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| | Testing Electromagnetic Fields for Potential Carcinogenic Activity: A Critical Review of Animal Models |
 | | In order to assess the potential of electromagnetic fields (EMF) to influence the process of carcinogenesis, it will be necessary to supplement epidemiological studies with controlled laboratory studies in animals. | | | As has been the case with numerous environmental chemicals and physical agents, definitive conclusions as to the potential carcinogenicity of EMF are likely to require supporting evidence from whole animal carcinogenesis bioassays along with a greater understanding of relevant biological mechanisms. | | | There are now a number of suitable assays available that focus on different histopathological forms of cancer and on different stages of carcinogenesis--induction, promotion, progression. |
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http://ehis.niehs.nih.gov/members/1997/Suppl-1/mccann-full.html
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| | Patricia Lorenzo, Ph.D. |
| | As tools to analyze diacylglycerol signaling pathways in carcinogenesis, we have been using a group of natural products that mimic some of the actions of this second messenger in the cell. | | | Our laboratory is interested in understanding the signaling pathways involving the second messenger diacylglycerol and their participation in carcinogenesis, particularly during tumor promotion. | | | Since tumor promotion accounts for most of the latent period in carcinogenesis and is a reversible process, the various components of this stage can be potential targets for the development of mechanism-based anticancer and chemopreventive drugs. |
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http://www.crch.org/ProfileLorenzo.htm
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| | Laboratory of Experimental Pathology |
| | Animal models and pathology of laryngeal, tracheobronchial, and peripheral lung carcinogenesis. | | | Saffiotti's research in the Laboratory of Experimental Pathology was devoted to epithelial carcinogenesis, especially respiratory tract carcinogenesis. | | | As Chief of the Laboratory of Experimental Pathology (1974-1998), he directed an intramural research program which developed and investigated animal and cellular models chiefly for respiratory and multifactorial carcinogenesis, mechanisms of inhibition by vitamin A, and the role of growth factors in the culture and transformation of epithelial cells. |
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http://www3.cancer.gov/intra/lep/leppage.htm
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| | EPA - Endocrine 70478-01 Organochlorine Exposure and Breast Cancer Risk |
| | Toachieve aim 3, it will be necessary to compensate for possible organochlorine-induced shifts in the timing of cellproliferation during puberty which is a critical element of the single carcinogen dose mammary carcinogenesis model inthe rat. | | | The results of these studies will demonstrate the mammary carcinogenesis-enhancing potential of estrogenic organochlorines, and they will establish differential effects of exposure at critical timesduring development and aging in relation to environmental mammary carcinogenesis. | | | Possible enhancing effects on breast carcinogenesis of estrogenic organochlorine exposuremay be most profound when endogenous estrogen production is low (before puberty or postmenopausal). |
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http://www.epa.gov/edrlupvx/inventory/NCI-027.html
(338 words)
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| | Rodney S. Nairn |
| | We are studying a platyfish-swordtail genetic cross in which exposure to UV light is necessary for melanomas to form, and we have cloned and genetically mapped oncogenes, several DNA repair genes, and tumor suppressor genes (e.g., p53 and CDKN2) from this organism in order to investigate their potential roles in UV carcinogenesis. | | | Because it is recognized that critical genes involved in carcinogenesis are often altered through genetic recombination, these studies address the crucial question of how DNA damage and damage processing by specific genes may lead directly to heritable alterations in cells, which can result in malignant transformation and cancer. | | | Genetic analysis of spontaneous and UV carcinogenesis in Xiphophorus hybrid fish. |
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http://sciencepark.mdanderson.org/Documents/rnairn/nairn.html
(625 words)
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| | Induction of apoptosis in mouse and human carcinoma cell lines by Emblica officinalis polyphenols and its effect on chemical carcinogenesis. |
| | Induction of apoptosis in mouse and human carcinoma cell lines by Emblica officinalis polyphenols and its effect on chemical carcinogenesis. | | | Induction of apoptosis in mouse and human carcinoma cell lines by Emblica officinalis polyphenols and its effect on chemical carcinogenesis.Plant-derived phenolic compounds manifest many beneficial effects and can potentially inhibit several stages of carcinogenesis. | | | In the present study, we investigated the efficacy of Emblica officinalis (E. officinalis) polyphenol fraction (EOP) on the induction of apoptosis in mouse and human carcinoma cell lineses and its modulatory effect on N- nitrosodiethylamine (NDEA) induced liver tumors in rats. |
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http://www.pdg.cnb.uam.es/UniPub/iHOP/gp/9911791.html
(5167 words)
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| | Beef Tallow Promotes Rat Prostate/Intestinal Ca |
| | The modifying effects of three kinds of fat (corn oil, beef tallow or perilla oil, each at 20% in the diet) on F344 rat prostate carcinogenesis induced by 3,2´-dimethyl-4-aminobiphenyl (DMAB) were investigated. | | | Thus the present data revealed carcinogenesis in the prostate and intestines to be promoted by beef tallow. | | | Of the three high fat diets, beef tallow was also found to increase intestinal carcinogenesis. |
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http://www.annieappleseedproject.org/beeftalpromr.html
(5167 words)
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| | Swanson |
| | Swanson, S.M. and Unterman, T.G. The growth hormone-deficient Spontaneous Dwarf Rat is resistant to chemically-induced mammary carcinogenesis. | | | Swanson, S.M., Guzman, R.C., Collins, G., Tafoya, P., Thordarson, G., Talamantes, F. and Nandi, S. Refractoriness to mammary carcinogenesis in the parous mouse is reversible by hormonal stimulation induced by pituitary isografts. | | | Abrams, T.J., Guzman, R.C., Swanson, S.M., Thordarson, G., Talamantes, F., Nandi S. Changes in the parous rat mammary gland environment are involved in parity-associated protection against mammary carcinogenesis. |
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http://www.uic.edu/pharmacy/depts/pmch/faculty_sites/Swanson.htm
(706 words)
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| | Nat' Academies Press, Air Quality and Stationary Source Emission Control (1975) |
| | In addition, it is not clear whether the findings represent an independent carcinogenic effect of sulfur dioxide in addition to benzopyrene or a potentiation of benzopyrene carcinogenesis by an otherwise unrelated consequence of sulfur dioxide exposure. | | | If this is confirmed, it would tend to support the hypothesis that sulfur dioxide promotes benzopyrene carcinogenesis through its action as a nospecific irritant. | | | Recent preliminary studies by this group appear to indicate that combined exposure to nitrogen dioxide and benzopyrene also results in lung carcinogenesis. |
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http://www.nap.edu/books/NI000512/html/138.html
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| | Experimental Pathology and Chemotherapy Division |
| | @Studies in the Experimental Pathology and Chemotherapy Division encompassed mechanisms of carcinogenesis using human c-Ha-ras proto-oncogene transgenic rats, prevention of carcinogenesis by bovine lactoferrin (bLF) and plant-derived compounds, inhibition of metastasis by bLF, characterization of a tumor suppressing factor and anti-angiogenic agents. | | | @The role of abrogation of gap junction and overexpression of p16 gene in experimental urinary bladder carcinogenesis was analyzed. | | | Histogenesis of phenotypically different rat kidney tumors was clarified in a stereoscopic reconstruction study. |
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http://www.ncc.go.jp/en/nccri/annrep/1998/03.Exper.html
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| | Records for Toxicology and carcinogenesis studies of chloroethane (ethyl chloride) (CAS no. 75-00-3) (in MARION) |
| | NTP technical report on the toxicology and carcinogenesis studies of chloroethane (ethyl chloride) (CAS no. 75-00-3) in F344/N rats and B6C3F mice (inhalation studies) / National Toxicology Program. | | | Toxicology and carcinogenesis studies of chloroethane (ethyl chloride) (CAS no. | | | Records for Toxicology and carcinogenesis studies of chloroethane (ethyl chloride) (CAS no. 75-00-3) (in MARION) |
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http://js-catalog.cpl.org/MARION/%2BTOXICOLOGY/f95d13005100/0
(2994 words)
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| | Center for Cancer Research - Staff Pages |
| | Peroxisome proliferator-activated receptor beta (delta)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis. | | | PPARgamma influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis. | | | PPARb(d)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis. |
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http://ccr.nci.nih.gov/Staff/publications.asp?profileid=5801
(2994 words)
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| | <font>Science Park faculty publications</font> |
| | Modulation of the angiogenesis response through Ha-ras control, placenta growth factor, and angiopoietin expression in mouse skin carcinogenesis. | | | Regulation of the differentiation-related gene Drg-1 during mouse skin carcinogenesis. | | | Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model. |
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http://sciencepark.mdacc.tmc.edu/library/mdapubs.html
(2994 words)
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| | q490.html |
| | Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 60,153,1991 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 68396 ug/kg/20W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors REFERENCE : CRNGDP Carcinogenesis (London). | | | Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 46,173,1989 TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 1 umol/plate REFERENCE : CRNGDP Carcinogenesis (London). | | | Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 44,173,1989 TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - hamster Cells - not otherwise specified DOSE/DURATION : 20 mmol/L REFERENCE : CRNGDP Carcinogenesis (London). |
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http://hazard.com/msds/tox/f/q73/q490.html
(173 words)
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| | Eppley Institute |
| | Toth, B.: Facts, myths, and reflections on the use of maximum tolerated dose in chemical carcinogenesis. | | | Toth, B., Erickson, J., Gannett, P.M., and Patil, K.: Carcinogenesis by the cultivated baked Agaricus bisporus mushroom in mice. | | | Toth, B., Erickson, J. and Gannett, P.: Lack of carcinogenesis by the baked mushroom Agaricus bisporus in mice: Different feeding regimen. |
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http://www.unmc.edu/Eppley/publications/pub_toth.html
(193 words)
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| | UV-B RADIATION and OZONE DEPLETION--Effects on Humans, Animals, Plants, Microorganisms, and Materials |
| | Now that we have an action spectrum for photocarcinogenesis, the correlation of incidence and effective UV dose has to be corrected; this correction depends on the action spectrum. | | | The action spectrum for carcinogenesis in humans is the same as that in mice. | | | When the correlation between skin cancer incidence and UV dose was made, the action spectrum for UV carcinogenesis was not yet known. |
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http://www.ciesin.org/docs/001-540/001-540.html
(193 words)
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| | Severity of promotion by sodium salts of succinic acid in rat urinary bladder carcinogenesis correlates with sodium ion concentration under conditions of equal urinary pH. |
| | In the present study, urinary bladder carcinogenesis in male F344 rats was promoted by feeding the mono- and di- sodium salts of succinic acid, and the activity was enhanced by varying urinary sodium ion concentration under conditions of equally high pH. | | | Severity of promotion by sodium salts of succinic acid in rat urinary bladder carcinogenesis correlates with sodium ion concentration under conditions of equal urinary pH. | | | Severity of promotion by sodium salts of succinic acid in rat urinary bladder carcinogenesis correlates with sodium ion concentration under conditions of equal urinary pH.2Na-Suc induced larger urinary bladder tumors than the Na-Suc. |
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http://www.pdg.cnb.uam.es/UniPub/iHOP/gp/7875569.html
(311 words)
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| | Dissection of Human Papillomavirus E6 and E7 Function in Transgenic Mouse Models of Cervical Carcinogenesis -- Riley et al. 63 (16): 4862 -- Cancer Research |
| | Elson D. A., Riley R. R., Lacey A., Thordarson G., Talamantes F., Arbeit J. Sensitivity of the cervical transformation zone to estrogen-induced squamous carcinogenesis.. | | | Arbeit J. M., Riley R. R., Huey B., Porter C., Kelloff G., Lubet R., Ward J. M., Pinkel D. DFMO chemoprevention of epidermal carcinogenesis in K14-HPV16 transgenic mice.. | | | Dissection of Human Papillomavirus E6 and E7 Function in Transgenic Mouse Models of Cervical Carcinogenesis -- Riley et al. |
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http://cancerres.aacrjournals.org/cgi/content/full/63/16/4862
(311 words)
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| | Profile |
| | Moolgavkar SH, Luebeck EG, de Gunst M, Port RE, Schwarz M, Quantitative analysis of enzyme-altered foci in rat hepatocarcinogenesis experiments--I. Single agent regimen, Carcinogenesis, 11(8), 1271-8, August 1990 | | | Luebeck EG, Curtis SB, Hazelton WD, Moolgavkar SH, The importance of promotion in lung carcinogenesis for protracted exposures to radon and radon progeny, Radiation Research, 154(6), 730;discussion 730-1, December 2000 | | | Grasl-Kraupp B, Luebeck G, Wagner A, Low-Baselli A, de Gunst M, Waldhor T, Moolgavkar S, Schulte-Hermann R, Quantitative analysis of tumor initiation in rat liver: role of cell replication and cell death (apoptosis), Carcinogenesis, 21(7), 1411-21, July 2000 |
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http://myprofile.cos.com/gluebeck
(1137 words)
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| | Marie H. Hanigan's CV |
| | Hanigan, H.M.* and Pitot, H.C. (1982), Isolation of Gamma Glutamyl Transpeptidase Positive Hepatocytes during the Early Stages of Hepatocarcinogenesis in the Rat. | | | Hanigan, M.H. (1996) Gamma-Glutamyl Transpeptidase, A Glutathionase: Its Expression in Carcinogenesis. | | | Hanigan, M.H. (1998) Gamma-Glutamyl Transpeptidase, A Glutathionase: Its Expression and Function in Carcinogenesis. |
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http://w3.ouhsc.edu/cell_biology/faculty/hanigancv.html
(2719 words)
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| | Brown bullhead (Ameiurus nebulosus) skin carcinogenesis. |
| | The present study is an initial morphologic and biochemical characterization of the normal and neoplastic brown bullhead skin to assess its suitability as a model of skin carcinogenesis. | | | The brown bullhead (Ameiurus nebulosus) has shown potential as a model for skin carcinogenesis studies due to its sensitivity to environmental chemical pollutants. | | | Brown bullhead were removed from Back River in the Chesapeake Bay region, an area historically polluted with heavy metals and polycyclic aromatic hydrocarbons. |
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http://www.pdg.cnb.uam.es/UniPub/iHOP/gp/8626059.html
(283 words)
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