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Topic: Calcitonin



  
 Journal of Family Practice: Calcitonin in the treatment of osteoporotic bone pain
Interest in using calcitonin to treat osteoporotic bone pain arose from clinical observations that it possessed analgesic qualities.[6-16] In several studies, pain relief induced by calcitonin preceded any significant effect on the skeletal disorder.[15,16] This suggests that calcitonin possesses a primary analgesic property that is independent of its effect on bone.
Calcitonin has been observed to have an analgesic effect on painful bone conditions.
Calcitonin; bone regeneration; pain; osteoporosis; spinal cord compression.
http://www.findarticles.com/p/articles/mi_m0689/is_n1_v35/ai_12436052   (1160 words)

  
 calcitonin - Osteoporosis: health and medical information about Osteoporosis, bone loss and bone density
Calcitonin can decrease bone turnover and bone pain in patients with Paget's disease.
Paget's disease is a bone disease characterized by a disorderly and accelerated remodeling of the bone, leading to bone weakness and pain.
Injectable calcitonin should be given using sterile technique.
http://www.medicinenet.com/calcitonin/article.htm   (590 words)

  
 Calcitonin for osteoporosis - [Medication]
Calcitonin slows thinning of bone in the spine, hip (pelvis), and ends of the long bones (trabecular bone), although it does not appear to be as effective as other medicines, such as raloxifene or alendronate, at building bone mass and reducing the risk of fractures.
Calcitonin helps relieve pain from broken bones caused by osteoporosis.
It helps regulate calcium levels in your body and is involved in the process of bone building.
http://www.peacehealth.org/kbase/topic/detail/drug/hw128456/detail.htm   (321 words)

  
 calcitonin nasal, Eastern Carolina
Before using calcitonin nasal, tell your doctor if you have any nasal or sinus problems such as nasal deformities, a chronic infection, or nasal pain.
There are no other known interactions between calcitonin nasal and other medicines; however, interactions may occur.
Your pharmacist has addition information about calcitonin written for health professionals that you may read.
http://www.uhseast.com/147794.cfm   (921 words)

  
 Endogenous calcitonin gene-related peptide modulates tachycardiac but not bradycardiac baroreflex in rats -- Kim et al. ...
Topographic localization of calcitonin gene-related peptide in the rat brain: an immunohistochemical analysis.
Modulation of voltage-activated channels by calcitonin gene-related peptide in cultured rat neurons.
Modulation of the aortic baroreceptor reflex by neuropeptide Y, neurotensin and vasopressin microinjected into the nucleus tractus solitarii of the rat.
http://ajpheart.physiology.org/cgi/content/full/274/5/H1489   (3237 words)

  
 Calcitonin Information and Resources Online at The Drug Database - Find Useful Articles and Websites on Calcitonin ...
Calcitonin inhibits bone resorption and can be used as a medication to treat several bone...
Most calcitonin in the human body is produced in...
By clicking into our directory you will be able to narrow down your search by the type of drug or medication you are looking for.
http://www.thedrugdatabase.com/directory/C/Calcitonin   (315 words)

  
 Ca2+-induced Ca2+ release involved in positive inotropic effect mediated by CGRP in ventricular myocytes -- Huang et ...
Calcitonin gene-related peptide stimulates a positive contractile response in rat ventricular cardiomyocytes.
The origin of circulating calcitonin gene-related peptide in the rat.
Localization and characterization of calcitonin gene-related peptide mRNA in rat heart.
http://ajpregu.physiology.org/cgi/content/full/276/1/R259   (3524 words)

  
 Calcitonin, Calcimar, Miacalcin Nasal
As a drug inhaled through the nose, it is used primarily to treat certain types of osteoporosis as well as to provide symptomatic relief from pain due to acute fractures or compression of the bones in the spine.
Supplementation with 1,500 mg per day of calcium enhances the effects of nasal calcitonin on bone mass of the lumbar spine.
Use of our encyclopedia will enable you to make well-informed, responsible decisions for the promotion of your own health and wellness.
http://www.truestarhealth.com/Notes/1333003.html   (308 words)

  
 MedlinePlus Drug Information: Calcitonin (Systemic)
This medicine may be used to treat other conditions as determined by your doctor.
Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing the use of calcitonin in children with use in other age groups.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do.
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202106.html   (1387 words)

  
 Calcitonin and bone formation: a knockout full of surprises -- Zaidi et al. 110 (12): 1769 -- Journal of Clinical ...
calcitonin formulations have been developed and are in use worldwide.
Regulation of extracellular calcium sensing in rat osteoclasts by femtomolar calcitonin concentrations.
Calcitonin and bone formation: a knockout full of surprises -- Zaidi et al.
http://www.jci.org/cgi/content/full/110/12/1769   (1645 words)

  
 VI. Meta-Analysis of Calcitonin for the Treatment of Postmenopausal Osteoporosis -- Cranney et al. 23 (4): 540 -- ...
Overgaard K 1994 Effect of intranasal calcitonin therapy on bone and bone turnover in early postmenopausal women; a dose response study.
bone density with calcitonin therapy in the lumbar spine for
Dottori L, D’Ottavio D, Brundisini B 1982 [Calcifediol and calcitonin in the therapy of rheumatoid arthritis.
http://edrv.endojournals.org/cgi/content/full/23/4/540   (5322 words)

  
 Calcitonin Injections
Human calcitonin (such as Cibacalcin) and synthetic salmon calcitonin (such as Miacalcin and Calcimar), are two types of calcitonin therapy used to:
This information is provided by the Cleveland Clinic and is not intended to replace the medical advice of your doctor or health care provider.
Always contact your doctor if you have questions about your personal situation.
http://www.clevelandclinic.org/health/health-info/docs/0600/0667.asp   (310 words)

  
 Progesterone Induces Calcitonin Expression in the Baboon Endometrium Within the Window of Uterine Receptivity -- Kumar ...
Progesterone regulates calcitonin expression in rat uterus [10,
The corresponding densitometric analysis expressed as the mean of three different experiments is shown in the lower panel.
Results are expressed relative to GAPDH and are plotted as the mean ± SEM for at least three separate experiments.
http://www.biolreprod.org/cgi/content/full/68/4/1318   (3210 words)

  
 ATP-sensitive K+ channel activation by calcitonin gene-related peptide and protein kinase A in pig coronary arterial ...
Calcitonin gene-related peptide (CGRP) is an extremely potent vasodilator in the coronary circulation of several species, including humans, pigs and rats (for review see Bell and McDermott, 1996).
CGRP-immunoreactive nerve fibres are present throughout the non-adrenergic non-cholinergic innervation of the vasculature, and in the coronary circulation local release of CGRP from these fibres may contribute substantially to basal coronary blood flow (Yaoita, Sato, Kawaguchi, Saito, Maehara and Maruyama, 1994).
Prieto, D., Benedito, S. and Nyborg, N. Heterogeneous involvement of endothelium in calcitonin gene-related peptide-induced relaxation in coronary arteries from the rat.
http://jp.physoc.org/cgi/content/full/507/1/117   (7677 words)

  
 NEUROPEPTIDES AND NEUROGENIC MECHANISMS IN ORAL AND PERIODONTAL INFLAMMATION -- Lundy and Linden 15 (2): 82 -- Critical ...
Quantitative analysis of substance P, neurokinin A and calcitonin gene-related peptide in gingival crevicular fluid associated with painful human teeth.
Quantitative analysis of substance P, neurokinin A and calcitonin gene-related peptide in pulp tissue from painful and healthy human teeth.
Selective antagonism of calcitonin-induced osteoclastic quiescence (q-effect) by human calcitonin gene-related peptide (Val8phe37).
http://crobm.iadrjournals.org/cgi/content/full/15/2/82   (8109 words)

  
 Calcitonin for Paget's disease - [Medication]
It helps manage bone pain and may relieve some symptoms of nerve problems such as ringing in the ears and hearing loss.
You or a family member usually learns how to give the shot properly.
Calcitonin can cause a decrease in symptoms such as bone pain.
http://www.peacehealth.org/kbase/topic/detail/drug/hw189307/detail.htm   (346 words)

  
 ARUP: Calcitonin
The most notable condition expressing elevated calcitonin levels is medullary thyroid carcinoma (MTC).
Elevated levels of calcitonin (>100 pg/mL) may be encountered in a variety of pathological conditions including leukemias and myeloproliferative disorders.
Calcitonin levels may be elevated before there is any clinical evidence of a tumor.
http://www.aruplab.com/guides/clt/tests/clt_a137.jsp   (308 words)

  
 Vascular Actions of Calcitonin Gene-Related Peptide and Adrenomedullin -- Brain and Grant 84 (3): 903 -- Physiological ...
Role of Nitric Oxide in Mediating In Vivo Vascular Responses to Calcitonin Gene-Related Peptide in Essential and Peripheral Circulations in the Fetus
of calcitonin gene-related peptide (CGRP) and the structurally
Calcitonin gene-related peptide antagonism attenuates the haemodynamic and glycaemic responses to acute hypoxaemia in the late gestation sheep fetus
http://physrev.physiology.org/cgi/content/abstract/84/3/903   (546 words)

  
 Calcitonin Expression in Rat Anterior Pituitary Gland Is Regulated by Ovarian Steroid Hormones -- Sun et al. 143 (10): ...
Sexton PM, Hilton JM 1992 Biologically active salmon calcitonin-like peptide is present in rat brain.
Stevenson JC 1980 The structure and function of calcitonin.
Freed WJ, Perlow MJ, Wyatt RJ 1979 Calcitonin: inhibitory effect on eating in rats.
http://endo.endojournals.org/cgi/content/full/143/10/4056   (5090 words)

  
 The immunohistochemical expression of calcitonin receptor-like receptor (CRLR) in human gliomas -- Benes et al. 57 (2): ...
Aim: To determine whether CRLR is expressed in human gliomas
The immunohistochemical expression of calcitonin receptor-like receptor (CRLR) in human gliomas
The immunohistochemical expression of calcitonin receptor-like receptor (CRLR) in human gliomas -- Benes et al.
http://jcp.bmjjournals.com/cgi/content/abstract/57/2/172   (272 words)

  
 Calcitonin - Wikipedia, the free encyclopedia
Salmon calcitonin is used for the treatment of:
Calcitonin is a a 32 amino acid polypeptide hormone that is produced in humans primarily by the C cells of the thyroid, and in many other animals in the ultimobrachial body.
Specifically, calcitonin reduces blood calcium levels in three ways:
http://en.wikipedia.org/wiki/Calcitonin   (186 words)

  
 Calcitonin
Bone biopsies from patients treated with the drug show no effects on mineralization.
Minor adverse effects such as nasal irritation are seen in a small number of patients.
Calcitonin does not reduce the serum calcium levels below normal in patients with postmenopausal osteoporosis.
http://courses.washington.edu/bonephys/opcalcitonin.html   (187 words)

  
 Human Calcitonin Acetate - HOR- 266
human calcitonin (hCT), which is more potent and longer lasting than human CT, has been used widely for the treatment of osteoporosis, paget's disease, hypercalcemic shock and chronic pain in terminal cancer patients.
[Effectiveness of intranasal salmon calcitonin treatment in postmenopausal osteoporosis]
O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
http://www.prospec.co.il/~prospec/cart/catalog/hCT.html   (352 words)

  
 Osteoporosis: Treating with Miacalcin and Fosamax.
Calcitonin is a powerful inhibitor of osteoclastic activity (the cells which continuously reabsorb bone: see our page on this).
Some physicians have reported that calcitonin may decrease bone pain associated with osteoporotic fractures.
The skeletal effects of calcitonin may be slightly less than they are for estrogens or biophosphonates.
http://www.endocrineweb.com/osteoporosis/fosamax.html   (511 words)

  
 Role of K+ATP Channels, Endothelin A Receptors, and Effect of Angiotensin II on Blood Flow in Oral Tissues -- Berggreen ...
ABT-627, an endothelin ET(A) receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain.
Calcitonin gene-related peptide relaxes porcine coronary arteries via cyclic AMP-dependent mechanisms, but not activation of ATP-sensitive potassium channels.
Response of pulpal blood flow to intra-arterial infusion of endothelin.
http://jdr.iadrjournals.org/cgi/content/full/82/1/33   (3121 words)

  
 Calcitonin gene expression induced by lipopolysaccharide in the rat pituitary -- Kiriyama et al. 282 (6): 1380 -- AJP - ...
Calcitonin gene expression induced by lipopolysaccharide in the rat pituitary
Calcitonin gene expression induced by lipopolysaccharide in the rat pituitary -- Kiriyama et al.
Procalcitonin (PCT), the precursor protein of calcitonin (CT), has been considered recently as a significant indicator of
http://ajpendo.physiology.org/cgi/content/abstract/282/6/E1380   (134 words)

  
 Receptor Activity Modifying Proteins (RAMPs) and Calcitonin Receptor Like Receptor (CRLR)
Calcitonin causes hypercalcemia by acting as an inhibitor of osteoclast induced bone resorption.
The calcitonin family of bioactive peptides comprises of
is a 37-aa peptide produced by tissue specific processing of the calcitonin gene.
http://www.4adi.com/flr/rampflr.html   (678 words)

  
 Calcitonin
Calcitonin levels greater than 100 pg/mL may occur in the following conditions: Medullary thyroid carcinomas (MTC), leukemias, and myeloproliferative disorders.
Provocative testing (calcium) is suggested in patients with MTC if the calcitonin is not clearly diagnostic.
Other orders for tests must be submitted as another sample.
http://www.medicine.uiowa.edu/Path_Handbook/handbook/test362.html   (93 words)

  
 International Union of Pharmacology. XXXII. The Mammalian Calcitonin Gene-Related Peptides, Adrenomedullin, Amylin, and ...
Hilton JM, Chai SY and Sexton PM (1995) In vitro autoradiographic localisation of the calcitonin receptor isoforms, C1a and C1b, in rat brain.
Champion HC, Santiago JA, Murphy WA, Coy DH and Kadowitz PJ (1997) Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat.
Giuliani S, Wimalawansa SJ and Maggi CA (1992) Involvement of multiple receptors in the biological effects of calcitonin gene-related peptide and amylin in rat and guinea-pig preparations.
http://pharmrev.aspetjournals.org/cgi/content/full/54/2/233   (7724 words)

  
 Characterization of binding sites for amylin, calcitonin, and CGRP in primate kidney -- Chai et al. 274 (1): 51 -- AJP ...
for amylin, calcitonin, and CGRP in primate renal function.
revealed peptide specificity profiles for CGRP and calcitonin
relatively higher affinity for calcitonin peptides but reduced
http://ajprenal.physiology.org/cgi/content/abstract/274/1/F51   (213 words)

  
 calcitonin - definition of calcitonin in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and ...
This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.
calcitonin - definition of calcitonin in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia.
A peptide hormone, produced by the thyroid gland in humans, that acts to lower plasma calcium and phosphate levels without augmenting calcium accretion.
http://medical-dictionary.thefreedictionary.com/calcitonin   (94 words)

  
 Calcitonin-Specific Transcription and Splicing Targets Gene-Directed Enzyme Prodrug Therapy to Medullary Thyroid ...
Zhang R, DeGroot LJ 2000 Gene therapy of established medullary thyroid carcinoma with herpes simplex viral thymidine kinase in a rat tumor model: relationship of bystander effect and antitumor efficacy.
Lou H, Cote GJ, Gagel RF 1994 The calcitonin exon and its flanking intronic sequences are sufficient for the regulation of human calcitonin/calcitonin gene-related peptide alternative RNA splicing.
Bennett MM, Amara SG 1992 Molecular mechanisms of cell-specific and regulated expression of the calcitonin/
http://jcem.endojournals.org/cgi/content/full/88/3/1310   (6179 words)

  
 Expression of calcitonin receptors in mouse preimplantation embryos and their function in the regulation of blastocyst ...
Calcitonin Down-regulates E-cadherin Expression in Rodent Uterine Epithelium during Implantation
Department of Obstetrics and Gynecology and Department of Anatomy and Cell Biology, C. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201-1415, USA.
Expression of calcitonin receptors in mouse preimplantation embryos and their function in the regulation of blastocyst differentiation by calcitonin -- Wang et al.
http://dev.biologists.org/cgi/content/abstract/125/21/4293   (504 words)

  
 Calcium intake by rats: influence of parathyroid hormone, calcitonin, and 1,25-dihydroxyvitamin D -- Tordoff et al. 274 ...
Calcium intake by rats: influence of parathyroid hormone, calcitonin, and 1,25-dihydroxyvitamin D
Calcitonin: regional distribution of the hormone and its binding sites in the human brain and pituitary.
Induction of hypocalcemia by intracerebroventricular injection of calcitonin: evidence for the control of blood calcium by the nervous system.
http://ajpregu.physiology.org/cgi/content/full/274/1/R214   (9941 words)

  
 Peritoneal Exudate Cells Treated with Calcitonin Gene-Related Peptide Suppress Murine Experimental Autoimmune ...
Peritoneal Exudate Cells Treated with Calcitonin Gene-Related Peptide Suppress Murine Experimental Autoimmune Uveoretinitis via IL-10 -- Kezuka et al.
Peritoneal Exudate Cells Treated with Calcitonin Gene-Related Peptide Suppress Murine Experimental Autoimmune Uveoretinitis via IL-10
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
http://www.jimmunol.org/cgi/content/abstract/173/2/1454   (280 words)

  
 News - FDA Approves Fortical (calcitonin-salmon), Unigene's Nasal Calcitonin Product for Postmenopausal Osteoporosis
Fortical is indicated for the treatment of postmenopausal osteoporosis in women greater than 5 years postmenopause with low bone mass relative to healthy premenopausal women.
FAIRFIELD, N.J. -- August 15, 2005 -- Unigene Laboratories, Inc. has received approval from the U.S. Food and Drug Administration ("FDA") for Fortical® calcitonin-salmon (rDNA origin) Nasal Spray, its patented nasal calcitonin product for the treatment of postmenopausal osteoporosis.
Click here if this is not your Personal Edition
http://www.docguide.com/news/content.nsf/news/8525697700573E188525705E004EBF1D   (464 words)

  
 Calcitonin gene-related peptide elevates calcium and polarizes membrane potential in MG-63 cells by both ...
Published data suggest that the neuropeptide calcitonin gene-related
This article has been cited by other articles:
Calcitonin gene-related peptide elevates calcium and polarizes membrane potential in MG-63 cells by both cAMP-independent and -dependent mechanisms -- Burns et al.
http://ajpcell.physiology.org/cgi/content/abstract/287/2/C457   (384 words)

  
 Miacalcin Online, Description, Chemistry, Ingredients - Calcitonin (salmon) - RxList Monographs
The activity of calcitonin (salmon) nasal spray is stated in International Units based on bioassay in comparison with the International Reference Preparation of calcitonin (salmon) for Bioassay, distributed by the National Institute of Biologic Standards and Control, Holly Hill, London.
This is shown by the following graphic formula:
Calcitonin (salmon) is a synthetic polypeptide of 32 amino acids in the same linear sequence that is found in calcitonin of salmon origin.
http://www.rxlist.com/cgi/generic2/calcit.htm   (246 words)

  
 Engineering Ex Vivo-Expanded Marrow Stromal Cells to Secrete Calcitonin Gene-Related Peptide Using Adenoviral Vector -- ...
Key Words: Marrow stromal cells · Calcitonin gene–related peptide · Adenovirus · Gene expression · Differentiation · Gene therapy
Engineering Ex Vivo-Expanded Marrow Stromal Cells to Secrete Calcitonin Gene-Related Peptide Using Adenoviral Vector -- Deng et al.
Engineering Ex Vivo–Expanded Marrow Stromal Cells to Secrete Calcitonin Gene–Related Peptide Using Adenoviral Vector
http://stemcells.alphamedpress.org/cgi/content/abstract/22/7/1279   (276 words)

  
 Regulation of the Cell-specific Calcitonin/Calcitonin Gene-related Peptide Enhancer by USF and the Foxa2 Forkhead ...
The abbreviations used are: CT, calcitonin; CGRP, calcitonin
To whom correspondence should be addressed: Dept. of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242.
RNA; TK, thymidine kinase; EMSA, electrophoretic mobility shift
http://www.jbc.org/cgi/content/full/279/48/49948   (5314 words)

  
 Ablation of calcitonin/calcitonin gene-related peptide-{alpha} impairs fetal magnesium but not calcium homeostasis -- ...
gene knockout model (Ct/Cgrp null) to determine whether calcitonin
Submitted 16 January 2004 ; accepted in final form 18 March 2004
http://ajpendo.physiology.org/cgi/content/abstract/287/2/E218   (297 words)

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