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| | The Mammalian Respiratory System and Critical Windows of Exposure for Children's Health |
 | | Differentiation of the tracheal epithelium has been most extensively studied in the respiratory system. | | | An understanding of critical windows of exposure of the respiratory system on children's health requires consideration that lung development is a multistep process and cannot be based on studies in adults. | | | Allometric relationships support the concept that there is a close relationship among these parameters and that they must be maintained in a similar manner to ensure the proper exchange of gases between the environment and the organism. |
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http://ehp.niehs.nih.gov/members/2000/suppl-3/457-462pinkerton/pinkerton-full.html
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| | Gene Activation Studied by Immunological Methods |
| | The differentiation kinetics of keratinocytes can be studied by BrdU pulse chase experiments. | | | Antisera and their antigens need to be extensively controlled under the employed conditions. | | | For this reason, combined in situ and biochemical techniques are necessary. |
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http://ehp.niehs.nih.gov/members/1994/Suppl-6/huitfield-full.html
(2557 words)
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| | Cellular Differentiation and Homeostasis |
| | A central role in the understanding of the nature of living systems, their stability in a changing environment, and how such systems fail in disease, such as cancer, is played by the process of differentiation. | | | The particular questions related to this objective are: do the cells exhibit homeostasis on the expression level by returning to their original states in the state-space and, if so, do they retrace the same trajectory on their way back? | | | A related goal is to characterize a particular differentiation process at the gene expression level. |
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http://www.systemsbiology.org/cellular_differentiation_and_homeostasis
(615 words)
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| | Cellular Differentiation in Photodynamic Therapy |
| | Differentiation therapy is the principle of converting cells to a more differentiated state in order to enhance the response to specific therapies. | | | The Role of Cellular Differentiation in Photodynamic Therapy | | | This is a proposal to use cellular differentiation as a way to modify ALA-mediated photodynamic therapy (PDT) in the treatment of cancer and other hyperproliferative diseases. |
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http://www.dartmouth.edu/~pdt/p1.html
(405 words)
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| | The cytoplasmic basis of cellular differentiation--redressing the injustice done to the cytoplasm. Kothari ML, Mehta LA ... |
| | Man, like any other metazoic organism starts as a featureless zygotic cell to end up as a fully formed individual comprising the indivisible neurones, the peripatetic polymorphs, and such other "few hundred different types"[20] that refuse[28] to tell anything about how they came into being. | | | A Textbook of Cytology[3] makes a confession: "The interphase nucleus is of great biological significance, as demonstrated by biochemists and others. | | | Such a theory must also explain some recent developments[1],[10],[11],[12],[13],[20] as the success of nuclear transplantation into somatic and zygotic cells to spawn some new cell types on the one hand, and some fully formed organisms on the other. |
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http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1984;volume=30;issue=4;spage=199;epage=206;aulast=Kothari
(2784 words)
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| | cbiol2 |
| | For example, the vascular studies could utilize vascular cells isolated from the Dahl rats (the model used by the cardiovascular group) to examine the function and behavior of these cells with the gravitational models that will be utilized. | | | Gravitational changes may affect cell function and differentiation through modulation of cytoskeletal organization and cell - extracellular matrix interactions. | | | The cell biology research group also provides cellular support for physiological research groups. |
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http://www.msm.edu/nasa/cbiol2.htm
(383 words)
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| | Cellular Differentiation |
| | With this knowledge in hand, it may someday be possible to replace cells that are lost in spinal cord injuries or neurodegenerative disorders. | | | A classic family of helix-loop-helix (HLH) transcription factors are the myogenic proteins, which are well known for their role in the differentiation of muscle cells. | | | He hypothesized that while transcription-independent mechanisms might allow cerebellar granule neurons to survive shortly after they are generated on the outer surface of the developing brain, transcription-dependent mechanisms might act later on, as these neurons differentiate and mature in the brain's interior. |
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http://www.hms.harvard.edu/armenise/old_site/4a_cell.htm
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| | This text represents only a theoretical supposition and has two parts |
| | The early development of mammalian embryo has, from this point of view, three stages. | | | This is very important but it is not the only one mechanism, which can induce the differentation. | | | Now the cells of type A are different from the cells of type B (by morphological point of view) being grouped and forming a distinctive embryonic structure. |
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http://www.geneticengineering.org/ideas/brehar.html
(1824 words)
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| | Equations for an Embryo |
| | In the October issue of Physical Review E a pair of physicists takes that approach with one of the miracles of Nature: embryo development. | | | Their model reproduces behaviors in the developing eye of a fly. | | | They also have difficulty generating basic observations of developing body parts of other animals, such as the ability of this type of wave to reverse itself if the outside signal isn't strong enough. |
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http://focus.aps.org/story/v4/st20
(553 words)
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| | IMMUNOTHERAPY OF CANCERS, Reviewed Materials, Guidelines & Links... |
| | First of all, the small structural difference between the xenogenic onco antigens and other human analogues make them (xenogenic structres) high immunogenic and enable them to trigger high immune responses in human beings. | | | Thirdly, the non tumoral xenoantigens, expressed on the cell surfaces can cause unspecific stimulating (adjuvant) effect in the antitumoral immune reactions. | | | In difference to the other kinds of immunotherapy, the targeted immunotherapy is capable to trigger specific and long-term anti tumor effect, which can possibly result into a complete cure, bearing no serious side effects. |
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http://www.anticancer.net/reviews
(3104 words)
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| | Cellular Differentiation in Response to Nutrient Availability: The Repressor of Meiosis, Rme1p, Positively Regulates ... |
| | Rme1p, we suggest that an Rme1p-dependent pathway may act as | | | , M., D., and I., 1999b Msn1p/Mss10p, Mss11p and Muc1p/Flo11p are part of a signal transduction pathway downstream of Mep2p regulating invasive growth and pseudohyphal differentiation in Saccharomyces cerevisiae. | | | Cellular Differentiation in Response to Nutrient Availability: The Repressor of Meiosis, Rme1p, Positively Regulates Invasive Growth in Saccharomyces cerevisiae |
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http://www.genetics.org/cgi/content/full/165/3/1045
(5682 words)
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| | Cellular differentiation - Wikipedia, the free encyclopedia |
| | Differentiation is the process by which an unspecialized cell becomes specialized into one of the many cells that make up the body, such as a heart, liver, or muscle cell. | | | For example, cells that make up the human skin are different from cells that make up the inner organs. | | | Cellular differentiation is a concept from developmental biology describing the process by which cells acquire a "type". |
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http://en.wikipedia.org/wiki/Cellular_differentiation
(701 words)
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| | cellular differentiation. The New Dictionary of Cultural Literacy, Third Edition. 2002 |
| | Differentiation is the process that takes place inside an embryo that determines which genes are expressed and hence what type of cell will result. | | | There are more than 250 general types of cells in the human body. | | | ‡ The ability of embryonic stem cells to undergo differentiation into any cell in the body is what makes them a focus of modern research. |
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http://www.aol.bartleby.com/59/21/cellulardiff.html
(197 words)
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| | Differentiation - Journal Information |
| | Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal. | | | Differentiation is a multidisciplinary journal dealing with all problems relating to cell differentiation, development, cellular structure and function, and cancer. | | | The journal will publish full-length articles containing original work in any of these areas. |
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http://www.blackwellpublishing.com/journal.asp?ref=0301-4681
(127 words)
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| | NIH Guide: ONTOGENY AND DIFFERENTIATION OF THE LIVER AND BILIARY TREE |
| | This is consistent with the PHS mission to protect and advance the physical and mental health of the American people. | | | However, the liver is a unique organ in the capacity to regenerate subsequent to specific forms of trauma, such as partial hepatectomy. |
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http://grants.nih.gov/grants/guide/pa-files/PA-96-079.html
(1206 words)
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| | Citebase - High-dimensional switches and the modeling of cellular differentiation |
| | Decision-making can be forced by a transient increase in competition, which could correspond to some unexplained experimental observations related to Id proteins; the speed of response varies with the initial conditions the network is subjected to, which could explain some aspects of cell behaviour upon reprogramming. | | | Many genes have been identified as driving cellular differentiation, but because of their complex interactions, the understanding of their collective behaviour requires mathematical modelling. | | | The coexistence of antagonistic factors at low levels, early in the differentiation process or in pluripotent stem cells, could be an intrinsic property of the interaction between those factors, not requiring a specific regulatory system. |
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http://citebase.eprints.org/cgi-bin/citations?id=oai:arXiv.org:q-bio/0410017
(377 words)
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| | Cellular differentiation: importance in hepatocarcinogenesis and modulator role of ß-carotene |
| | This review focuses the relationship between oval cell differentiation and the cellular origin of hepatic cancer, as well as the recent studies on the action of ß-carotene in cellular differentiation. | | | Moreover, it has been observed in in vivo models of hepatocarcinogenesis and of cellular differentiation, that the carotenoid reduces the number of oval cells at the end of the experimental period. | | | These findings indicate that ß-carotene can promote complete terminal differentiation of oval cells and suggest that these effect may have implications for chemoprevention of hepatic cancer. |
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http://www.inca.gov.br/rbc/n_46/v04/english/article4.html
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| | Regulation of Cellular Differentiation and Proliferation During Development and Tumorigenesis |
| | Ongoing work is focused on further characterization of the cellular pathways that mediate Id-gene induced cell growth. | | | Research in Dr Israel's laboratory concerns the molecular pathways over which these two key biologic activities, growth and differentiation, are coordinately regulated. | | | Experiments have been conducted to understand the precise cell types in which tumors of the CNS arise, and the molecular alterations that characterize histologically indistinguishable tumors of astrocytes are being studied. |
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http://www.dartmouth.edu/~genetics/Israel/Israel.html
(598 words)
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| | Ubiquitination and Cellular Differentiation |
| | In addition, we are examining whether ligases other than APC are involved in cellular differentiation and are developing experimental approaches to identify such ligases. | | | Ubiquitin-proteasome pathways not only control cell cycle progression, but also cellular differentiation. | | | In addition, APC is active in terminal differentiated cells, such as in neurons and in muscle cells, suggesting a requirement for its ligase activity outside the cell cycle. |
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http://www.stanford.edu/group/fanglab/science/research_differentiation.html
(79 words)
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| | Cellular Differentiation and Therapy |
| | T- and NK-cell based therapeutic strategies are being tested in murine models of leukaemia and lymphoma. | | | The central human stem cell culture and sorter laboratory of the faculty is situated in the department as a service facility to support stem cell research in somatic and embryonic stem cell research in close collaboration with several groups working in the faculty as well as the Max-Planck-Institute. | | | Projects of the group focus on the role of TGFß in stem cell differentiation by using adenoviral transfection strategies with deletion vectors, the immunogenicity of embryonic stem cell derived hemopoietic precurso cells and the utilization of mesenchymal stem cells from human tissue and their differentiation capacity. |
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http://www.gwdg.de/~haemonk/Forschung/therapy-differentiation.htm
(228 words)
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| | The cellular aging of rat fibroblasts in vitro is a differentiation process. |
| | The cellular aging of rat fibroblasts in vitro is a differentiation process. | | | Cellular aging of diploid rat fibroblasts in vitro occurs as the result of a three-stage differentiation sequence, taking place in the morphologically recognizable differentiating cell compartment of the fibroblast stem cell system. | | | In cell strains with the genetic background Lewis, the cellular differentiation state, the major histocompatibility complex composition (H-1) and the H-1 complex-controlled expression of endogenous type C viruses determine the ultimate fate of the senescent cell, leading either to cellular degeneration or to cellular neoplastic transformation. |
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http://www.arclab.org/medlineupdates/abstract_510926.html
(126 words)
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| | Regulation of cellular trans-activating activities in two different promonocytic leukemia cell lines. |
| | The state of the art may have changed since the publication date. | | | Since these two cell lines have shown subtle differences in these responses, it may be speculated that monocytes at different stages of differentiation may respond in different ways, qualitatively and/or quantitatively, to signal transduction factors involved in the transactivation of cellular genes. | | | Trans-activating activities of certain cellular promoter/enhancer genes may reflect the underlying mechanism for cellular differentiation. |
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http://www.aegis.com/aidsline/1992/jan/M9210661.html
(570 words)
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| | Multicellular organisms |
| | Somehow the germ cells exchange proliferation by fission within the organism for reproduction by seed across generations, and the specialized somatic cells gain in reproductive opportunities by fission within the organism. | | | The path from multicellularity to cellular differentiation, however, proved a far less porous filter. | | | Heylighen F. and Campbell D.T. Selection of Organization at the Social Level: obstacles and facilitators of metasystem transitions ", World Futures: the Journal of General Evolution 45, p. |
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http://pespmc1.vub.ac.be/MULTICEL.html
(377 words)
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| | Loss of intragenomic DNA repair heterogeneity with cellular differentiation. |
| | As a result of 3T3-T cell differentiation, lipoprotein lipase and beta-actin expression was modified, whereas adenosine deaminase and dihydrofolate reductase expression was not affected. | | | In contrast, similar dimer repair rates were found for each DNA fragment in terminally differentiated 3T3-T cells. | | | For undifferentiated stem cells, the rate and extent of dimer repair was higher in the actively transcribed adenosine deaminase and dihydrofolate reductase genes than in the inactive lipoprotein lipase or 70-38 fragments, the greater difference being observed in the first 8 h post-UV irradiation. |
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http://www.ihop-net.org/UniPub/iHOP/gp/46013.html
(238 words)
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| | Serrero and Hayashi (1986) Cellular endocrinology: Hormonal control of embryonic and cellular differentiation : ... |
| | Cell differentiation; Developmental cytology; Embryology; Hormones; Embryo; Congresses; Physiological effect; drug effects; physiology | | | To view the the latter's ratings, click on Chapters/Papers/Articles in the STATISTICS box, select a publication from the list that appears, and then click on either Quality or Interest in that publication's STATISTICS box. | | | Cellular endocrinology: Hormonal control of embryonic and cellular differentiation : proceedings of the First International Symposium on Cellular Endocrinology, held in Lake Placid, New York, August 12-16, 1985 |
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http://www.getcited.org/?PUB=102542928&showStat=Ratings
(138 words)
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| | [No title] |
| | A possible involvement of the intracellular Ca2+-concentration 1201 Transition of starving Dictyostelium cells to differentiation phase at a particular position of the cell cycle 1202 How do transcription factors work? | | | Effect of electrical shape 1128 High-resolution separation and accurate size determination in pulsed-field gel electrophoresis of DNA. |
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http://www.amherst.edu/~ccs/summer2002/ccsp/21/notes/1.4.txt
(260 words)
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| | Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations |
| | Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link. | | | 550300 -- Cytology ;550900 -- Pathology; ;CLONE CELLS-- CELL DIFFERENTIATION;STEM CELLS-- CELL DIFFERENTIATION;TUMOR CELLS-- CELL DIFFERENTIATION; CARCINOMAS;EXPERIMENTAL NEOPLASMS;IN VIVO;RATS | | | Energy Citations Database (ECD) Document #6163414 - Unstable cellular differentiation in adenosquamous cell carcinoma |
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http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=6163414
(86 words)
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| | Laboratory of cellular differentiation - Publications |
| | Smith EM, Gisler R, Sigvardsson M. Cloning and characterization of a promoter flanking the early B cell factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression. | | | Liberg D, Sigvardsson M, Akerblad P. The EBF/Olf/Collier Family of Transcription Factors: Regulators of Differentiation in Cells Originating from All Three Embryonal Germ Layers. | | | Akerblad P, Lind U, Liberg D, Bamberg K, Sigvardsson M. Early B-cell factor (O/E-1) is a promoter of adipogenesis and involved in control of genes important for terminal adipocyte differentiation. |
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http://www.stemcell.lu.se/celldiff/publications.html
(646 words)
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