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| | Buffalo Field Campaign- Carfentanil |
 | | BFC is concerned that bison immobilized with this drug have not been properly monitored and may have suffered fatal outcomes. | | | As little as 20 ug (micrograms, an almost invisible drop) of Carfentanil is lethal to humans. | | | This drug combination is also used within the YNP for immobilizing bison when biologists collect samples for research. |
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http://buffalofieldcampaign.org/science/carfentanil.html
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| | NADA 141-074 |
| | In accordance with 21 CFR 514.111(a)(5)(ii), the effectiveness of naltrexone HCl as an antagonist to carfentanil in elk and moose is conclusively established by the alternative procedure utilized in the clinical field trials. | | | a) Purpose: To demonstrate that naltrexone hydrochloride will effectively reverse carfentanil immobilization of elk under field conditions. | | | PIVOTAL STUDY 3: Following is a pivotal clinical field study which demonstrated the efficacy of Trexonil in reversing the effects of carfentanil citrate in elk. |
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http://www.fda.gov/cvm/FOI/937.htm
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| | Moskvagas |
| | A better appreciation of some of the pharmacokinetic and toxicokinetic issues relating to carfentanil redistribution might have heightened concerns about recurrent toxicity. | | | A review of the use of fentanyl analgesia in the management of acute pain in adults. | | | The wide therapeutic margin of drugs, such as carfentanil, may have lulled some scientists into believing that the poison gas could not have produced lethality. |
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http://www.tjetjenien.org/Moskvagas.htm
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| | 06/20/05 Report from SNM: PET measures brain chemistry associated with bulimia |
| | It could help identify patients who are best suited for specific behavior treatment regimes and could provide quantitative measures to guide program design to improve treatment effectiveness. | | | Opioids play a role in quelling painful sensations, heightening positive emotions, and creating a sense of reward. | | | Carbon-11 carfentanil PET imaging identified reduced µ-opioid receptor binding in the prefrontal cortex and insula of patients who responded positively to a 10-week course of cognitive behavior treatment, said Dr. Badreddine Bencherif, a nuclear medicine researcher at Johns Hopkins University. |
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http://www.dimag.com/showNews.jhtml?articleID=164901242
(308 words)
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| | BASIS+ Tools: Simple Search |
| | Under field conditions, 7 bison were immobilized with 4.8mg carfentanil and 50mg xylazine, and antagonized with naltrexone and tolazoline (300-400mg IM). | | | The second group of 12 recieved 5.1mg carfentanil and 20mg xylazine without any tolazoline antagonist. |
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http://www.pwrc.usgs.gov/brd/BasisSimpleSearch.cfm?PTS=834899L.9.0&Show=Logo,PTS,Title,Keywords,Leaders,Narrative,Product
(767 words)
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| | Limbic Blood Flow and Opiate Receptor PET in Posttraumatic Stress Disorder |
| | For the combat control and PTSD patient groups, analysis of these (within group and between groups) is ongoing and results should be available shortly. | | | Britton JC, Taylor SF, Phan KL, Neibuhr AE, Olmos V, Decker LR, Liberzon I. Emotional stimuli reveal an association between right amygdala/hippocampal blood flow and skin conductance response. | | | The psychiatric diagnosis will be established using the structured clinical interview for DSM-IV (SCID IV) for patients and SCID NP for controls. |
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http://www.gulflink.osd.mil/medsearch/BrainNervous/PosttraumaticStress/DoD89.shtml
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| | Veterinary Products... carfentanil citrate |
| | These immobilizations were effectively antagonized by a narcotic antagonist. | | | Six milligrams of diprenorphine effectively antagonized the immobilization effects of this dose range of Carfentanil. | | | Adverse Reactions: Six mortalities were observed (6.5%) some of which may have been treatment related. |
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http://www.betterchem.com/vet/carfentanil.htm
(2163 words)
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| | 2_opioids |
| | Narcan is the preferred drug for antagonizing opioids in a human emergency. | | | A pure opioid antagonist that is the drug of choice for reversal of carfentanil and etorphine. | | | Cleared for use in Cervidae but is used in many free-ranging Bovidae when carfentanil is used. |
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http://www.uaf.edu/iacuc/training/module_2/2_opioids.htm
(301 words)
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| | Synthetic Narcotics |
| | The first three drugs are approved for use in human medical practice. | | | These drugs include fentanyl citrate inself, alfentanil hydrocholride, sufentanil citrate, and carfentanil citrate. | | | The fourth, carfentanil citrate, is approved for use in veterinary medicine. |
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http://www.tpub.com/maa/70.htm
(869 words)
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| | Muskox of the Yukon & Alaska North Slope Fact Sheet #12: Muskox - Capture & Handling |
| | But because Carfentanil is a very potent and dangerous drug to humans, biologists in the Yukon are attempting to switch to safer drugs for use in wildlife captures. | | | Until recently, the drugs most commonly used on animals such as muskox, bison and moose were a combination of Carfentanil and the sedative Xyzaline. | | | The drug combination of Medetomidine and Ketamine appears to be safer than Carfentanil for humans and animals. |
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http://www.taiga.net/wmac/species/muskox/factsheet12_capture.html
(790 words)
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| | NTI: Global Security Newswire |
| | The new drugs are still in the early stages of research and it is not yet clear whether they could be both safe and effective enough to use, he said. | | | “The fact that carfentanil is 100 times more potent than fentanyl makes it 100 times easier to use than fentanyl &; and that makes it a logical choice,” he added. | | | Subsequent research involved mixing or chasing it with an antidote naloxone to reduce the danger of respiratory failure, he said. |
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http://www.nti.org/d_newswire/issues/thisweek/2002_11_11_chmw.html
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| | Carfentanil |
| | c) A 5000 kg Asian elephant was given 10 mg carfentanil for surgical curettage of a foot abscess (Honeyman et.al. | | | Based upon these findings, both etorphine hydrochloride and carfentanil citrate are not recommended as the primary agent in performing major invasive surgical procedures in African elephants. | | | All elephants were positioned with the affected tusk up. |
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http://www.elephantcare.org/Drugs/carfenta.htm
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| | Effects of Buprenorphine Maintenance Dose on -Opioid Receptor Availability, Plasma Concentrations, and Antagonist ... |
| | carfentanil, has been developed and validated (Frost et al, 1989; Titeler et al, 1989), prompting our use of this radiotracer in the present work. | | | carfentanil used to measure receptor concentrations, that is, such that competition from nor-BUP would weaken the relationship. | | | carfentanil), increase plasma levels of BUP and its metabolite nor-BUP, and decrease withdrawal symptoms and hydromorphone (HYD) responses. |
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http://www.nature.com/npp/journal/v28/n11/full/1300251a.html
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| | Synthesis of Carfentanil |
| | "For instance, carfentanil is approximately 4000 times as potent as heroin and has an extremely favorable therapeutic index [...]. | | | Donald A. Cooper (DEA) in "Future Synthetic Drugs of Abuse" | | | Hence, an easy week's work for two chemists could provide 1 (one) kilogram of carfentanil which would be equivalent to four metric tons of pure heroin" |
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http://www.erowid.org/archive/rhodium/chemistry/carfentanil.html
(1150 words)
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| | Opium-like drug likely suspect in Moscow theater deaths / Mixing compounds may explain why gas was so lethal |
| | The therapeutic index of carfentanil in rats is 10,000, meaning that a lethal dose is about 10,000 times more than the dose required to relieve pain. | | | Halothane, in contrast, has a therapeutic index of about 3, meaning that a lethal dose is only 3 times that required to put someone to sleep. | | | Carfentanil's safety margin may be what Russian officials were referring to when they expressed amazement at the fatalities. |
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http://www.sfgate.com/cgi-bin/article.cgi?f=/chronicle/archive/2002/11/09/MN75975.DTL&type=health
(913 words)
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| | Highlights of the May 2003 Issue |
| | Authors speculate the therapeutic use of drugs, such as carfentanil, may have lulled some scientists into believing the poison gas could not have been lethal. | | | Through trial and error, physicians discovered naloxone, a treatment for opioid poisoning, worked to reverse the symptoms. | | | However, there are few studies on the use of these kinds of agents to sedate people under these circumstances. |
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http://www.acep.org/webportal/Newsroom/NR/AnnalsOfEmergencyMedicinePressReleases/Arvchive2003/HighlightsoftheMay2003Issue.htm
(1079 words)
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| | Carfentanil from Wildlife Pharmaceuticals |
| | Carfentanil citrate is a synthetic opiate with a clinical potency 10,000 times that of morphine, (Mather, L.E., Clin. | | | Carfentanil citrate is a Schedule ll Controlled drug substance. | | | Indications: Carfentanil citrate is for immobilization of free ranging or confined members of the family Cervidae (deer, elk, moose). |
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http://www.wildpharm.com/carfentanil.html
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| | Anesthesia and immobilization of wild ruminants |
| | Carfentanil can also be used at 0.01 mg/Kg. | | | Carfentanil should work well, but it will be expensive as well. | | | These animals will have a "telazol hangover" but will be able to control their airway and be up and about in a few minutes. |
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http://www.vetandwild.com/ruminants.html
(856 words)
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| | bmj.com Rapid Responses for Helfand et al., 324 (7333) 356-359 |
| | This theory has been confuted by elementary notions about clinical and pharmacokinetic characteristics, which make these products unable to produce the disastrous effects observed at Moscow theatre (2). | | | Carfentanil induces rapid catatonic immobilization, characterized by limb and neck hyperextension. | | | Carfentanil is a potent opioid which is used as rapid immobilizing agent for veterinary procedures in large wild animals, like bisons, bears, elks, ostriches, horses or domestic goats, often associated with other agents, like xylazine or detomidine, by darting (even from a helicopter), or delivering directly in the buccal cavity. |
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http://bmj.bmjjournals.com/cgi/eletters/324/7333/356
(484 words)
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| | Center for Bison Studies-Current Articles on Ecology and Management |
| | The mean dose of carfentanil used was 7.0 mu g/kg. | | | Subsequently, carfentanil alone, or in combination with xylazine, was used. | | | Small doses of xylazine were used when required to control head and hind limb movement of recumbent bison. |
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http://www.montana.edu/~wwwcbs/ecollit.html
(2388 words)
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| | Thinking the pain away? PET Study Shows the Brain’s Painkillers May Cause “Placebo Effect” |
| | The imaging method used in the study involves tiny doses of a medicine called carfentanil that is attached to a short lived radioactive form of carbon ( | | | The researchers also made MRI scans of the participants’ brains, which they cross-registered with the PET scans to give accurate information on exactly which brain regions were active. | | | The stronger the positron signal from a particular brain region, the less active the mu opioid system, and vice versa. |
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http://interactive.snm.org/index.cfm?PageID=4287&RPID=10
(1189 words)
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| | A comparison of carfentanil/xylazine and Telazol/xylazine for immobilization of white-tailed deer -- Miller et al. 39 ... |
| | From this study, we selected a dose of carfentanil/xylazine for the purpose of comparing immobilization parameters and physiologic effects with those of a combination of tiletamine and zolazepam (Telazol) and xylazine. | | | Time to first observable drug effects and to induction were significantly longer for deer treated with carfentanil/xylazine than with Telazol/xylazine (P | | | A carfentanil dose of 1.2 mg (x +/- SD = 23.5 +/- 3.2 microg/kg) and 10 mg xylazine (0.2 +/- 0.03 mg/kg) were selected, based on induction times and previously published reports, to compare with a combination of 230 mg of Telazol (4.5 +/- 0.6 mg/kg) and 120 mg xylazine (2.3 +/- 0.3 mg/kg). |
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http://www.jwildlifedis.org/cgi/content/abstract/39/4/851
(265 words)
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| | vpexotic |
| | A-3080 is an investigational opioid agonist that possess a high degree of potency but has a greater therapeutic index than etorphine or carfentanil. | | | Early clinical trials have indicated that it is safer to use and produces comparable results as the previous agents at equipotent doses. | | | The antidote for carfentanil overdose is naloxone at a dose of 80-100 times the total dose of carfentanil or diprenorphine at 7 times the carfentanil dose. |
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http://faculty.swosu.edu/scott.long/vtph/vpexotic.htm
(672 words)
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| | eMedicine - CBRNE - Incapacitating Agents, Opioids/Benzodiazepines : Article by Christopher P Holstege, MD |
| | Fentanyl and its derivatives (ie, sufentanil, alfentanil, remifentanil, carfentanil) are the only opioids that have been described as potential aerosolized opioid agents. | | | Alfentanil, remifentanil, fentanyl, and carfentanil are 75, 220, 300, and 10,000 times more potent than morphine, respectively. | | | Numerous opioid agonists also exist; each has varying affinity for each receptor. |
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http://www.emedicine.com/emerg/topic944.htm
(3000 words)
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| | "Information resources on elephants" |
| | Descriptors: carfentanil and etorphine, effects, heart, respiratory system, blood pressure, body temperature, haemodynamics, Loxodonta. | | | NAL call no: SF601.J6 Descriptors: analgesic drug, etorphine, carfentanil, efficacy, safety, general anesthetic. | | | Physiologic effects of etorphine and carfentanil in African elephants. |
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http://www.nal.usda.gov/awic/pubs/elephants/afanes.htm
(921 words)
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| | Sciencemadness Discussion Board - Powered by XMB 1.8 Partagium Final SP3 |
| | I'm kind of full of shit here, but a few 100micrograms of LSD is all you need to feel a strong effect. | | | Actually an avaerage hit of LSD has only about 30 micrograms(though you can take upto 300 or so).After this comes carfentanil with an ED50 of 0.6 micrograms/kilo in humans. | | | Got that of rhodium archive and erowid(and some experiance |
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http://www.sciencemadness.org/talk/viewthread.php?tid=2715
(1228 words)
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| | [No title] |
| | [11C]-labeled carfentanil is use with PET to study opiate receptors in the brain (Dannals, et al., 1985, 1993). | | | Carfentanil is a mu-opiate receptor agonist that is approximately 8000 times more potent than morphine. | | | Copyright © 1998 Crump Institute for Biogical Imaging. |
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http://laxmi.nuc.ucla.edu:8000/NM-Mediabook/tracers/carfent.html
(62 words)
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| | Re: CS Storage |
| | Even if the Vet is licensed for schedule 2 they cannot order this drug. | | | The Doctor should contact the DEA about these requirements before attempting to order Carfentanil. | | | If you have any comments concerning the operation of this forum please send them to Virginia R. Crossett |
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http://www.azvt.org/vettech/_disc3/0000024e.htm
(63 words)
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| | [No title] |
| | In fact lately there has been some renewed interest. | | | It's an opiate antagonist analogous to naloxone, and thus the precursor isn't controlled to the extent of that for carfentanil, which is an agonist. | | | Mike offered to find out whether the precursor is still available. |
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http://www.ps.uci.edu/~markm/mayer/cyclofoxy.txt
(282 words)
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| | 2_legal |
| | Note that although carfentanil and etorphine are schedule II, DEA maintains a list of approved individuals who may obtain these potent narcotics. |
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http://mercury.bio.uaf.edu/~jblake.faculty/bio655/module2/2_legal.htm
(916 words)
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| | [No title] |
| | The licensed veterinarian shall be a veterinarian engaged in zoo and exotic animal practice, wildlife management programs, or research. | | | Each milliliter of sterile aqueous solution contains 3 milligrams of carfentanil citrate. |
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http://dil.vetmed.vt.edu/cfr/522/311.txt
(154 words)
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| | Thieme : Fachzeitschriften : Pharmacopsychiatry 2001 : Autoren |
| | A genetic polymorphism in interleukin-1beta is associated with altered brain structure in schizophrenia | | | Machulla, HJ Mu-opioid receptor genotype and in vivo availability - association with craving and relapse in alcoholism | | | Machulla, HJ Carfentanil opioid receptor PET in alcoholism |
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http://www.thieme.de/abstracts/pharmaco/abstracts2001/daten/a_m.html
(1310 words)
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| | Arch Gen Psychiatry -- Error in Byline in: Correlation of Stable Elevations in Striatal {micro}-Opioid Receptor ... |
| | Error in Byline in: Correlation of Stable Elevations in Striatal µ-Opioid Receptor Availability in Detoxified Alcoholic Patients With Alcohol Craving: A Positron Emission Tomography Study Using Carbon 11–Labeled Carfentanil | | | Arch Gen Psychiatry -- Error in Byline in: Correlation of Stable Elevations in Striatal {micro}-Opioid Receptor Availability in Detoxified Alcoholic Patients With Alcohol Craving: A Positron Emission Tomography Study Using Carbon 11-Labeled Carfentanil, September 2005, 62 (9): 983 |
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http://archpsyc.ama-assn.org/cgi/content/full/62/9/983
(120 words)
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| | [No title] |
| | One-quarter of the dose should be administered intravenously and three-quarters of the dose should be administered subcutaneously. | | | 100 milligrams of naltrexone hydrochloride for each milligram of carfentanil citrate administered. | | | Available data are inadequate to recommend use in pregnant animals. |
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http://dil.vetmed.vt.edu/cfr/522/1465.txt
(107 words)
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| | cfr1305-7 |
| | (1) Order forms for carfentanil etorphine hydrochloride and diprenorphine shall only contain these substances in reasonable quantities and | | | (a) The purchaser of carfentanil etorphine hydrochloride or diprenorphine shall submit copy 1 and 2 of the order form to the supplier and retain copy 3 in his own files. |
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http://www.ncbop.org/cfr1305-7.htm
(323 words)
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| | METHADONE AND RELATED DRUGS |
| | carfentanil are all considered to have a high abuse | | | carfentanil citrate, is approved for use in veterinary |
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http://www.tpub.com/content/combat/14137/css/14137_182.htm
(386 words)
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| | FDA > CDRH > CFR Title 21 Database Search |
| | (a) A DEA Form 222 or an electronic order for carfentanil, etorphine hydrochloride, and diprenorphine must contain only these substances in reasonable quantities. | | | PART 1305 -- ORDERS FOR SCHEDULE I AND II CONTROLLED SUBSTANCES |
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http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?FR=1305.07
(81 words)
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| | Untitled |
| | DIFFERENTIAL RESPONSE TO IV CARFENTANIL IN CHRONIC COCAINE USERS, DEPRESSED PATIENTS, AND CONTROLS |
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http://www.cpdd.vcu.edu/97abs/stauffer.html
(336 words)
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