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Topic: Capsid



  
 ICTVdB Virus Description - 00.001. Adenoviridae
Virions have a simple construction and consist of a capsid, fibers, a core, and associated protein(s).
Antigenic determinants may be found on capsids, or hexons, or fibers.
Virions consist of 10 structural protein(s) located in the capsid, fibers, and core.
http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/01000000.htm   (1926 words)

  
 Identification of the sites of interaction between the scaffold and outer shell in herpes simplex virus-1 capsids by ...
large cored B capsids to the small cored form (10).
relate to the biological role of the capsid.
Three-Dimensional Structure of the Human Herpesvirus 8 Capsid
http://www.pnas.org/cgi/content/full/95/6/2778   (4403 words)

  
 Naturally Occurring Capsid Substitutions Render HIV-1 Cyclophilin A Independent in Human Cells and ...
This experiment is representative of two independent experiments.
capsid) that resist to Debio-025, our study suggests that the
During the course of this study, Ikeda et al.
http://www.jbc.org/cgi/content/full/280/48/40293   (4485 words)

  
 Herpes Simplex Virus Type 1 Entry into Host Cells: Reconstitution of Capsid Binding and Uncoating at the Nuclear Pore ...
capsids to untreated capsids, we subjected them to immunoprecipitation
The changes that allow such altered capsid behavior
improve capsid recovery after lysis and subjected to proteinase
http://mcb.asm.org/cgi/content/full/20/13/4922   (6946 words)

  
 A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly -- Stray et al. 102 (23): ...
Our studies with capsid suggest that HAP actually lowers the
such drugs can destabilize preformed capsids and thus could
In contrast, at higher temperature and [NaCl], conditions that
http://www.pnas.org/cgi/content/full/102/23/8138   (3911 words)

  
 CDC - Induction of Inflammation by West Nile virus Capsid through the Caspase-9 Apoptotic Pathway
Therefore, creating a WNV isolate that no longer localizes the capsid to the nucleus may result in a virus that loses pathogenesis, providing a novel approach for vaccine studies.
Induction of inflammatino by West Nile virus capsid through the caspase-9 apoptotic pathway.
These studies demonstrate that the capsid protein of WNV may be responsible for aspects of viral pathogenesis through induction of the apoptotic cascade.
http://www.cdc.gov/ncidod/EID/vol8no12/02-0224.htm   (3340 words)

  
 Caspase-mediated cleavage of the feline calicivirus capsid protein -- Al-Molawi et al. 84 (5): 1237 -- Journal of ...
capsid cleavage, we studied the ability of recombinant human
study the protease responsible for capsid cleavage remained
Caspases Mediate Processing of the Capsid Precursor and Cell Release of Human Astroviruses
http://vir.sgmjournals.org/cgi/content/full/84/5/1237   (4655 words)

  
 Function of Dynein and Dynactin in Herpes Simplex Virus Capsid Transport -- Döhner et al. 13 (8): 2795 -- ...
double-labeling experiments for dynein or dynactin with HSV1 capsids
these capsids have lost their electron-dense core (Sodeik et al.
Ohara, P.T., Chin, M.S., and LaVail, J.H. The spread of herpes simplex virus type 1 from trigeminal neurons to the murine cornea: an immunoelectron microscopy study.
http://www.molbiolcell.org/cgi/content/full/13/8/2795   (7584 words)

  
 Adeno-Associated Virus Type 2 VP2 Capsid Protein Is Nonessential and Can Tolerate Large Peptide Insertions at Its N ...
The major goal of the present study was
VP3 alone provided that the VP3 is fused to a nuclear localization
An alternative approach to eliminating VP3 expression has been
http://jvi.asm.org/cgi/content/full/78/12/6595   (9340 words)

  
 Herpes Virus Research Laboratory
This shape supports the view that packaging begins with procapsids rather than with capsids having the mature, icosahedral structure.
Virus and cell membranes then fuse in a process that introduces the capsid into the cytoplasm as shown diagramatically below.
VP5 (the major capsid protein) is the structural subunit of the capsomers, both the hexons and the pentons.
http://www.people.virginia.edu/~jcb2g/research/background.htm   (1198 words)

  
 Adenovirus Protein VI Mediates Membrane Disruption following Capsid Disassembly -- Wiethoff et al. 79 (4): 1992 -- The ...
to the penton base facilitates capsid disassembly and subsequent
in the hexon tertiary structure occur during capsid disassembly.
metastable upon proteolytic processing of capsid proteins (17).
http://jvi.asm.org/cgi/content/full/79/4/1992   (6009 words)

  
 Capsid: Facts and details from Encyclopedia Topic
[For more facts and a topic of this subject, click this link] (isometric) capsids, EHandler: no quick summary.
[Follow this hyperlink for a summary of this subject] capsids, EHandler: no quick summary.
[For more facts and a topic of this subject, click this link] is called the capsid.
http://www.absoluteastronomy.com/encyclopedia/c/ca/capsid.htm   (814 words)

  
 Virus Structure
One of the most useful techniques proved to be the use of electron-dense dyes such as phosphotungstic acid or uranyl acetate to examine virus particles by negative staining.
Therefore, a specific virus-encoded capsid or nucleocapsid protein is required to achieve this end.
Like many other aspects of virus assembly, the way in which packaging is controlled is not well understood, but the key must lie in the specific molecular interactions between the genome and the capsid.
http://www-micro.msb.le.ac.uk/109/structure.html   (2769 words)

  
 detailed project page
These studies represent our research efforts to establish a structural basis for HCMV infection and assembly.
The results of these experiments will lead to a better understanding of the process of KSHV lytic replication and the identification of potential targets for therapeutic intervention.
The long-term objective of this project is to understand the structural basis of HCMV capsid maturation and pathogenesis at high resolution and provide useful structural information for developing therapeutic strategies against HCMV infections.
http://hub.med.uth.tmc.edu/~hong/framepages/p1.htm   (980 words)

  
 capsid
Study supports ongoing development of experimental HIV maturation...
The capsid often determines the shape of the virus.
...and partnering activities." AAV naturally exists as several different serotypes, which differ physically in the composition of their capsid proteins and genome...
http://www.mongabay.com/igapo/biotech/capsid.html   (334 words)

  
 Assembly into single-shelled virus-like particles by major capsid protein VP1 encoded by genome segment S1 of Bombyx ...
role in maintaining capsid integrity (Zhang et al., 2002
SDS-PAGE and Western blot analyses of VP1 protein expressed by baculovirus.
Viruses in the family Reoviridae have a capsid made up of concentric
http://vir.sgmjournals.org/cgi/content/full/84/9/2439   (1278 words)

  
 Capsid
Most viral structures are based on the structure of their capsids.
Minor changes in the capsid pose significant challenges as well, as an antiviral specified for one structure won’t work on the new capsid structure and must be redeveloped.
It is the capsid of the virus that most antiviral medications are designed to attack.
http://www.iscid.org/encyclopedia/Capsid   (228 words)

  
 Capsid - Wikipedia, the free encyclopedia
For example, the bacteriophage PRD1, Paramecium bursaria Chlorella algal virus, and mammalian adenovirus have been placed in the same family.
A capsid is also a leaf bug of the family Miridae.
During this process, the capsid subunits are synthesized according to the genetic material of the virus, using the protein biosynthesis mechanism of the cell.
http://en.wikipedia.org/wiki/Capsid   (302 words)

  
 Studies on intracellular processing of the capsid protein of human astrovirus serotype 1 in infected cells -- ...
However, studies on the processing of the capsid protein
Caspases Mediate Processing of the Capsid Precursor and Cell Release of Human Astroviruses
was fused at the C terminus of the capsid protein, where no
http://vir.sgmjournals.org/cgi/content/full/83/7/1691   (2742 words)

  
 ScienceDaily: Same Fold In Viral Shells Point To Common Ancestry
To study the structure of gp24, the researchers first turned the protein into a crystal form and then analyzed it with X-ray crystallography, a technique in which X-rays pass through a crystal, creating a "diffraction pattern" that can be interpreted with various computational procedures.
Researchers used a technique called cryoelectron microscopy to determine the three-dimensional structure of phi 29 down to a resolution of 7.9 angstroms.
Researchers are studying the T4 virus for many fundamental biological studies, some of which might be used to create new vaccines to fight viral infections in humans.
http://www.sciencedaily.com/releases/2005/05/050518200805.htm   (2552 words)

  
 HIV-1 Capsid Assembly is a Step-wise Pathway
Further confirmation of the existence of a pathway for assembly of immature HIV-1 capsids came from analysis of 16 HIV-1 Gag mutants that other groups had identified as being assembly-defective or assembly-competent in mammalian cells.
The existence of a step-wise pathway was demonstrated through the use of pulse-chase studies in the cell-free system but assembly intermediates are also found in mammalian cells that are assembling primate lentivirus capsids.
Furthermore, we demonstrated that a host factor complex was required for post-translational progression along the capsid assembly pathway.
http://faculty.washington.edu/jais/stepWise.html   (305 words)

  
 Genetic Recombination between Two Genotypes of Genogroup III Bovine Noroviruses (BoNVs) and Capsid Sequence Diversity ...
Sequence identity and phylogenetic analysis of the capsid genes of BoNV and NB-like BECV.
Multiple alignments and phylogenetic analysis of the capsid
Calicivirus capsid proteins expressed in a baculovirus expression
http://jcm.asm.org/cgi/content/full/42/11/5214   (4618 words)

  
 Differentiation of Two Bovine Lentiviruses by a Monoclonal Antibody on the Basis of Epitope Specificity -- Zheng et al. ...
Two different BIV constructs expressing capsid proteins were used in this experiment: pATH and pQE32.
This study describes the production of such a monoclonal
Topographical analysis of antigenic determinants on capsid protein.
http://cdli.asm.org/cgi/content/full/8/2/283   (3337 words)

  
 Virus - Wikipedia, the free encyclopedia
This self-assembly is often aided by molecular chaperones, or proteins made by the host that help the capsid parts come together.
The nucleic acid genome varies among different viruses and may be either DNA, or RNA; single- or double-stranded; linear or circular; and positive or negative sense.
This arrangement results in rod-shaped virions which can either be short and rigid or long and flexible; the nature of long helical particles neccessitates flexibility, as they are prone to damage if they are too rigid.
http://en.wikipedia.org/wiki/Virus   (3388 words)

  
 Capsid definition - Medical Dictionary definitions of popular medical terms
Capsid definition - Medical Dictionary definitions of popular medical terms
MedicineNet Home > MedTerms medical dictionary A-Z List > Capsid
Please consult your healthcare provider before beginning any course of supplementation or treatment.
http://www.medterms.com/script/main/art.asp?articlekey=24448   (138 words)

  
 Virus Capsid Poster
Atomic interactions between the capsid and RNA are shown.
Code to read these matrices and generate the multimeric structure is a basic requirement for visualizing large multimeric structures.
All available atomic resolution virus capsid structures are icosahedral or helical.
http://www.cgl.ucsf.edu/Research/virus/poster/poster.html   (1178 words)

  
 CAPSID - at the BBC
CapsID is useful if you have a good idea of what species your sample is but want to know more specifically.
For example, if your sample is a blowfly and believe there are only 20 species of blowfly that it might be, you could choose a gene (or gener fragment ~ 300bp) that is common to most blowflys and relatively conserved(or most species in general) such as ribosomal DNA.
CapsID will design the set of CAPS markers that will give the best guess as to which species your sample is when the CAPS are tested on your sample.
http://bbc.botany.utoronto.ca/capsid   (257 words)

  
 Bugs in the News - What the Heck is a Virus?
The capsid is actually made of many, many identical individual proteins which are assembled very precisely to form the capsid structure.
Moving from the outside to the inside, here are some parts of a virus which are common to many different kinds of viruses: capsid, core, genetic material (DNA or RNA).
Sometimes there will be a protein core underneath the capsid which also surrounds the genetic material.
http://people.ku.edu/~jbrown/virus.html   (1463 words)

  
 Royal Horticultural Society - Gardening Advice: Capsid Bugs
These blemishes are only skin deep and do not affect the eating and keeping qualities of the fruits.
Vegetables generally tolerate capsid damage and do not need spraying for this pest.
As they feed they secrete a toxic saliva into the plants which kills cells immediately around the feeding area.
http://www.rhs.org.uk/advice/profiles0600/capsid_bug.asp   (298 words)

  
 The Encyclopedia of Life Project - Index
Hepatitis B virus causes both acute and chronic liver infections in man. An unusual feature is the prolonged viraemia, lasting for up to several months in acute infections and for many years (even for life) in chronic infections.
Replication has been documented in the parotid gland, as well as other lymphatic tissues.
Hepatitis A virus (HAV) is classified with the enterovirus group of the Picornaviridae family.
http://www.eolproject.org:8080/alphaindex.jsp?char=h   (711 words)

  
 InterPro: IPR008980 Viral capsid/hemagglutinin protein
The beta sandwich domain described here is structurally very similar in vp6 and vp7, and may be involved in the attachment of the virus to the cell.
P03531 VP6 protein (Major capsid protein) (Major internal structural protein)
The vp7 and vp6 capsid proteins each consist of two domains, one a beta sandwich, and the other an alpha helical bundle.
http://www.ebi.ac.uk/interpro/IEntry?ac=IPR008980   (2978 words)

  
 HIV Gag p24 Capsid 3D Structures Index
Proline residues in the HIV-1 NH2-terminal capsid domain: structure determinants for proper core assembly and subsequent steps of early replication.
Use the buttons below each entry in the list to get the PubMed entry, protein structure database (PDB) entry, open a Protein Explorer session with the entry, or get the NCBI entry (allowing Cn3D viewing) of the entry.
Inhibition of human immunodeficiency virus type 1 particle formation by alterations of defined amino acids within the C terminus of the capsid protein.
http://hiv-web.lanl.gov/content/hiv-db/STRUCTURE/GAGP24.HTML   (147 words)

  
 capsid - definition of capsid by the Free Online Dictionary, Thesaurus and Encyclopedia.
This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.
capsid - definition of capsid by the Free Online Dictionary, Thesaurus and Encyclopedia.
virion - (virology) a complete viral particle; nucleic acid and capsid (and a lipid envelope in some viruses)
http://www.thefreedictionary.com/capsid   (216 words)

  
 Synthetic Life
The chemical sequence (4, 5), the genetic map of the genome (4), and the three-dimensional crystal structure of the virion (6) were determined 2 decades ago.
Poliovirus can be crystallized (1) and its empirical formula can be calculated (2), yet this "chemical" replicates naturally in humans with high efficiency, occasionally causing the paralyzing and lethal poliomyelitis.
Poliovirus, an enterovirus of the Picornaviridae, is a small, nonenveloped, icosahedral virus consisting of five different macromolecules: 60 copies each of capsid polypeptides VP1, -2, -3, and -4 and one copy of the positive-sense, single-stranded RNA genome (~7.5 kilobases in length) (Fig.
http://www.evilbible.com/Synthetic_Life.htm   (2376 words)

  
 Drug Discovery & Development
Long a mainstay of the industry, natural products fell out of favor in the 1980s and 1990s, but there are signs of renewed interest.
A virion precursor that consists only of the viral capsid without the nucleic acid.
http://www.dddmag.com/scripts/Glossary.asp?RPTID=KWSRCH&SEARCHMETHOD=WORD&SEARCHWORD=Capsid   (207 words)

  
 Lifestyles Therapeutics
The weak enzyme coatings on cells which make them vulnerable to invasion by viruses make them susceptible to oxidation and elimination from the body, which then replaces them with healthy cells.
With viruses, the ozone damages the viral capsid and upsets the reproductive cycle by disrupting the virus-to-cell contact with peroxidation.
http://www.lifestylestherapeutics.com/TSOOzone.html   (13231 words)

  
 Capsid
The Foot-and-Mouth Disease Virus page provides information on the structure of the virus particle.
Viruses / ultrastructure; Virion; Database [Publication Type]; Capsid;
http://bioresearch.ac.uk/browse/mesh/D002213.html   (269 words)

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