|
| |
| | CCBP2 - Chemokine binding protein 2 |
 | | The present study was designed to better characterize the spectrum of CC chemokines scavenged by D6, focusing in particular on CCR4 ligands and analyzing the influence of NH(2)-terminal processing on recognition by this promiscuous receptor. | | | CLA initiates skin homing by mediating E-selectin-dependent tethering and rolling within cutaneous venules, but the specific roles of CCR4 and CCR10 are unclear. | | | In contrast, CCL27, which is most similar to CCL28 and shares CCR10, showed no such potent antimicrobial activity. |
|
http://www.pdg.cnb.uam.es/UniPub/iHOP/gg/87286.html
(3639 words)
|
|
| |
| | Chemokine Therapeutics is a biotechnology company with expertise in chemokine based drugs |
| | Chemokine Therapeutics Corp. discovers and develops peptide analogs of chemokines for cancer treatment, and immune system recovery. | | | Chemokine Therapeutics Corp. is a publicly-held biotechnology company with expertise in chemokines-based drugs. | | | Chemokine Therapeutics is a biotechnology company with expertise in chemokine based drugs |
|
http://www.chemokine.net
(42 words)
|
|
| |
| | Chemokine completes initial public offering |
| | In addition, Chemokine Therapeutics maintains a drug discovery program to identify new chemokine-based drug candidates. | | | Chemokine Therapeutics is developing synthetic chemokines to address a number of diseases and disorders. | | | Chemokines play a role in controlling normal body functions such as immune response and stem cell development and in the physiological processes of a variety of diseases including cancer, viral infections, and autoimmune diseases. |
|
http://www.forrelease.com/D20041230/to279.P1.12302004092904.08489.html
(581 words)
|
|
| |
| | Chemokine Information available thru RDI Divison of Fitzgerald Industries Intl |
| | All in all, the field of chemokine research is deservedly flourishing. | | | Consequently, chemokines, by displacing HIV-1, interfere with the cell-to-cell spread of the virus and provide potential therapeutics for AIDS patients. | | | This view is supported by experiments showing that pertussis toxin, which blocks signal transduction by such receptors, does not interfere with the inhibitory effect of the chemokines. |
|
http://www.researchd.com/cytokines/chemokin.htm
(879 words)
|
|
| |
| | Chemokine Genes Incorporated into an African Green Monkey SCMV-Derived Stealth Virus |
| | Further clarification of this important issue should be forthcoming from sequencing studies on SCMV isolates. | | | The human MGSA/GRO-alpha chemokine gene has been more extensively studied than the other chemokines because of its possible role in the autocrine stimulation of melanoma cell growth (7-8). | | | BlastX analysis matched this region to a human alpha chemokine that is only distantly related to the MGSA/GRO-alpha chemokine. |
|
http://www.ccid.org/articles/mgsa.htm
(1797 words)
|
|
| |
| | Welcome to Torrey Pines Biolabs |
| | Through our tireless research effort, we continue to bring to the research community new antibodies that are suitable for immmunoprecipitation, immunohistochemistry, western blot, and neutralization assays. | | | Many of our products are unique or hard to find elsewhere. | | | Located in Houston, Torrey Pines Biolabs is specialized in providing quality immunological reagents to the chemokine and cytokine research community. |
|
http://www.chemokine.com
(72 words)
|
|
| |
| | Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours |
| | With the aim of understanding chemokine action in this cancer, we investigated receptors for CC chemokines and their ligands in 25 biopsies of human ovarian cancer. | | | Thus, CCR1 may be a novel therapeutic target in ovarian cancer. | | | To understand the chemokine network in a tissue, both chemokine and chemokine receptor expression should be studied. |
|
http://www.nature.com/cgi-taf/dynapage.taf?file=/bjc/journal/v85/n6/abs/6692020a.html
(268 words)
|
|
| |
| | Chemokine - definition of Chemokine in Encyclopedia |
| | Chemokines are divided on the basis of the protein structure according to cysteine motifs. | | | Chemokines are specifically trophic molecules; that is, they signal leukocytes to move in a specific direction, up the gradient of chemokine concentration. | | | The CxC group includes such molecules as interleukin-8 and platelet factor 4; the C C group includes such molecules as eotaxin and monocyte chemoattractant protein-3. |
|
http://encyclopedia.laborlawtalk.com/Chemokine
(117 words)
|
|
| |
| | Chemokine Receptor Related Genetic Sequences in an African Green Monkey |
| | In this regard, it is worth noting that certain therapeutic modalities commonly prescribed for patients with chronic fatigue syndromes, and with other stealth virus related conditions, may be achieving their beneficial effects by regulating chemokine levels. | | | It may also help explain the apparent therapeutic benefit achieved in certain stealth virus infected patients treated with agents that down regulate chemokine production. | | | A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1. |
|
http://www.ccid.org/stealth/publications/US28modified.htm
(3349 words)
|
|
| |
| | InterPro: IPR000355 Chemokine receptor |
| | Chemokines are proteins that have important physiological and pathophysiological roles in a wide range of acute and chronic inflammatory processes. | | | C-C chemokine receptors are found in monocytes, lymphocytes, basophils and eosinophils; mRNA is also found in some cell lines. | | | Their sequences are similar and are characterised by a 4-cysteine motif: the family can be divided according to whether the first 2 Cys residues are adjacent (the C-C family), or separated by an intervening residue (the C-x-C family). |
|
http://www.ebi.ac.uk/interpro/IEntry?ac=IPR000355
(2957 words)
|
|
| |
| | NIH Press Release - Scientists to Discuss Chemokine Receptor Research - 01/23/1997 |
| | This research may also lead to the development of better animal models of HIV infection, essential tools for evaluating new drugs and vaccines. | | | Strains of HIV that infect the immune system's macrophages and T cells are most often found in an HIV-infected individual early in the course of disease; as disease progresses, strains appear that replicate efficiently in T cells but not in macrophages. | | | Many scientists believe these findings could point the way toward more effective treatment and prevention strategies for HIV/AIDS. |
|
http://www.nih.gov/news/pr/jan97/niaid-23.htm
(693 words)
|
|
| |
| | Int. J. Dev. Biol. The chemokine network in cancer - much more than directing cell movement |
| | Most cancers have a complex chemokine network which can influence immune responses to the tumor, direct the extent and cellular composition of the leukocyte infiltrate and also play a role in angiogenesis. | | | Cytokine and chemokine gradients are central to the directed movement of cells in both homeostatic and pathological processes. | | | Chemokine receptor expression and activation on malignant cells may be central to the growth, survival and migration of cancer cells from the primary tumor. |
|
http://www.ijdb.ehu.es/abstract.04056/a489.htm
(189 words)
|
|
| |
| | What is a Chemokine? |
| | Chemokines are a family of structurally related glycoproteins with potent leukocyte activation and/or chemotactic activity. | | | The C chemokine seems to be lymphocyte specific. | | | It lacks one of the cysteines in the four-cysteine motif, but shares homology at its carboxyl terminus with the C-C chemokines. |
|
http://www.umdnj.edu/pathnweb/genpath/lec_1/What_is_a_Chemokine_/what_is_a_chemokine_.htm
(203 words)
|
|
| |
| | tab001cbb: Chemokine nomenclature |
| | ; SDF, stromal-cell-derived factor; SLC, secondary lymphoid tissue chemokine; TARC, thymus- and activation-regulated chemokine; TECK, thymus-expressed chemokine. | | | Expert Reviews in Molecular Medicine © Cambridge University Press ISSN 1462-3994 (Disclaimer and copyright) | | | 95 Rossi, D. and Zlotnik, A. (2000) The biology of chemokines and their receptors. |
|
http://www.expertreviews.org/02005318h.htm
(131 words)
|
|
|
