facilitation of dopamine-mediated locomotor activity in adult rats following cholinergic denervation.
These results suggest that cholinergic denervation of the forebrain causes a marked enhancement of behavioral responses related to dopaminergic activity, probably mainly mediated presynaptically.
Facilitation of dopamine-mediated locomotor activity in adult rats following cholinergic denervation.
Therefore, the main aim of this study was to examine the effect of central cholinergic denervation on dopamine-mediated functions.
http://www.arclab.org/medlineupdates/abstract_11869038.html   (310 words)

  
 J.J. Askenasi
However, perfusion of NBTI in ventrolateral and ventroanterior thalamic nuclei did not affect behavioral state, although local adenosine concentration was increased to the same extent as with BF perfusion.
This suggests that adenosine may have specific effects on cholinergic zones important in arousal.
A subpopulation of these neurons selectively discharges just before and during REM sleep, and a variety of in vivo and in vitro experiments indicate they excite effector neurons in the pontine reticular neurons to produce the brainstem-generated signs of REM sleep.
http://www.websciences.org/takeda/mccarley.html   (440 words)

  
 [Frontiers in Bioscience 2, d309-316, June 15, 1997]
Similar results were found in response to application of carbachol (110).
CET does not produce any reliable change in basal or stimulus-dependent [
The effects of the specific muscarinic cholinergic antagonist atropine are also similar (113).
http://www.bioscience.org/1997/v2/d/peris/6.htm   (686 words)

  
 Biochemistry of Neurotransmitters
The responses of cholinergic neurons can also be enhanced by administration of cholinesterase (ChE) inhibitors.
ChE inhibitors have been used as components of nerve gases but also have significant medical application in the treatment of disorders such as glaucoma and myasthenia gravis as well as in terminating the effects of neuromuscular blocking agents such as atropine.
Several naturally occurring compounds have been shown to affect cholinergic nerons, either positively or negatively.
http://web.indstate.edu/thcme/mwking/nerves.html   (1588 words)

  
 Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration.
Previous lesion and aging studies in the rat have shown that intracerebroventricular NGF infusions can prevent degenerative changes in basal forebrain cholinergic neurons.
This finding may be relevant to the hypothesis that NGF has potential use as a cholinergic "neurotrophic-factor therapy," given that loss of basal forebrain cholinergic neurons is common in Alzheimer's disease.
Cholinergic fibers of the septohippocampal projection in the primate were surgically transected, followed by infusion of either a vehicle or an NGF solution into the ventricular system for a 4-week period.
http://www.arclab.org/medlineupdates/abstract_2230949.html   (226 words)

  
 Nervous System
This action permits drainage of the aqueous humor and thus relieves the pressure due to a glaucoma condition.
The effects of cholinergic stimulation include: vasodilation of blood vessels; slower heart rate; constriction of bronchioles and reduced secretion of mucus in the respiratory tract; intestinal cramps; secretion of salvia; sweat and tears; and constriction of eye pupils.
Stimulation of cholinergic nerves is achieved either directly or indirectly.
http://www.elmhurst.edu/~chm/vchembook/662cholinergic.html   (579 words)

  
 Muscarinic and Nicotinic Cholinergic Mechanisms in the Mesostriatal Dopamine Systems -- Zhou et al. 9 (1): 23 -- The ...
Cholinergic Control of Firing Pattern and Neurotransmission in Rat Neostriatal Projection Neurons: Role of CaV2.1 and CaV2.2 Ca2+ Channels
Cholinergic Drugs for Alzheimer's Disease Enhance in Vitro Dopamine Release
Muscarinic and Nicotinic Cholinergic Mechanisms in the Mesostriatal Dopamine Systems -- Zhou et al.
http://nro.sagepub.com/cgi/content/abstract/9/1/23   (298 words)

  
 Cholinergic plasticity in the hippocampus -- Colgin et al. 100 (5): 2872 -- Proceedings of the National Academy of ...
periods of intense cholinergic activity induce lasting changes
that endogenous cholinergic activity is responsible for the persistence
that cholinergic synapses are also the sites at which the plasticity
http://www.pnas.org/cgi/content/abstract/100/5/2872   (222 words)

  
 Cellular Mechanisms for Amyloid {beta}-Protein Activation of Rat Cholinergic Basal Forebrain Neurons -- Jhamandas et ...
Human Amylin Actions on Rat Cholinergic Basal Forebrain Neurons: Antagonism of Beta-Amyloid Effects
) in the brain and the loss of cholinergic neurons in the basal forebrain are two pathological
The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development
http://jn.physiology.org/cgi/content/abstract/86/3/1312   (341 words)

  
 The developmental expression of vasoactive intestinal peptide (VIP) in cholinergic sympathetic neurons depends on ...
Thus, the physiological importance of cytokines for cholinergic
Guidry, G. and Landis, S. Absence of cholinergic sympathetic innervation from limb muscle vasculature in rats and mice.
family members in the development of cholinergic sympathetic
http://dev.biologists.org/cgi/content/full/129/6/1387   (5984 words)

  
 High Dose CPT-11 Infusion - Cholinergic Symptoms
Also, they studied the role of atropine in treating the cholinergic symptoms.
Cholinergic symptoms of sweating, flushing and abdominal cramping occurred in 68.5% of the patients, usually during the infusion.
Forty-one of the 92 CRC patients took atropine.
http://www.meds.com/conrad/asco97/petit.html   (514 words)

  
 Cholinergic systems in progressive supranuclear palsy -- Warren et al. 128 (2): 239 -- Brain
Symptomatic treatment using cholinergic drugs may thus be improved
dysfunction is related to loss of cholinergic interneurons in
from other cholinergic nuclei, such as the pedunculopontine
http://brain.oxfordjournals.org/cgi/content/abstract/128/2/239   (282 words)

  
 MedlinePlus Drug Information: Antiglaucoma Agents, Cholinergic, Long-acting (Ophthalmic )
MedlinePlus Drug Information: Antiglaucoma Agents, Cholinergic, Long-acting (Ophthalmic)
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202059.html   (2425 words)

  
 cholinergic - definition of cholinergic in Encyclopedia
A cholinergic agent, also known as a parasympathomimetic is a chemical which functions to enhance the effects mediated by acetylcholine in the central nervous system, the peripheral nervous system, or both.
Embed a dictionary search in your own web page
A synapse is cholinergic if it uses acetylcholine as its neurotransmitter.
http://encyclopedia.laborlawtalk.com/cholinergic   (83 words)

  
 Calcium-Dependent Regulation of Cholinergic Cell Phenotype in the Hypothalamus In Vitro -- Belousov et al. 88 (3): 1352 ...
the development of cholinergic properties in hypothalamic neurons.
the number of cholinergic neurons were detected in cortical cultures
Calcium-Dependent Regulation of Cholinergic Cell Phenotype in the Hypothalamus In Vitro -- Belousov et al.
http://jn.physiology.org/cgi/content/abstract/88/3/1352   (355 words)

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