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| | Calcium channel blockers AHealthyMe.com |
 | | Calcium channel blockers are used to treat high blood pressure, to correct abnormal heart rhythms, and to relieve the type of chest pain called angina pectoris. | | | Patients taking certain calcium channel blockers may need to check their pulse regularly, as the drugs may slow the pulse too much. | | | The expected result of taking a calcium channel blocker is to either correct abnormal heart rhythms, return blood pressure to normal, or relieve chest pain. |
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http://www.ahealthyme.com/article/gale/100084284
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| | Calcium Channel Blockers- Health Encyclopedia and Reference |
| | Without calcium, the muscles relax and the arteries dilate. | | | The result is almost as if the drug told the heart to sit back, relax, and take a few deep breaths. | | | They help the heart to work with less effort and, at the same time, relax the coronary arteries, improving the supply of oxygen-enriched blood of the heart itself. |
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http://www.healthcentral.com/encyclopedia/408/478/Calcium_Channel_Blockers.html
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| | Calcium Channel Blockers - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com |
| | CCBs differ in their duration of action, the process by which they are eliminated from the body, and, most importantly, in their ability to affect heart rate and contraction. | | | Angina (heart pain) occurs when the supply of oxygen to the heart is inadequate for the amount of work the heart must do. | | | This makes it easier for the heart to pump blood, and, as a result, the heart needs less oxygen. |
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http://www.medicinenet.com/calcium_channel_blockers/article.htm
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| | Calcium Channel Blockers Not Carcinogenic |
| | "Calcium channel blocker use was unrelated to the risk of cancer overall," Rosenberg and colleagues report in The Journal of the American Medical Association. | | | The investigators add that "Recent use, use for 5 or more years, and use of individual calcium channel blocker drugs were also not associated with cancer incidence." | | | Lynn Rosenberg of Boston University School of Medicine in Brookline, Massachusetts, and colleagues conducted another study to assess the risk. |
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http://www.personalmd.com/news/a1998040304.shtml
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| | Calcium Channel Blockers |
| | Calcium channel blockers are: negative inotropes, positive lusitropes (meaning they relax heart muscle/make it more compliance), and negative dromotropes (meaning that they slow conduction through the AV node). | | | In terms of treating hypotension, nifedipine and amlodipine seem to be the main drugs that affect arteriolar smooth muscle. | | | Skeletal muscle doesn't need extracellular calcium for muscle contraction. |
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http://www.vin.com/vin_ce/abvp/html/calcium_channel_blockers.html
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| | Poison Pearls and Perils: Calcium Channel Blockers |
| | Calcium flux plays an integral role in cardiac contractillity, intrinsic cardiac conduction pacemaker function and the regulation of systemic vascular tone. | | | The effects of a given calcium channel blocker on the myocardium, the conduction system, or the peripheral vascular system are unpredictable and a Swan Ganz catheter is helpful in managing patients with unstable cardiovascular parameters. | | | Cardiopulmonary bypass, transvenous pacing, and intra-aortic balloon pumps have all been used effectively as supportive care. |
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http://www.gwemed.edu/ncpc/Ccb.HTM
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| | Calcium channel blockers: the continuing controversy |
| | As with much pharmacoepidemiological data, the results have been difficult to interpret because of problems in separating the effects of the drug from the consequences of the diseases being treated. | | | In the Systolic Hypertension in Europe (Syst-Eur) trial, the long-acting drug nitrendipine reduced the incidence of stroke and a favourable trend was noted in the incidence of myocardial infarction. | | | Only large morbidity-mortality studies can confirm that a preventive intervention in low-risk patients is accomplishing more good than harm. |
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http://www.australianprescriber.com/magazines/vol22no1/calcium.htm
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| | MedlinePlus Drug Information: Calcium Channel Blocking Agents (Systemic) |
| | Some of the calcium channel blocking agents are used to relieve and control angina pectoris (chest pain). | | | Other calcium channel blocking agents may also be used for these and other conditions as determined by your doctor. | | | When taking calcium channel blocking agents it is especially important that your health care professional know if you are taking any of the following: |
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http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202107.html
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| | Calcium Channel Blockers |
| | Calcium influx is postulated to be the final common pathway for irreversible neuronal injury ( | | | The aim is to prevent worsening bradycardia due to enhanced vagal tone associated with nausea and gastrointestinal decontamination. | | | The aim is to reverse enhanced vagal tone associated with nausea and gastrointestinal decontamination. |
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http://www.chelationtherapyonline.com/articles/p199.htm
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| | Interactions with Calcium-Channel Blockers |
| | This is an important distinction, as patients with hypertension or other cardiac conditions may experience more pronounced effects on heart rate and blood pressure. | | | Although these results differ from the above study, the clinical significance of this interaction appears to be minimal. | | | Patients receiving these medications and drinking grapefruit juice regularly should be monitored for increased response. |
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http://www.powernetdesign.com/grapefruit/interactions/ccbs.html
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| | Calcium-Channel Blockers - Patient UK |
| | Because of their action to relax and widen arteries, some people develop flushing and headache. | | | This can interact with the medicine and alter it's effect. | | | You should not take verapamil in addition to a beta-blocker medicine. |
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http://www.patient.co.uk/showdoc.asp?doc=27000290
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| | Calcium Channel Blockers and Hypertension [Oct 1995; 20-1] |
| | Patients had to have been taking antihypertensive medicines for at least 30 days because preliminary analysis showed that recent starting of ß-blockers and calcium channel blockers was strongly associated with a risk of myocardial infarction. | | | Analysis across all patients showed the same relationship, a relationship which was not apparent for other medicines, for example, ß-blockers. | | | Dose-related increase in mortality in patients with coronary heart disease. |
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http://www.jr2.ox.ac.uk/bandolier/band20/b20-1.html
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| | Do Some Blood Pressure Drugs Up Heart Risk? |
| | When one blood pressure drug isn't enough, doctors often recommend combination therapy. | | | The new findings do not change those recommendations, says American Heart Association spokesman Daniel Jones, MD, dean of the University of Mississippi School of Medicine. | | | It's dangerous to stop taking any prescribed medicine -- blood pressure drugs in particular -- before seeing one's doctor. |
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http://my.webmd.com/content/article/98/104780
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| | Calcium Channel Blockers |
| | channels (but can lead to the proarrhythmia, torsades de pointes) | | | Efficacy can be enhanced by combination with other types of antihypertensives, but specific drug combinations should be avoided: | | | "Stretch"-operated or "leaky" Ca -channels (may be important in maintaining vascular smooth muscle tone): Do not appear to be sensitive to Ca -channel blockers |
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http://lysine.pharm.utah.edu/netpharm/netpharm_00/notes/cablockers.html
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| | USATODAY.com - Study links blood pressure drugs to heart disease |
| | CHICAGO — A popular class of blood pressure medicines may double a woman's risk of dying from heart disease, especially when given in certain combinations, a large study out today indicates. | | | Previous studies, including ALLHAT, found that the drugs can contribute to heart failure, but they did not increase death rates. | | | The authors cautioned that the study's design, in which patients are followed for a number of years, doesn't yield the same "gold standard" evidence that comes from randomly dividing patients into treatment and control groups. |
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http://www.usatoday.com/news/health/2004-12-14-blood-pressure-risk_x.htm
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| | UMHS - Calcium Channel Blockers |
| | The research describing the possible association between calcium channel blocking agents and heart attacks is a preliminary study. | | | If you have ongoing concerns, discuss these with your physician before making any change in your medicines. | | | A large number of patients are on these calcium blocking drugs. |
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http://www.med.umich.edu/1libr/heart/highbp02.htm
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| | Calcium Channel Blockers |
| | Valsartan Significant Better Than Amlodipine for Improving Long-term Heart-rate Variability in Patients With LVH: Presented at EMH - Doctor's Guide, 6/20/05 | | | Nifedipine And Verapamil Differ Pharmacologically But Are Equally Effective - Doctor's Guide, 3/19/01 | | | Nifedipine Might Interfere With Exercise-Induced Blood Pressure Changes - Doctor's Guide, 1/30/01 |
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http://qualitycounts.com/drugs/hypertension/fpcalcium_channel_blockers.html
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| | Calcium-Channel Blockers, Bepadin, Bepridil, Cardene, DynaCirc, Isradipine, Lacidipine, Lercanidipine, Nicardipine, ... |
| | Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. | | | The information in this article may not necessarily apply to drugs in this class for which no separate article exists. | | | Calcium-channel blockers are a family of drugs used to treat |
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http://www.truestarhealth.com/Notes/1335005.html
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| | Calcium Channel Blockers, Hypertension Medications on: The Nurse Friendly |
| | Calcium Channel Blockers:"There was a recent press release in which a class of drugs used commonly in the treatment of hypertension was purported to have been associated with an increased risk of heart attack." | | | Calcium Channel Blockers:"Pharmacology of Ca++ Channel Blockers Effects on Vascular Smooth Muscle Effects on Cardiac Cells Hemodynamic Effects Drug-Specific Effects Pharmacokinetics Toxicities and Side Effects Therapeutic Uses of Ca++ Channel Blockers Angina Arrhythmias Hypertension Less Common/Experimental Uses of Calcium Antagonists" | | | Calcium Channel Blockers, Hypertension Medications on: The Nurse Friendly |
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http://www.lopez1.com/lopez/drugs/calcium.channel.blockers.htm
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| | Heart Disease Medicine: Calcium Channel Blockers |
| | Discuss the risks and benefits of giving your child calcium channel blockers with your child's doctor. | | | Calcium channel blockers are also used to treat migraine headaches. | | | Caduet is a combination of a statin cholesterol drug and amlodipine (above). |
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http://my.webmd.com/content/pages/9/1675_57814
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| | Calcium antagonists (calcium channel blockers) - MayoClinic.com |
| | Under special circumstances, your doctor might prescribe a calcium antagonist along with other antihypertensive drugs or with a statin. | | | Which one is best for you depends on your health and the condition being treated. | | | Doctors prescribe calcium antagonists to prevent, treat or improve symptoms in a variety of conditions, such as: |
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http://mayoclinic.com/invoke.cfm?ObjectID=CB1CED06-E45C-41E1-B860780817DE5EEE
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| | CALCIUM CHANNEL BLOCKERS |
| | The exact incidence depends on which CCB is used. | | | All of these effects allow the heart to make do with a reduced blood supply and help treat the symptoms of angina. | | | Some time ago, there were reports that use of CCBs in high blood pressure patients may increase the risk of a heart attack. |
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http://www.healthyhearts.com/ccb.htm
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| | High Blood Pressure -- What Can Be Done |
| | The calcium antagonists can decrease the heart's pumping strength and relax blood vessels. | | | These can cause the muscle in blood vessel walls to relax, allowing the vessel to dilate (widen). | | | They're especially effective in the arterioles, the very small arteries that connect larger arteries to the tiny capillaries. |
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http://www.americanheart.org/presenter.jhtml?identifier=4630
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| | Slide 1 - Selective Calcium Channel Blockers for Hypertension |
| | Calcium channel blockers are commonly used antihypertensive agents that relax vascular smooth muscle and reduce vascular resistance. | | | Often considered a homogeneous family of drugs, selective calcium channel blockers actually have marked individual differences in chemical structure, binding site, tissue selectivity, and, consequently, clinical activity and therapeutic indications. | | | Two types of calcium channel blockers are used in clinical situations: those that are selective for L-type (long-lasting, large-current, or slow), voltage-dependent calcium channels, and those that are nonselective. |
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http://www.med.emory.edu/CME/CCB/slide1.html
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| | Calcium Channel Blockers |
| | All of the calcium channel blockers that have been approved for clinical use decrease coronary vascular resistance and increase coronary blood flow. | | | The calcium channel blockers relax arterial smooth muscle resulting in decreased afterload. | | | Beta-blockers will block the reflex if given with the dihydropyridines. |
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http://www.md.huji.ac.il/mirror/netpharm/AngCC.htm
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| | Calcium Channel Blockers |
| | Most short-acting calcium channel blockers have been taken off the market, and replaced by the longer-acting ones that have not been associated with increased risk for heart disease. | | | Older studies showed that short and intermediate acting calcium channel blocker may increases risk for heart attacks, and a recent study shows that longer acting calcium channel blockers also may also cause heart attacks (5). | | | There are not enough studies to prove that calcium channel blockers cause heart attacks, but the studies are suggestive enough for most doctors to reserve them for special cases. |
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http://www.healthyheartmiracle.com/reports/H204.shtml
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| | CALCIUM CHANNEL BLOCKERS |
| | Note that an inhibitor of the T-type (Transient current) cardiac calcium channel, MIBEFRADIL, has recently been terminated due to unacceptable drug interactions. | | | Most agents are negatively inotropic - non-DHP CCBs more so than DHPs. | | | Inhibit passage of calcium through the voltage gated L-type (for Large/Long-lasting current) calcium channel on vascular smooth muscle cells and cardiac myocytes, reducing calcium availability for muscle contraction. |
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http://www-clinpharm.medschl.cam.ac.uk/pages/teaching/topics/hyper/hyper8.html
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| | - Google Scholar |
| | Found no articles citing Marino: Intracellular calcium changes induced by the endozepine triakontatetraneuropeptide in human... |
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http://www.biomedcentral.com/pubmed/gs/15228623
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| | Calcium supplements and Calcium Channel Blockers |
| | Questions in The Heart Forum are being answered by doctors from The Cleveland Clinic Heart Center, consistently ranked the #1 Heart Center in America. | | | If you would like to make an appointment at the Cleveland Clinic, please call 216-444-2200 or inquire online by using The Cleveland Clinic Web site. | | | Calcium will decrease the effects of ca channel blockers at high doses. |
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http://www.medhelp.org/forums/cardio/messages/31424.html
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| | Calcium Channel Blockers - Page 1 - HeartCenterOnline: |
| | First used in the 1980s, calcium channel blockers (also called CCBs or calcium antagonists) are non–habit–forming medications that prevent the flow of calcium ions into the muscle cells of the heart and | | | (Calcium Antagonists, Calcium Channel Antagonists, Slow Channel Calcium Antagonists, Slow Channel Blockers, CCB) | | | Calcium Channel Blockers - Page 1 - HeartCenterOnline: |
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http://heart.healthcentersonline.com/bloodpressure/calciumchannelblockers.cfm
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| | Slide 3 - Selective Calcium Channel Blockers: Pharmacokinetics |
| | With verapamil and diltiazem, protein binding is independent of drug concentrations, making displacement interactions unlikely. | | | Because the older calcium channel blockers have relatively short half-lives, extended-release formulations have been developed to permit once- or twice-daily administration. | | | All the selective calcium channel blockers are well absorbed after oral administration, although there are marked differences in oral bioavailability that relate to differences in first-pass metabolism. |
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http://www.med.emory.edu/CME/CCB/slide3.html
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